The efficacy and safety of lenvatinib for advanced hepatocellular carcinoma in a real-world setting View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-22

AUTHORS

Shuntaro Obi, Takahisa Sato, Shinpei Sato, Miho Kanda, Yuta Tokudome, Yuichiro Kojima, Yoji Suzuki, Kenji Hosoda, Toshihiro Kawai, Yuji Kondo, Yoshihiro Isomura, Hiroshi Ohyama, Keiko Nakagomi, Hiroshi Ashizawa, Yuko Miura, Hiroyuki Amano, Hitoshi Mochizuki, Masao Omata

ABSTRACT

Background/purposeLenvatinib (an inhibitor of vascular endothelial growth factor (GF) receptors 1–3, fibroblast GF receptors 1–4, platelet-derived GF receptor α, rearranged during transfection, and stem cell factor receptor) was non-inferior to sorafenib in a phase 3 (REFLECT) trial of advanced hepatocellular carcinoma. This study examined the efficacy and safety of lenvatinib in a real-world setting.MethodsThis was a retrospective, multicenter, observational study. Inclusion and exclusion criteria were based on the phase 3 trial, and participants were observed for at least 12 weeks. Therapeutic effect was determined using the modified Response Evaluation Criteria In Solid Tumors (m-RECIST) at the 8th week. Patients received oral lenvatinib 12 mg/day (body weight > 60 kg) or 8 mg/day (body weight < 60 kg). Dose interruptions followed by reductions for lenvatinib-related toxicities were permitted. Grades of adverse events (AEs) complied with the Common Terminology Criteria for Adverse Events version 4.0.ResultsAll 16 patients included in this study had prior treatment history, and a median 3.9 years had passed since the first treatment. Fatigue, hypertension, and proteinuria were the most frequent AEs, and were higher than Grade 2. AEs could be controlled by appropriate dose reduction, interruption, and symptomatic treatment according to the protocol. In the m-RECIST evaluation at the 8th week, 0, 6, 8, and 1 patients had achieved complete response, partial response, stable disease, and progressive disease, respectively. The objective response rate was 40%.ConclusionLenvatinib treatment could be accomplished with safety and good response in a real-world setting. More... »

PAGES

199-204

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12072-019-09929-4

DOI

http://dx.doi.org/10.1007/s12072-019-09929-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111602329

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30671808


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