Optimized production and quality control of 68Ga-EDTMP for small clinical trials View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-07

AUTHORS

Alireza Mirzaei, Amir R. Jalilian, Ali Badbarin, Mohammad Mazidi, Fatemeh Mirshojaei, Parham Geramifar, Davood Beiki

ABSTRACT

OBJECTIVE: Optimized production and quality control of gallium-68 labeled ethylenediamine tetramethylene phosphonate ((68)Ga-EDTMP) as an efficient PET radiotracer for bone scans have been presented. METHODS: Efforts have been made to present a fast, efficient, cost-effective and facile protocol for (68)Ga-EDTMP productions for clinical trials. (68)Ga-EDTMP was prepared using generator-based (68)GaCl3 and EDTMP at optimized conditions for time, temperature, ligand amount, gallium content followed by proper formulation. The biodistribution of the tracer in rats was studied using tissue counting and PET/CT imaging up to 155 min. RESULTS: (68)Ga-EDTMP was prepared at optimized conditions in 5-10 min at 50-60 °C (radiochemical purity ≈99 ± 0.88 % ITLC, >99 % HPLC, specific activity: 15-18 GBq/mM). The biodistribution of the tracer demonstrated high bone uptake of the tracer in 10-20 min while yielding the best images in 2 h. CONCLUSION: The whole production and quality control of (68)Ga-EDTMP including labeling, purification, HPLC analysis, sterilization and LAL test took 18-20 min with significant specific activity for administration to limited number of patients in a PET center. More... »

PAGES

506-511

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12149-015-0971-9

DOI

http://dx.doi.org/10.1007/s12149-015-0971-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035542478

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25903357


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