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    "description": "PurposeGlutathione (GSH) plays a critical role in detoxification reactions by reducing the levels of reactive oxygen species in cancer cells. This study aimed to develop technetium (Tc)-99m diethylenetriaminepentaacetic acid (DTPA)\u2013GSH as a tumor imaging agent, and to evaluate the diagnostic performance of Tc-99m DTPA\u2013GSH in terms of its ability to differentiate tumors from inflammatory lesions.MethodsDTPA\u2013GSH was synthesized by reaction of GSH with DTPA anhydride under anhydrous conditions in a nitrogen atmosphere. DTPA\u2013GSH was then reacted with Tc-99m sodium pertechnetate in a tin (II) chloride (SnCl2) solution. Gamma camera imaging was performed after intravenous injection of Tc-99m DTPA\u2013GSH into a mouse CT-26 colon cancer model, or a mouse model of inflammation induced by the intramuscular injection of Freund\u2019s complete adjuvant.ResultsDTPA\u2013GSH was successfully prepared via a straightforward synthetic procedure and radiolabeled with Tc-99m at a high labeling efficiency (>95\u00a0%). Tc-99m DTPA\u2013GSH was strongly internalized by tumors in colon cancer model mice, with the tumor-to-normal muscle ratio of the complex reaching 4.3\u00a0\u00b1\u00a00.9 at 4\u00a0h. By contrast, Tc-99m DTPA\u2013GSH showed relatively weak uptake in inflammatory lesions (target-to-non-target ratio\u00a0=\u00a02.0\u00a0\u00b1\u00a00.3 at 4\u00a0h). A competition study showed that the uptake of Tc-99m DTPA\u2013GSH into tumors was blocked by co-injection with high concentrations of free GSH.ConclusionsThe results of this work indicate that Tc-99m DTPA\u2013GSH is a good candidate for development as a non-invasive tumor imaging agent. Furthermore, Tc-99m DTPA\u2013GSH effectively distinguished between cancerous tissue and inflammatory lesions.", 
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