Rsu1-dependent control of PTEN expression is regulated via ATF2 and cJun View Full Text


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Article Info

DATE

2019-01-25

AUTHORS

Yong-Chul Kim, Reyda Gonzalez-Nieves, Mary L. Cutler

ABSTRACT

The Rsu1 protein contributes to cell adhesion and migration via its association with the adaptor complex of Integrin linked kinase (ILK), PINCH, and Parvin (IPP), which binds to the cytoplasmic domain of β1 integrins joining integrins to the actin cytoskeleton. Rsu1 binding to PINCH in the IPP complex is required for EGF-induced adhesion, spreading and migration in MCF10A mammary epithelial cells. In addition, Rsu1 expression inhibits Jun kinase but is necessary for the activation of MKK4 and p38 Map kinase signaling essential for migration in MCF10A cells. The data reported here examines the links between MKK4-p38-ATF2 signaling and AKT regulation in MCF10A cells. Ectopic Rsu1 inhibited AKT1 phosphorylation while Rsu1 depletion induced AKT activation and AKT1 phosphorylation of MKK4 on serine 80, blocking MKK4 activity. Rsu1 depletion also reduced the RNA for lipid phosphatase PTEN thus implicating PTEN in modulating levels of activated AKT in these conditions. ChIP analysis of the PTEN promoter revealed that Rsu1 depletion prevented binding of ATF2 to a positive regulatory site in the PTEN promoter and the enhanced binding of cJun to a negatively regulatory PTEN promoter site. These results demonstrate a mechanism by which Rsu1 adhesion signaling alters the balance between MKK4-p38-ATF2 and cJun activation thus altering PTEN expression in MCF10A cells. More... »

PAGES

1-11

References to SciGraph publications

  • 2014-09. Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2008-09. Identification of genes that regulate epithelial cell migration using an siRNA screening approach in NATURE CELL BIOLOGY
  • 2000-05. Ectopic expression of Rsu-1 results in elevation of p21CIP and inhibits anchorage-independent growth of MCF7 breast cancer cells in BREAST CANCER RESEARCH AND TREATMENT
  • 2015-12. Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly in NATURE CELL BIOLOGY
  • 2013-12. Rsu1 contributes to regulation of cell adhesion and spreading by PINCH1-dependent and - independent mechanisms in JOURNAL OF CELL COMMUNICATION AND SIGNALING
  • 2007-02. c-Jun promotes cellular survival by suppression of PTEN in CELL DEATH & DIFFERENTIATION
  • 2002-12. Identification of an Alternatively Spliced RNA for the Ras Suppressor RSU-1 in Human Gliomas in JOURNAL OF NEURO-ONCOLOGY
  • 2016-12. Mechanism of early dissemination and metastasis in Her2+ mammary cancer in NATURE
  • 2014-02. Selective regulation of p38β protein and signaling by integrin-linked kinase mediates bladder cancer cell migration in ONCOGENE
  • 2012-06. Whole-genome analysis informs breast cancer response to aromatase inhibition in NATURE
  • 2006-01. ILK, PINCH and parvin: the tIPP of integrin signalling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2015-05. Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis in ONCOGENE
  • 2005-05. Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth in ONCOGENE
  • 2012-09-23. Comprehensive molecular portraits of human breast tumours in NATURE
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    http://scigraph.springernature.com/pub.10.1007/s12079-018-00504-4

    DOI

    http://dx.doi.org/10.1007/s12079-018-00504-4

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30680530


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