Assessment of human effective absorbed dose of 67 Ga–ECC based on biodistribution rat data View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-02

AUTHORS

Saeed Shanehsazzadeh, Hassan Yousefnia, Afsaneh Lahooti, Samaneh Zolghadri, Amir Reza Jalilian, Hossien Afarideh

ABSTRACT

OBJECTIVE: In a diagnostic context, determination of absorbed dose is required before the introduction of a new radiopharmaceutical to the market to obtain marketing authorization from the relevant agencies. In this work, the absorbed dose of [67 Ga]-ethylenecysteamine cysteine [(67 Ga)ECC] to human organs was determined by using distribution data for rats. METHODS: For biodistribution data, the animals were sacrificed by CO2 asphyxiation at selected times after injection (0.5, 2 and 48 h, n = 3 for each time interval), then the tissue (blood, heart, lung, brain, intestine, feces, skin, stomach, kidneys, liver, muscle and bone) were removed. The absorbed dose was determined by Medical Internal Radiation Dose (MIRD) method after calculating cumulated activities in each organ. RESULTS: Our prediction shows that a 185-MBq injection of (67)Ga-ECC into the humans might result in an estimated absorbed dose of 0.029 mGy in the whole body. The highest absorbed doses are observed in the spleen and liver with 33.766 and 16.847 mGy, respectively. CONCLUSION: The results show that this radiopharmaceutical can be a good SPECT tracer since it can be produced easily and also the absorbed dose in each organ is less than permitted absorbed dose. More... »

PAGES

118-124

References to SciGraph publications

  • 2011-12. Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine – a review in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2008-10. Preparation and biodistribution of [67Ga]-DTPA-gonadorelin in normal rats in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • 2010-04. Development of radiogallium–ethylenecysteamine cysteine complex as a possible renal imaging agent in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • 2013-02. Biodistribution of ultra small superparamagnetic iron oxide nanoparticles in BALB mice in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • 2012. Radiation Damage in Biomolecular Systems in NONE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12149-014-0917-7

    DOI

    http://dx.doi.org/10.1007/s12149-014-0917-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018237375

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25311500


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