Synthesis and evaluation of Tc-99m DTPA–glutathione as a non-invasive tumor imaging agent in a mouse colon cancer model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-03-14

AUTHORS

Dae-Weung Kim, Woo Hyoung Kim, Myoung Hyoun Kim, Chang Guhn Kim, Chang-Sok Oh, Jung-Joon Min

ABSTRACT

PurposeGlutathione (GSH) plays a critical role in detoxification reactions by reducing the levels of reactive oxygen species in cancer cells. This study aimed to develop technetium (Tc)-99m diethylenetriaminepentaacetic acid (DTPA)–GSH as a tumor imaging agent, and to evaluate the diagnostic performance of Tc-99m DTPA–GSH in terms of its ability to differentiate tumors from inflammatory lesions.MethodsDTPA–GSH was synthesized by reaction of GSH with DTPA anhydride under anhydrous conditions in a nitrogen atmosphere. DTPA–GSH was then reacted with Tc-99m sodium pertechnetate in a tin (II) chloride (SnCl2) solution. Gamma camera imaging was performed after intravenous injection of Tc-99m DTPA–GSH into a mouse CT-26 colon cancer model, or a mouse model of inflammation induced by the intramuscular injection of Freund’s complete adjuvant.ResultsDTPA–GSH was successfully prepared via a straightforward synthetic procedure and radiolabeled with Tc-99m at a high labeling efficiency (>95 %). Tc-99m DTPA–GSH was strongly internalized by tumors in colon cancer model mice, with the tumor-to-normal muscle ratio of the complex reaching 4.3 ± 0.9 at 4 h. By contrast, Tc-99m DTPA–GSH showed relatively weak uptake in inflammatory lesions (target-to-non-target ratio = 2.0 ± 0.3 at 4 h). A competition study showed that the uptake of Tc-99m DTPA–GSH into tumors was blocked by co-injection with high concentrations of free GSH.ConclusionsThe results of this work indicate that Tc-99m DTPA–GSH is a good candidate for development as a non-invasive tumor imaging agent. Furthermore, Tc-99m DTPA–GSH effectively distinguished between cancerous tissue and inflammatory lesions. More... »

PAGES

447-454

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12149-014-0835-8

DOI

http://dx.doi.org/10.1007/s12149-014-0835-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018289061

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24627293


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