A Case of Primary Mammary Analog Secretory Carcinoma (MASC) of the Thyroid Masquerading as Papillary Thyroid Carcinoma: Potentially More than ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-09

AUTHORS

S. Reynolds, M. Shaheen, G. Olson, M. Barry, J. Wu, T. Bocklage

ABSTRACT

We present the second reported mammary analog secretory carcinoma (MASC) apparently arising in the thyroid and propose a potential close relationship to ETV6-NTRK3 fusion papillary thyroid carcinoma. The patient, a 36 year old woman, presented with a neck mass of 1 year's duration. Imaging studies showed a tumor involving most of the thyroid with enlarged regional lymph nodes. FNA biopsy yielded a diagnosis of "papillary thyroid carcinoma". Resection revealed a 4.5 cm infiltrative tumor. Final diagnosis was "papillary thyroid carcinoma (PTC) consistent with diffuse sclerosing variant" with positive lymph nodes (2+/4) and margins. Histologic features included mixed microcystic, solid, follicular and papillary architecture, prominent nucleoli, abundant nuclear grooves and rare nuclear pseudo-inclusions. Despite radioactive iodine, radiotherapy and multiagent chemotherapy, the patient progressed over 6 years with local recurrence and additional lymph node involvement finally developing widespread distant metastases. Prompted by the breast carcinoma-like histopathology of a metastasis, immunohistochemical staining was performed and revealed strong expression of GATA3 and mammaglobin with no reactivity for thyroglobulin or TTF-1. The original tumor was then tested and showed the same immunoprofile. RT-PCR confirmed the presence of an ETV6-NTRK3 fusion consistent with a diagnosis of MASC. Our patient's clinical, imaging and morphologic features remarkably mimicked papillary thyroid carcinoma. At the molecular level, the ETV6-NTRK3 fusion in this patient involved exons reported in the rare "papillary thyroid carcinoma" with this translocation. Given the immunophenotype of this case, it is possible that at least some ETV6-NTRK3 fusion positive PTC are actually MASC masquerading as papillary thyroid carcinoma. More... »

PAGES

405-413

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12105-016-0715-8

DOI

http://dx.doi.org/10.1007/s12105-016-0715-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051533449

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27075025


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biopsy, Fine-Needle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Papillary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diagnostic Errors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammary Analogue Secretory Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Proteins, Fusion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Cancer, Papillary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thyroid Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of New Mexico", 
          "id": "https://www.grid.ac/institutes/grid.266832.b", 
          "name": [
            "Department of Pathology, University of New Mexico School of Medicine (UNM SOM), MSC08-4640, 87131-0001, Albuquerque, NM, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reynolds", 
        "givenName": "S.", 
        "id": "sg:person.014354004515.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014354004515.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of New Mexico", 
          "id": "https://www.grid.ac/institutes/grid.266832.b", 
          "name": [
            "Division of Hematology/Oncology, Department of Internal Medicine, University of New Mexico School of Medicine (UNM SOM), Albuquerque, NM, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shaheen", 
        "givenName": "M.", 
        "id": "sg:person.015151365115.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015151365115.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of New Mexico", 
          "id": "https://www.grid.ac/institutes/grid.266832.b", 
          "name": [
            "Division of Otolaryngology, Department of Surgery, University of New Mexico School of Medicine (UNM SOM), Albuquerque, NM, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olson", 
        "givenName": "G.", 
        "id": "sg:person.01326532450.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326532450.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of New Mexico", 
          "id": "https://www.grid.ac/institutes/grid.266832.b", 
          "name": [
            "Department of Pathology, University of New Mexico School of Medicine (UNM SOM), MSC08-4640, 87131-0001, Albuquerque, NM, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barry", 
        "givenName": "M.", 
        "id": "sg:person.016544326115.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016544326115.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of New Mexico", 
          "id": "https://www.grid.ac/institutes/grid.266832.b", 
          "name": [
            "Department of Pathology, University of New Mexico School of Medicine (UNM SOM), MSC08-4640, 87131-0001, Albuquerque, NM, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "J.", 
        "id": "sg:person.0757307761.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757307761.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of New Mexico", 
          "id": "https://www.grid.ac/institutes/grid.266832.b", 
          "name": [
            "Department of Pathology, University of New Mexico School of Medicine (UNM SOM), MSC08-4640, 87131-0001, Albuquerque, NM, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bocklage", 
        "givenName": "T.", 
        "id": "sg:person.0662621006.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662621006.24"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/modpathol.2015.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001196222", 
          "https://doi.org/10.1038/modpathol.2015.64"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-014-1701-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001415198", 
          "https://doi.org/10.1007/s00428-014-1701-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-014-1701-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001415198", 
          "https://doi.org/10.1007/s00428-014-1701-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.3593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003655983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.3593", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003655983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.09.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006907054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2014.09.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006907054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.28484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009162233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci72725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016832152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci72725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016832152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019934485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019934485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181d9efcc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025753852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181d9efcc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025753852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181d9efcc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025753852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318231542a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027367099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e318231542a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027367099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12105-013-0455-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031072881", 
          "https://doi.org/10.1007/s12105-013-0455-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2013.0573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035302500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2013.0573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035302500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-015-1786-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036072803", 
          "https://doi.org/10.1007/s00428-015-1786-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65732-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037180372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037752187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037752187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(02)00180-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038314162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci69766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043718343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci69766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043718343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jop.12226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047290939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0298-184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047807659", 
          "https://doi.org/10.1038/ng0298-184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12105-013-0429-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052054180", 
          "https://doi.org/10.1007/s12105-013-0429-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.29887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052712110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.29887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052712110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079043087", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083386190", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-09", 
    "datePublishedReg": "2016-09-01", 
    "description": "We present the second reported mammary analog secretory carcinoma (MASC) apparently arising in the thyroid and propose a potential close relationship to ETV6-NTRK3 fusion papillary thyroid carcinoma. The patient, a 36\u00a0year old woman, presented with a neck mass of 1\u00a0year's duration. Imaging studies showed a tumor involving most of the thyroid with enlarged regional lymph nodes. FNA biopsy yielded a diagnosis of \"papillary thyroid carcinoma\". Resection revealed a 4.5\u00a0cm infiltrative tumor. Final diagnosis was \"papillary thyroid carcinoma (PTC) consistent with diffuse sclerosing variant\" with positive lymph nodes (2+/4) and margins. Histologic features included mixed microcystic, solid, follicular and papillary architecture, prominent nucleoli, abundant nuclear grooves and rare nuclear pseudo-inclusions. Despite radioactive iodine, radiotherapy and multiagent chemotherapy, the patient progressed over 6\u00a0years with local recurrence and additional lymph node involvement finally developing widespread distant metastases. Prompted by the breast carcinoma-like histopathology of a metastasis, immunohistochemical staining was performed and revealed strong expression of GATA3 and mammaglobin with no reactivity for thyroglobulin or TTF-1. The original tumor was then tested and showed the same immunoprofile. RT-PCR confirmed the presence of an ETV6-NTRK3 fusion consistent with a diagnosis of MASC. Our patient's clinical, imaging and morphologic features remarkably mimicked papillary thyroid carcinoma. At the molecular level, the ETV6-NTRK3 fusion in this patient involved exons reported in the rare \"papillary thyroid carcinoma\" with this translocation. Given the immunophenotype of this case, it is possible that at least some ETV6-NTRK3 fusion positive PTC are actually MASC masquerading as papillary thyroid carcinoma. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12105-016-0715-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1038557", 
        "issn": [
          "1936-055X", 
          "1936-0568"
        ], 
        "name": "Head and Neck Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "A Case of Primary Mammary Analog Secretory Carcinoma (MASC) of the Thyroid Masquerading as Papillary Thyroid Carcinoma: Potentially More than a One Off", 
    "pagination": "405-413", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f57bcb99156a80c0573d25384281f3b3519c37511453b34690a1f7a06e24869b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27075025"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101304010"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12105-016-0715-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051533449"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12105-016-0715-8", 
      "https://app.dimensions.ai/details/publication/pub.1051533449"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99803_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12105-016-0715-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12105-016-0715-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12105-016-0715-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12105-016-0715-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12105-016-0715-8'


 

This table displays all metadata directly associated to this object as RDF triples.

232 TRIPLES      21 PREDICATES      65 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12105-016-0715-8 schema:about N00c0bafd20c841e5834fb19ec879701f
2 N25d40b11b53b46678e682bd2da6bb674
3 N30e50fd8863844a5adc06aeba38ba4f3
4 N370b29bc0f2743bb9a8026884e4a75b4
5 N51ef25b315d44f9fa2378de763c32877
6 N80fc6263081b48528b3cd6f17644660c
7 N873973f01ef64666a4d8cd87986199b7
8 N8b7e2b6584bd4478a3e37356e53deea3
9 N9fe53f2823914142b939befa41e0a07d
10 Na24bd129be0d49908dfaa554f180566e
11 Nb8bddd2eb54c483e9972ac18b94c4de5
12 Ncc34dc465c1746939bb82508ac5e9ee2
13 Nf5b5bf46e59c4c89a733da07e7c74a40
14 Nf840a52b85b04c29a2ba2b822d1783a9
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N1758407664764f968ed15d8edc13c7de
18 schema:citation sg:pub.10.1007/s00428-014-1701-8
19 sg:pub.10.1007/s00428-015-1786-8
20 sg:pub.10.1007/s12105-013-0429-0
21 sg:pub.10.1007/s12105-013-0455-y
22 sg:pub.10.1038/modpathol.2015.64
23 sg:pub.10.1038/ng0298-184
24 https://app.dimensions.ai/details/publication/pub.1079043087
25 https://app.dimensions.ai/details/publication/pub.1083386190
26 https://doi.org/10.1002/cncr.28484
27 https://doi.org/10.1002/cncr.29887
28 https://doi.org/10.1016/j.cell.2014.09.050
29 https://doi.org/10.1016/s0002-9440(10)65732-x
30 https://doi.org/10.1016/s1535-6108(02)00180-0
31 https://doi.org/10.1089/thy.2013.0573
32 https://doi.org/10.1097/pas.0000000000000088
33 https://doi.org/10.1097/pas.0000000000000537
34 https://doi.org/10.1097/pas.0b013e3181d9efcc
35 https://doi.org/10.1097/pas.0b013e318231542a
36 https://doi.org/10.1111/jop.12226
37 https://doi.org/10.1172/jci69766
38 https://doi.org/10.1172/jci72725
39 https://doi.org/10.18632/oncotarget.3593
40 schema:datePublished 2016-09
41 schema:datePublishedReg 2016-09-01
42 schema:description We present the second reported mammary analog secretory carcinoma (MASC) apparently arising in the thyroid and propose a potential close relationship to ETV6-NTRK3 fusion papillary thyroid carcinoma. The patient, a 36 year old woman, presented with a neck mass of 1 year's duration. Imaging studies showed a tumor involving most of the thyroid with enlarged regional lymph nodes. FNA biopsy yielded a diagnosis of "papillary thyroid carcinoma". Resection revealed a 4.5 cm infiltrative tumor. Final diagnosis was "papillary thyroid carcinoma (PTC) consistent with diffuse sclerosing variant" with positive lymph nodes (2+/4) and margins. Histologic features included mixed microcystic, solid, follicular and papillary architecture, prominent nucleoli, abundant nuclear grooves and rare nuclear pseudo-inclusions. Despite radioactive iodine, radiotherapy and multiagent chemotherapy, the patient progressed over 6 years with local recurrence and additional lymph node involvement finally developing widespread distant metastases. Prompted by the breast carcinoma-like histopathology of a metastasis, immunohistochemical staining was performed and revealed strong expression of GATA3 and mammaglobin with no reactivity for thyroglobulin or TTF-1. The original tumor was then tested and showed the same immunoprofile. RT-PCR confirmed the presence of an ETV6-NTRK3 fusion consistent with a diagnosis of MASC. Our patient's clinical, imaging and morphologic features remarkably mimicked papillary thyroid carcinoma. At the molecular level, the ETV6-NTRK3 fusion in this patient involved exons reported in the rare "papillary thyroid carcinoma" with this translocation. Given the immunophenotype of this case, it is possible that at least some ETV6-NTRK3 fusion positive PTC are actually MASC masquerading as papillary thyroid carcinoma.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N0c7c0d32c38f4fe88c5b3e06b6ea9a40
47 N3c6e78869ea7465fa907fa5fb0889706
48 sg:journal.1038557
49 schema:name A Case of Primary Mammary Analog Secretory Carcinoma (MASC) of the Thyroid Masquerading as Papillary Thyroid Carcinoma: Potentially More than a One Off
50 schema:pagination 405-413
51 schema:productId N8838833d10d241688a2247f6a20f2284
52 Na05f82d3195a41a8b04a72faed6b4138
53 Naa2a40ce41cb4dc18e517e1c251ca81a
54 Nafc1ea7303ad4d5aa4fab1baf95c4f2a
55 Ndcb8fefe8e344ceb9dfb82cf961c54f7
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051533449
57 https://doi.org/10.1007/s12105-016-0715-8
58 schema:sdDatePublished 2019-04-11T09:31
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher Ne48a21e7c4b042a3aad01561a58fb260
61 schema:url http://link.springer.com/10.1007%2Fs12105-016-0715-8
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N00c0bafd20c841e5834fb19ec879701f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Thyroid Neoplasms
67 rdf:type schema:DefinedTerm
68 N0c7c0d32c38f4fe88c5b3e06b6ea9a40 schema:issueNumber 3
69 rdf:type schema:PublicationIssue
70 N1121b5a2c4b748619ca696c36ed7153f rdf:first sg:person.0662621006.24
71 rdf:rest rdf:nil
72 N1758407664764f968ed15d8edc13c7de rdf:first sg:person.014354004515.76
73 rdf:rest Nc0b66a5fdbd544a5a615325dd8887224
74 N25d40b11b53b46678e682bd2da6bb674 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Carcinoma, Papillary
76 rdf:type schema:DefinedTerm
77 N30e50fd8863844a5adc06aeba38ba4f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Biopsy, Fine-Needle
79 rdf:type schema:DefinedTerm
80 N370b29bc0f2743bb9a8026884e4a75b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Diagnostic Errors
82 rdf:type schema:DefinedTerm
83 N3c6e78869ea7465fa907fa5fb0889706 schema:volumeNumber 10
84 rdf:type schema:PublicationVolume
85 N51ef25b315d44f9fa2378de763c32877 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Adult
87 rdf:type schema:DefinedTerm
88 N69e59d378ea447dcb6335876daef0b3e rdf:first sg:person.01326532450.38
89 rdf:rest Nb54eb6ca73d54d1293af76e0ba7ba9e5
90 N80fc6263081b48528b3cd6f17644660c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Oncogene Proteins, Fusion
92 rdf:type schema:DefinedTerm
93 N873973f01ef64666a4d8cd87986199b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Reverse Transcriptase Polymerase Chain Reaction
95 rdf:type schema:DefinedTerm
96 N8838833d10d241688a2247f6a20f2284 schema:name nlm_unique_id
97 schema:value 101304010
98 rdf:type schema:PropertyValue
99 N8b7e2b6584bd4478a3e37356e53deea3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Carcinoma
101 rdf:type schema:DefinedTerm
102 N9fe53f2823914142b939befa41e0a07d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Mammary Analogue Secretory Carcinoma
104 rdf:type schema:DefinedTerm
105 Na05f82d3195a41a8b04a72faed6b4138 schema:name pubmed_id
106 schema:value 27075025
107 rdf:type schema:PropertyValue
108 Na24bd129be0d49908dfaa554f180566e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Thyroid Cancer, Papillary
110 rdf:type schema:DefinedTerm
111 Naa2a40ce41cb4dc18e517e1c251ca81a schema:name dimensions_id
112 schema:value pub.1051533449
113 rdf:type schema:PropertyValue
114 Nafc1ea7303ad4d5aa4fab1baf95c4f2a schema:name doi
115 schema:value 10.1007/s12105-016-0715-8
116 rdf:type schema:PropertyValue
117 Nb54eb6ca73d54d1293af76e0ba7ba9e5 rdf:first sg:person.016544326115.47
118 rdf:rest Ncbe37a12b708422a9f84f35c420299a7
119 Nb8bddd2eb54c483e9972ac18b94c4de5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Biomarkers, Tumor
121 rdf:type schema:DefinedTerm
122 Nc0b66a5fdbd544a5a615325dd8887224 rdf:first sg:person.015151365115.69
123 rdf:rest N69e59d378ea447dcb6335876daef0b3e
124 Ncbe37a12b708422a9f84f35c420299a7 rdf:first sg:person.0757307761.31
125 rdf:rest N1121b5a2c4b748619ca696c36ed7153f
126 Ncc34dc465c1746939bb82508ac5e9ee2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Humans
128 rdf:type schema:DefinedTerm
129 Ndcb8fefe8e344ceb9dfb82cf961c54f7 schema:name readcube_id
130 schema:value f57bcb99156a80c0573d25384281f3b3519c37511453b34690a1f7a06e24869b
131 rdf:type schema:PropertyValue
132 Ne48a21e7c4b042a3aad01561a58fb260 schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 Nf5b5bf46e59c4c89a733da07e7c74a40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Immunohistochemistry
136 rdf:type schema:DefinedTerm
137 Nf840a52b85b04c29a2ba2b822d1783a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Female
139 rdf:type schema:DefinedTerm
140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
141 schema:name Medical and Health Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
144 schema:name Oncology and Carcinogenesis
145 rdf:type schema:DefinedTerm
146 sg:journal.1038557 schema:issn 1936-055X
147 1936-0568
148 schema:name Head and Neck Pathology
149 rdf:type schema:Periodical
150 sg:person.01326532450.38 schema:affiliation https://www.grid.ac/institutes/grid.266832.b
151 schema:familyName Olson
152 schema:givenName G.
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326532450.38
154 rdf:type schema:Person
155 sg:person.014354004515.76 schema:affiliation https://www.grid.ac/institutes/grid.266832.b
156 schema:familyName Reynolds
157 schema:givenName S.
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014354004515.76
159 rdf:type schema:Person
160 sg:person.015151365115.69 schema:affiliation https://www.grid.ac/institutes/grid.266832.b
161 schema:familyName Shaheen
162 schema:givenName M.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015151365115.69
164 rdf:type schema:Person
165 sg:person.016544326115.47 schema:affiliation https://www.grid.ac/institutes/grid.266832.b
166 schema:familyName Barry
167 schema:givenName M.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016544326115.47
169 rdf:type schema:Person
170 sg:person.0662621006.24 schema:affiliation https://www.grid.ac/institutes/grid.266832.b
171 schema:familyName Bocklage
172 schema:givenName T.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662621006.24
174 rdf:type schema:Person
175 sg:person.0757307761.31 schema:affiliation https://www.grid.ac/institutes/grid.266832.b
176 schema:familyName Wu
177 schema:givenName J.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757307761.31
179 rdf:type schema:Person
180 sg:pub.10.1007/s00428-014-1701-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001415198
181 https://doi.org/10.1007/s00428-014-1701-8
182 rdf:type schema:CreativeWork
183 sg:pub.10.1007/s00428-015-1786-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036072803
184 https://doi.org/10.1007/s00428-015-1786-8
185 rdf:type schema:CreativeWork
186 sg:pub.10.1007/s12105-013-0429-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052054180
187 https://doi.org/10.1007/s12105-013-0429-0
188 rdf:type schema:CreativeWork
189 sg:pub.10.1007/s12105-013-0455-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1031072881
190 https://doi.org/10.1007/s12105-013-0455-y
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/modpathol.2015.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001196222
193 https://doi.org/10.1038/modpathol.2015.64
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/ng0298-184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047807659
196 https://doi.org/10.1038/ng0298-184
197 rdf:type schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1079043087 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1083386190 schema:CreativeWork
200 https://doi.org/10.1002/cncr.28484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009162233
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/cncr.29887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052712110
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.cell.2014.09.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006907054
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/s0002-9440(10)65732-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037180372
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/s1535-6108(02)00180-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038314162
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1089/thy.2013.0573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035302500
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1097/pas.0000000000000088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019934485
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1097/pas.0000000000000537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037752187
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1097/pas.0b013e3181d9efcc schema:sameAs https://app.dimensions.ai/details/publication/pub.1025753852
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1097/pas.0b013e318231542a schema:sameAs https://app.dimensions.ai/details/publication/pub.1027367099
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1111/jop.12226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047290939
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1172/jci69766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043718343
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1172/jci72725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016832152
225 rdf:type schema:CreativeWork
226 https://doi.org/10.18632/oncotarget.3593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003655983
227 rdf:type schema:CreativeWork
228 https://www.grid.ac/institutes/grid.266832.b schema:alternateName University of New Mexico
229 schema:name Department of Pathology, University of New Mexico School of Medicine (UNM SOM), MSC08-4640, 87131-0001, Albuquerque, NM, USA
230 Division of Hematology/Oncology, Department of Internal Medicine, University of New Mexico School of Medicine (UNM SOM), Albuquerque, NM, USA
231 Division of Otolaryngology, Department of Surgery, University of New Mexico School of Medicine (UNM SOM), Albuquerque, NM, USA
232 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...