Phase I feasibility trial of stereotactic body radiation therapy for primary hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-03

AUTHORS

Higinia R. Cárdenes, Tracy R. Price, Susan M. Perkins, Mary Maluccio, P. Kwo, T. E. Breen, Mark A. Henderson, Tracey E. Schefter, Kathy Tudor, Jill Deluca, Peter A. S. Johnstone

ABSTRACT

BACKGROUND: Hepatocellular carcinoma (HCC) is increasing in incidence and the majority of patients are not candidates for radical therapies. Therefore, interest in minimally invasive therapies in growing. METHODS: A Phase I dose escalation trial was conducted at Indiana University to determine the feasibility and toxicity of stereotactic body radiation therapy (SBRT) for primary HCC. Eligible patients had Child-Turcotte-Pugh's Class (CTP) A or B, were not candidates for resection, had 1-3 lesions and cumulative tumour diameter less than or equal to 6 cm. Dose escalation started at 36 Gy in 3 fractions (12 Gy/fraction) with a subsequent planned escalation of 2 Gy/ fraction/level. Dose-limiting toxicity (DLT) was defined as Common Terminology Criteria for Adverse Events v3.0 grade 3 or greater toxicity. RESULTS: Seventeen patients with 25 lesions were enrolled. Dose was escalated to 48 Gy (16 Gy/fraction) in CTP-A patients without DLT. Two patients with CPC-B disease developed grade 3 hepatic toxicity at the 42-Gy (14 Gy/fraction) level. The protocol was amended for subsequent CTP-B patients to receive a regimen of 5 fractions starting at 40 Gy (8 Gy/fraction) with one patient experiencing progressive liver failure. Four additional patients were enrolled (one died of unrelated causes after an incomplete SBRT course) without DLT. The only factor related to more than one grade 3 or greater liver toxicity or death within 6 months was the CTP score (p=0.03). Six patients underwent a liver transplant. Ten patients are alive without progression with a median FU of 24 months (10-42 months), with local control/stabilisation of the disease of 100%. One and two-year Kaplan-Meier estimates for overall survival are 75% and 60%, respectively. CONCLUSIONS: SBRT is a non-invasive feasible and well tolerated therapy in adequately selected patients with HCC. The preliminary local control and survival are encouraging. A confirmatory Phase II trial is currently open to accrual. More... »

PAGES

218-225

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12094-010-0492-x

DOI

http://dx.doi.org/10.1007/s12094-010-0492-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026025835

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20231127


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Hepatocellular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feasibility Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Maximum Tolerated Dose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiosurgery", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Dr (RT041), 46202, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "C\u00e1rdenes", 
        "givenName": "Higinia R.", 
        "id": "sg:person.01141564755.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141564755.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Dr (RT041), 46202, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Price", 
        "givenName": "Tracy R.", 
        "id": "sg:person.01204037055.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204037055.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Medicine-Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perkins", 
        "givenName": "Susan M.", 
        "id": "sg:person.01372076013.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372076013.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maluccio", 
        "givenName": "Mary", 
        "id": "sg:person.01365542561.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365542561.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Internal Medicine-Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwo", 
        "givenName": "P.", 
        "id": "sg:person.0606704573.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606704573.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Medicine-Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Breen", 
        "givenName": "T. E.", 
        "id": "sg:person.01164242127.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164242127.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Dr (RT041), 46202, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henderson", 
        "givenName": "Mark A.", 
        "id": "sg:person.01366400655.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366400655.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Colorado Denver", 
          "id": "https://www.grid.ac/institutes/grid.241116.1", 
          "name": [
            "Department of Radiation Oncology, University of Colorado-Denver, Denver, CO, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schefter", 
        "givenName": "Tracey E.", 
        "id": "sg:person.0616432022.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616432022.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Dr (RT041), 46202, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tudor", 
        "givenName": "Kathy", 
        "id": "sg:person.01037051513.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037051513.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Dr (RT041), 46202, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Deluca", 
        "givenName": "Jill", 
        "id": "sg:person.01105164713.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105164713.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
          "id": "https://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Dr (RT041), 46202, Indianapolis, IN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnstone", 
        "givenName": "Peter A. S.", 
        "id": "sg:person.016423326537.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016423326537.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/b:jora.0000010880.40483.c4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000187065", 
          "https://doi.org/10.1023/b:jora.0000010880.40483.c4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.10.059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007139921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2006.06.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007301148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02841860600897934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012333316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)03283-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012841835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(89)90530-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015253874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.3529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015883962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-8140(02)00061-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021466976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2004.05.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022997333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02841869509127197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023036250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02841869409121782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025889846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800600817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028384325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2005.11.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029002866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(03)01135-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030179267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(03)01135-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030179267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/02841860600904821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030251382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/jhep.2003.50047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030703205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(92)90651-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031041601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.07.1343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031568922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.3.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032301848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2005.07.170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033907811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2005.03.072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034018731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyh089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034943237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2006.02.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035058076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.124.5.1946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035470007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035519247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035519247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510300629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035926160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyi236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039927609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)02864-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041823191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199903113401001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046766119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/canjclin.55.2.74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048020321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.1840160212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049451442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2004.06.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050335682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1118/1.597396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052148927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(02)02846-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052821361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199603143341104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053195733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0708857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053513212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01621459.1958.10501452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058299418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3574407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070377434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3576626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070379390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.11.2210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074645669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.1.164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074743439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3583506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080002642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083272386", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-03", 
    "datePublishedReg": "2010-03-01", 
    "description": "BACKGROUND: Hepatocellular carcinoma (HCC) is increasing in incidence and the majority of patients are not candidates for radical therapies. Therefore, interest in minimally invasive therapies in growing.\nMETHODS: A Phase I dose escalation trial was conducted at Indiana University to determine the feasibility and toxicity of stereotactic body radiation therapy (SBRT) for primary HCC. Eligible patients had Child-Turcotte-Pugh's Class (CTP) A or B, were not candidates for resection, had 1-3 lesions and cumulative tumour diameter less than or equal to 6 cm. Dose escalation started at 36 Gy in 3 fractions (12 Gy/fraction) with a subsequent planned escalation of 2 Gy/ fraction/level. Dose-limiting toxicity (DLT) was defined as Common Terminology Criteria for Adverse Events v3.0 grade 3 or greater toxicity.\nRESULTS: Seventeen patients with 25 lesions were enrolled. Dose was escalated to 48 Gy (16 Gy/fraction) in CTP-A patients without DLT. Two patients with CPC-B disease developed grade 3 hepatic toxicity at the 42-Gy (14 Gy/fraction) level. The protocol was amended for subsequent CTP-B patients to receive a regimen of 5 fractions starting at 40 Gy (8 Gy/fraction) with one patient experiencing progressive liver failure. Four additional patients were enrolled (one died of unrelated causes after an incomplete SBRT course) without DLT. The only factor related to more than one grade 3 or greater liver toxicity or death within 6 months was the CTP score (p=0.03). Six patients underwent a liver transplant. Ten patients are alive without progression with a median FU of 24 months (10-42 months), with local control/stabilisation of the disease of 100%. One and two-year Kaplan-Meier estimates for overall survival are 75% and 60%, respectively.\nCONCLUSIONS: SBRT is a non-invasive feasible and well tolerated therapy in adequately selected patients with HCC. The preliminary local control and survival are encouraging. A confirmatory Phase II trial is currently open to accrual.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12094-010-0492-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1035367", 
        "issn": [
          "1699-048X", 
          "1699-3055"
        ], 
        "name": "Clinical and Translational Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Phase I feasibility trial of stereotactic body radiation therapy for primary hepatocellular carcinoma", 
    "pagination": "218-225", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7bfc3de971e18977163051b670755dae31cc98c01648271bcb212e912aa39fad"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20231127"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101247119"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12094-010-0492-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026025835"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12094-010-0492-x", 
      "https://app.dimensions.ai/details/publication/pub.1026025835"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54336_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12094-010-0492-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12094-010-0492-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12094-010-0492-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12094-010-0492-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12094-010-0492-x'


 

This table displays all metadata directly associated to this object as RDF triples.

318 TRIPLES      21 PREDICATES      83 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12094-010-0492-x schema:about N19cc9619a7a04c8ca148457f7759840f
2 N4fe97200f3704b05b93d573f1140ee07
3 N51af282d72394b2cb3b8f5bf5e043295
4 N582d9567794f42938c821529c6b72c34
5 N7d4af4cbacb3493daa84387ba931aa3a
6 N9f4760664a9d456bba07394048cf6d12
7 N9f7dd57a15304e579de2e08a859e558e
8 Ndcd008557ed34114b16bfca7beb32b9e
9 Nddeb6d33864b418dab966973fa9b6826
10 Nfd227b1aeb5c465aaeae3b4111208dfc
11 Nfddb2152db00406cacdacb7095faeb16
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author N57b0fe954e11474a89098671466190b1
15 schema:citation sg:pub.10.1023/b:jora.0000010880.40483.c4
16 https://app.dimensions.ai/details/publication/pub.1083272386
17 https://doi.org/10.1002/bjs.1800600817
18 https://doi.org/10.1002/hep.1840160212
19 https://doi.org/10.1002/hep.20933
20 https://doi.org/10.1002/hep.510300629
21 https://doi.org/10.1016/0360-3016(89)90530-0
22 https://doi.org/10.1016/0360-3016(92)90651-w
23 https://doi.org/10.1016/j.ijrobp.2004.05.048
24 https://doi.org/10.1016/j.ijrobp.2004.06.069
25 https://doi.org/10.1016/j.ijrobp.2005.03.072
26 https://doi.org/10.1016/j.ijrobp.2005.07.170
27 https://doi.org/10.1016/j.ijrobp.2005.11.034
28 https://doi.org/10.1016/j.ijrobp.2006.02.061
29 https://doi.org/10.1016/j.ijrobp.2006.06.015
30 https://doi.org/10.1016/j.ijrobp.2007.07.1343
31 https://doi.org/10.1016/j.ijrobp.2007.10.059
32 https://doi.org/10.1016/s0167-8140(02)00061-0
33 https://doi.org/10.1016/s0360-3016(02)02846-8
34 https://doi.org/10.1016/s0360-3016(02)02864-x
35 https://doi.org/10.1016/s0360-3016(02)03283-2
36 https://doi.org/10.1016/s0360-3016(03)01135-0
37 https://doi.org/10.1053/jhep.2003.50047
38 https://doi.org/10.1056/nejm199603143341104
39 https://doi.org/10.1056/nejm199903113401001
40 https://doi.org/10.1056/nejmoa0708857
41 https://doi.org/10.1080/01621459.1958.10501452
42 https://doi.org/10.1080/02841860600897934
43 https://doi.org/10.1080/02841860600904821
44 https://doi.org/10.1093/jjco/hyh089
45 https://doi.org/10.1093/jjco/hyi236
46 https://doi.org/10.1093/jnci/92.3.205
47 https://doi.org/10.1118/1.597396
48 https://doi.org/10.1200/jco.2000.18.11.2210
49 https://doi.org/10.1200/jco.2001.19.1.164
50 https://doi.org/10.1200/jco.2007.14.3529
51 https://doi.org/10.1378/chest.124.5.1946
52 https://doi.org/10.2307/3574407
53 https://doi.org/10.2307/3576626
54 https://doi.org/10.2307/3583506
55 https://doi.org/10.3109/02841869409121782
56 https://doi.org/10.3109/02841869509127197
57 https://doi.org/10.3322/canjclin.55.2.74
58 schema:datePublished 2010-03
59 schema:datePublishedReg 2010-03-01
60 schema:description BACKGROUND: Hepatocellular carcinoma (HCC) is increasing in incidence and the majority of patients are not candidates for radical therapies. Therefore, interest in minimally invasive therapies in growing. METHODS: A Phase I dose escalation trial was conducted at Indiana University to determine the feasibility and toxicity of stereotactic body radiation therapy (SBRT) for primary HCC. Eligible patients had Child-Turcotte-Pugh's Class (CTP) A or B, were not candidates for resection, had 1-3 lesions and cumulative tumour diameter less than or equal to 6 cm. Dose escalation started at 36 Gy in 3 fractions (12 Gy/fraction) with a subsequent planned escalation of 2 Gy/ fraction/level. Dose-limiting toxicity (DLT) was defined as Common Terminology Criteria for Adverse Events v3.0 grade 3 or greater toxicity. RESULTS: Seventeen patients with 25 lesions were enrolled. Dose was escalated to 48 Gy (16 Gy/fraction) in CTP-A patients without DLT. Two patients with CPC-B disease developed grade 3 hepatic toxicity at the 42-Gy (14 Gy/fraction) level. The protocol was amended for subsequent CTP-B patients to receive a regimen of 5 fractions starting at 40 Gy (8 Gy/fraction) with one patient experiencing progressive liver failure. Four additional patients were enrolled (one died of unrelated causes after an incomplete SBRT course) without DLT. The only factor related to more than one grade 3 or greater liver toxicity or death within 6 months was the CTP score (p=0.03). Six patients underwent a liver transplant. Ten patients are alive without progression with a median FU of 24 months (10-42 months), with local control/stabilisation of the disease of 100%. One and two-year Kaplan-Meier estimates for overall survival are 75% and 60%, respectively. CONCLUSIONS: SBRT is a non-invasive feasible and well tolerated therapy in adequately selected patients with HCC. The preliminary local control and survival are encouraging. A confirmatory Phase II trial is currently open to accrual.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree false
64 schema:isPartOf Ne71b41f7ffe34822b3b9d71f57ffe7e0
65 Nf6b4828c56f648d7bf3a5d73419546dc
66 sg:journal.1035367
67 schema:name Phase I feasibility trial of stereotactic body radiation therapy for primary hepatocellular carcinoma
68 schema:pagination 218-225
69 schema:productId N2cf0ff96232b48778c3aced6567b740b
70 N4c4d840816c64f9c937046c84c6eb57b
71 Nb064ba95352b47d2b257a88ada18a009
72 Ne9acbc182923494a81c651e499769e79
73 Nff09a1a602d44727a06bfc0eb79730f8
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026025835
75 https://doi.org/10.1007/s12094-010-0492-x
76 schema:sdDatePublished 2019-04-11T10:21
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nfa0e4d647b7f449194626b9949263642
79 schema:url http://link.springer.com/10.1007%2Fs12094-010-0492-x
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N0c578b7e484e47a4bb377ef52f1a77d5 rdf:first sg:person.01164242127.14
84 rdf:rest N39f3b5d321314045b2d66726a57db57c
85 N19cc9619a7a04c8ca148457f7759840f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Aged, 80 and over
87 rdf:type schema:DefinedTerm
88 N2605f235caac4e778577202134ce25d6 rdf:first sg:person.0606704573.89
89 rdf:rest N0c578b7e484e47a4bb377ef52f1a77d5
90 N2ba2791e92664c5393f8bb8c8739bdad rdf:first sg:person.01105164713.53
91 rdf:rest N8f3ef5343d5b480494a724a5970a1453
92 N2cf0ff96232b48778c3aced6567b740b schema:name readcube_id
93 schema:value 7bfc3de971e18977163051b670755dae31cc98c01648271bcb212e912aa39fad
94 rdf:type schema:PropertyValue
95 N31a7a77f24aa404db0db83bb56dc3851 rdf:first sg:person.01365542561.48
96 rdf:rest N2605f235caac4e778577202134ce25d6
97 N39f3b5d321314045b2d66726a57db57c rdf:first sg:person.01366400655.51
98 rdf:rest Na0b71ddbac6949e386f9621207d1404d
99 N4c4d840816c64f9c937046c84c6eb57b schema:name pubmed_id
100 schema:value 20231127
101 rdf:type schema:PropertyValue
102 N4fe97200f3704b05b93d573f1140ee07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Carcinoma, Hepatocellular
104 rdf:type schema:DefinedTerm
105 N51af282d72394b2cb3b8f5bf5e043295 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Female
107 rdf:type schema:DefinedTerm
108 N57b0fe954e11474a89098671466190b1 rdf:first sg:person.01141564755.06
109 rdf:rest Na896baa37dd84cc49b817af7e667b2bb
110 N582d9567794f42938c821529c6b72c34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Humans
112 rdf:type schema:DefinedTerm
113 N7b0863cb16854d23a5c9f11c4988fcb8 rdf:first sg:person.01372076013.34
114 rdf:rest N31a7a77f24aa404db0db83bb56dc3851
115 N7d4af4cbacb3493daa84387ba931aa3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Middle Aged
117 rdf:type schema:DefinedTerm
118 N8f3ef5343d5b480494a724a5970a1453 rdf:first sg:person.016423326537.14
119 rdf:rest rdf:nil
120 N948163dca27b4154b9b81162a36b00ec rdf:first sg:person.01037051513.73
121 rdf:rest N2ba2791e92664c5393f8bb8c8739bdad
122 N9f4760664a9d456bba07394048cf6d12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Maximum Tolerated Dose
124 rdf:type schema:DefinedTerm
125 N9f7dd57a15304e579de2e08a859e558e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Liver Neoplasms
127 rdf:type schema:DefinedTerm
128 Na0b71ddbac6949e386f9621207d1404d rdf:first sg:person.0616432022.02
129 rdf:rest N948163dca27b4154b9b81162a36b00ec
130 Na896baa37dd84cc49b817af7e667b2bb rdf:first sg:person.01204037055.31
131 rdf:rest N7b0863cb16854d23a5c9f11c4988fcb8
132 Nb064ba95352b47d2b257a88ada18a009 schema:name doi
133 schema:value 10.1007/s12094-010-0492-x
134 rdf:type schema:PropertyValue
135 Ndcd008557ed34114b16bfca7beb32b9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Male
137 rdf:type schema:DefinedTerm
138 Nddeb6d33864b418dab966973fa9b6826 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Aged
140 rdf:type schema:DefinedTerm
141 Ne71b41f7ffe34822b3b9d71f57ffe7e0 schema:issueNumber 3
142 rdf:type schema:PublicationIssue
143 Ne9acbc182923494a81c651e499769e79 schema:name dimensions_id
144 schema:value pub.1026025835
145 rdf:type schema:PropertyValue
146 Nf6b4828c56f648d7bf3a5d73419546dc schema:volumeNumber 12
147 rdf:type schema:PublicationVolume
148 Nfa0e4d647b7f449194626b9949263642 schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 Nfd227b1aeb5c465aaeae3b4111208dfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Feasibility Studies
152 rdf:type schema:DefinedTerm
153 Nfddb2152db00406cacdacb7095faeb16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Radiosurgery
155 rdf:type schema:DefinedTerm
156 Nff09a1a602d44727a06bfc0eb79730f8 schema:name nlm_unique_id
157 schema:value 101247119
158 rdf:type schema:PropertyValue
159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical and Health Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
163 schema:name Oncology and Carcinogenesis
164 rdf:type schema:DefinedTerm
165 sg:journal.1035367 schema:issn 1699-048X
166 1699-3055
167 schema:name Clinical and Translational Oncology
168 rdf:type schema:Periodical
169 sg:person.01037051513.73 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
170 schema:familyName Tudor
171 schema:givenName Kathy
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037051513.73
173 rdf:type schema:Person
174 sg:person.01105164713.53 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
175 schema:familyName Deluca
176 schema:givenName Jill
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105164713.53
178 rdf:type schema:Person
179 sg:person.01141564755.06 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
180 schema:familyName Cárdenes
181 schema:givenName Higinia R.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141564755.06
183 rdf:type schema:Person
184 sg:person.01164242127.14 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
185 schema:familyName Breen
186 schema:givenName T. E.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164242127.14
188 rdf:type schema:Person
189 sg:person.01204037055.31 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
190 schema:familyName Price
191 schema:givenName Tracy R.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204037055.31
193 rdf:type schema:Person
194 sg:person.01365542561.48 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
195 schema:familyName Maluccio
196 schema:givenName Mary
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365542561.48
198 rdf:type schema:Person
199 sg:person.01366400655.51 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
200 schema:familyName Henderson
201 schema:givenName Mark A.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366400655.51
203 rdf:type schema:Person
204 sg:person.01372076013.34 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
205 schema:familyName Perkins
206 schema:givenName Susan M.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372076013.34
208 rdf:type schema:Person
209 sg:person.016423326537.14 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
210 schema:familyName Johnstone
211 schema:givenName Peter A. S.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016423326537.14
213 rdf:type schema:Person
214 sg:person.0606704573.89 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
215 schema:familyName Kwo
216 schema:givenName P.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606704573.89
218 rdf:type schema:Person
219 sg:person.0616432022.02 schema:affiliation https://www.grid.ac/institutes/grid.241116.1
220 schema:familyName Schefter
221 schema:givenName Tracey E.
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616432022.02
223 rdf:type schema:Person
224 sg:pub.10.1023/b:jora.0000010880.40483.c4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000187065
225 https://doi.org/10.1023/b:jora.0000010880.40483.c4
226 rdf:type schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1083272386 schema:CreativeWork
228 https://doi.org/10.1002/bjs.1800600817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028384325
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/hep.1840160212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049451442
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/hep.20933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035519247
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1002/hep.510300629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035926160
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/0360-3016(89)90530-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015253874
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/0360-3016(92)90651-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1031041601
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.ijrobp.2004.05.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022997333
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.ijrobp.2004.06.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050335682
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.ijrobp.2005.03.072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034018731
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.ijrobp.2005.07.170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033907811
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.ijrobp.2005.11.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029002866
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.ijrobp.2006.02.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035058076
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.ijrobp.2006.06.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007301148
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.ijrobp.2007.07.1343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031568922
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.ijrobp.2007.10.059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007139921
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s0167-8140(02)00061-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021466976
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0360-3016(02)02846-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052821361
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s0360-3016(02)02864-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041823191
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/s0360-3016(02)03283-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012841835
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s0360-3016(03)01135-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030179267
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1053/jhep.2003.50047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030703205
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1056/nejm199603143341104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053195733
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1056/nejm199903113401001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046766119
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1056/nejmoa0708857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053513212
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1080/01621459.1958.10501452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058299418
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1080/02841860600897934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012333316
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1080/02841860600904821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030251382
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1093/jjco/hyh089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034943237
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1093/jjco/hyi236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039927609
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1093/jnci/92.3.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032301848
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1118/1.597396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052148927
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1200/jco.2000.18.11.2210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074645669
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1200/jco.2001.19.1.164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074743439
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1200/jco.2007.14.3529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015883962
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1378/chest.124.5.1946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035470007
297 rdf:type schema:CreativeWork
298 https://doi.org/10.2307/3574407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070377434
299 rdf:type schema:CreativeWork
300 https://doi.org/10.2307/3576626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070379390
301 rdf:type schema:CreativeWork
302 https://doi.org/10.2307/3583506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080002642
303 rdf:type schema:CreativeWork
304 https://doi.org/10.3109/02841869409121782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025889846
305 rdf:type schema:CreativeWork
306 https://doi.org/10.3109/02841869509127197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023036250
307 rdf:type schema:CreativeWork
308 https://doi.org/10.3322/canjclin.55.2.74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048020321
309 rdf:type schema:CreativeWork
310 https://www.grid.ac/institutes/grid.241116.1 schema:alternateName University of Colorado Denver
311 schema:name Department of Radiation Oncology, University of Colorado-Denver, Denver, CO, USA
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.257413.6 schema:alternateName Indiana University – Purdue University Indianapolis
314 schema:name Department of Internal Medicine-Hepatology, Indiana University School of Medicine, Indianapolis, IN, USA
315 Department of Medicine-Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA
316 Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Dr (RT041), 46202, Indianapolis, IN, USA
317 Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
318 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...