Prediction of the very early occurrence of HCC right after DAA therapy for HCV infection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09-21

AUTHORS

Yoshihiko Ooka, Kanda Miho, Obi Shuntaro, Masato Nakamura, Sadahisa Ogasawara, Eiichiro Suzuki, Shin Yasui, Tetsuhiro Chiba, Makoto Arai, Tatsuo Kanda, Hitoshi Maruyama, Osamu Yokosuka, Naoya Kato, Hitoshi Mochizuki, Masao Omata

ABSTRACT

BackgroundAlthough direct-acting antiviral (DAA) developments make most of hepatitis C virus (HCV) infection curable, some HCV patients develop hepatocellular carcinoma (HCC) after curative treatment of HCV. There is much dispute whether the rapid clearance of the virus enhances the HCC development. In advance of the dispute, we should make clear the characteristics of the patients with very early occurrence and recurrence of HCC after DAA therapy because it was still unclear.MethodsWe prospectively followed consecutive patients with HCV who had received sofosbuvir (SOF)-based treatment at two hospitals. The baseline characteristics, laboratory data, and liver imaging findings were acquired. We evaluated the rate of HCC occurrence and recurrence within 1-year after DAA therapy and analyzed the associated factors of very early HCC occurrence and recurrence right after SOF therapy.ResultsBetween July 2013 and October 2016, we studied two cohorts with HCV infection that received SOF therapy. 402 and 462 patients in Yamanashi Central Hospital and Chiba University Hospital were included in this analysis, respectively. The SVR12 rates of genotypes 1 and 2 were 98.9% (561/567) and 96.0% (285/297), respectively. 41 patients developed HCC within 1 year after SOF therapy. The cumulative HCC occurrence and recurrence rate after SOF therapy was 5.0%. The common associated factor of 1-year HCC occurrence and recurrence in all cohorts was the existence of imaging “dysplastic nodule”.ConclusionsSOF regimens for HCV also have very high rates of SVR 12 in the post-market distribution. The appearance of imaging “dysplastic nodule” was an associated factor of 1-year HCC occurrence and recurrence. To investigate existence of “dysplastic nodule” by imaging surveillance before DAA treatment is useful to detect high-risk patients of very early HCC occurrence and recurrence and it should be performed. More... »

PAGES

523-530

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12072-018-9895-5

DOI

http://dx.doi.org/10.1007/s12072-018-9895-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107124110

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30242733


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28 schema:description BackgroundAlthough direct-acting antiviral (DAA) developments make most of hepatitis C virus (HCV) infection curable, some HCV patients develop hepatocellular carcinoma (HCC) after curative treatment of HCV. There is much dispute whether the rapid clearance of the virus enhances the HCC development. In advance of the dispute, we should make clear the characteristics of the patients with very early occurrence and recurrence of HCC after DAA therapy because it was still unclear.MethodsWe prospectively followed consecutive patients with HCV who had received sofosbuvir (SOF)-based treatment at two hospitals. The baseline characteristics, laboratory data, and liver imaging findings were acquired. We evaluated the rate of HCC occurrence and recurrence within 1-year after DAA therapy and analyzed the associated factors of very early HCC occurrence and recurrence right after SOF therapy.ResultsBetween July 2013 and October 2016, we studied two cohorts with HCV infection that received SOF therapy. 402 and 462 patients in Yamanashi Central Hospital and Chiba University Hospital were included in this analysis, respectively. The SVR12 rates of genotypes 1 and 2 were 98.9% (561/567) and 96.0% (285/297), respectively. 41 patients developed HCC within 1 year after SOF therapy. The cumulative HCC occurrence and recurrence rate after SOF therapy was 5.0%. The common associated factor of 1-year HCC occurrence and recurrence in all cohorts was the existence of imaging “dysplastic nodule”.ConclusionsSOF regimens for HCV also have very high rates of SVR 12 in the post-market distribution. The appearance of imaging “dysplastic nodule” was an associated factor of 1-year HCC occurrence and recurrence. To investigate existence of “dysplastic nodule” by imaging surveillance before DAA treatment is useful to detect high-risk patients of very early HCC occurrence and recurrence and it should be performed.
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35 schema:keywords BackgroundAlthough
36 Central Hospital
37 Chiba University Hospital
38 DAA therapy
39 DAA treatment
40 HCC development
41 HCC occurrence
42 HCV
43 HCV infection
44 HCV patients
45 MethodsWe
46 SOF therapy
47 SVR 12
48 SVR12 rates
49 University Hospital
50 advances
51 analysis
52 antiviral development
53 appearance
54 baseline characteristics
55 carcinoma
56 characteristics
57 clearance
58 cohort
59 consecutive patients
60 curative treatment
61 data
62 development
63 disputes
64 distribution
65 dysplastic nodules
66 early HCC occurrence
67 early occurrence
68 existence
69 factors
70 findings
71 genotype 1
72 hepatitis C virus infection
73 hepatocellular carcinoma
74 high rate
75 high-risk patients
76 hospital
77 imaging findings
78 infection
79 laboratory data
80 liver imaging findings
81 nodules
82 occurrence
83 patients
84 prediction
85 rapid clearance
86 rate
87 recurrence
88 recurrence of HCC
89 recurrence rate
90 sofosbuvir
91 surveillance
92 therapy
93 treatment
94 virus
95 virus infection
96 years
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