Coffee prevents CCl4-induced liver cirrhosis in the rat View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-09

AUTHORS

Mario G. Moreno, Enrique Chávez, Liseth R. Aldaba-Muruato, José Segovia, Paula Vergara, Víctor Tsutsumi, Mineko Shibayama, Yadira Rivera-Espinoza, Pablo Muriel

ABSTRACT

PURPOSE: Previous clinical observations suggested that coffee may have beneficial effects on the liver. In fact, an inverse relationship between coffee consumption and liver cirrhosis has been reported in humans. However, the causative role of coffee has not been established; therefore, the aim of this work was to study the effect of coffee in an experimental model of liver damage. METHODS: In this work, cirrhosis was induced by chronic CCl(4) administration and soluble or grain coffee (SC, GC, respectively) were co-administered for 8 weeks. RESULTS: CCl(4) administration elevated serum alkaline phosphatase and alanine aminotranspherase, liver lipid peroxidation, collagen content (fourfold) and TGF-β mRNA, and protein levels; depleted liver glycogen and reduced glutathione (GSH) content. Coffee prevented most of the changes produced by CCl(4). Histopathological analysis was in agreement with biochemical and molecular data. The best effect was produced by GC. It is worth noting that GC preserved the normal collagen content as well as the normal TGF-β mRNA and protein levels. CONCLUSIONS: Our results suggest (1) that coffee plays a causative role in preventing cirrhosis (at least experimental cirrhosis); (2) that action mechanisms are probably associated with down regulation of the profibrogenic cytokine TGF-β and to its antioxidant properties and, (3) that GC is more potent than SC. These findings suggest a beneficial effect of coffee on the liver. However, more clinical and basic studies must be performed before reaching a final recommendation. More... »

PAGES

857-863

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12072-010-9247-6

DOI

http://dx.doi.org/10.1007/s12072-010-9247-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027060754

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21484136


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Instituto Polit\u00e9cnico Nacional", 
          "id": "https://www.grid.ac/institutes/grid.418275.d", 
          "name": [
            "Departamento de Farmacolog\u00eda, Cinvestav-IPN, Apdo. Postal 14-740, 07000, M\u00e9xico, DF, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moreno", 
        "givenName": "Mario G.", 
        "id": "sg:person.015166044302.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015166044302.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Polit\u00e9cnico Nacional", 
          "id": "https://www.grid.ac/institutes/grid.418275.d", 
          "name": [
            "Departamento de Farmacolog\u00eda, Cinvestav-IPN, Apdo. Postal 14-740, 07000, M\u00e9xico, DF, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ch\u00e1vez", 
        "givenName": "Enrique", 
        "id": "sg:person.01057077537.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057077537.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Polit\u00e9cnico Nacional", 
          "id": "https://www.grid.ac/institutes/grid.418275.d", 
          "name": [
            "Departamento de Farmacolog\u00eda, Cinvestav-IPN, Apdo. Postal 14-740, 07000, M\u00e9xico, DF, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aldaba-Muruato", 
        "givenName": "Liseth R.", 
        "id": "sg:person.0621011703.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621011703.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Polit\u00e9cnico Nacional", 
          "id": "https://www.grid.ac/institutes/grid.418275.d", 
          "name": [
            "Departamento de Fisiolog\u00eda Biof\u00edsica y Neurociencias, Cinvestav-IPN, Apdo. Postal 14-740, 07000, M\u00e9xico, DF, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Segovia", 
        "givenName": "Jos\u00e9", 
        "id": "sg:person.01273101622.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273101622.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Polit\u00e9cnico Nacional", 
          "id": "https://www.grid.ac/institutes/grid.418275.d", 
          "name": [
            "Departamento de Fisiolog\u00eda Biof\u00edsica y Neurociencias, Cinvestav-IPN, Apdo. Postal 14-740, 07000, M\u00e9xico, DF, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vergara", 
        "givenName": "Paula", 
        "id": "sg:person.01045330303.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045330303.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Polit\u00e9cnico Nacional", 
          "id": "https://www.grid.ac/institutes/grid.418275.d", 
          "name": [
            "Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, Cinvestav-IPN, Apdo. Postal 14-740, 07000, M\u00e9xico, DF, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsutsumi", 
        "givenName": "V\u00edctor", 
        "id": "sg:person.0757167474.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757167474.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Polit\u00e9cnico Nacional", 
          "id": "https://www.grid.ac/institutes/grid.418275.d", 
          "name": [
            "Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, Cinvestav-IPN, Apdo. Postal 14-740, 07000, M\u00e9xico, DF, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shibayama", 
        "givenName": "Mineko", 
        "id": "sg:person.01371323724.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371323724.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Polit\u00e9cnico Nacional", 
          "id": "https://www.grid.ac/institutes/grid.418275.d", 
          "name": [
            "Departamento de Graduados e Investigaci\u00f3n en Alimentos, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Carpio y Plan de Ayala, 11340, M\u00e9xico, CP, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rivera-Espinoza", 
        "givenName": "Yadira", 
        "id": "sg:person.01254275213.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254275213.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Instituto Polit\u00e9cnico Nacional", 
          "id": "https://www.grid.ac/institutes/grid.418275.d", 
          "name": [
            "Departamento de Farmacolog\u00eda, Cinvestav-IPN, Apdo. Postal 14-740, 07000, M\u00e9xico, DF, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muriel", 
        "givenName": "Pablo", 
        "id": "sg:person.0710631770.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710631770.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0003-2697(79)90738-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004403568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10408390500400009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006790471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(60)90050-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013214274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2008.03.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015035650"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016110230", 
          "https://doi.org/10.1038/sj.gt.3302929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2007.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016396952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m700194200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017100161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.03270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021674086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fitote.2009.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021678447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2007.03319.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023877678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1047-2797(93)90064-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024158128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(76)90527-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025529346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(76)90326-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027571646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/28.1.56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031482018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00432-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035867530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01719277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036898763", 
          "https://doi.org/10.1007/bf01719277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01719277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036898763", 
          "https://doi.org/10.1007/bf01719277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jgm.894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038192702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1047-2797(01)00223-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038718782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2008.00260.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039405350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(02)03102-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039738580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1078/0065-1281-00591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041055078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1047-2797(02)00462-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045141030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1047-2797(02)00462-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045141030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.510300425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046900398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048078745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1047-2797(01)00304-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048948013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1386-6346(03)00115-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051503230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1386-6346(03)00115-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051503230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.275.6.458", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054159923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.asn.0000025282.48298.7b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060318857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/gressner", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070919310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.13.13.1774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074528517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.2000.279.5.g845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074719137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075030022", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.aje.a116433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076634385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076905306", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1201/9781420050134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1095904623"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-09", 
    "datePublishedReg": "2011-09-01", 
    "description": "PURPOSE: Previous clinical observations suggested that coffee may have beneficial effects on the liver. In fact, an inverse relationship between coffee consumption and liver cirrhosis has been reported in humans. However, the causative role of coffee has not been established; therefore, the aim of this work was to study the effect of coffee in an experimental model of liver damage.\nMETHODS: In this work, cirrhosis was induced by chronic CCl(4) administration and soluble or grain coffee (SC, GC, respectively) were co-administered for 8\u00a0weeks.\nRESULTS: CCl(4) administration elevated serum alkaline phosphatase and alanine aminotranspherase, liver lipid peroxidation, collagen content (fourfold) and TGF-\u03b2 mRNA, and protein levels; depleted liver glycogen and reduced glutathione (GSH) content. Coffee prevented most of the changes produced by CCl(4). Histopathological analysis was in agreement with biochemical and molecular data. The best effect was produced by GC. It is worth noting that GC preserved the normal collagen content as well as the normal TGF-\u03b2 mRNA and protein levels.\nCONCLUSIONS: Our results suggest (1) that coffee plays a causative role in preventing cirrhosis (at least experimental cirrhosis); (2) that action mechanisms are probably associated with down regulation of the profibrogenic cytokine TGF-\u03b2 and to its antioxidant properties and, (3) that GC is more potent than SC. These findings suggest a beneficial effect of coffee on the liver. However, more clinical and basic studies must be performed before reaching a final recommendation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12072-010-9247-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1038556", 
        "issn": [
          "1936-0533", 
          "1936-0541"
        ], 
        "name": "Hepatology International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Coffee prevents CCl4-induced liver cirrhosis in the rat", 
    "pagination": "857-863", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "80e939e580139c5a9030b4f81cd3291c292c1955001fa0013f80c904d7ce3243"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21484136"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101304009"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12072-010-9247-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027060754"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12072-010-9247-6", 
      "https://app.dimensions.ai/details/publication/pub.1027060754"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12072-010-9247-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12072-010-9247-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12072-010-9247-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12072-010-9247-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12072-010-9247-6'


 

This table displays all metadata directly associated to this object as RDF triples.

233 TRIPLES      21 PREDICATES      64 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12072-010-9247-6 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nc1aa1dd776284d3fa107863dd02ff712
4 schema:citation sg:pub.10.1007/bf01719277
5 sg:pub.10.1038/sj.gt.3302929
6 https://app.dimensions.ai/details/publication/pub.1075030022
7 https://app.dimensions.ai/details/publication/pub.1076905306
8 https://doi.org/10.1001/jama.275.6.458
9 https://doi.org/10.1002/hep.21806
10 https://doi.org/10.1002/hep.510300425
11 https://doi.org/10.1002/jgm.894
12 https://doi.org/10.1016/0003-2697(60)90050-6
13 https://doi.org/10.1016/0003-2697(76)90326-2
14 https://doi.org/10.1016/0003-2697(76)90527-3
15 https://doi.org/10.1016/0003-2697(79)90738-3
16 https://doi.org/10.1016/1047-2797(93)90064-b
17 https://doi.org/10.1016/j.fitote.2009.10.003
18 https://doi.org/10.1016/j.jhep.2007.05.015
19 https://doi.org/10.1016/j.jhep.2008.03.029
20 https://doi.org/10.1016/s0006-8993(02)03102-5
21 https://doi.org/10.1016/s0092-8674(03)00432-x
22 https://doi.org/10.1016/s1047-2797(01)00223-x
23 https://doi.org/10.1016/s1047-2797(01)00304-0
24 https://doi.org/10.1016/s1047-2797(02)00462-3
25 https://doi.org/10.1016/s1386-6346(03)00115-3
26 https://doi.org/10.1074/jbc.m700194200
27 https://doi.org/10.1078/0065-1281-00591
28 https://doi.org/10.1080/10408390500400009
29 https://doi.org/10.1093/ajcp/28.1.56
30 https://doi.org/10.1093/oxfordjournals.aje.a116433
31 https://doi.org/10.1096/fasebj.13.13.1774
32 https://doi.org/10.1097/01.asn.0000025282.48298.7b
33 https://doi.org/10.1111/j.1365-2036.2007.03319.x
34 https://doi.org/10.1111/j.1582-4934.2008.00260.x
35 https://doi.org/10.1152/ajpgi.2000.279.5.g845
36 https://doi.org/10.1201/9781420050134
37 https://doi.org/10.1242/jcs.03270
38 https://doi.org/10.2741/gressner
39 schema:datePublished 2011-09
40 schema:datePublishedReg 2011-09-01
41 schema:description PURPOSE: Previous clinical observations suggested that coffee may have beneficial effects on the liver. In fact, an inverse relationship between coffee consumption and liver cirrhosis has been reported in humans. However, the causative role of coffee has not been established; therefore, the aim of this work was to study the effect of coffee in an experimental model of liver damage. METHODS: In this work, cirrhosis was induced by chronic CCl(4) administration and soluble or grain coffee (SC, GC, respectively) were co-administered for 8 weeks. RESULTS: CCl(4) administration elevated serum alkaline phosphatase and alanine aminotranspherase, liver lipid peroxidation, collagen content (fourfold) and TGF-β mRNA, and protein levels; depleted liver glycogen and reduced glutathione (GSH) content. Coffee prevented most of the changes produced by CCl(4). Histopathological analysis was in agreement with biochemical and molecular data. The best effect was produced by GC. It is worth noting that GC preserved the normal collagen content as well as the normal TGF-β mRNA and protein levels. CONCLUSIONS: Our results suggest (1) that coffee plays a causative role in preventing cirrhosis (at least experimental cirrhosis); (2) that action mechanisms are probably associated with down regulation of the profibrogenic cytokine TGF-β and to its antioxidant properties and, (3) that GC is more potent than SC. These findings suggest a beneficial effect of coffee on the liver. However, more clinical and basic studies must be performed before reaching a final recommendation.
42 schema:genre research_article
43 schema:inLanguage en
44 schema:isAccessibleForFree false
45 schema:isPartOf N87f005cc385e44f4ac9467a574b7e115
46 Ncdb7e26352d9490286ab03c6889e3ac4
47 sg:journal.1038556
48 schema:name Coffee prevents CCl4-induced liver cirrhosis in the rat
49 schema:pagination 857-863
50 schema:productId N294f41334c364a3b98f7d0989f154375
51 N60b53b5e85c643beacdf333359e5155c
52 N758e891dd5b245ed9c0c2f239b9d3f1c
53 Na429ddbce9694e14b842d8bd36a4b9de
54 Nd80578e5513d402aac7eb2aa9d2bb28b
55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027060754
56 https://doi.org/10.1007/s12072-010-9247-6
57 schema:sdDatePublished 2019-04-11T01:09
58 schema:sdLicense https://scigraph.springernature.com/explorer/license/
59 schema:sdPublisher N4cef28268cd74a2580945f9f725b0831
60 schema:url http://link.springer.com/10.1007%2Fs12072-010-9247-6
61 sgo:license sg:explorer/license/
62 sgo:sdDataset articles
63 rdf:type schema:ScholarlyArticle
64 N0fd0d7bbeae54137b6589913299cf390 rdf:first sg:person.01057077537.67
65 rdf:rest Nbbc0385271f0429b8a0784c3cb401859
66 N294f41334c364a3b98f7d0989f154375 schema:name readcube_id
67 schema:value 80e939e580139c5a9030b4f81cd3291c292c1955001fa0013f80c904d7ce3243
68 rdf:type schema:PropertyValue
69 N49053916fa714fe683dd342634808fb9 rdf:first sg:person.0710631770.27
70 rdf:rest rdf:nil
71 N4cef28268cd74a2580945f9f725b0831 schema:name Springer Nature - SN SciGraph project
72 rdf:type schema:Organization
73 N60b53b5e85c643beacdf333359e5155c schema:name pubmed_id
74 schema:value 21484136
75 rdf:type schema:PropertyValue
76 N6fa90fd8328b4447b03b43a2b3a1bff9 rdf:first sg:person.01371323724.28
77 rdf:rest Na780b3d1f2014322944b4730d3843f3c
78 N72381b63bd5e417b93130309f4fa8afa rdf:first sg:person.01045330303.80
79 rdf:rest N93ba86958f124206a9ce193ebdf8cc48
80 N758e891dd5b245ed9c0c2f239b9d3f1c schema:name doi
81 schema:value 10.1007/s12072-010-9247-6
82 rdf:type schema:PropertyValue
83 N87f005cc385e44f4ac9467a574b7e115 schema:volumeNumber 5
84 rdf:type schema:PublicationVolume
85 N93ba86958f124206a9ce193ebdf8cc48 rdf:first sg:person.0757167474.32
86 rdf:rest N6fa90fd8328b4447b03b43a2b3a1bff9
87 Na429ddbce9694e14b842d8bd36a4b9de schema:name nlm_unique_id
88 schema:value 101304009
89 rdf:type schema:PropertyValue
90 Na780b3d1f2014322944b4730d3843f3c rdf:first sg:person.01254275213.77
91 rdf:rest N49053916fa714fe683dd342634808fb9
92 Nbbc0385271f0429b8a0784c3cb401859 rdf:first sg:person.0621011703.11
93 rdf:rest Nec59faabd3794d1cbfa9b4e3f30b9039
94 Nc1aa1dd776284d3fa107863dd02ff712 rdf:first sg:person.015166044302.14
95 rdf:rest N0fd0d7bbeae54137b6589913299cf390
96 Ncdb7e26352d9490286ab03c6889e3ac4 schema:issueNumber 3
97 rdf:type schema:PublicationIssue
98 Nd80578e5513d402aac7eb2aa9d2bb28b schema:name dimensions_id
99 schema:value pub.1027060754
100 rdf:type schema:PropertyValue
101 Nec59faabd3794d1cbfa9b4e3f30b9039 rdf:first sg:person.01273101622.30
102 rdf:rest N72381b63bd5e417b93130309f4fa8afa
103 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
104 schema:name Medical and Health Sciences
105 rdf:type schema:DefinedTerm
106 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
107 schema:name Clinical Sciences
108 rdf:type schema:DefinedTerm
109 sg:journal.1038556 schema:issn 1936-0533
110 1936-0541
111 schema:name Hepatology International
112 rdf:type schema:Periodical
113 sg:person.01045330303.80 schema:affiliation https://www.grid.ac/institutes/grid.418275.d
114 schema:familyName Vergara
115 schema:givenName Paula
116 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045330303.80
117 rdf:type schema:Person
118 sg:person.01057077537.67 schema:affiliation https://www.grid.ac/institutes/grid.418275.d
119 schema:familyName Chávez
120 schema:givenName Enrique
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057077537.67
122 rdf:type schema:Person
123 sg:person.01254275213.77 schema:affiliation https://www.grid.ac/institutes/grid.418275.d
124 schema:familyName Rivera-Espinoza
125 schema:givenName Yadira
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254275213.77
127 rdf:type schema:Person
128 sg:person.01273101622.30 schema:affiliation https://www.grid.ac/institutes/grid.418275.d
129 schema:familyName Segovia
130 schema:givenName José
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273101622.30
132 rdf:type schema:Person
133 sg:person.01371323724.28 schema:affiliation https://www.grid.ac/institutes/grid.418275.d
134 schema:familyName Shibayama
135 schema:givenName Mineko
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371323724.28
137 rdf:type schema:Person
138 sg:person.015166044302.14 schema:affiliation https://www.grid.ac/institutes/grid.418275.d
139 schema:familyName Moreno
140 schema:givenName Mario G.
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015166044302.14
142 rdf:type schema:Person
143 sg:person.0621011703.11 schema:affiliation https://www.grid.ac/institutes/grid.418275.d
144 schema:familyName Aldaba-Muruato
145 schema:givenName Liseth R.
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621011703.11
147 rdf:type schema:Person
148 sg:person.0710631770.27 schema:affiliation https://www.grid.ac/institutes/grid.418275.d
149 schema:familyName Muriel
150 schema:givenName Pablo
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710631770.27
152 rdf:type schema:Person
153 sg:person.0757167474.32 schema:affiliation https://www.grid.ac/institutes/grid.418275.d
154 schema:familyName Tsutsumi
155 schema:givenName Víctor
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757167474.32
157 rdf:type schema:Person
158 sg:pub.10.1007/bf01719277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036898763
159 https://doi.org/10.1007/bf01719277
160 rdf:type schema:CreativeWork
161 sg:pub.10.1038/sj.gt.3302929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016110230
162 https://doi.org/10.1038/sj.gt.3302929
163 rdf:type schema:CreativeWork
164 https://app.dimensions.ai/details/publication/pub.1075030022 schema:CreativeWork
165 https://app.dimensions.ai/details/publication/pub.1076905306 schema:CreativeWork
166 https://doi.org/10.1001/jama.275.6.458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054159923
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1002/hep.21806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048078745
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1002/hep.510300425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046900398
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1002/jgm.894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038192702
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/0003-2697(60)90050-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013214274
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/0003-2697(76)90326-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027571646
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/0003-2697(76)90527-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025529346
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/0003-2697(79)90738-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004403568
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/1047-2797(93)90064-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1024158128
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.fitote.2009.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021678447
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.jhep.2007.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016396952
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.jhep.2008.03.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015035650
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/s0006-8993(02)03102-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039738580
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0092-8674(03)00432-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035867530
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s1047-2797(01)00223-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038718782
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s1047-2797(01)00304-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048948013
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s1047-2797(02)00462-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045141030
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/s1386-6346(03)00115-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051503230
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1074/jbc.m700194200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017100161
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1078/0065-1281-00591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041055078
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1080/10408390500400009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006790471
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1093/ajcp/28.1.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031482018
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1093/oxfordjournals.aje.a116433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076634385
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1096/fasebj.13.13.1774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074528517
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1097/01.asn.0000025282.48298.7b schema:sameAs https://app.dimensions.ai/details/publication/pub.1060318857
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1111/j.1365-2036.2007.03319.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023877678
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1111/j.1582-4934.2008.00260.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039405350
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1152/ajpgi.2000.279.5.g845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074719137
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1201/9781420050134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1095904623
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1242/jcs.03270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021674086
225 rdf:type schema:CreativeWork
226 https://doi.org/10.2741/gressner schema:sameAs https://app.dimensions.ai/details/publication/pub.1070919310
227 rdf:type schema:CreativeWork
228 https://www.grid.ac/institutes/grid.418275.d schema:alternateName Instituto Politécnico Nacional
229 schema:name Departamento de Farmacología, Cinvestav-IPN, Apdo. Postal 14-740, 07000, México, DF, México
230 Departamento de Fisiología Biofísica y Neurociencias, Cinvestav-IPN, Apdo. Postal 14-740, 07000, México, DF, México
231 Departamento de Graduados e Investigación en Alimentos, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Carpio y Plan de Ayala, 11340, México, CP, México
232 Departamento de Infectómica y Patogénesis Molecular, Cinvestav-IPN, Apdo. Postal 14-740, 07000, México, DF, México
233 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...