Does Mesenchymal Stem Cell Population in Umbilical Cord Blood Vary at Different Gestational Periods? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-05

AUTHORS

Ashish Jain, Nitin Mathur, M. Jeevashankar, Asok Mukhopadhyay, Ramesh Agarwal, A. K Deorari, V. K Paul

ABSTRACT

OBJECTIVE: To identify and quantitatively determine Mesenchymal stem cells (MSCs) in the umbilical cord blood (UCB) of neonates born at different gestational periods. METHODS: UCB was collected at birth in neonates of three different gestational groups. The mononuclear cells (MNCs) were phenotypically analyzed by flow cytometer. RESULTS: The yield of total MNCs did not differ much with gestation; the average values were 22.6 ± 6.48 × 106 cells/ml. The MSCs were significantly higher in the lower gestation group. These were 0.0219 ± 0.012 %, 0.0044 ± 0.003 % and 0.0022 ± 0.003 % in 28 to 31 wk, 32 to 35 wk and >36 wk, respectively (P = 0.00). There was a significant inverse correlation between the gestational age and the presence of MSCs with a correlation co-efficient of -0.54 (P = 0.0001). CONCLUSIONS: The MSCs population was significantly higher in infants born at lesser gestation than those born at term gestation. More... »

PAGES

375-379

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12098-012-0844-3

DOI

http://dx.doi.org/10.1007/s12098-012-0844-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009412538

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22965461


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