Mammary Analogue Secretory Carcinoma Mimicking Salivary Adenoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Lindsay Williams, Simion I. Chiosea

ABSTRACT

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor characterized by ETV6 translocation. It appears that prior studies have identified MASC by reviewing salivary gland carcinomas, such as acinic cell carcinoma and adenocarcinoma, not otherwise specified. To address the possibility of MASC mimicking benign salivary neoplasms we reviewed 12 salivary gland (cyst)adenomas diagnosed prior to the discovery of MASC. One encapsulated (cyst)adenoma of the parotid gland demonstrated features of MASC. The diagnosis was confirmed by fluorescence in situ hybridization with an ETV6 break-apart probe. An unusual complex pattern of ETV6 rearrangement with duplication of the telomeric/distal ETV6 probe was identified. This case illustrates that MASC may mimic salivary (cyst)adenomas. To more accurately assess true clinical and morphologic spectrum of MASC, future studies may have to include review of salivary (cyst)adenomas. The differential diagnosis of MASC may have to be expanded to include cases resembling salivary (cyst)adenomas. More... »

PAGES

316-319

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12105-013-0443-2

DOI

http://dx.doi.org/10.1007/s12105-013-0443-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013444043

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23620147


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