Mammary Analogue Secretory Carcinoma: The First Submandibular Case Reported Including Findings on Fine Needle Aspiration Cytology View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-03

AUTHORS

Fredrik Petersson, Derrick Lian, Yuk Ping Chau, Benedict Yan

ABSTRACT

We present the first case (male, 35 years old) of a mammary analogue secretory carcinoma occurring in a submandibular gland and document findings on fine needle aspiration cytology. On histology, the tumor displayed characteristic features: circumscribed nodules composed of bland, pink to light red neoplastic cells with low proliferative/mitotic activity arranged in tubular, vaguely cribriform, and microcystic structures containing Periodic acid Schiff-positive, diastase-resistant secretory material. Immunohistochemistry showed strong and diffuse positivity for cytokeratin 7, S100 protein, and vimentin, as well as moderate to strong immunoreactivity for c-kit in the majority of tumor cells. A rearrangement of the ETV6 gene on fluorescence in situ hybridization was documented. The patient underwent an ipsilateral selective (levels I-IV) neck dissection which showed metastasis in 3 out of 36 lymph nodes (levels 1-3). Adjuvant radiotherapy was administered. No local recurrence or metastatic disease has been detected during a follow up period of 28 months. More... »

PAGES

135-139

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12105-011-0283-x

DOI

http://dx.doi.org/10.1007/s12105-011-0283-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029280954

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21773954


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