A cross-eyed geneticist’s view View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06

AUTHORS

Durgadas P Kasbekar

ABSTRACT

The vertebrate inner nuclear membrane protein, lamin B receptor, has an N-terminal ~200 residue nucleoplasmic domain (NTD), and a ~420 residue C-terminal domain (CTD) that anchors the NTD to the INM. Chen et al (2016) showed the NTD interacts with Xist long noncoding RNA to effect X chromosome inactivation in female mammals. Tsai et al (2016) showed the CTD has sterol reductase activity that is essential for viability. And Nikolakaki et al (2017) proposed a model to interconnect these disparate functions of this chimeric protein. It amuses me now to think back to 24 years ago, when I was concerned that these domains might have come together in a cloning artifact. More... »

PAGES

235-237

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12038-018-9757-2

DOI

http://dx.doi.org/10.1007/s12038-018-9757-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103521875

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29872011


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