Usefulness of scintigraphy to predict electrical storms in severe idiopathic dilated cardiomyopathy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02-19

AUTHORS

Masateru Takigawa, Keisuke Kiso, Takashi Noda, Takashi Kurita, Yuko Yamada, Hideo Okamura, Kazuhiro Satomi, Kazuhiro Suyama, Naohiko Aihara, Mamoru Nanasato, Haruo Hirayama, Shiro Kamakura, Wataru Shimizu, Yoshio Ishida

ABSTRACT

BackgroundAlthough several predictors of an electrical storm (ES) are indicated in patients with idiopathic dilated cardiomyopathy (IDCM), whether the severity of the myocardial tissue damage (SMTD) evaluated by myocardial perfusion SPECT (MPS) has an association with an ES remains unclear. The purpose of this study was to elucidate the clinical significance of SMTD for the prediction of ES in IDCM patients with an ICD.MethodsThirty-seven (27 men, mean age 58 ± 15 years) IDCM patients receiving ICD implantations for secondary prevention with preoperative MPS were enrolled in this study. The medical history, physical and laboratory findings, electrocardiograms, echocardiograms and MPS findings were evaluated. The SMTD was assessed by the summed scores of 17 segments using a 4-point system (0, normal ~3, severe defect).ResultsDuring a mean follow-up of 43.9 ± 30.7 months, an ES developed in 12/37 (32.4 %) patients. The SMTD score predicted an ES with a 92 % sensitivity and 56 % specificity, at a cut-off score of 10. In addition, a multivariate analysis showed that the SMTD score remained an independent predictor of an ES (HR 1.09/score 1 increase, 95 % CI 1.01–1.19, p = 0.02). The SMTD score was significantly associated with three indices of late potentials on the signal-averaged electrocardiograms, and was significantly higher in patients with positive late potentials (p = 0.0006).ConclusionSMTD score assessed by MPS has a strong correlation to the late potentials and higher SMTD score may increase the risk of ES among patients with IDCM and an ICD. More... »

PAGES

407-415

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12149-013-0699-3

DOI

http://dx.doi.org/10.1007/s12149-013-0699-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019609286

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23417226


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34 SMTD
35 SPECT
36 addition
37 analysis
38 association
39 cardiomyopathy
40 clinical significance
41 correlation
42 cut
43 damage
44 echocardiogram
45 electrical storm
46 electrocardiogram
47 findings
48 history
49 implantation
50 independent predictors
51 index
52 laboratory findings
53 late potentials
54 medical history
55 months
56 multivariate analysis
57 myocardial perfusion SPECT
58 myocardial tissue damage
59 patients
60 perfusion SPECT
61 positive late potentials
62 potential
63 prediction
64 predictors
65 prevention
66 purpose
67 risk
68 scintigraphy
69 scores
70 secondary prevention
71 segments
72 sensitivity
73 severity
74 signal-averaged electrocardiogram
75 significance
76 specificity
77 storms
78 strong correlation
79 study
80 system
81 tissue damage
82 usefulness
83 usefulness of scintigraphy
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