Effects of single dose methylprednisolone on patient recovery after cardiopulmonary bypass View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-06

AUTHORS

Amber Malhotra, Sudesh Sharda, Ram Prasad Kaushal, Praveen Sharma, Sanjay Ranganath Pawar, Moolchand Songra

ABSTRACT

Ischaemic reperfusion injury, systemic inflammatory response and multi-organ dysfunction are not infrequent following Cardiopulmonary Bypass (CPB). We investigated the role of methylprednisolone in minimizing this state. Hundred consecutive patients undergoing elective single heart valve replacement surgery were randomized to receive methylprednisolone 30 mg/kg (M group) or placebo (P group) after induction of anaesthesia. Data were analyzed using the‘t’ test and Fischer test. The cardiac indices in the M and P group were 2.79 ± 0.13 L/min/m2 and 2.52 ± 0.26 L/min/m2 respectively (p < 0.0001). The amount of blood loss in the test versus control group was 268.3 ± 65.78 ml/24 hours versus 318.7 ± 55.5 ml/24 h respectively (p < 0.0001) and the amount of blood transfused in the test versus control group was 1.26 ± 0.57 units versus 1.76 ± 0.8 units respectively (p = 0.005). Patients in the test group had a lower incidence of early postoperative fever and new-onset atrial fibrillation during the first 3 days postoperatively. There was a statistically significant reduction in the intensive care unit stay (3.52 ± 1.16 days versus 4.14 ± 1.29 days in the M versus P group, p = 0.01) but not in hospital length of stay (13.7 ± 1.78 days versus 14.2 ± 1.52 days in the M versus P group, p = 0.13), or in overall morbidity and mortality. The use of methylprednisolone prior to initiation of CPB is associated with a more stable postoperative course with a higher cardiac index, shorter duration of Intensive Care Unit (ICU) stay and fewer blood transfusions. Methylprednisolone use also appears to be associated with a lower incidence of early postoperative fever and new-onset atrial fibrillation. More... »

PAGES

109-115

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12055-012-0146-4

DOI

http://dx.doi.org/10.1007/s12055-012-0146-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026562175


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