Ubiquitin Immunostaining in Thyroid Neoplasms Marks True Intranuclear Cytoplasmic Pseudoinclusions and May Help Differentiate Papillary Carcinoma from NIFTP View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Vincent Cracolici, Thomas Krausz, Nicole A. Cipriani

ABSTRACT

Papillary thyroid carcinoma (PTC) is defined by an invasive growth pattern and classic nuclear features: enlarged, grooved, overlapping nuclei with chromatin clearing and intranuclear cytoplasmic pseudoinclusions (INCP). True INCPs are characteristic of PTC, but may infrequently be seen in noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP). Nuclear abnormalities that mimic INCP ("pseudo-pseudoinclusions") are common in a variety of thyroid lesions. H&E and ubiquitin-stained whole tissue sections of classic PTC (n = 25) and NIFTP (n = 35) were evaluated. On H&E, true INCPs were present in all (100%) PTCs and absent in all NIFTPs (0%). Pseudo-pseudoinclusions were present in 13 (37%) NIFTPs. In 24 (96%) PTCs, ubiquitin was strongly expressed within INCPs. In NIFTPs, optically clear nuclei or pseudo-pseudoinclusions did not express ubiquitin (0/35). Occasionally, nuclear vacuoles in NIFTP demonstrated a marginated staining pattern, in which strong ubiquitin expression was seen at the periphery of the nucleus, but the central pale area was negative. In addition, 2 NIFTPs demonstrated intrafollicular psammomatoid calcifications which were strongly ubiquitin-positive. Psammoma bodies in PTC were ubiquitin-negative in the majority of cases. We report a previously undescribed finding: strong ubiquitin expression in true INCPs in PTC, absence of true INCPs in NIFTP, and absence of ubiquitin expression in pseudo-pseudoinclusions in NIFTP. This finding supports the difference between true INCPs (found only in PTC) and pseudo-pseudoinclusions (found in NIFTP). Using strict histologic criteria and ubiquitin immunostaining, the presence of true pseudoinclusions may exclude a diagnosis of NIFTP. Caution should be exercised when interpreting nuclear vacuoles or pseudo-pseudoinclusions. More... »

PAGES

522-528

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12105-018-0905-7

DOI

http://dx.doi.org/10.1007/s12105-018-0905-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101358799

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29512025


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma, Follicular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diagnosis, Differential", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inclusion Bodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Cancer, Papillary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Department of Pathology, The University of Chicago Medical Center, 5841 S. Maryland Avenue, 60637, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cracolici", 
        "givenName": "Vincent", 
        "id": "sg:person.012013316113.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012013316113.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Department of Pathology, The University of Chicago Medical Center, 5841 S. Maryland Avenue, 60637, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krausz", 
        "givenName": "Thomas", 
        "id": "sg:person.01322466221.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322466221.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Chicago Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412578.d", 
          "name": [
            "Department of Pathology, The University of Chicago Medical Center, 5841 S. Maryland Avenue, 60637, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cipriani", 
        "givenName": "Nicole A.", 
        "id": "sg:person.01355724171.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355724171.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/cncy.21777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002223901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncy.21777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002223901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1134/s0006297910090087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012052290", 
          "https://doi.org/10.1134/s0006297910090087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1134/s0006297910090087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012052290", 
          "https://doi.org/10.1134/s0006297910090087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1134/s0006297910090087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012052290", 
          "https://doi.org/10.1134/s0006297910090087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12022-013-9242-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012119469", 
          "https://doi.org/10.1007/s12022-013-9242-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12022-013-9242-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012119469", 
          "https://doi.org/10.1007/s12022-013-9242-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2016.0386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012269166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamaoncol.2016.0386", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012269166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(20000225)90:1<41::aid-cncr6>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012961681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000327273", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012975536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0504842102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017056900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0504842102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017056900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00027.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018831114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2006.02451.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026779558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038046854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000763", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038046854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000333892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041163804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2009.03259.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042877820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.2009.03259.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042877820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.48.7.676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048332998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1507/endocrj.ej12-0294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050953032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2006.16.161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059319813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2015.0227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059322070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/ajcpeie12poiculi", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064985057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/ajcpeie12poiculi", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064985057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/yy72m308wpekl1yy", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064985320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14670/hh-16.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074762152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077267216", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077817144", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1066896910385342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078301977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1066896910385342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078301977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079155139", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079155139", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082332714", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2017.130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092347394", 
          "https://doi.org/10.1038/modpathol.2017.130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/his.13363", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099668543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5858/arpa.2017-0118-oa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101782511"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Papillary thyroid carcinoma (PTC) is defined by an invasive growth pattern and classic nuclear features: enlarged, grooved, overlapping nuclei with chromatin clearing and intranuclear cytoplasmic pseudoinclusions (INCP). True INCPs are characteristic of PTC, but may infrequently be seen in noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP). Nuclear abnormalities that mimic INCP (\"pseudo-pseudoinclusions\") are common in a variety of thyroid lesions. H&E and ubiquitin-stained whole tissue sections of classic PTC (n\u2009=\u200925) and NIFTP (n\u2009=\u200935) were evaluated. On H&E, true INCPs were present in all (100%) PTCs and absent in all NIFTPs (0%). Pseudo-pseudoinclusions were present in 13 (37%) NIFTPs. In 24 (96%) PTCs, ubiquitin was strongly expressed within INCPs. In NIFTPs, optically clear nuclei or pseudo-pseudoinclusions did not express ubiquitin (0/35). Occasionally, nuclear vacuoles in NIFTP demonstrated a marginated staining pattern, in which strong ubiquitin expression was seen at the periphery of the nucleus, but the central pale area was negative. In addition, 2 NIFTPs demonstrated intrafollicular psammomatoid calcifications which were strongly ubiquitin-positive. Psammoma bodies in PTC were ubiquitin-negative in the majority of cases. We report a previously undescribed finding: strong ubiquitin expression in true INCPs in PTC, absence of true INCPs in NIFTP, and absence of ubiquitin expression in pseudo-pseudoinclusions in NIFTP. This finding supports the difference between true INCPs (found only in PTC) and pseudo-pseudoinclusions (found in NIFTP). Using strict histologic criteria and ubiquitin immunostaining, the presence of true pseudoinclusions may exclude a diagnosis of NIFTP. Caution should be exercised when interpreting nuclear vacuoles or pseudo-pseudoinclusions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12105-018-0905-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1038557", 
        "issn": [
          "1936-055X", 
          "1936-0568"
        ], 
        "name": "Head and Neck Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Ubiquitin Immunostaining in Thyroid Neoplasms Marks True Intranuclear Cytoplasmic Pseudoinclusions and May Help Differentiate Papillary Carcinoma from NIFTP", 
    "pagination": "522-528", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "583172f8238c9fee030e185fa2a4f1e5d32f00218a84b163288bcfcd647f109b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29512025"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101304010"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12105-018-0905-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101358799"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12105-018-0905-7", 
      "https://app.dimensions.ai/details/publication/pub.1101358799"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11698_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12105-018-0905-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12105-018-0905-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12105-018-0905-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12105-018-0905-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12105-018-0905-7'


 

This table displays all metadata directly associated to this object as RDF triples.

203 TRIPLES      21 PREDICATES      66 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12105-018-0905-7 schema:about N04ad2c4815f144bdb7cf6938ba23787c
2 N0965c1c1bbba4a4eb5d3e1ed8c9161d0
3 N1f99897c61884c22a5c5d6dd3313f1b6
4 N39d1c518020544a9aa0c4993312011ba
5 N47c117e90c824ff5a9e5aecc1ae41c27
6 N4fc653f4337940a5b1c4542ded7d7653
7 N95d5a5e78f7741d3a9f15d2a6396c3c7
8 Nba9c61f460a94575a8740193f7c4533c
9 Nbf5b038889b2465fa9bbffdfd834ff4f
10 Nddc80e1fac454dba81337dde9370662b
11 anzsrc-for:11
12 anzsrc-for:1107
13 schema:author Nd27c26dc2f9b489996e85f1b270561b1
14 schema:citation sg:pub.10.1007/s12022-013-9242-2
15 sg:pub.10.1038/modpathol.2017.130
16 sg:pub.10.1134/s0006297910090087
17 https://app.dimensions.ai/details/publication/pub.1077267216
18 https://app.dimensions.ai/details/publication/pub.1077817144
19 https://app.dimensions.ai/details/publication/pub.1079155139
20 https://app.dimensions.ai/details/publication/pub.1082332714
21 https://doi.org/10.1001/jamaoncol.2016.0386
22 https://doi.org/10.1002/(sici)1097-0142(20000225)90:1<41::aid-cncr6>3.0.co;2-1
23 https://doi.org/10.1002/cncy.21777
24 https://doi.org/10.1073/pnas.0504842102
25 https://doi.org/10.1089/thy.2006.16.161
26 https://doi.org/10.1089/thy.2015.0227
27 https://doi.org/10.1097/pas.0000000000000763
28 https://doi.org/10.1111/his.13363
29 https://doi.org/10.1111/j.1365-2559.2006.02451.x
30 https://doi.org/10.1111/j.1365-2559.2009.03259.x
31 https://doi.org/10.1136/jcp.48.7.676
32 https://doi.org/10.1152/physrev.00027.2001
33 https://doi.org/10.1159/000327273
34 https://doi.org/10.1159/000333892
35 https://doi.org/10.1177/1066896910385342
36 https://doi.org/10.1309/ajcpeie12poiculi
37 https://doi.org/10.1309/yy72m308wpekl1yy
38 https://doi.org/10.14670/hh-16.1
39 https://doi.org/10.1507/endocrj.ej12-0294
40 https://doi.org/10.5858/arpa.2017-0118-oa
41 schema:datePublished 2018-12
42 schema:datePublishedReg 2018-12-01
43 schema:description Papillary thyroid carcinoma (PTC) is defined by an invasive growth pattern and classic nuclear features: enlarged, grooved, overlapping nuclei with chromatin clearing and intranuclear cytoplasmic pseudoinclusions (INCP). True INCPs are characteristic of PTC, but may infrequently be seen in noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP). Nuclear abnormalities that mimic INCP ("pseudo-pseudoinclusions") are common in a variety of thyroid lesions. H&E and ubiquitin-stained whole tissue sections of classic PTC (n = 25) and NIFTP (n = 35) were evaluated. On H&E, true INCPs were present in all (100%) PTCs and absent in all NIFTPs (0%). Pseudo-pseudoinclusions were present in 13 (37%) NIFTPs. In 24 (96%) PTCs, ubiquitin was strongly expressed within INCPs. In NIFTPs, optically clear nuclei or pseudo-pseudoinclusions did not express ubiquitin (0/35). Occasionally, nuclear vacuoles in NIFTP demonstrated a marginated staining pattern, in which strong ubiquitin expression was seen at the periphery of the nucleus, but the central pale area was negative. In addition, 2 NIFTPs demonstrated intrafollicular psammomatoid calcifications which were strongly ubiquitin-positive. Psammoma bodies in PTC were ubiquitin-negative in the majority of cases. We report a previously undescribed finding: strong ubiquitin expression in true INCPs in PTC, absence of true INCPs in NIFTP, and absence of ubiquitin expression in pseudo-pseudoinclusions in NIFTP. This finding supports the difference between true INCPs (found only in PTC) and pseudo-pseudoinclusions (found in NIFTP). Using strict histologic criteria and ubiquitin immunostaining, the presence of true pseudoinclusions may exclude a diagnosis of NIFTP. Caution should be exercised when interpreting nuclear vacuoles or pseudo-pseudoinclusions.
44 schema:genre research_article
45 schema:inLanguage en
46 schema:isAccessibleForFree false
47 schema:isPartOf N33df19da0a014f878e357c5776ee72d7
48 N4e24de0c2d95466c9ab9d978c5e8fdfa
49 sg:journal.1038557
50 schema:name Ubiquitin Immunostaining in Thyroid Neoplasms Marks True Intranuclear Cytoplasmic Pseudoinclusions and May Help Differentiate Papillary Carcinoma from NIFTP
51 schema:pagination 522-528
52 schema:productId N52d5bb5b31834bc0a5a3796c490abb29
53 N67a0daa49db644cca3e83c421f0b931e
54 N8871b86cf22f4293967fe12eecb94d2d
55 N938c3880c22d4532b93b2999788b19a2
56 Nf4c7749960f04ae99c6f9e13de1700e7
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101358799
58 https://doi.org/10.1007/s12105-018-0905-7
59 schema:sdDatePublished 2019-04-11T11:17
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher N684543f22d5e4db7abacd73020429c9c
62 schema:url https://link.springer.com/10.1007%2Fs12105-018-0905-7
63 sgo:license sg:explorer/license/
64 sgo:sdDataset articles
65 rdf:type schema:ScholarlyArticle
66 N04ad2c4815f144bdb7cf6938ba23787c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Immunohistochemistry
68 rdf:type schema:DefinedTerm
69 N0965c1c1bbba4a4eb5d3e1ed8c9161d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Humans
71 rdf:type schema:DefinedTerm
72 N1f99897c61884c22a5c5d6dd3313f1b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Thyroid Neoplasms
74 rdf:type schema:DefinedTerm
75 N2a71e4325cb14e6ab579b0eeef46f3fc rdf:first sg:person.01322466221.26
76 rdf:rest N61b661975867415bb24a6128c505c98c
77 N33df19da0a014f878e357c5776ee72d7 schema:volumeNumber 12
78 rdf:type schema:PublicationVolume
79 N39d1c518020544a9aa0c4993312011ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Diagnosis, Differential
81 rdf:type schema:DefinedTerm
82 N47c117e90c824ff5a9e5aecc1ae41c27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Cell Nucleus
84 rdf:type schema:DefinedTerm
85 N4e24de0c2d95466c9ab9d978c5e8fdfa schema:issueNumber 4
86 rdf:type schema:PublicationIssue
87 N4fc653f4337940a5b1c4542ded7d7653 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Thyroid Cancer, Papillary
89 rdf:type schema:DefinedTerm
90 N52d5bb5b31834bc0a5a3796c490abb29 schema:name pubmed_id
91 schema:value 29512025
92 rdf:type schema:PropertyValue
93 N61b661975867415bb24a6128c505c98c rdf:first sg:person.01355724171.20
94 rdf:rest rdf:nil
95 N67a0daa49db644cca3e83c421f0b931e schema:name dimensions_id
96 schema:value pub.1101358799
97 rdf:type schema:PropertyValue
98 N684543f22d5e4db7abacd73020429c9c schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N8871b86cf22f4293967fe12eecb94d2d schema:name nlm_unique_id
101 schema:value 101304010
102 rdf:type schema:PropertyValue
103 N938c3880c22d4532b93b2999788b19a2 schema:name readcube_id
104 schema:value 583172f8238c9fee030e185fa2a4f1e5d32f00218a84b163288bcfcd647f109b
105 rdf:type schema:PropertyValue
106 N95d5a5e78f7741d3a9f15d2a6396c3c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Ubiquitin
108 rdf:type schema:DefinedTerm
109 Nba9c61f460a94575a8740193f7c4533c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Inclusion Bodies
111 rdf:type schema:DefinedTerm
112 Nbf5b038889b2465fa9bbffdfd834ff4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Biomarkers, Tumor
114 rdf:type schema:DefinedTerm
115 Nd27c26dc2f9b489996e85f1b270561b1 rdf:first sg:person.012013316113.35
116 rdf:rest N2a71e4325cb14e6ab579b0eeef46f3fc
117 Nddc80e1fac454dba81337dde9370662b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Adenocarcinoma, Follicular
119 rdf:type schema:DefinedTerm
120 Nf4c7749960f04ae99c6f9e13de1700e7 schema:name doi
121 schema:value 10.1007/s12105-018-0905-7
122 rdf:type schema:PropertyValue
123 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
124 schema:name Medical and Health Sciences
125 rdf:type schema:DefinedTerm
126 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
127 schema:name Immunology
128 rdf:type schema:DefinedTerm
129 sg:journal.1038557 schema:issn 1936-055X
130 1936-0568
131 schema:name Head and Neck Pathology
132 rdf:type schema:Periodical
133 sg:person.012013316113.35 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
134 schema:familyName Cracolici
135 schema:givenName Vincent
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012013316113.35
137 rdf:type schema:Person
138 sg:person.01322466221.26 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
139 schema:familyName Krausz
140 schema:givenName Thomas
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322466221.26
142 rdf:type schema:Person
143 sg:person.01355724171.20 schema:affiliation https://www.grid.ac/institutes/grid.412578.d
144 schema:familyName Cipriani
145 schema:givenName Nicole A.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355724171.20
147 rdf:type schema:Person
148 sg:pub.10.1007/s12022-013-9242-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012119469
149 https://doi.org/10.1007/s12022-013-9242-2
150 rdf:type schema:CreativeWork
151 sg:pub.10.1038/modpathol.2017.130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092347394
152 https://doi.org/10.1038/modpathol.2017.130
153 rdf:type schema:CreativeWork
154 sg:pub.10.1134/s0006297910090087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012052290
155 https://doi.org/10.1134/s0006297910090087
156 rdf:type schema:CreativeWork
157 https://app.dimensions.ai/details/publication/pub.1077267216 schema:CreativeWork
158 https://app.dimensions.ai/details/publication/pub.1077817144 schema:CreativeWork
159 https://app.dimensions.ai/details/publication/pub.1079155139 schema:CreativeWork
160 https://app.dimensions.ai/details/publication/pub.1082332714 schema:CreativeWork
161 https://doi.org/10.1001/jamaoncol.2016.0386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012269166
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1002/(sici)1097-0142(20000225)90:1<41::aid-cncr6>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012961681
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1002/cncy.21777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002223901
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1073/pnas.0504842102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017056900
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1089/thy.2006.16.161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059319813
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1089/thy.2015.0227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059322070
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1097/pas.0000000000000763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038046854
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1111/his.13363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099668543
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1111/j.1365-2559.2006.02451.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026779558
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1111/j.1365-2559.2009.03259.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042877820
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1136/jcp.48.7.676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048332998
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1152/physrev.00027.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018831114
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1159/000327273 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012975536
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1159/000333892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041163804
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1177/1066896910385342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078301977
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1309/ajcpeie12poiculi schema:sameAs https://app.dimensions.ai/details/publication/pub.1064985057
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1309/yy72m308wpekl1yy schema:sameAs https://app.dimensions.ai/details/publication/pub.1064985320
194 rdf:type schema:CreativeWork
195 https://doi.org/10.14670/hh-16.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074762152
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1507/endocrj.ej12-0294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050953032
198 rdf:type schema:CreativeWork
199 https://doi.org/10.5858/arpa.2017-0118-oa schema:sameAs https://app.dimensions.ai/details/publication/pub.1101782511
200 rdf:type schema:CreativeWork
201 https://www.grid.ac/institutes/grid.412578.d schema:alternateName University of Chicago Medical Center
202 schema:name Department of Pathology, The University of Chicago Medical Center, 5841 S. Maryland Avenue, 60637, Chicago, IL, USA
203 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...