Stereotactic ablative radiotherapy in castration-resistant prostate cancer patients with oligoprogression during androgen receptor-targeted therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-01-25

AUTHORS

G. Ingrosso, B. Detti, A. Fodor, S. Caini, S. Borghesi, L. Triggiani, F. Trippa, D. Russo, A. Bruni, G. Francolini, A. Lancia, L. Marinelli, N. Di Muzio, L. Livi, S. M. Magrini, E. Maranzano, D. Musio, C. Aristei, M. Valeriani

ABSTRACT

ObjectivesTo report outcomes of stereotactic body radiotherapy (SBRT) in metastatic castration-resistant prostate cancer (mCRPC) patients with oligoprogression (≤ 5 metastases) during first-line treatment with androgen receptor-targeted therapy (ARTT).Patients and methodsRetrospective multi-institutional analysis of mCRPC patients treated with SBRT to oligoprogressive lesions during ARTT. End-points were time to next-line systemic treatment (NEST), radiological progression-free survival (r-PFS) and overall survival (OS). Toxicity was registered according to Common Terminology Criteria for Adverse Events (CTCAE) v4.0. Survival analysis was performed using the Kaplan–Meier method, univariate and multivariate analysis (MVA) were performed.ResultsData from 34 patients were analyzed. Median NEST-free survival, r-PFS, and OS were 16.97, 13.47, and 38.3 months, respectively. At MVA, factors associated with worse NEST-free survival and r-PFS were polymetastatic burden at diagnosis of metastatic hormone-sensitive disease (hazard ratio [HR] 3.66, p = 0.009; HR 3.03, p = 0.034), PSA ≤ 7 ng/ml at mCRPC diagnosis (HR 0.23, p = 0.017; HR 0.19, p = 0.006) and PSADT ≤ 3 months at mCRPC diagnosis (HR 3.39, p = 0.026; HR 2.79, p = 0.037). Polymetastatic state at mHSPC diagnosis was associated with a decreased OS (HR 4.68, p = 0.029). No patient developed acute or late grade ≥ 2 toxicity.ConclusionOur results suggest that SBRT in oligoprogressive mCPRC is safe, effective and seems to prolong the efficacy of the ongoing systemic treatment positively affecting disease progression. Prospective trials are needed. More... »

PAGES

1577-1584

References to SciGraph publications

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  • Journal

    TITLE

    Clinical and Translational Oncology

    ISSUE

    8

    VOLUME

    23

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12094-021-02553-5

    DOI

    http://dx.doi.org/10.1007/s12094-021-02553-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1134858827

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33495981


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