Genetically modified mouse models in cancer studies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-12

AUTHORS

Javier Santos, Pablo Fernández-Navarro, María Villa-Morales, Laura González-Sánchez, José Fernández-Piqueras

ABSTRACT

Genetically modified animals represent a resource of immense potential for cancer research. Classically, genetic modifications in mice were obtained through selected breeding experiments or treatments with powerful carcinogens capable of inducing random mutagenesis. A new era began in the early 1980s when genetic modifications by inserting foreign DNA genes into the cells of an animal allowed for the development of transgenic mice. Since that moment, genetic modifications have been able to be made in a predetermined way. Gene targeting emerged later as a method of in vivo mutagenesis whereby the sequence of a predetermined gene is selectively modified within an intact cell. In this review we focus on how genetically modified mice can be created to study tumour development, and how these models have contributed to an understanding of the genetic alterations involved in human cancer. We also discuss the strengths and weaknesses of the different mouse models for identifying cancer genes, and understanding the consequences of their alterations in order to obtain the maximum benefit for cancer patients. More... »

PAGES

794-803

References to SciGraph publications

  • 2007-05. Impaired microRNA processing enhances cellular transformation and tumorigenesis in NATURE GENETICS
  • 2003-02. Thymopoiesis independent of common lymphoid progenitors in NATURE IMMUNOLOGY
  • 1998-12. Engineering chromosomes in mice through targeted meiotic recombination (TAMERE) in NATURE GENETICS
  • 1994-07. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1 in NATURE GENETICS
  • 1992-03. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours in NATURE
  • 1992-09. Effects of an Rb mutation in the mouse in NATURE
  • 2005-01. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer in NATURE MEDICINE
  • 2007-07. Delayed ageing through damage protection by the Arf/p53 pathway in NATURE
  • 2008-04. Translating insights from the cancer genome into clinical practice in NATURE
  • 2005-11. Retroviral insertional mutagenesis: past, present and future in ONCOGENE
  • 2000-02. Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycERTM mice in ONCOGENE
  • 2000-12. Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing in NATURE GENETICS
  • 2005-08. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis in NATURE
  • 2005-06. MicroRNA expression profiles classify human cancers in NATURE
  • 2005-07. Temporal dissection of p53 function in vitro and in vivo in NATURE GENETICS
  • 2002-07. Cre-loxP chromosome engineering of a targeted deletion in the mouse corresponding to the 3p21.3 region of homozygous loss in human tumours in ONCOGENE
  • 2007-09. Cancer and ageing: convergent and divergent mechanisms in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-09. The mouse ascending: perspectives for human-disease models in NATURE CELL BIOLOGY
  • 2005-03. The promise of genetically engineered mice for cancer prevention studies in NATURE REVIEWS CANCER
  • 2006-07. Tumorigenic activity of p21<sup>Waf1/Cip1</sup> in thymic lymphoma in ONCOGENE
  • 2001-05. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells in NATURE
  • 2007-01. The mouse as a model for human biology: a resource guide for complex trait analysis in NATURE REVIEWS GENETICS
  • 2007-07. Vagaries of conditional gene targeting in NATURE IMMUNOLOGY
  • 1985-12. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice in NATURE
  • 2006-09. Model organisms: The mighty mouse: genetically engineered mouse models in cancer drug development in NATURE REVIEWS DRUG DISCOVERY
  • 2004-09. Genetically modified mouse models for pharmacogenomic research in NATURE REVIEWS GENETICS
  • 2001-04. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice in NATURE
  • 1998-08. Pten is essential for embryonic development and tumour suppression in NATURE GENETICS
  • 2005-08. Distinct epigenetic changes in the stromal cells of breast cancers in NATURE GENETICS
  • 2007-02. Humanized mice in translational biomedical research in NATURE REVIEWS IMMUNOLOGY
  • 1998-04. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells in NATURE
  • 2005-08. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants in NATURE
  • 2001-10. Generating mice with targeted mutations in NATURE MEDICINE
  • 2007-09. Maximizing mouse cancer models in NATURE REVIEWS CANCER
  • 1995-04. A site–directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination in NATURE GENETICS
  • 2002-11. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas in NATURE GENETICS
  • 2000-08. Mice without telomerase: what can they teach us about human cancer? in NATURE MEDICINE
  • 2003-09. Cancer susceptibility in the mouse: genetics, biology and implications for human cancer in NATURE REVIEWS GENETICS
  • 2007-03. Strategies for silencing human disease using RNA interference in NATURE REVIEWS GENETICS
  • 2007-10. Telomere length, stem cells and aging in NATURE CHEMICAL BIOLOGY
  • 1992-09. Requirement for a functional Rb-1 gene in murine development in NATURE
  • 2002-05. Modelling the molecular circuitry of cancer in NATURE REVIEWS CANCER
  • 2007-03. Cancer: Drivers and passengers in NATURE
  • 2003-04. Senescence, apoptosis and therapy — cutting the lifelines of cancer in NATURE REVIEWS CANCER
  • 2006-03. Functional Fas (Cd95/Apo-1) promoter polymorphisms in inbred mouse strains exhibiting different susceptibility to γ-radiation-induced thymic lymphoma in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12094-008-0292-8

    DOI

    http://dx.doi.org/10.1007/s12094-008-0292-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016150839

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19068450


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Knockdown Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Targeting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Transgenic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Xenograft Model Antitumor Assays", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Instituto de Salud Carlos III", 
              "id": "https://www.grid.ac/institutes/grid.413448.e", 
              "name": [
                "Dpto. Biolog\u00eda CSIC/UAM, Centro de Biolog\u00eda Molecular Severo Ochoa, C/ Nicol\u00e1s Cabrera 1, ES-28049, Madrid, Spain", 
                "Ministerio de Sanidad y Consumo, Ciber en Enfermedades Raras, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Santos", 
            "givenName": "Javier", 
            "id": "sg:person.01323366573.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323366573.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto de Salud Carlos III", 
              "id": "https://www.grid.ac/institutes/grid.413448.e", 
              "name": [
                "\u00c1rea de Epidemiolog\u00eda Ambiental y C\u00e1ncer, Centro Nacional de Epidemiolog\u00eda Instituto de Salud Carlos III, Madrid, Spain", 
                "Ministerio de Sanidad y Consumo, Ciber en Epidemiolog\u00eda y Salud P\u00fablica, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fern\u00e1ndez-Navarro", 
            "givenName": "Pablo", 
            "id": "sg:person.01020112445.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020112445.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto de Salud Carlos III", 
              "id": "https://www.grid.ac/institutes/grid.413448.e", 
              "name": [
                "Dpto. Biolog\u00eda CSIC/UAM, Centro de Biolog\u00eda Molecular Severo Ochoa, C/ Nicol\u00e1s Cabrera 1, ES-28049, Madrid, Spain", 
                "Ministerio de Sanidad y Consumo, Ciber en Enfermedades Raras, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Villa-Morales", 
            "givenName": "Mar\u00eda", 
            "id": "sg:person.0731265667.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731265667.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto de Salud Carlos III", 
              "id": "https://www.grid.ac/institutes/grid.413448.e", 
              "name": [
                "Dpto. Biolog\u00eda CSIC/UAM, Centro de Biolog\u00eda Molecular Severo Ochoa, C/ Nicol\u00e1s Cabrera 1, ES-28049, Madrid, Spain", 
                "Ministerio de Sanidad y Consumo, Ciber en Enfermedades Raras, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gonz\u00e1lez-S\u00e1nchez", 
            "givenName": "Laura", 
            "id": "sg:person.01342057115.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342057115.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto de Salud Carlos III", 
              "id": "https://www.grid.ac/institutes/grid.413448.e", 
              "name": [
                "Dpto. Biolog\u00eda CSIC/UAM, Centro de Biolog\u00eda Molecular Severo Ochoa, C/ Nicol\u00e1s Cabrera 1, ES-28049, Madrid, Spain", 
                "Ministerio de Sanidad y Consumo, Ciber en Enfermedades Raras, Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fern\u00e1ndez-Piqueras", 
            "givenName": "Jos\u00e9", 
            "id": "sg:person.01106347624.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106347624.32"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrg1429", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000062399", 
              "https://doi.org/10.1038/nrg1429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1429", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000062399", 
              "https://doi.org/10.1038/nrg1429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.19.8969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000531425"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(03)00005-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002816566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0959-437x(03)00005-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002816566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003654899", 
              "https://doi.org/10.1038/nrg1157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003654899", 
              "https://doi.org/10.1038/nrg1157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0604130103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004375878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)80006-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004868239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/318533a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005012397", 
              "https://doi.org/10.1038/318533a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/318533a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005012397", 
              "https://doi.org/10.1038/318533a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/33423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005145915", 
              "https://doi.org/10.1038/33423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/33423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005145915", 
              "https://doi.org/10.1038/33423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35074129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005772949", 
              "https://doi.org/10.1038/35074129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35074129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005772949", 
              "https://doi.org/10.1038/35074129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/446145a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006489736", 
              "https://doi.org/10.1038/446145a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.943001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007211161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007822900", 
              "https://doi.org/10.1038/sj.onc.1209043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007822900", 
              "https://doi.org/10.1038/sj.onc.1209043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007822900", 
              "https://doi.org/10.1038/sj.onc.1209043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008760692", 
              "https://doi.org/10.1038/nrd2110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008760692", 
              "https://doi.org/10.1038/nrd2110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1596", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009581629", 
              "https://doi.org/10.1038/ng1596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1596", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009581629", 
              "https://doi.org/10.1038/ng1596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209234", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009974115", 
              "https://doi.org/10.1038/sj.onc.1209234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209234", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009974115", 
              "https://doi.org/10.1038/sj.onc.1209234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci20476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011836453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.embor.7400667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011838697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/sj.embor.7400667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011838697"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0959-437x(95)80049-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012832916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/359295a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013123356", 
              "https://doi.org/10.1038/359295a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bies.950161202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014796159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/82593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014936510", 
              "https://doi.org/10.1038/82593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/82593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014936510", 
              "https://doi.org/10.1038/82593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0707-665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015282106", 
              "https://doi.org/10.1038/ni0707-665"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0794-353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015902905", 
              "https://doi.org/10.1038/ng0794-353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016433101", 
              "https://doi.org/10.1038/3861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016433101", 
              "https://doi.org/10.1038/3861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018271980", 
              "https://doi.org/10.1038/ni878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018271980", 
              "https://doi.org/10.1038/ni878"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0168-9525(93)90104-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019985929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020025073", 
              "https://doi.org/10.1038/sj.onc.1205530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020025073", 
              "https://doi.org/10.1038/sj.onc.1205530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80452-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021286113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.12.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022163647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1535-6108(03)00106-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022586708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023061383", 
              "https://doi.org/10.1038/sj.onc.1209432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1209432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023061383", 
              "https://doi.org/10.1038/sj.onc.1209432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb437", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023498683", 
              "https://doi.org/10.1038/ncb437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-4006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023894047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgi331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024479456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80580-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024660332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024825726", 
              "https://doi.org/10.1038/nature03702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024825726", 
              "https://doi.org/10.1038/nature03702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0495-376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026103982", 
              "https://doi.org/10.1038/ng0495-376"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026380926", 
              "https://doi.org/10.1038/nri2017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81902-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026392285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1097-2765(00)80367-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027021943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027424701", 
              "https://doi.org/10.1038/nature03918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03918", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027424701", 
              "https://doi.org/10.1038/nature03918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/356215a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027559823", 
              "https://doi.org/10.1038/356215a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35078107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028423924", 
              "https://doi.org/10.1038/35078107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35078107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028423924", 
              "https://doi.org/10.1038/35078107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029198606", 
              "https://doi.org/10.1038/nrg2006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.01.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029487514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029874726", 
              "https://doi.org/10.1038/nrc1565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029874726", 
              "https://doi.org/10.1038/nrc1565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029874726", 
              "https://doi.org/10.1038/nrc1565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.2007.38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030185521", 
              "https://doi.org/10.1038/nchembio.2007.38"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.09.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031496607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032103889", 
              "https://doi.org/10.1038/nature03845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032103889", 
              "https://doi.org/10.1038/nature03845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03845", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032103889", 
              "https://doi.org/10.1038/nature03845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2006.11.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032527480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-4195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032859718"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2007.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032956129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033012733", 
              "https://doi.org/10.1038/ng1013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033012733", 
              "https://doi.org/10.1038/ng1013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archopht.1997.01100150647013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033153511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/cdf595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033235876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05949", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033532665", 
              "https://doi.org/10.1038/nature05949"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2242", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033612140", 
              "https://doi.org/10.1038/nrm2242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/1235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033843315", 
              "https://doi.org/10.1038/1235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/1235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033843315", 
              "https://doi.org/10.1038/1235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0962-8924(01)02151-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033844135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.pharmtox.45.120403.100007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034203358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.pharmtox.45.120403.100007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034203358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1001-1086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034245766", 
              "https://doi.org/10.1038/nm1001-1086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1001-1086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034245766", 
              "https://doi.org/10.1038/nm1001-1086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034282407", 
              "https://doi.org/10.1038/nrc2192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.310304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034394169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035826997", 
              "https://doi.org/10.1038/nm1173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035826997", 
              "https://doi.org/10.1038/nm1173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036221931", 
              "https://doi.org/10.1038/ng2003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036221931", 
              "https://doi.org/10.1038/ng2003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgg057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036625088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/359328a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036861399", 
              "https://doi.org/10.1038/359328a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/78595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036912323", 
              "https://doi.org/10.1038/78595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/78595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036912323", 
              "https://doi.org/10.1038/78595"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81079-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037997315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040048209", 
              "https://doi.org/10.1038/sj.onc.1203321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040048209", 
              "https://doi.org/10.1038/sj.onc.1203321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.8.9.1019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040640333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(07)00488-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041868214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2005.04.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042185129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2005.04.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042185129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/20.23.6637", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042684334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0168-9525(89)90029-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042901717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043444548", 
              "https://doi.org/10.1038/nrg2025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043444548", 
              "https://doi.org/10.1038/nrg2025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045099768", 
              "https://doi.org/10.1038/nrc795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045099768", 
              "https://doi.org/10.1038/nrc795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046768621", 
              "https://doi.org/10.1038/ng1572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046768621", 
              "https://doi.org/10.1038/ng1572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046768621", 
              "https://doi.org/10.1038/ng1572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.4.1563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047977012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.05.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048448198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-010x(19970215)277:3<245::aid-jez5>3.0.co;2-o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048609455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(00)00002-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049621852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049745772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0076-6879(93)25048-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051738738"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2008.04.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051991611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052830524", 
              "https://doi.org/10.1038/nrc1044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052830524", 
              "https://doi.org/10.1038/nrc1044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06914", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053461506", 
              "https://doi.org/10.1038/nature06914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053575430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/pr070202v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056291606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/01926230490424716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058308058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/01926230490424716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058308058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1350108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062477270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.5.10.2734", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072298433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075105055", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2008-12", 
        "datePublishedReg": "2008-12-01", 
        "description": "Genetically modified animals represent a resource of immense potential for cancer research. Classically, genetic modifications in mice were obtained through selected breeding experiments or treatments with powerful carcinogens capable of inducing random mutagenesis. A new era began in the early 1980s when genetic modifications by inserting foreign DNA genes into the cells of an animal allowed for the development of transgenic mice. Since that moment, genetic modifications have been able to be made in a predetermined way. Gene targeting emerged later as a method of in vivo mutagenesis whereby the sequence of a predetermined gene is selectively modified within an intact cell. In this review we focus on how genetically modified mice can be created to study tumour development, and how these models have contributed to an understanding of the genetic alterations involved in human cancer. We also discuss the strengths and weaknesses of the different mouse models for identifying cancer genes, and understanding the consequences of their alterations in order to obtain the maximum benefit for cancer patients.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s12094-008-0292-8", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1035367", 
            "issn": [
              "1699-048X", 
              "1699-3055"
            ], 
            "name": "Clinical and Translational Oncology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "Genetically modified mouse models in cancer studies", 
        "pagination": "794-803", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "4cf4612521941a35bc7b24a71893e9196ed4a8c77e05ab514f1bf2bb0cf4b229"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19068450"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101247119"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12094-008-0292-8"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1016150839"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12094-008-0292-8", 
          "https://app.dimensions.ai/details/publication/pub.1016150839"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T19:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000521.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs12094-008-0292-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12094-008-0292-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12094-008-0292-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12094-008-0292-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12094-008-0292-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    467 TRIPLES      21 PREDICATES      133 URIs      32 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12094-008-0292-8 schema:about N063f45d93f22462ba51ef89926dca6f6
    2 N154a5fd06560491ca8b1fe9f64217f64
    3 N33394590f8c648f9827b8ad4588a087c
    4 N42f1cf799d7048e18c7004a8444ec294
    5 N92f03b475ba24e3fa1a9e734358f6187
    6 N97c1da277d0e4fd48906b5b32a9eee4d
    7 Nbaf09a837e3748398827d370b82b931a
    8 Nc7f107232f1e4968b3e3f03d7db1b118
    9 Nd49f730b28e9451287c5816446323e24
    10 Nf085e61f202e49af813b329e4053756d
    11 Nfa6d957e14b04348a33c8fe08a05398a
    12 anzsrc-for:11
    13 anzsrc-for:1112
    14 schema:author Ne0c5e4f4662e459984d0369dc5fb9a60
    15 schema:citation sg:pub.10.1038/1235
    16 sg:pub.10.1038/318533a0
    17 sg:pub.10.1038/33423
    18 sg:pub.10.1038/35074129
    19 sg:pub.10.1038/35078107
    20 sg:pub.10.1038/356215a0
    21 sg:pub.10.1038/359295a0
    22 sg:pub.10.1038/359328a0
    23 sg:pub.10.1038/3861
    24 sg:pub.10.1038/446145a
    25 sg:pub.10.1038/78595
    26 sg:pub.10.1038/82593
    27 sg:pub.10.1038/nature03702
    28 sg:pub.10.1038/nature03845
    29 sg:pub.10.1038/nature03918
    30 sg:pub.10.1038/nature05949
    31 sg:pub.10.1038/nature06914
    32 sg:pub.10.1038/ncb437
    33 sg:pub.10.1038/nchembio.2007.38
    34 sg:pub.10.1038/ng0495-376
    35 sg:pub.10.1038/ng0794-353
    36 sg:pub.10.1038/ng1013
    37 sg:pub.10.1038/ng1572
    38 sg:pub.10.1038/ng1596
    39 sg:pub.10.1038/ng2003
    40 sg:pub.10.1038/ni0707-665
    41 sg:pub.10.1038/ni878
    42 sg:pub.10.1038/nm1001-1086
    43 sg:pub.10.1038/nm1173
    44 sg:pub.10.1038/nrc1044
    45 sg:pub.10.1038/nrc1565
    46 sg:pub.10.1038/nrc2192
    47 sg:pub.10.1038/nrc795
    48 sg:pub.10.1038/nrd2110
    49 sg:pub.10.1038/nrg1157
    50 sg:pub.10.1038/nrg1429
    51 sg:pub.10.1038/nrg2006
    52 sg:pub.10.1038/nrg2025
    53 sg:pub.10.1038/nri2017
    54 sg:pub.10.1038/nrm2242
    55 sg:pub.10.1038/sj.onc.1203321
    56 sg:pub.10.1038/sj.onc.1205530
    57 sg:pub.10.1038/sj.onc.1209043
    58 sg:pub.10.1038/sj.onc.1209234
    59 sg:pub.10.1038/sj.onc.1209432
    60 https://app.dimensions.ai/details/publication/pub.1075105055
    61 https://doi.org/10.1001/archopht.1997.01100150647013
    62 https://doi.org/10.1002/(sici)1097-010x(19970215)277:3<245::aid-jez5>3.0.co;2-o
    63 https://doi.org/10.1002/bies.950161202
    64 https://doi.org/10.1016/0076-6879(93)25048-7
    65 https://doi.org/10.1016/0168-9525(89)90029-2
    66 https://doi.org/10.1016/0168-9525(93)90104-p
    67 https://doi.org/10.1016/0959-437x(95)80049-2
    68 https://doi.org/10.1016/j.ccr.2005.04.023
    69 https://doi.org/10.1016/j.ccr.2007.01.012
    70 https://doi.org/10.1016/j.ccr.2007.01.017
    71 https://doi.org/10.1016/j.ccr.2008.04.018
    72 https://doi.org/10.1016/j.cell.2004.11.004
    73 https://doi.org/10.1016/j.cell.2005.09.030
    74 https://doi.org/10.1016/j.cell.2006.11.044
    75 https://doi.org/10.1016/j.cell.2006.12.018
    76 https://doi.org/10.1016/j.cell.2007.05.013
    77 https://doi.org/10.1016/j.cell.2007.07.003
    78 https://doi.org/10.1016/s0092-8674(00)80452-3
    79 https://doi.org/10.1016/s0092-8674(00)80580-2
    80 https://doi.org/10.1016/s0092-8674(00)81079-x
    81 https://doi.org/10.1016/s0092-8674(00)81902-9
    82 https://doi.org/10.1016/s0092-8674(01)80006-4
    83 https://doi.org/10.1016/s0959-437x(03)00005-4
    84 https://doi.org/10.1016/s0960-9822(00)00002-6
    85 https://doi.org/10.1016/s0960-9822(07)00488-5
    86 https://doi.org/10.1016/s0962-8924(01)02151-1
    87 https://doi.org/10.1016/s1097-2765(00)80367-6
    88 https://doi.org/10.1016/s1535-6108(03)00106-5
    89 https://doi.org/10.1021/pr070202v
    90 https://doi.org/10.1038/sj.embor.7400667
    91 https://doi.org/10.1073/pnas.0604130103
    92 https://doi.org/10.1073/pnas.91.19.8969
    93 https://doi.org/10.1073/pnas.96.4.1563
    94 https://doi.org/10.1080/01926230490424716
    95 https://doi.org/10.1093/carcin/bgg057
    96 https://doi.org/10.1093/carcin/bgi331
    97 https://doi.org/10.1093/emboj/20.23.6637
    98 https://doi.org/10.1093/emboj/cdf595
    99 https://doi.org/10.1101/gad.310304
    100 https://doi.org/10.1101/gad.8.9.1019
    101 https://doi.org/10.1101/gad.943001
    102 https://doi.org/10.1126/science.1350108
    103 https://doi.org/10.1146/annurev.pharmtox.45.120403.100007
    104 https://doi.org/10.1158/0008-5472.can-04-4195
    105 https://doi.org/10.1158/0008-5472.can-06-4006
    106 https://doi.org/10.1172/jci20476
    107 https://doi.org/10.4161/cc.5.10.2734
    108 schema:datePublished 2008-12
    109 schema:datePublishedReg 2008-12-01
    110 schema:description Genetically modified animals represent a resource of immense potential for cancer research. Classically, genetic modifications in mice were obtained through selected breeding experiments or treatments with powerful carcinogens capable of inducing random mutagenesis. A new era began in the early 1980s when genetic modifications by inserting foreign DNA genes into the cells of an animal allowed for the development of transgenic mice. Since that moment, genetic modifications have been able to be made in a predetermined way. Gene targeting emerged later as a method of in vivo mutagenesis whereby the sequence of a predetermined gene is selectively modified within an intact cell. In this review we focus on how genetically modified mice can be created to study tumour development, and how these models have contributed to an understanding of the genetic alterations involved in human cancer. We also discuss the strengths and weaknesses of the different mouse models for identifying cancer genes, and understanding the consequences of their alterations in order to obtain the maximum benefit for cancer patients.
    111 schema:genre research_article
    112 schema:inLanguage en
    113 schema:isAccessibleForFree false
    114 schema:isPartOf N7f46cf3456ea4fd5b960a972f112a9e3
    115 Ne903dcf749f34dfb81a4281e0c8fb8a6
    116 sg:journal.1035367
    117 schema:name Genetically modified mouse models in cancer studies
    118 schema:pagination 794-803
    119 schema:productId N118e3d62b5b943aca8923f6977867cb5
    120 N68c763b15c0240e5b1df6857d16fb939
    121 N8f9a62f78ac94ff8b8800fdbc0156cc1
    122 Nc8f5d5842673499ba2f1d703655e62d1
    123 Nfc73ad27f437452d85bfb058f8c89c71
    124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016150839
    125 https://doi.org/10.1007/s12094-008-0292-8
    126 schema:sdDatePublished 2019-04-10T19:59
    127 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    128 schema:sdPublisher Na7838a5dae314b70ad4732dac1b7a513
    129 schema:url http://link.springer.com/10.1007%2Fs12094-008-0292-8
    130 sgo:license sg:explorer/license/
    131 sgo:sdDataset articles
    132 rdf:type schema:ScholarlyArticle
    133 N063f45d93f22462ba51ef89926dca6f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Animals
    135 rdf:type schema:DefinedTerm
    136 N118e3d62b5b943aca8923f6977867cb5 schema:name readcube_id
    137 schema:value 4cf4612521941a35bc7b24a71893e9196ed4a8c77e05ab514f1bf2bb0cf4b229
    138 rdf:type schema:PropertyValue
    139 N154a5fd06560491ca8b1fe9f64217f64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Biomarkers, Tumor
    141 rdf:type schema:DefinedTerm
    142 N33394590f8c648f9827b8ad4588a087c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Neoplasms
    144 rdf:type schema:DefinedTerm
    145 N3c1aa6eb13a64b6ca3942884f4fce4a7 rdf:first sg:person.01020112445.40
    146 rdf:rest Nfe78d201650740c0afa20db9f5739dbf
    147 N42f1cf799d7048e18c7004a8444ec294 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Gene Targeting
    149 rdf:type schema:DefinedTerm
    150 N68c763b15c0240e5b1df6857d16fb939 schema:name pubmed_id
    151 schema:value 19068450
    152 rdf:type schema:PropertyValue
    153 N7f46cf3456ea4fd5b960a972f112a9e3 schema:issueNumber 12
    154 rdf:type schema:PublicationIssue
    155 N8f9a62f78ac94ff8b8800fdbc0156cc1 schema:name dimensions_id
    156 schema:value pub.1016150839
    157 rdf:type schema:PropertyValue
    158 N92f03b475ba24e3fa1a9e734358f6187 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Mice, Transgenic
    160 rdf:type schema:DefinedTerm
    161 N97c1da277d0e4fd48906b5b32a9eee4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Gene Knockdown Techniques
    163 rdf:type schema:DefinedTerm
    164 Na0c868ce2f794cf28e3bd0704c9aa9fc rdf:first sg:person.01342057115.20
    165 rdf:rest Nc264b32640784099923e7386c902f93c
    166 Na7838a5dae314b70ad4732dac1b7a513 schema:name Springer Nature - SN SciGraph project
    167 rdf:type schema:Organization
    168 Nbaf09a837e3748398827d370b82b931a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Genetic Predisposition to Disease
    170 rdf:type schema:DefinedTerm
    171 Nc264b32640784099923e7386c902f93c rdf:first sg:person.01106347624.32
    172 rdf:rest rdf:nil
    173 Nc7f107232f1e4968b3e3f03d7db1b118 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Mice
    175 rdf:type schema:DefinedTerm
    176 Nc8f5d5842673499ba2f1d703655e62d1 schema:name doi
    177 schema:value 10.1007/s12094-008-0292-8
    178 rdf:type schema:PropertyValue
    179 Nd49f730b28e9451287c5816446323e24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Xenograft Model Antitumor Assays
    181 rdf:type schema:DefinedTerm
    182 Ne0c5e4f4662e459984d0369dc5fb9a60 rdf:first sg:person.01323366573.33
    183 rdf:rest N3c1aa6eb13a64b6ca3942884f4fce4a7
    184 Ne903dcf749f34dfb81a4281e0c8fb8a6 schema:volumeNumber 10
    185 rdf:type schema:PublicationVolume
    186 Nf085e61f202e49af813b329e4053756d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Disease Models, Animal
    188 rdf:type schema:DefinedTerm
    189 Nfa6d957e14b04348a33c8fe08a05398a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Models, Biological
    191 rdf:type schema:DefinedTerm
    192 Nfc73ad27f437452d85bfb058f8c89c71 schema:name nlm_unique_id
    193 schema:value 101247119
    194 rdf:type schema:PropertyValue
    195 Nfe78d201650740c0afa20db9f5739dbf rdf:first sg:person.0731265667.46
    196 rdf:rest Na0c868ce2f794cf28e3bd0704c9aa9fc
    197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Medical and Health Sciences
    199 rdf:type schema:DefinedTerm
    200 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    201 schema:name Oncology and Carcinogenesis
    202 rdf:type schema:DefinedTerm
    203 sg:journal.1035367 schema:issn 1699-048X
    204 1699-3055
    205 schema:name Clinical and Translational Oncology
    206 rdf:type schema:Periodical
    207 sg:person.01020112445.40 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
    208 schema:familyName Fernández-Navarro
    209 schema:givenName Pablo
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020112445.40
    211 rdf:type schema:Person
    212 sg:person.01106347624.32 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
    213 schema:familyName Fernández-Piqueras
    214 schema:givenName José
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106347624.32
    216 rdf:type schema:Person
    217 sg:person.01323366573.33 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
    218 schema:familyName Santos
    219 schema:givenName Javier
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323366573.33
    221 rdf:type schema:Person
    222 sg:person.01342057115.20 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
    223 schema:familyName González-Sánchez
    224 schema:givenName Laura
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342057115.20
    226 rdf:type schema:Person
    227 sg:person.0731265667.46 schema:affiliation https://www.grid.ac/institutes/grid.413448.e
    228 schema:familyName Villa-Morales
    229 schema:givenName María
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731265667.46
    231 rdf:type schema:Person
    232 sg:pub.10.1038/1235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033843315
    233 https://doi.org/10.1038/1235
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1038/318533a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005012397
    236 https://doi.org/10.1038/318533a0
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1038/33423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005145915
    239 https://doi.org/10.1038/33423
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/35074129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005772949
    242 https://doi.org/10.1038/35074129
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/35078107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028423924
    245 https://doi.org/10.1038/35078107
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/356215a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027559823
    248 https://doi.org/10.1038/356215a0
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/359295a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013123356
    251 https://doi.org/10.1038/359295a0
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/359328a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036861399
    254 https://doi.org/10.1038/359328a0
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/3861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016433101
    257 https://doi.org/10.1038/3861
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/446145a schema:sameAs https://app.dimensions.ai/details/publication/pub.1006489736
    260 https://doi.org/10.1038/446145a
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/78595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036912323
    263 https://doi.org/10.1038/78595
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/82593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014936510
    266 https://doi.org/10.1038/82593
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nature03702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024825726
    269 https://doi.org/10.1038/nature03702
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nature03845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032103889
    272 https://doi.org/10.1038/nature03845
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nature03918 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027424701
    275 https://doi.org/10.1038/nature03918
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/nature05949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033532665
    278 https://doi.org/10.1038/nature05949
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/nature06914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053461506
    281 https://doi.org/10.1038/nature06914
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/ncb437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023498683
    284 https://doi.org/10.1038/ncb437
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/nchembio.2007.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030185521
    287 https://doi.org/10.1038/nchembio.2007.38
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/ng0495-376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026103982
    290 https://doi.org/10.1038/ng0495-376
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/ng0794-353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015902905
    293 https://doi.org/10.1038/ng0794-353
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/ng1013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033012733
    296 https://doi.org/10.1038/ng1013
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/ng1572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046768621
    299 https://doi.org/10.1038/ng1572
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/ng1596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009581629
    302 https://doi.org/10.1038/ng1596
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/ng2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036221931
    305 https://doi.org/10.1038/ng2003
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/ni0707-665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015282106
    308 https://doi.org/10.1038/ni0707-665
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/ni878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018271980
    311 https://doi.org/10.1038/ni878
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/nm1001-1086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034245766
    314 https://doi.org/10.1038/nm1001-1086
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/nm1173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035826997
    317 https://doi.org/10.1038/nm1173
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/nrc1044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052830524
    320 https://doi.org/10.1038/nrc1044
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/nrc1565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029874726
    323 https://doi.org/10.1038/nrc1565
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nrc2192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034282407
    326 https://doi.org/10.1038/nrc2192
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nrc795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045099768
    329 https://doi.org/10.1038/nrc795
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/nrd2110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008760692
    332 https://doi.org/10.1038/nrd2110
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/nrg1157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003654899
    335 https://doi.org/10.1038/nrg1157
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/nrg1429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000062399
    338 https://doi.org/10.1038/nrg1429
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/nrg2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029198606
    341 https://doi.org/10.1038/nrg2006
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/nrg2025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043444548
    344 https://doi.org/10.1038/nrg2025
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/nri2017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026380926
    347 https://doi.org/10.1038/nri2017
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1038/nrm2242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033612140
    350 https://doi.org/10.1038/nrm2242
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1038/sj.onc.1203321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040048209
    353 https://doi.org/10.1038/sj.onc.1203321
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1038/sj.onc.1205530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020025073
    356 https://doi.org/10.1038/sj.onc.1205530
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1038/sj.onc.1209043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007822900
    359 https://doi.org/10.1038/sj.onc.1209043
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1038/sj.onc.1209234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009974115
    362 https://doi.org/10.1038/sj.onc.1209234
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1038/sj.onc.1209432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023061383
    365 https://doi.org/10.1038/sj.onc.1209432
    366 rdf:type schema:CreativeWork
    367 https://app.dimensions.ai/details/publication/pub.1075105055 schema:CreativeWork
    368 https://doi.org/10.1001/archopht.1997.01100150647013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033153511
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1002/(sici)1097-010x(19970215)277:3<245::aid-jez5>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1048609455
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1002/bies.950161202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014796159
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1016/0076-6879(93)25048-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051738738
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1016/0168-9525(89)90029-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042901717
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1016/0168-9525(93)90104-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1019985929
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1016/0959-437x(95)80049-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012832916
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1016/j.ccr.2005.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042185129
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1016/j.ccr.2007.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029487514
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1016/j.ccr.2007.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032956129
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1016/j.ccr.2008.04.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051991611
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1016/j.cell.2004.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049745772
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1016/j.cell.2005.09.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031496607
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1016/j.cell.2006.11.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032527480
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1016/j.cell.2006.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022163647
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1016/j.cell.2007.05.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048448198
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1016/j.cell.2007.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053575430
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1016/s0092-8674(00)80452-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021286113
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1016/s0092-8674(00)80580-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024660332
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1016/s0092-8674(00)81079-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037997315
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1016/s0092-8674(00)81902-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026392285
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1016/s0092-8674(01)80006-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004868239
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1016/s0959-437x(03)00005-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002816566
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1016/s0960-9822(00)00002-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049621852
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1016/s0960-9822(07)00488-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041868214
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1016/s0962-8924(01)02151-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033844135
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1016/s1097-2765(00)80367-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027021943
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1016/s1535-6108(03)00106-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022586708
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1021/pr070202v schema:sameAs https://app.dimensions.ai/details/publication/pub.1056291606
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1038/sj.embor.7400667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011838697
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1073/pnas.0604130103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004375878
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1073/pnas.91.19.8969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000531425
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1073/pnas.96.4.1563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047977012
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1080/01926230490424716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058308058
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1093/carcin/bgg057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036625088
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1093/carcin/bgi331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024479456
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1093/emboj/20.23.6637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042684334
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1093/emboj/cdf595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033235876
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1101/gad.310304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034394169
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1101/gad.8.9.1019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040640333
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1101/gad.943001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007211161
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1126/science.1350108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062477270
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1146/annurev.pharmtox.45.120403.100007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034203358
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1158/0008-5472.can-04-4195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032859718
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1158/0008-5472.can-06-4006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023894047
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1172/jci20476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011836453
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.4161/cc.5.10.2734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072298433
    461 rdf:type schema:CreativeWork
    462 https://www.grid.ac/institutes/grid.413448.e schema:alternateName Instituto de Salud Carlos III
    463 schema:name Dpto. Biología CSIC/UAM, Centro de Biología Molecular Severo Ochoa, C/ Nicolás Cabrera 1, ES-28049, Madrid, Spain
    464 Ministerio de Sanidad y Consumo, Ciber en Enfermedades Raras, Madrid, Spain
    465 Ministerio de Sanidad y Consumo, Ciber en Epidemiología y Salud Pública, Madrid, Spain
    466 Área de Epidemiología Ambiental y Cáncer, Centro Nacional de Epidemiología Instituto de Salud Carlos III, Madrid, Spain
    467 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...