Point shear wave elastography predicts fibrosis severity and steatohepatitis in alcohol-related liver disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12-19

AUTHORS

Yuri Cho, Youn I. Choi, Sohee Oh, Jimin Han, Sae Kyung Joo, Dong Hyeon Lee, Yong Jin Jung, Byeong Gwan Kim, Kook Lae Lee, Won Kim

ABSTRACT

BackgroundPoint shear wave elastography (pSWE) is a convenient noninvasive tool for assessing liver fibrosis in chronic liver disease. However, there is little information on the correlation between pSWE and the histological findings of alcohol-related liver disease (ALD). Thus, we investigated the diagnostic performance of pSWE in discriminating the fibrosis stage of patients with ALD.MethodsA total of 251 Korean patients with ALD were prospectively enrolled. The diagnostic performance of pSWE was evaluated on the basis of histological fibrosis severity according to Kleiner/Brunt et al.’s criteria and the Laennec classification.ResultsMedian liver stiffness on pSWE significantly increased as liver fibrosis stage increased (p < 0.001). Liver stiffness measurement proved to be an excellent diagnostic indicator in the evaluation of a ≥ F2 stage (area under the receiver operating characteristics curve [AUROC] 0.93; cutoff > 1.46 m/s), ≥ F3 stage (AUROC 0.90; cutoff > 1.47 m/s), and F4 stage (AUROC 0.91; cutoff > 1.66 m/s). Compared with noninvasive serum fibrosis tests, pSWE had the highest AUROC for predicting ≥ F2, ≥ F3, and = F4 stages and the highest Obuchowski index (0.931 ± 0.007; all p < 0.001). The AUROC for discriminating steatohepatitis from simple steatosis was 0.93 (> 1.49 m/s) and the AUROC for discriminating cirrhosis with steatohepatitis from cirrhosis without steatohepatitis was 0.92 (> 2.52 m/s).ConclusionpSWE not only gives an accurate indication of liver fibrosis stage in ALD, but also can allow patients with severe alcoholic steatohepatitis to begin corticosteroid treatment without exposing them to the risks of liver biopsy.Clinical trial registrationClincialtrials.gov Identifier NCT01943318.Graphic abstract More... »

PAGES

270-280

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12072-019-10009-w

DOI

http://dx.doi.org/10.1007/s12072-019-10009-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1123533253

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31858403


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