Patient-derived xenografts for childhood solid tumors: a valuable tool to test new drugs and personalize treatments View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01

AUTHORS

P. Zarzosa, N. Navarro, I. Giralt, C. Molist, A. Almazán-Moga, I. Vidal, A. Soriano, M. F. Segura, R. Hladun, A. Villanueva, S. Gallego, J. Roma

ABSTRACT

The use of preclinical models is essential in translational cancer research and especially important in pediatric cancer given the low incidence of each particular type of cancer. Cell line cultures have led to significant advances in cancer biology. However, cell lines have adapted to growth in artificial culture conditions, thereby undergoing genetic and phenotypic changes which may hinder the translational application. Tumor grafts developed in mice from patient tumor tissues, generally known as patient-derived xenografts (PDXs), are interesting alternative approaches to reproducing the biology of the original tumor. This review is focused on highlighting the interest of PDX models in pediatric cancer research and supporting strategies of personalized medicine. This review provides: (1) a description of the background of PDX in cancer, (2) the particular case of PDX in pediatric cancer, (3) how PDX can improve personalized medicine strategies, (4) new methods to increase engraftment, and, finally, (5) concluding remarks. More... »

PAGES

44-50

References to SciGraph publications

  • 1985. Development of Three Human Small Cell Lung Cancer Models in Nude Mice in SMALL CELL LUNG CANCER
  • 2012-06. Patient-derived tumour xenografts as models for oncology drug development in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2011-11. Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes in NATURE MEDICINE
  • 2001. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials in BRITISH JOURNAL OF CANCER
  • 1997. The NCI In Vitro Anticancer Drug Discovery Screen in ANTICANCER DRUG DEVELOPMENT GUIDE
  • 2009-02. Direct In Vivo Xenograft Tumor Model for Predicting Chemotherapeutic Drug Response in Cancer Patients in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2009-11. Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice in NATURE PROTOCOLS
  • 2012-07. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion in NATURE
  • 2012-12. Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2012-11. Humanized mice for immune system investigation: progress, promise and challenges in NATURE REVIEWS IMMUNOLOGY
  • 2015-12. Establishment of a patient-derived orthotopic osteosarcoma mouse model in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2016-03. Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12094-016-1557-2

    DOI

    http://dx.doi.org/10.1007/s12094-016-1557-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048558767

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27718156


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