Role of 18F-fluoride PET/CT in the assessment of multiple myeloma: initial experience View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-08-23

AUTHORS

Yuji Nishiyama, Ukihide Tateishi, Kazuya Shizukuishi, Ayako Shishikura, Etsuko Yamazaki, Hiroto Shibata, Tomohiro Yoneyama, Yoshiaki Ishigatsubo, Tomio Inoue

ABSTRACT

PurposeThe aim of this study was to report our early experience with 18F-fluoride PET/CT for detecting lesions and evaluate the usefulness of this modality in the assessment of multiple myeloma (MM).Materials and methods18F-fluoride PET/CT and 99mTc-MDP bone scintigraphy (BS) studies from 7 myeloma patients (4 male and 3 female, mean age 55 years) diagnosed according to standard criteria were reviewed retrospectively. Two reviewers visually and quantitatively analyzed the images and recorded their findings after reaching a consensus. Diagnostic certainty regarding the presence or absence of myeloma lesions was evaluated according to the reference standard consisting of whole-body magnetic resonance imaging and whole-body X-ray.ResultsA total of 93 affected areas were definite according to the reference standard. Of these, 83 affected areas (89 %) were identified on 18F-fluoride PET/CT, whereas 54 affected areas (58 %) were found on BS. Mean SUVmax in the affected areas was 9.8 ± 3.2 (standard deviation) ranging from 5.0 to 21.2. A total of s17 lesions with bone fracture were also detected by 18F-fluoride PET/CT and 2 lesions (12 %) were negative on BS.ConclusionOur result showed that 18F-fluoride PET was a possible modality to detect areas of lesions in patients with MM. More... »

PAGES

78-83

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12149-012-0647-7

DOI

http://dx.doi.org/10.1007/s12149-012-0647-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022705686

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22914967


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