CalliSpheres® drug-eluting beads (DEB) transarterial chemoembolization (TACE) is equally efficient and safe in liver cancer patients with different times of ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

X. Zhang, J. Zhou, D.-D. Zhu, J. Huang, J.-H. Sun, T.-F. Li, C.-S. Shi, Z.-C. Sun, Q.-M. Hou, Z.-Y. Peng, W.-Q. Yu, J.-S. Ji, W.-J. Gu, G.-H. Zhou, X.-X Xie, X.-H. Guo, G.-H. Cao, Z.-H. Yu, H.-H. Xu, J. Fang, S.-H. Ying, W.-H. Hu, W.-B. Ji, J. Han, X. Wu, J.-P. Zheng, J. Luo, Y.-T. Chen, T.-Y. Hu, L. Li, H.-J. Hu, H.-J. Du, G.-L. Shao

ABSTRACT

PURPOSE: To assess the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) in liver cancer patients with different times of previous conventional transarterial chemoembolization (cTACE) treatments. METHODS: 367 liver cancer patients about to receive DEB-TACE treatment were enrolled in this prospective cohort study. All patients were divided into no previous cTACE group (NPC group), 1-2 times previous cTACE group (PC group) and triple or above previous cTACE group (TPC group) according to the times of previous cTACE treatments. RESULTS: There was no difference in complete response (CR) (P = 0.671) and objective response rate (ORR) (P = 0.062) among three groups. Additionally, no difference in overall survival (OS) among groups (P = 0.899) was found. As to liver function, most liver function indexes were deteriorative at 1 week after DEB-TACE operation, but returned to baseline at 1-3 months after DEB-TACE operation in all three groups, while percentage of abnormal total bile acid (TBA) patients was higher in TPC group than NPC and PC groups at 1-3 month post-DEB-TACE (P = 0.018). As for safety profiles, the incidence of pain during DEB-TACE operation was lower in TPC group compared to NPC and PC groups (P = 0.005), while no difference of other adverse events was found during and 1 month post-DEB-TACE treatment among three groups. CONCLUSION: DEB-TACE treatment was equally efficient and tolerated in liver cancer patients with different times of previous cTACE treatments. More... »

PAGES

1-11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12094-018-1902-8

DOI

http://dx.doi.org/10.1007/s12094-018-1902-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105563320

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30003530


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