Designing exons for human olfactory receptor gene subfamilies using a mathematical paradigm View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-09

AUTHORS

Sk. Sarif Hassan, Pabitra Pal Choudhury, Amita Pal, R. L. Brahmachary, Arunava Goswami

ABSTRACT

Ligands for only two human olfactory receptors are known. One of them, OR1D2, binds to Bourgeonal, a volatile chemical constituent of the fragrance of the mythical flower, Lily of the valley or Our Lady's tears, Convallaria majalis (also the national flower of Finland). OR1D2, OR1D4 and OR1D5 are three full-length olfactory receptors present in an olfactory locus in the human genome. These receptors are more than 80% identical in DNA sequences and have 108 base pair mismatches among them. Apparently, these mismatch positions show no striking pattern using computer pattern recognition tools. In an attempt to find a mathematical rule in those mismatches, we find that an L-system generated sequence can be inserted into the OR1D2 subfamily-specific star model and novel full-length olfactory receptors can be generated. This remarkable mathematical principle could be utilized for making new subfamily olfactory receptor members from any olfactory receptor subfamily. The aroma and electronic nose industry might utilize this rule in future. More... »

PAGES

389-393

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12038-010-0044-0

DOI

http://dx.doi.org/10.1007/s12038-010-0044-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038605048

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20826948


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