Clinical implications of the deregulated TP73 isoforms expression in cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

N. Rodríguez, A. Peláez, R. Barderas, G. Domínguez

ABSTRACT

TP73 is a member of the TP53 family whose expression has been observed altered in most human cancers and associated with the prognosis. TP73 translates into a complex number of isoforms with both oncogenic and tumour-suppressor functions and presents a complex cross-talk with other members of the family (TP53 and TP63). In this revision, we focus on the evidence that may support TP73 variants as prognostic markers in cancer. Nowadays, most publications in this topic highlight the association between overexpression of the oncogenic variants and failure to respond to chemotherapy and/or shorter survival. In addition, we comment on the putative possibilities that the detection through a liquid biopsy of TP73 variants may provide, and finally, the significance of determining the value of the combined alteration of the TP53 family members in the clinical setting. More... »

PAGES

827-836

References to SciGraph publications

  • 2006-10. Prognostic value of increase in transcript levels of Tp73 ΔEx2-3 isoforms in low-grade glioma patients in BRITISH JOURNAL OF CANCER
  • 2001-11. p73 is over-expressed in vulval cancer principally as the Δ2 isoform in BRITISH JOURNAL OF CANCER
  • 2001-01. Transactivation-deficient p73α (p73Δexon2) inhibits apoptosis and competes with p53 in ONCOGENE
  • 2008-04. ΔNp73α regulates MDR1 expression by inhibiting p53 function in ONCOGENE
  • 2008-04. Wild-type p53 and p73 negatively regulate expression of proliferation related genes in ONCOGENE
  • 2007-12. Overexpressed TP73 induces apoptosis in medulloblastoma in BMC CANCER
  • 2014-10. p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells in CELL DEATH & DIFFERENTIATION
  • 2001-08. P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63? in ONCOGENE
  • 1997-09. p73 is a human p53-related protein that can induce apoptosis in NATURE
  • 2004-11. Analysis of p73 expression pattern in acute myeloid leukemias: lack of ΔN-p73 expression is a frequent feature of acute promyelocytic leukemia in LEUKEMIA
  • 2002-08. p73: Friend or foe in tumorigenesis in NATURE REVIEWS CANCER
  • 2001-12. Human ΔNp73 regulates a dominant negative feedback loop for TAp73 and p53 in CELL DEATH & DIFFERENTIATION
  • 2009-01. Recent advances in p53 research: an interdisciplinary perspective in CANCER GENE THERAPY
  • 2015-08. p73 is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF and TGFβ signaling in CELL DEATH & DIFFERENTIATION
  • 2007-12. p73 expression in medulloblastoma: TAp73/ΔNp73 transcript detection and possible association of p73α/ΔNp73 immunoreactivity with survival in ACTA NEUROPATHOLOGICA
  • 2007-06. p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance in JOURNAL OF MOLECULAR HISTOLOGY
  • 2010-10. Characterization of ΔNp73 expression and regulation in gastric and esophageal tumors in ONCOGENE
  • 2006-08. Differential expression of p73 isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia in LEUKEMIA
  • 2011-04. p73: A Multifunctional Protein in Neurobiology in MOLECULAR NEUROBIOLOGY
  • 2016-08. TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma in CELL DEATH & DIFFERENTIATION
  • 2002-03. Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients in CELL DEATH & DIFFERENTIATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12094-017-1802-3

    DOI

    http://dx.doi.org/10.1007/s12094-017-1802-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1099691203

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29230693


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Isoforms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Protein p73", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Hospital Universitario La Paz", 
              "id": "https://www.grid.ac/institutes/grid.81821.32", 
              "name": [
                "Servicio de Oncolog\u00eda M\u00e9dica, Hospital Universitario La Paz, CIBERONC, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rodr\u00edguez", 
            "givenName": "N.", 
            "id": "sg:person.01176023105.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176023105.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Universitario La Paz", 
              "id": "https://www.grid.ac/institutes/grid.81821.32", 
              "name": [
                "Servicio de Anatom\u00eda Patol\u00f3gica and Molecular Pathology and Therapeutic Targets Group, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pel\u00e1ez", 
            "givenName": "A.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto de Salud Carlos III", 
              "id": "https://www.grid.ac/institutes/grid.413448.e", 
              "name": [
                "UFIEC, ISCIII, Majadahonda, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barderas", 
            "givenName": "R.", 
            "id": "sg:person.01263627317.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263627317.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Alberto Sols Biomedical Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.466793.9", 
              "name": [
                "Departamento de Medicina, Facultad de Medicina, Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols\u201d, CSIC-Universidad Aut\u00f3noma de Madrid, CIBERONC, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dom\u00ednguez", 
            "givenName": "G.", 
            "id": "sg:person.01166154641.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166154641.35"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10735-007-9084-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001549452", 
              "https://doi.org/10.1007/s10735-007-9084-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210898", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005069153", 
              "https://doi.org/10.1038/sj.onc.1210898"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007241916", 
              "https://doi.org/10.1038/sj.leu.2404288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2404288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007241916", 
              "https://doi.org/10.1038/sj.leu.2404288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1873910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007945638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007961480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00313020600696298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008678598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00313020600696298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008678598"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.20107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009055747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci30866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009522405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4400962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009558943", 
              "https://doi.org/10.1038/sj.cdd.4400962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4400962", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009558943", 
              "https://doi.org/10.1038/sj.cdd.4400962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010028675", 
              "https://doi.org/10.1038/sj.bjc.6603410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6603410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010028675", 
              "https://doi.org/10.1038/sj.bjc.6603410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2016.18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011007110", 
              "https://doi.org/10.1038/cdd.2016.18"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-2573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012224313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m200480200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013353037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.7600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013368254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-7-127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013856669", 
              "https://doi.org/10.1186/1471-2407-7-127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cmr.0b013e3283036aa1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015187907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cmr.0b013e3283036aa1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015187907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2015-01-623330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016145397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-1060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018888744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-1060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018888744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023000792", 
              "https://doi.org/10.1038/sj.onc.1210862"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2014.214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023337419", 
              "https://doi.org/10.1038/cdd.2014.214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.02.2350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023611270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-2388", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024081142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.11552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024265218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-011-8172-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024755782", 
              "https://doi.org/10.1007/s12035-011-8172-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2014.61", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024804206", 
              "https://doi.org/10.1038/cdd.2014.61"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.2005.026955", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026676819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2013.08.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026840273"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cgt.2008.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030761525", 
              "https://doi.org/10.1038/cgt.2008.69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/38298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030867943", 
              "https://doi.org/10.1038/38298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/38298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030867943", 
              "https://doi.org/10.1038/38298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1054/bjoc.2001.2138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031286326", 
              "https://doi.org/10.1054/bjoc.2001.2138"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/10298190310001623829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031383444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1410609111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034417797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1410609111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034417797"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nano.2014.09.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034784839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20020179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036530745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-0899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037234134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jclinpath-2015-203150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038166235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039158235", 
              "https://doi.org/10.1038/sj.leu.2403483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2403483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039158235", 
              "https://doi.org/10.1038/sj.leu.2403483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2273.2003.00743.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039649317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddt437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040240918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80540-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041015753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(99)00038-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041076025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.319", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041645099", 
              "https://doi.org/10.1038/onc.2010.319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e3181bcb2da", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042063474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e3181bcb2da", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042063474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/pai.0b013e3181bcb2da", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042063474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4400993", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043484024", 
              "https://doi.org/10.1038/sj.cdd.4400993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4400993", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043484024", 
              "https://doi.org/10.1038/sj.cdd.4400993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/hupa.2002.30722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044003465"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045087741", 
              "https://doi.org/10.1038/sj.onc.1204118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045087741", 
              "https://doi.org/10.1038/sj.onc.1204118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/jto.0b013e31820b86b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045930285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejso.2005.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045956127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.anndiagpath.2014.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046042436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.anndiagpath.2014.12.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046042436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047430174", 
              "https://doi.org/10.1038/nrc861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047430174", 
              "https://doi.org/10.1038/nrc861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047461416", 
              "https://doi.org/10.1038/sj.onc.1204687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204687", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047461416", 
              "https://doi.org/10.1038/sj.onc.1204687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0215(19990820)84:4<365::aid-ijc6>3.0.co;2-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047747563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2014.57.6660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047815341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1695308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049915607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0045(19990501)39:2<94::aid-pros3>3.0.co;2-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049950159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-0290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050285977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.289.5477.304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050892904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0298-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050987774", 
              "https://doi.org/10.1007/s00401-007-0298-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-007-0298-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050987774", 
              "https://doi.org/10.1007/s00401-007-0298-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cmr.0000000000000151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051640458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cmr.0000000000000151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051640458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1221172110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053140506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/dneu.22356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053657159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.10296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053688574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15384101.2015.1078038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058402019"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijmm.8.1.67", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071509338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.29.4.889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071516160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2015.3052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071526014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2015.3052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071526014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3906/sag-1304-136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071569319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.7.11.5894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072299463"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.9.13.12110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5301/tj.5000506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072754378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5301/tj.5000506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072754378"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074984073", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074993534", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076607168", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/030089160409000214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076862668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/030089160409000214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076862668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.14670/hh-29.207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078780075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/cbm-140393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078928262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083269021", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-07", 
        "datePublishedReg": "2018-07-01", 
        "description": "TP73 is a member of the TP53 family whose expression has been observed altered in most human cancers and associated with the prognosis. TP73 translates into a complex number of isoforms with both oncogenic and tumour-suppressor functions and presents a complex cross-talk with other members of the family (TP53 and TP63). In this revision, we focus on the evidence that may support TP73 variants as prognostic markers in cancer. Nowadays, most publications in this topic highlight the association between overexpression of the oncogenic variants and failure to respond to chemotherapy and/or shorter survival. In addition, we comment on the putative possibilities that the detection through a liquid biopsy of TP73 variants may provide, and finally, the significance of determining the value of the combined alteration of the TP53 family members in the clinical setting.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s12094-017-1802-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3712429", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1035367", 
            "issn": [
              "1699-048X", 
              "1699-3055"
            ], 
            "name": "Clinical and Translational Oncology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "20"
          }
        ], 
        "name": "Clinical implications of the deregulated TP73 isoforms expression in cancer", 
        "pagination": "827-836", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0048e50584ce1b08f846749a4fc870c0ef72856f2d0ab7a09cfe7be5bcf8389e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29230693"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101247119"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12094-017-1802-3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1099691203"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12094-017-1802-3", 
          "https://app.dimensions.ai/details/publication/pub.1099691203"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:22", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000603.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs12094-017-1802-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12094-017-1802-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12094-017-1802-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12094-017-1802-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12094-017-1802-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    370 TRIPLES      21 PREDICATES      112 URIs      27 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12094-017-1802-3 schema:about N0845131b76854a09be46071244887fd4
    2 N2718d9dde3dc4837a6bcff48c8d7d08d
    3 N273832be3c8046f691e66a5f9e2e8c1c
    4 N58501b9a958946919ee6c668df3ef114
    5 N6f4f178ab84f40498e990e7a9f96314e
    6 N700862fceb2446c1bd6a8ed5dbdfddf2
    7 anzsrc-for:11
    8 anzsrc-for:1112
    9 schema:author Nb266a0a564f0428bba8d0be52954d569
    10 schema:citation sg:pub.10.1007/s00401-007-0298-2
    11 sg:pub.10.1007/s10735-007-9084-7
    12 sg:pub.10.1007/s12035-011-8172-6
    13 sg:pub.10.1038/38298
    14 sg:pub.10.1038/cdd.2014.214
    15 sg:pub.10.1038/cdd.2014.61
    16 sg:pub.10.1038/cdd.2016.18
    17 sg:pub.10.1038/cgt.2008.69
    18 sg:pub.10.1038/nrc861
    19 sg:pub.10.1038/onc.2010.319
    20 sg:pub.10.1038/sj.bjc.6603410
    21 sg:pub.10.1038/sj.cdd.4400962
    22 sg:pub.10.1038/sj.cdd.4400993
    23 sg:pub.10.1038/sj.leu.2403483
    24 sg:pub.10.1038/sj.leu.2404288
    25 sg:pub.10.1038/sj.onc.1204118
    26 sg:pub.10.1038/sj.onc.1204687
    27 sg:pub.10.1038/sj.onc.1210862
    28 sg:pub.10.1038/sj.onc.1210898
    29 sg:pub.10.1054/bjoc.2001.2138
    30 sg:pub.10.1186/1471-2407-7-127
    31 https://app.dimensions.ai/details/publication/pub.1074984073
    32 https://app.dimensions.ai/details/publication/pub.1074993534
    33 https://app.dimensions.ai/details/publication/pub.1076607168
    34 https://app.dimensions.ai/details/publication/pub.1083269021
    35 https://doi.org/10.1002/(sici)1097-0045(19990501)39:2<94::aid-pros3>3.0.co;2-w
    36 https://doi.org/10.1002/(sici)1097-0215(19990820)84:4<365::aid-ijc6>3.0.co;2-x
    37 https://doi.org/10.1002/dneu.22356
    38 https://doi.org/10.1002/ijc.10296
    39 https://doi.org/10.1002/ijc.11552
    40 https://doi.org/10.1016/j.anndiagpath.2014.12.004
    41 https://doi.org/10.1016/j.ccr.2013.08.023
    42 https://doi.org/10.1016/j.ejso.2005.09.014
    43 https://doi.org/10.1016/j.nano.2014.09.010
    44 https://doi.org/10.1016/s0092-8674(00)80540-1
    45 https://doi.org/10.1016/s0959-437x(99)00038-6
    46 https://doi.org/10.1046/j.1365-2273.2003.00743.x
    47 https://doi.org/10.1053/hupa.2002.30722
    48 https://doi.org/10.1073/pnas.1221172110
    49 https://doi.org/10.1073/pnas.1410609111
    50 https://doi.org/10.1074/jbc.m200480200
    51 https://doi.org/10.1080/00313020600696298
    52 https://doi.org/10.1080/10298190310001623829
    53 https://doi.org/10.1080/15384101.2015.1078038
    54 https://doi.org/10.1084/jem.20020179
    55 https://doi.org/10.1093/hmg/ddt437
    56 https://doi.org/10.1097/cmr.0000000000000151
    57 https://doi.org/10.1097/cmr.0b013e3283036aa1
    58 https://doi.org/10.1097/jto.0b013e31820b86b0
    59 https://doi.org/10.1097/pai.0b013e3181bcb2da
    60 https://doi.org/10.1101/gad.1695308
    61 https://doi.org/10.1101/gad.1873910
    62 https://doi.org/10.1126/science.289.5477.304
    63 https://doi.org/10.1136/jclinpath-2015-203150
    64 https://doi.org/10.1136/jcp.2005.026955
    65 https://doi.org/10.1158/0008-5472.can-03-1060
    66 https://doi.org/10.1158/1078-0432.ccr-04-0290
    67 https://doi.org/10.1158/1078-0432.ccr-05-0899
    68 https://doi.org/10.1158/1078-0432.ccr-05-2573
    69 https://doi.org/10.1158/1078-0432.ccr-10-2388
    70 https://doi.org/10.1172/jci30866
    71 https://doi.org/10.1177/030089160409000214
    72 https://doi.org/10.1182/blood-2015-01-623330
    73 https://doi.org/10.1200/jco.2005.02.2350
    74 https://doi.org/10.1200/jco.2014.57.6660
    75 https://doi.org/10.1371/journal.pgen.1000680
    76 https://doi.org/10.14670/hh-29.207
    77 https://doi.org/10.18632/oncotarget.7600
    78 https://doi.org/10.3233/cbm-140393
    79 https://doi.org/10.3322/caac.20107
    80 https://doi.org/10.3892/ijmm.8.1.67
    81 https://doi.org/10.3892/ijo.29.4.889
    82 https://doi.org/10.3892/ol.2015.3052
    83 https://doi.org/10.3906/sag-1304-136
    84 https://doi.org/10.4161/cc.7.11.5894
    85 https://doi.org/10.4161/cc.9.13.12110
    86 https://doi.org/10.5301/tj.5000506
    87 schema:datePublished 2018-07
    88 schema:datePublishedReg 2018-07-01
    89 schema:description TP73 is a member of the TP53 family whose expression has been observed altered in most human cancers and associated with the prognosis. TP73 translates into a complex number of isoforms with both oncogenic and tumour-suppressor functions and presents a complex cross-talk with other members of the family (TP53 and TP63). In this revision, we focus on the evidence that may support TP73 variants as prognostic markers in cancer. Nowadays, most publications in this topic highlight the association between overexpression of the oncogenic variants and failure to respond to chemotherapy and/or shorter survival. In addition, we comment on the putative possibilities that the detection through a liquid biopsy of TP73 variants may provide, and finally, the significance of determining the value of the combined alteration of the TP53 family members in the clinical setting.
    90 schema:genre research_article
    91 schema:inLanguage en
    92 schema:isAccessibleForFree false
    93 schema:isPartOf N09814e4ffbcf4d3daab89a0e55ae28f0
    94 N7a39fbc42c9d430292691955d5a1b61c
    95 sg:journal.1035367
    96 schema:name Clinical implications of the deregulated TP73 isoforms expression in cancer
    97 schema:pagination 827-836
    98 schema:productId N078736a1371841458862e711f2f3bcdc
    99 N2335bfe352af4afbb22a1eec33f99238
    100 N2bd3ad4e80f14bfbbae916e959e2ea86
    101 N7bf4e740ddea47368942b2204a715c9a
    102 N989afc3989094d06af2a23df89d5ede1
    103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099691203
    104 https://doi.org/10.1007/s12094-017-1802-3
    105 schema:sdDatePublished 2019-04-11T01:22
    106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    107 schema:sdPublisher Nfad51cd3a13544b999da7dce0590b8ca
    108 schema:url https://link.springer.com/10.1007%2Fs12094-017-1802-3
    109 sgo:license sg:explorer/license/
    110 sgo:sdDataset articles
    111 rdf:type schema:ScholarlyArticle
    112 N078736a1371841458862e711f2f3bcdc schema:name readcube_id
    113 schema:value 0048e50584ce1b08f846749a4fc870c0ef72856f2d0ab7a09cfe7be5bcf8389e
    114 rdf:type schema:PropertyValue
    115 N0845131b76854a09be46071244887fd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Humans
    117 rdf:type schema:DefinedTerm
    118 N09814e4ffbcf4d3daab89a0e55ae28f0 schema:volumeNumber 20
    119 rdf:type schema:PublicationVolume
    120 N2335bfe352af4afbb22a1eec33f99238 schema:name pubmed_id
    121 schema:value 29230693
    122 rdf:type schema:PropertyValue
    123 N2718d9dde3dc4837a6bcff48c8d7d08d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Protein Isoforms
    125 rdf:type schema:DefinedTerm
    126 N273832be3c8046f691e66a5f9e2e8c1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Tumor Protein p73
    128 rdf:type schema:DefinedTerm
    129 N2bd3ad4e80f14bfbbae916e959e2ea86 schema:name doi
    130 schema:value 10.1007/s12094-017-1802-3
    131 rdf:type schema:PropertyValue
    132 N58501b9a958946919ee6c668df3ef114 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Gene Expression Regulation, Neoplastic
    134 rdf:type schema:DefinedTerm
    135 N6f4f178ab84f40498e990e7a9f96314e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Neoplasms
    137 rdf:type schema:DefinedTerm
    138 N700862fceb2446c1bd6a8ed5dbdfddf2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Animals
    140 rdf:type schema:DefinedTerm
    141 N7288baea8dfa4fa886ae4aa5208cd59d rdf:first sg:person.01166154641.35
    142 rdf:rest rdf:nil
    143 N7a39fbc42c9d430292691955d5a1b61c schema:issueNumber 7
    144 rdf:type schema:PublicationIssue
    145 N7bf4e740ddea47368942b2204a715c9a schema:name nlm_unique_id
    146 schema:value 101247119
    147 rdf:type schema:PropertyValue
    148 N989afc3989094d06af2a23df89d5ede1 schema:name dimensions_id
    149 schema:value pub.1099691203
    150 rdf:type schema:PropertyValue
    151 Na42db1cb93c047919a0c34b9b592788d schema:affiliation https://www.grid.ac/institutes/grid.81821.32
    152 schema:familyName Peláez
    153 schema:givenName A.
    154 rdf:type schema:Person
    155 Nb266a0a564f0428bba8d0be52954d569 rdf:first sg:person.01176023105.34
    156 rdf:rest Nec04d5cd99d647499471004edb6ad98a
    157 Nc8d9eec3586b4087a55fc7b97579fddb rdf:first sg:person.01263627317.25
    158 rdf:rest N7288baea8dfa4fa886ae4aa5208cd59d
    159 Nec04d5cd99d647499471004edb6ad98a rdf:first Na42db1cb93c047919a0c34b9b592788d
    160 rdf:rest Nc8d9eec3586b4087a55fc7b97579fddb
    161 Nfad51cd3a13544b999da7dce0590b8ca schema:name Springer Nature - SN SciGraph project
    162 rdf:type schema:Organization
    163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    164 schema:name Medical and Health Sciences
    165 rdf:type schema:DefinedTerm
    166 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    167 schema:name Oncology and Carcinogenesis
    168 rdf:type schema:DefinedTerm
    169 sg:grant.3712429 http://pending.schema.org/fundedItem sg:pub.10.1007/s12094-017-1802-3
    170 rdf:type schema:MonetaryGrant
    171 sg:journal.1035367 schema:issn 1699-048X
    172 1699-3055
    173 schema:name Clinical and Translational Oncology
    174 rdf:type schema:Periodical
    175 sg:person.01166154641.35 schema:affiliation https://www.grid.ac/institutes/grid.466793.9
    176 schema:familyName Domínguez
    177 schema:givenName G.
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166154641.35
    179 rdf:type schema:Person
    180 sg:person.01176023105.34 schema:affiliation https://www.grid.ac/institutes/grid.81821.32
    181 schema:familyName Rodríguez
    182 schema:givenName N.
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176023105.34
    184 rdf:type schema:Person
    185 sg:person.01263627317.25 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
    186 schema:familyName Barderas
    187 schema:givenName R.
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263627317.25
    189 rdf:type schema:Person
    190 sg:pub.10.1007/s00401-007-0298-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050987774
    191 https://doi.org/10.1007/s00401-007-0298-2
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1007/s10735-007-9084-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001549452
    194 https://doi.org/10.1007/s10735-007-9084-7
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1007/s12035-011-8172-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024755782
    197 https://doi.org/10.1007/s12035-011-8172-6
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/38298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030867943
    200 https://doi.org/10.1038/38298
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/cdd.2014.214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023337419
    203 https://doi.org/10.1038/cdd.2014.214
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/cdd.2014.61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024804206
    206 https://doi.org/10.1038/cdd.2014.61
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/cdd.2016.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011007110
    209 https://doi.org/10.1038/cdd.2016.18
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/cgt.2008.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030761525
    212 https://doi.org/10.1038/cgt.2008.69
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1038/nrc861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047430174
    215 https://doi.org/10.1038/nrc861
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1038/onc.2010.319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041645099
    218 https://doi.org/10.1038/onc.2010.319
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1038/sj.bjc.6603410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010028675
    221 https://doi.org/10.1038/sj.bjc.6603410
    222 rdf:type schema:CreativeWork
    223 sg:pub.10.1038/sj.cdd.4400962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009558943
    224 https://doi.org/10.1038/sj.cdd.4400962
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1038/sj.cdd.4400993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043484024
    227 https://doi.org/10.1038/sj.cdd.4400993
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1038/sj.leu.2403483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039158235
    230 https://doi.org/10.1038/sj.leu.2403483
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1038/sj.leu.2404288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007241916
    233 https://doi.org/10.1038/sj.leu.2404288
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/sj.onc.1204118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045087741
    236 https://doi.org/10.1038/sj.onc.1204118
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/sj.onc.1204687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047461416
    239 https://doi.org/10.1038/sj.onc.1204687
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/sj.onc.1210862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023000792
    242 https://doi.org/10.1038/sj.onc.1210862
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/sj.onc.1210898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005069153
    245 https://doi.org/10.1038/sj.onc.1210898
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1054/bjoc.2001.2138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031286326
    248 https://doi.org/10.1054/bjoc.2001.2138
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1186/1471-2407-7-127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013856669
    251 https://doi.org/10.1186/1471-2407-7-127
    252 rdf:type schema:CreativeWork
    253 https://app.dimensions.ai/details/publication/pub.1074984073 schema:CreativeWork
    254 https://app.dimensions.ai/details/publication/pub.1074993534 schema:CreativeWork
    255 https://app.dimensions.ai/details/publication/pub.1076607168 schema:CreativeWork
    256 https://app.dimensions.ai/details/publication/pub.1083269021 schema:CreativeWork
    257 https://doi.org/10.1002/(sici)1097-0045(19990501)39:2<94::aid-pros3>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1049950159
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1002/(sici)1097-0215(19990820)84:4<365::aid-ijc6>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047747563
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1002/dneu.22356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053657159
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1002/ijc.10296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053688574
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1002/ijc.11552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024265218
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.anndiagpath.2014.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046042436
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.ccr.2013.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026840273
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.ejso.2005.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045956127
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/j.nano.2014.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034784839
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/s0092-8674(00)80540-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041015753
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/s0959-437x(99)00038-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041076025
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1046/j.1365-2273.2003.00743.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039649317
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1053/hupa.2002.30722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044003465
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1073/pnas.1221172110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053140506
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1073/pnas.1410609111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034417797
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1074/jbc.m200480200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013353037
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1080/00313020600696298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008678598
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1080/10298190310001623829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031383444
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1080/15384101.2015.1078038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058402019
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1084/jem.20020179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036530745
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1093/hmg/ddt437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040240918
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1097/cmr.0000000000000151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051640458
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1097/cmr.0b013e3283036aa1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015187907
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1097/jto.0b013e31820b86b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045930285
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1097/pai.0b013e3181bcb2da schema:sameAs https://app.dimensions.ai/details/publication/pub.1042063474
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1101/gad.1695308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049915607
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1101/gad.1873910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007945638
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1126/science.289.5477.304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050892904
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1136/jclinpath-2015-203150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038166235
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1136/jcp.2005.026955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026676819
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1158/0008-5472.can-03-1060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018888744
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1158/1078-0432.ccr-04-0290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050285977
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1158/1078-0432.ccr-05-0899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037234134
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1158/1078-0432.ccr-05-2573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012224313
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1158/1078-0432.ccr-10-2388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024081142
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1172/jci30866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009522405
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1177/030089160409000214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076862668
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1182/blood-2015-01-623330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016145397
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1200/jco.2005.02.2350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023611270
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1200/jco.2014.57.6660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047815341
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1371/journal.pgen.1000680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007961480
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.14670/hh-29.207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078780075
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.18632/oncotarget.7600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013368254
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.3233/cbm-140393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078928262
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.3322/caac.20107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055747
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.3892/ijmm.8.1.67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071509338
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.3892/ijo.29.4.889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071516160
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.3892/ol.2015.3052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071526014
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.3906/sag-1304-136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071569319
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.4161/cc.7.11.5894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299463
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.4161/cc.9.13.12110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300878
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.5301/tj.5000506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072754378
    360 rdf:type schema:CreativeWork
    361 https://www.grid.ac/institutes/grid.413448.e schema:alternateName Instituto de Salud Carlos III
    362 schema:name UFIEC, ISCIII, Majadahonda, Madrid, Spain
    363 rdf:type schema:Organization
    364 https://www.grid.ac/institutes/grid.466793.9 schema:alternateName Alberto Sols Biomedical Research Institute
    365 schema:name Departamento de Medicina, Facultad de Medicina, Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC-Universidad Autónoma de Madrid, CIBERONC, Madrid, Spain
    366 rdf:type schema:Organization
    367 https://www.grid.ac/institutes/grid.81821.32 schema:alternateName Hospital Universitario La Paz
    368 schema:name Servicio de Anatomía Patológica and Molecular Pathology and Therapeutic Targets Group, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain
    369 Servicio de Oncología Médica, Hospital Universitario La Paz, CIBERONC, Madrid, Spain
    370 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...