Prevention of irinotecan associated diarrhea by intestinal alkalization. A pilot study in gastrointestinal cancer patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-03

AUTHORS

Vicente Valentí Moreno, Joan Brunet Vidal, Hermini Manzano Alemany, Antonia Saulud Salvia, Montserrat Llobera Serentill, Inés Cabezas Montero, Sonia Servitja Tormo, Eugenia Sopena Bert, Josep Gumà Padró

ABSTRACT

Aim and backgroundIntestinal alkalization could prevent irinotecan associated diarrhea modulating some chemical equilibria between irinotecan metabolites. The aim of this study was to evaluate the efficacy of this procedure in advanced gastrointestinal cancer patients (GICP).Materials and methodIn this prospective study advanced GICP, receiving irinotecan based chemotherapy regimens, were well trained, to add sodium bicarbonate to the water intake in order to accomplish intestinal alkalization.ResultsA total of twenty four advanced GICP were enrolled. Grade III–IV diarrhea has been observed in four patients (16%), some of whom had several risk factors for diarrhea. Only one out of seventeen colorectal cancer patients, receiving the irinotecan combination as first line therapy, had grade III–IV diarrhea. No side effects of the procedure have been appreciated.ConclusionsIntestinal alkalization may be effective as a preventive treatment for irinotecan associated diarrhea in chemotherapy regimens used in GICP. This procedure deserves further investigation. More... »

PAGES

208-212

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12094-006-0012-1

DOI

http://dx.doi.org/10.1007/s12094-006-0012-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002063308

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16648121


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