The MTHFR polymorphism affect the susceptibility of HCC and the prognosis of HCC liver transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-11-28

AUTHORS

C. Wang, H. Xie, D. Lu, Q. Ling, P. Jin, H. Li, R. Zhuang, X. Xu, S. Zheng

ABSTRACT

Background Methylenetetrahyfrofolate reductase (MTHFR) is the key enzyme for one carbon and folate metabolism. Previous studies have drawn different conclusions about the relationship between the mutation of MTHFR and hepatocellular carcinoma (HCC) occurrence. MTHFR polymorphisms' influence on liver transplantation for HCC recurrence has yet not been reported. Aim of this study was to clarify the impact of MTHFR polymorphism on hepatocarcinogenesis and the prognosis of liver transplant recipient with HCC.MethodsThis study enrolled 244 HCC patients and 487 healthy individuals in Chinese Han population to analyze the influence of MTHFR polymorphism on HCC susceptibility first. Furthermore, this research choose another 100 donors’ and 104 recipients’ specimens to detect the association between polymorphism of MTHFR and post-transplant HCC recurrence.Resultrs1801131 polymorphism A to C was associated with the occurrence of HCC in Chinese Han population (p < 0.05), especially in age exceeding 50 years (p < 0.01). No association was observed with rs1801133 polymorphism and HCC occurrence. The mean tumor-free survival for recipients with donor liver graft rs1801133 C to T variants was shorter than CC type (12.63 ± 3.84 vs 22.43 ± 4.74 months, p < 0.05). Multivariate analysis revealed that Donor rs1801133 and Hangzhou criteria were two independent prognostic factors for tumor-free survival (p < 0.05). Neither donor rs1801131 polymorphism nor recipients’ MTHFR polymorphisms was associated with HCC recurrence.ConclusionThis study demonstrated that MTHFR polymorphism was associated with HCC occurrence and post-transplant HCC recurrence. rs1801131 mutation A to C is a valuable molecular biomarker for predicting HCC occurrence in Chinese Han population. Donor MTHFR rs1801133 C to T polymorphism could present as a promising prognostic biomarkers for HCC recurrence in liver transplant recipients. More... »

PAGES

448-456

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12094-017-1729-8

DOI

http://dx.doi.org/10.1007/s12094-017-1729-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1093054422

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29185200


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33 schema:description Background Methylenetetrahyfrofolate reductase (MTHFR) is the key enzyme for one carbon and folate metabolism. Previous studies have drawn different conclusions about the relationship between the mutation of MTHFR and hepatocellular carcinoma (HCC) occurrence. MTHFR polymorphisms' influence on liver transplantation for HCC recurrence has yet not been reported. Aim of this study was to clarify the impact of MTHFR polymorphism on hepatocarcinogenesis and the prognosis of liver transplant recipient with HCC.MethodsThis study enrolled 244 HCC patients and 487 healthy individuals in Chinese Han population to analyze the influence of MTHFR polymorphism on HCC susceptibility first. Furthermore, this research choose another 100 donors’ and 104 recipients’ specimens to detect the association between polymorphism of MTHFR and post-transplant HCC recurrence.Resultrs1801131 polymorphism A to C was associated with the occurrence of HCC in Chinese Han population (p < 0.05), especially in age exceeding 50 years (p < 0.01). No association was observed with rs1801133 polymorphism and HCC occurrence. The mean tumor-free survival for recipients with donor liver graft rs1801133 C to T variants was shorter than CC type (12.63 ± 3.84 vs 22.43 ± 4.74 months, p < 0.05). Multivariate analysis revealed that Donor rs1801133 and Hangzhou criteria were two independent prognostic factors for tumor-free survival (p < 0.05). Neither donor rs1801131 polymorphism nor recipients’ MTHFR polymorphisms was associated with HCC recurrence.ConclusionThis study demonstrated that MTHFR polymorphism was associated with HCC occurrence and post-transplant HCC recurrence. rs1801131 mutation A to C is a valuable molecular biomarker for predicting HCC occurrence in Chinese Han population. Donor MTHFR rs1801133 C to T polymorphism could present as a promising prognostic biomarkers for HCC recurrence in liver transplant recipients.
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39 schema:keywords CC type
40 Chinese Han population
41 ConclusionThis study
42 HCC
43 HCC liver transplantation
44 HCC occurrence
45 HCC patients
46 HCC recurrence
47 HCC susceptibility
48 Han population
49 Hangzhou criteria
50 MTHFR polymorphisms
51 MethodsThis study
52 T polymorphism
53 T variant
54 age
55 analysis
56 association
57 background
58 biomarkers
59 carbon
60 carcinoma occurrence
61 conclusion
62 criteria
63 different conclusions
64 donors
65 enzyme
66 factors
67 healthy individuals
68 hepatocarcinogenesis
69 hepatocellular carcinoma occurrence
70 impact
71 independent prognostic factor
72 individuals
73 influence
74 key enzyme
75 liver transplant recipients
76 liver transplantation
77 metabolism
78 molecular biomarkers
79 multivariate analysis
80 mutation A
81 mutations
82 occurrence
83 occurrence of HCC
84 patients
85 polymorphism
86 polymorphism A
87 polymorphism influences
88 population
89 post-transplant HCC recurrence
90 previous studies
91 prognosis
92 prognostic biomarker
93 prognostic factors
94 promising prognostic biomarker
95 recipients
96 recurrence
97 reductase
98 relationship
99 research
100 rs1801131 polymorphism
101 rs1801133
102 rs1801133 polymorphism
103 specimens
104 study
105 survival
106 susceptibility
107 susceptibility of HCC
108 transplant recipients
109 transplantation
110 tumor-free survival
111 types
112 valuable molecular biomarker
113 variants
114 years
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