Prediction of the very early occurrence of HCC right after DAA therapy for HCV infection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09-21

AUTHORS

Yoshihiko Ooka, Kanda Miho, Obi Shuntaro, Masato Nakamura, Sadahisa Ogasawara, Eiichiro Suzuki, Shin Yasui, Tetsuhiro Chiba, Makoto Arai, Tatsuo Kanda, Hitoshi Maruyama, Osamu Yokosuka, Naoya Kato, Hitoshi Mochizuki, Masao Omata

ABSTRACT

BackgroundAlthough direct-acting antiviral (DAA) developments make most of hepatitis C virus (HCV) infection curable, some HCV patients develop hepatocellular carcinoma (HCC) after curative treatment of HCV. There is much dispute whether the rapid clearance of the virus enhances the HCC development. In advance of the dispute, we should make clear the characteristics of the patients with very early occurrence and recurrence of HCC after DAA therapy because it was still unclear.MethodsWe prospectively followed consecutive patients with HCV who had received sofosbuvir (SOF)-based treatment at two hospitals. The baseline characteristics, laboratory data, and liver imaging findings were acquired. We evaluated the rate of HCC occurrence and recurrence within 1-year after DAA therapy and analyzed the associated factors of very early HCC occurrence and recurrence right after SOF therapy.ResultsBetween July 2013 and October 2016, we studied two cohorts with HCV infection that received SOF therapy. 402 and 462 patients in Yamanashi Central Hospital and Chiba University Hospital were included in this analysis, respectively. The SVR12 rates of genotypes 1 and 2 were 98.9% (561/567) and 96.0% (285/297), respectively. 41 patients developed HCC within 1 year after SOF therapy. The cumulative HCC occurrence and recurrence rate after SOF therapy was 5.0%. The common associated factor of 1-year HCC occurrence and recurrence in all cohorts was the existence of imaging “dysplastic nodule”.ConclusionsSOF regimens for HCV also have very high rates of SVR 12 in the post-market distribution. The appearance of imaging “dysplastic nodule” was an associated factor of 1-year HCC occurrence and recurrence. To investigate existence of “dysplastic nodule” by imaging surveillance before DAA treatment is useful to detect high-risk patients of very early HCC occurrence and recurrence and it should be performed. More... »

PAGES

523-530

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12072-018-9895-5

DOI

http://dx.doi.org/10.1007/s12072-018-9895-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107124110

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30242733


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28 schema:description BackgroundAlthough direct-acting antiviral (DAA) developments make most of hepatitis C virus (HCV) infection curable, some HCV patients develop hepatocellular carcinoma (HCC) after curative treatment of HCV. There is much dispute whether the rapid clearance of the virus enhances the HCC development. In advance of the dispute, we should make clear the characteristics of the patients with very early occurrence and recurrence of HCC after DAA therapy because it was still unclear.MethodsWe prospectively followed consecutive patients with HCV who had received sofosbuvir (SOF)-based treatment at two hospitals. The baseline characteristics, laboratory data, and liver imaging findings were acquired. We evaluated the rate of HCC occurrence and recurrence within 1-year after DAA therapy and analyzed the associated factors of very early HCC occurrence and recurrence right after SOF therapy.ResultsBetween July 2013 and October 2016, we studied two cohorts with HCV infection that received SOF therapy. 402 and 462 patients in Yamanashi Central Hospital and Chiba University Hospital were included in this analysis, respectively. The SVR12 rates of genotypes 1 and 2 were 98.9% (561/567) and 96.0% (285/297), respectively. 41 patients developed HCC within 1 year after SOF therapy. The cumulative HCC occurrence and recurrence rate after SOF therapy was 5.0%. The common associated factor of 1-year HCC occurrence and recurrence in all cohorts was the existence of imaging “dysplastic nodule”.ConclusionsSOF regimens for HCV also have very high rates of SVR 12 in the post-market distribution. The appearance of imaging “dysplastic nodule” was an associated factor of 1-year HCC occurrence and recurrence. To investigate existence of “dysplastic nodule” by imaging surveillance before DAA treatment is useful to detect high-risk patients of very early HCC occurrence and recurrence and it should be performed.
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35 schema:keywords BackgroundAlthough
36 C virus (HCV) infection
37 Central Hospital
38 Chiba University Hospital
39 ConclusionsSOF
40 DAA therapy
41 DAA treatment
42 HCC development
43 HCC occurrence
44 HCV
45 HCV infection
46 HCV patients
47 MethodsWe
48 SOF therapy
49 SVR 12
50 SVR12 rates
51 University Hospital
52 Yamanashi Central Hospital
53 acting antiviral (DAA) developments
54 advances
55 analysis
56 antiviral development
57 appearance
58 baseline characteristics
59 carcinoma
60 characteristics
61 clearance
62 cohort
63 consecutive patients
64 cumulative HCC occurrence
65 curative treatment
66 data
67 development
68 disputes
69 distribution
70 dysplastic nodules
71 early HCC occurrence
72 early occurrence
73 existence
74 factors
75 findings
76 genotype 1
77 hepatitis C virus (HCV) infection
78 hepatocellular carcinoma
79 high rate
80 high-risk patients
81 hospital
82 imaging findings
83 infection
84 laboratory data
85 liver imaging findings
86 nodules
87 occurrence
88 patients
89 post-market distribution
90 prediction
91 rapid clearance
92 rate
93 recurrence
94 recurrence of HCC
95 recurrence rate
96 sofosbuvir
97 surveillance
98 therapy
99 treatment
100 virus
101 virus infection
102 years
103 schema:name Prediction of the very early occurrence of HCC right after DAA therapy for HCV infection
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