Strain Improvement of Streptomyces xanthochromogenes RIA 1098 for Enhanced Pravastatin Production at High Compactin Concentrations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Vakhtang V. Dzhavakhiya, Tatiana M. Voinova, Elena V. Glagoleva, Dmitry V. Petukhov, Alexander I. Ovchinnikov, Maksim I. Kartashov, Boris B. Kuznetsov, Konstantin G. Skryabin

ABSTRACT

Pravastatin is one of the most popular cholesterol-lowering drugs. Its industrial production represents a two-stage process including the microbial production of compactin and its further biocatalytic conversion to pravastatin. To increase a conversion rate, a higher compactin content in fermentation medium should be used; however, high compactin concentrations inhibit microbial growth. Therefore, the improvement of the compactin resistance of a producer still remains a relevant problem. A multi-step random UV mutagenesis of a Streptomyces xanthochromogenes strain RIA 1098 and the further selection of high-yield compactin-resistant mutants have resulted in a highly productive compactin-resistant strain S 33-1. After the fermentation medium improvement, the maximum bioconversion rate of this strain has reached 91 % at the daily compactin dose equal to 1 g/L and still remained high (83 %) even at the doubled dose (2 g/L). A 1-year study of the mutant strain stability has proved a stable inheritance of its characteristics that provides this strain to be very promising for the pravastatin-producing industry. More... »

PAGES

440-446

Journal

TITLE

Indian Journal of Microbiology

ISSUE

4

VOLUME

55

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12088-015-0537-5

DOI

http://dx.doi.org/10.1007/s12088-015-0537-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023832190

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26543270


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