ROS dependent antitumour activity of photo-activated iron(III) complexes of amino acids View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

S Binita Chanu, MD Kausar Raza, Samya Banerjee, Pooja Rani Mina, Dulal Musib, Mithun Roy

ABSTRACT

Several amino acid-based photo-active monomeric iron(III) complexes of the general formula, [Fe(L)2]-, where L= Schiff base ligands (salisalidene arginine, salicylidenetryptophan, 3,5-di-tert-butyl benzalidine arginine and salicylidene tryptophan) were synthesized, characterized and explored for photo-activated anticancer activity to Chang Liver Cells, HeLa and MCF-7 cells. Complexes exhibited remarkable photo-cytotoxicity with IC50 value to the extent of 0.7μM to Chang Liver Cells in visible light and there was a 40-fold enhancement in cytotoxicity in comparison to the cytotoxicity in dark. Complexes were non-toxic to MCF-10A (normal cells) in dark and visible light (IC50>100μM in dark; IC50>80μM in visible light) signifying target-specific nature of the anti-tumour activity of the complexes. Increased ROS concentration, as probed by DCFDA assay, in the cancer cells was responsible for apoptotic cell death. Decarboxylation or phenolate-Fe(III) charge transfer of photo-activated iron(III) complexes generating ∙OH radicals (ROS) were responsible for the apoptosis. Overall, the tumour-selective photo-activated anticancer activity of the amino acid-based iron(III) complexes have shown a promising aspect in developing iron-based photo-chemotherapeutics as the next generation PDT agents. Monomeric iron(III) complexes are explored for photo-activated antitumour activity. Photodecarboxylation or photo-induced charge transfer of phenolate-O→Fe(III) has led to the generation of hydroxyl radicals causing apoptotic cell death. More... »

PAGES

9

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URI

http://scigraph.springernature.com/pub.10.1007/s12039-018-1584-3

DOI

http://dx.doi.org/10.1007/s12039-018-1584-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111390125


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47 schema:description Several amino acid-based photo-active monomeric iron(III) complexes of the general formula, [Fe(L)2]-, where L= Schiff base ligands (salisalidene arginine, salicylidenetryptophan, 3,5-di-tert-butyl benzalidine arginine and salicylidene tryptophan) were synthesized, characterized and explored for photo-activated anticancer activity to Chang Liver Cells, HeLa and MCF-7 cells. Complexes exhibited remarkable photo-cytotoxicity with IC50 value to the extent of 0.7μM to Chang Liver Cells in visible light and there was a 40-fold enhancement in cytotoxicity in comparison to the cytotoxicity in dark. Complexes were non-toxic to MCF-10A (normal cells) in dark and visible light (IC50>100μM in dark; IC50>80μM in visible light) signifying target-specific nature of the anti-tumour activity of the complexes. Increased ROS concentration, as probed by DCFDA assay, in the cancer cells was responsible for apoptotic cell death. Decarboxylation or phenolate-Fe(III) charge transfer of photo-activated iron(III) complexes generating ∙OH radicals (ROS) were responsible for the apoptosis. Overall, the tumour-selective photo-activated anticancer activity of the amino acid-based iron(III) complexes have shown a promising aspect in developing iron-based photo-chemotherapeutics as the next generation PDT agents. Monomeric iron(III) complexes are explored for photo-activated antitumour activity. Photodecarboxylation or photo-induced charge transfer of phenolate-O→Fe(III) has led to the generation of hydroxyl radicals causing apoptotic cell death.
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