Ontology type: schema:ScholarlyArticle
2011-12
AUTHORSMohammed A. Sharawey, Eglal M. Shawky, Lamia H. Ali, Ahmed Ali Mohammed, Hatem A. Hassan, Yasser M. Fouad
ABSTRACTBACKGROUND: Recent studies suggest that serum cystatin C (CysC) is a more sensitive marker of renal functions than serum creatinine (Cr). AIM: Evaluation of the clinical significance of cystatin C as a predictor of hepatorenal syndrome (HRS) in patients with liver cirrhosis, ascites, and normal serum Cr level. METHODS: Eighty patients with cirrhotic ascites were enrolled in this study (53 men and 27 women; age: 59.5 ± 7.5 years). All patients were subjected to full clinical assessment and laboratory investigations focussing on renal functions, glomerular filtration rate, and measurement of serum cystatin level. RESULTS: The Serum Cr and CysC levels were 1.04 ± 0.1 and 1.8 ± 0.8 mg/L, respectively. HRS developed in 18 patients during the follow-up period (6 months). Type 1 HRS was found in 5 patients and type 2 HRS was found in 13 patients with no significant difference between both types regarding baseline characteristics. Age (p < 0.001), albumin (p < 0.001), sodium (p < 0.005), cystatin C (p < 0.001), and e-GFRMDRD (estimated glomerular filtration rate-modification of the diet in renal disease) (p < 0.007) were significant dependent predictive factors for the development of HRS. The CysC level was the most independent predictive factor for HRS (OR, 2.1; 95% CI, 0.75-0.97; p < 0.002). Eighteen patients died during the follow-up period. Age (p < 0.001), INR (p < 0.001), e-GFRMDRD (p < 0.03), sodium (p < 0.01), MELD score (p < 0.05), albumin (p < 0.001), and CysC (p < 0.001) levels were significant dependent factors for predicting mortality. CysC (OR, 5.3; p < 0.006) level and INR (OR, 1.01; p < 0.006) were the most independent factors for predicting mortality. CONCLUSION: Serum CysC level may be considered a predictor of HRS and mortality in patients with liver cirrhosis and ascites. More... »
PAGES927-933
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DOIhttp://dx.doi.org/10.1007/s12072-011-9266-y
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"description": "BACKGROUND: Recent studies suggest that serum cystatin C (CysC) is a more sensitive marker of renal functions than serum creatinine (Cr).\nAIM: Evaluation of the clinical significance of cystatin C as a predictor of hepatorenal syndrome (HRS) in patients with liver cirrhosis, ascites, and normal serum Cr level.\nMETHODS: Eighty patients with cirrhotic ascites were enrolled in this study (53 men and 27 women; age: 59.5\u00a0\u00b1\u00a07.5\u00a0years). All patients were subjected to full clinical assessment and laboratory investigations focussing on renal functions, glomerular filtration rate, and measurement of serum cystatin level.\nRESULTS: The Serum Cr and CysC levels were 1.04\u00a0\u00b1\u00a00.1 and 1.8\u00a0\u00b1\u00a00.8\u00a0mg/L, respectively. HRS developed in 18 patients during the follow-up period (6\u00a0months). Type 1 HRS was found in 5 patients and type 2 HRS was found in 13 patients with no significant difference between both types regarding baseline characteristics. Age (p\u00a0<\u00a00.001), albumin (p\u00a0<\u00a00.001), sodium (p\u00a0<\u00a00.005), cystatin C (p\u00a0<\u00a00.001), and e-GFRMDRD (estimated glomerular filtration rate-modification of the diet in renal disease) (p\u00a0<\u00a00.007) were significant dependent predictive factors for the development of HRS. The CysC level was the most independent predictive factor for HRS (OR, 2.1; 95% CI, 0.75-0.97; p\u00a0<\u00a00.002). Eighteen patients died during the follow-up period. Age (p\u00a0<\u00a00.001), INR (p\u00a0<\u00a00.001), e-GFRMDRD (p\u00a0<\u00a00.03), sodium (p\u00a0<\u00a00.01), MELD score (p\u00a0<\u00a00.05), albumin (p\u00a0<\u00a00.001), and CysC (p\u00a0<\u00a00.001) levels were significant dependent factors for predicting mortality. CysC (OR, 5.3; p\u00a0<\u00a00.006) level and INR (OR, 1.01; p\u00a0<\u00a00.006) were the most independent factors for predicting mortality.\nCONCLUSION: Serum CysC level may be considered a predictor of HRS and mortality in patients with liver cirrhosis and ascites.",
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