miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-02

AUTHORS

S. Yasmeen, S. Kaur, A. H. Mirza, B. Brodin, F. Pociot, C. Kruuse

ABSTRACT

Endothelial dysfunction is a key element in cerebral small vessel disease (CSVD), which may cause stroke and cognitive decline. Cyclic nucleotide signaling modulates endothelial function. The cyclic adenosine monophosphate-degrading enzyme phosphodiesterase 3 (PDE3) is an important treatment target which may be modulated by microRNAs (miRNAs) important for regulating gene expression. We aimed to identify PDE3-targeting miRNAs to highlight potential therapeutic targets for endothelial dysfunction and CSVD. PDE3-targeting miRNAs were identified by in silico analysis (TargetScan, miRWalk, miRanda, and RNA22). The identified miRNAs were ranked on the basis of TargetScan context scores and their expression (log2 read counts) in a human brain endothelial cell line (hCMEC/D3) described recently. miRNAs were subjected to co-expression meta-analysis (CoMeTa) to create miRNA clusters. The pathways targeted by the miRNAs were assigned functional annotations via the KEGG pathway and COOL. hCMEC/D3 cells were transfected with miRNA mimics miR-27a-3p and miR-222-3p, and the effect on PDE3A protein expression was analyzed by Western blotting. Only PDE3A is expressed in hCMEC/D3 cells. The in silico prediction identified 67 PDE3A-related miRNAs, of which 49 were expressed in hCMEC/D3 cells. Further analysis of the top two miRNA clusters (miR-221/miR-222 and miR-27a/miR-27b/miR-128) indicated a potential link to pathways relevant to cerebral and vascular integrity and repair. hCMEC/D3 cells transfected with miR-27a-3p and miR-222-3p mimics had reduced relative expression of PDE3A protein. PDE3A-related miRNAs miR-221/miR-222 and miR-27a/miR-27b/miR-128 are potentially linked to pathways essential for immune regulation as well as cerebral and vascular integrity/function. Furthermore, relative PDE3A protein expression was reduced by miR27a-3p and miR-222-3p. More... »

PAGES

1-11

References to SciGraph publications

  • 2017-09. Plasma miR-34a-5p and miR-545-3p as Early Biomarkers of Alzheimer’s Disease: Potential and Limitations in MOLECULAR NEUROBIOLOGY
  • 2015-06. PDE3A mutations cause autosomal dominant hypertension with brachydactyly in NATURE GENETICS
  • 2017-12. Elevation of brain-enriched miRNAs in cerebrospinal fluid of patients with acute ischemic stroke in BIOMARKER RESEARCH
  • 2018-04. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes in NATURE GENETICS
  • 2017-12. Cilostazol improves endothelial function in acute cerebral ischemia patients: a double-blind placebo controlled trial with flow-mediated dilation technique in BMC NEUROLOGY
  • 2015-06. Hypertension linked to PDE3A activation in NATURE GENETICS
  • 2017-12. MiR-126 and miR-126* regulate shear-resistant firm leukocyte adhesion to human brain endothelium in SCIENTIFIC REPORTS
  • 2017-12. Secreted miR-27a Induced by Cyclic Stretch Modulates the Proliferation of Endothelial Cells in Hypertension via GRK6 in SCIENTIFIC REPORTS
  • 2017-03. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases in NATURE REVIEWS DRUG DISCOVERY
  • 2014-12. miRNA Expression Profiles in Cerebrospinal Fluid and Blood of Patients with Acute Ischemic Stroke in TRANSLATIONAL STROKE RESEARCH
  • 2011-05-06. Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases in PHOSPHODIESTERASES AS DRUG TARGETS
  • 2015-04. Endothelial dysfunction is associated with the severity of cerebral small vessel disease in HYPERTENSION RESEARCH
  • 2014-12. The efficacy and safety of cilostazol for the secondary prevention of ischemic stroke in acute and chronic phases in Asian population- an updated meta-analysis in BMC NEUROLOGY
  • 2010-06. Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes in DIABETOLOGIA
  • 2013-03. Cilostazol Strengthens Barrier Integrity in Brain Endothelial Cells in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12035-018-1446-5

    DOI

    http://dx.doi.org/10.1007/s12035-018-1446-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111058483

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30603956


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Copenhagen", 
              "id": "https://www.grid.ac/institutes/grid.5254.6", 
              "name": [
                "Stroke Unit and Neurovascular Research Unit, Department of Neurology, Herlev and Gentofte Hospital, Herlev ringvej 75, Herlev, Denmark", 
                "Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yasmeen", 
            "givenName": "S.", 
            "id": "sg:person.01041742054.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041742054.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Steno Diabetes Center", 
              "id": "https://www.grid.ac/institutes/grid.419658.7", 
              "name": [
                "Pediatric Department, Herlev University Hospital, Herlev ringvej 75, Herlev, Denmark", 
                "Steno Diabetes Center Copenhagen, Niels Steensens vej 2-4, 2820, Gentofte, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaur", 
            "givenName": "S.", 
            "id": "sg:person.01044036077.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044036077.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Herlev Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411900.d", 
              "name": [
                "Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark", 
                "Pediatric Department, Herlev University Hospital, Herlev ringvej 75, Herlev, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mirza", 
            "givenName": "A. H.", 
            "id": "sg:person.01013001674.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013001674.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Copenhagen", 
              "id": "https://www.grid.ac/institutes/grid.5254.6", 
              "name": [
                "Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark", 
                "CNS Drug Delivery and Barrier Modelling, University of Copenhagen, N\u00f8rre alle 67, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brodin", 
            "givenName": "B.", 
            "id": "sg:person.01025156504.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025156504.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Steno Diabetes Center", 
              "id": "https://www.grid.ac/institutes/grid.419658.7", 
              "name": [
                "Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark", 
                "Pediatric Department, Herlev University Hospital, Herlev ringvej 75, Herlev, Denmark", 
                "Steno Diabetes Center Copenhagen, Niels Steensens vej 2-4, 2820, Gentofte, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pociot", 
            "givenName": "F.", 
            "id": "sg:person.01043742117.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043742117.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Copenhagen", 
              "id": "https://www.grid.ac/institutes/grid.5254.6", 
              "name": [
                "Stroke Unit and Neurovascular Research Unit, Department of Neurology, Herlev and Gentofte Hospital, Herlev ringvej 75, Herlev, Denmark", 
                "Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kruuse", 
            "givenName": "C.", 
            "id": "sg:person.0601735511.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601735511.25"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2012.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001596757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.04-3458fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002742563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.107.153916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003793114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.107.153916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003793114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.107.153916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003793114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12883-014-0251-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005165106", 
              "https://doi.org/10.1186/s12883-014-0251-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12883-014-0251-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005165106", 
              "https://doi.org/10.1186/s12883-014-0251-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0268355513497361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005589736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0268355513497361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005589736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10571-012-9896-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006478380", 
              "https://doi.org/10.1007/s10571-012-9896-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbi.2011.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006493344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.107.500736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006587292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.107.500736", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006587292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jns.2012.06.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007560175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjcard.2013.05.067", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007865528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12975-014-0364-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007933636", 
              "https://doi.org/10.1007/s12975-014-0364-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/00207454.2016.1261291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009355678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.25056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009516914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3316", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010952235", 
              "https://doi.org/10.1038/ng.3316"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1105254108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010967358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2012-1996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011952757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pharmthera.2005.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012330802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pharmthera.2005.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012330802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-08-373886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013041116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.130435.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013886899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.110.206201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014513638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.110.206201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014513638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/dc13-1847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016684242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2008.157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017726445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2008.157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017726445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/nxi.0000000000000267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018972319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/nxi.0000000000000267", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018972319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jnnp.2009.172072", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020842647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1260-14.2014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020994189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.25.1.136-146.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022053730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mtna.2016.62", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022488351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m308952200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023007600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.2011.01729.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023735247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028848086", 
              "https://doi.org/10.1038/ng.3302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2012/896362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028919042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.atherosclerosis.2010.12.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030833099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-01-012369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031346338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-14-0209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031395813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejphar.2004.02.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032263705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/10623320009072215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033991269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-016-0088-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034940219", 
              "https://doi.org/10.1007/s12035-016-0088-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-016-0088-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034940219", 
              "https://doi.org/10.1007/s12035-016-0088-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000265065.26744.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036694006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000265065.26744.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036694006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2009.07.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036914750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.0000157667.06542.b7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038035957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.str.0000157667.06542.b7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038035957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms15011418", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038700236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.atherosclerosissup.2005.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039857449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/ern.11.118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042363159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-010-1667-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043914303", 
              "https://doi.org/10.1007/s00125-010-1667-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-010-1667-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043914303", 
              "https://doi.org/10.1007/s00125-010-1667-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-010-1667-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043914303", 
              "https://doi.org/10.1007/s00125-010-1667-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.107.500124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045828004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.107.500124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045828004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.05005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046247280"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnins.2016.00071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046255259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2015.4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046742966", 
              "https://doi.org/10.1038/hr.2015.4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.185363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046869411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.108.185363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046869411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1139/y96-081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047913532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.104.004853", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053137326"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkt852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053262454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/jscd.2000.7216", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053436644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-17969-3_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053441577", 
              "https://doi.org/10.1007/978-3-642-17969-3_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-17969-3_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053441577", 
              "https://doi.org/10.1007/978-3-642-17969-3_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep41058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053983096", 
              "https://doi.org/10.1038/srep41058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000437306.37850.22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064351218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000437306.37850.22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064351218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000437306.37850.22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064351218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079259469", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd.2016.246", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083845449", 
              "https://doi.org/10.1038/nrd.2016.246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci.insight.89656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083939631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci.insight.89656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083939631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci.insight.89656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083939631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep45284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084133121", 
              "https://doi.org/10.1038/srep45284"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40364-017-0104-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090603809", 
              "https://doi.org/10.1186/s40364-017-0104-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40364-017-0104-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090603809", 
              "https://doi.org/10.1186/s40364-017-0104-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12883-017-0950-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091371041", 
              "https://doi.org/10.1186/s12883-017-0950-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2017.08.073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091490091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2018.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100211796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0058-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101510806", 
              "https://doi.org/10.1038/s41588-018-0058-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0058-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101510806", 
              "https://doi.org/10.1038/s41588-018-0058-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0058-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101510806", 
              "https://doi.org/10.1038/s41588-018-0058-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0058-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101510806", 
              "https://doi.org/10.1038/s41588-018-0058-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0058-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101510806", 
              "https://doi.org/10.1038/s41588-018-0058-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0058-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101510806", 
              "https://doi.org/10.1038/s41588-018-0058-3"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-01-02", 
        "datePublishedReg": "2019-01-02", 
        "description": "Endothelial dysfunction is a key element in cerebral small vessel disease (CSVD), which may cause stroke and cognitive decline. Cyclic nucleotide signaling modulates endothelial function. The cyclic adenosine monophosphate-degrading enzyme phosphodiesterase 3 (PDE3) is an important treatment target which may be modulated by microRNAs (miRNAs) important for regulating gene expression. We aimed to identify PDE3-targeting miRNAs to highlight potential therapeutic targets for endothelial dysfunction and CSVD. PDE3-targeting miRNAs were identified by in silico analysis (TargetScan, miRWalk, miRanda, and RNA22). The identified miRNAs were ranked on the basis of TargetScan context scores and their expression (log2 read counts) in a human brain endothelial cell line (hCMEC/D3) described recently. miRNAs were subjected to co-expression meta-analysis (CoMeTa) to create miRNA clusters. The pathways targeted by the miRNAs were assigned functional annotations via the KEGG pathway and COOL. hCMEC/D3 cells were transfected with miRNA mimics miR-27a-3p and miR-222-3p, and the effect on PDE3A protein expression was analyzed by Western blotting. Only PDE3A is expressed in hCMEC/D3 cells. The in silico prediction identified 67 PDE3A-related miRNAs, of which 49 were expressed in hCMEC/D3 cells. Further analysis of the top two miRNA clusters (miR-221/miR-222 and miR-27a/miR-27b/miR-128) indicated a potential link to pathways relevant to cerebral and vascular integrity and repair. hCMEC/D3 cells transfected with miR-27a-3p and miR-222-3p mimics had reduced relative expression of PDE3A protein. PDE3A-related miRNAs miR-221/miR-222 and miR-27a/miR-27b/miR-128 are potentially linked to pathways essential for immune regulation as well as cerebral and vascular integrity/function. Furthermore, relative PDE3A protein expression was reduced by miR27a-3p and miR-222-3p.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s12035-018-1446-5", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1098844", 
            "issn": [
              "0893-7648", 
              "1559-1182"
            ], 
            "name": "Molecular Neurobiology", 
            "type": "Periodical"
          }
        ], 
        "name": "miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells", 
        "pagination": "1-11", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0599aca76c7d84cb91895cf252a6b84963a657acebe1d2c70ecce62f687dc139"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30603956"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8900963"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12035-018-1446-5"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111058483"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12035-018-1446-5", 
          "https://app.dimensions.ai/details/publication/pub.1111058483"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T08:33", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000310_0000000310/records_90721_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs12035-018-1446-5"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1446-5'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1446-5'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1446-5'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1446-5'


     

    This table displays all metadata directly associated to this object as RDF triples.

    318 TRIPLES      21 PREDICATES      91 URIs      18 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12035-018-1446-5 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N022c132cb7eb426cad218a5e9f82fe64
    4 schema:citation sg:pub.10.1007/978-3-642-17969-3_8
    5 sg:pub.10.1007/s00125-010-1667-2
    6 sg:pub.10.1007/s10571-012-9896-1
    7 sg:pub.10.1007/s12035-016-0088-8
    8 sg:pub.10.1007/s12975-014-0364-8
    9 sg:pub.10.1038/hr.2015.4
    10 sg:pub.10.1038/ng.3302
    11 sg:pub.10.1038/ng.3316
    12 sg:pub.10.1038/nrd.2016.246
    13 sg:pub.10.1038/s41588-018-0058-3
    14 sg:pub.10.1038/srep41058
    15 sg:pub.10.1038/srep45284
    16 sg:pub.10.1186/s12883-014-0251-7
    17 sg:pub.10.1186/s12883-017-0950-y
    18 sg:pub.10.1186/s40364-017-0104-9
    19 https://app.dimensions.ai/details/publication/pub.1079259469
    20 https://doi.org/10.1002/jcp.25056
    21 https://doi.org/10.1016/j.amjcard.2013.05.067
    22 https://doi.org/10.1016/j.atherosclerosis.2010.12.024
    23 https://doi.org/10.1016/j.atherosclerosissup.2005.09.003
    24 https://doi.org/10.1016/j.celrep.2017.08.073
    25 https://doi.org/10.1016/j.ejphar.2004.02.038
    26 https://doi.org/10.1016/j.jbi.2011.05.002
    27 https://doi.org/10.1016/j.jneuroim.2018.01.005
    28 https://doi.org/10.1016/j.jns.2012.06.005
    29 https://doi.org/10.1016/j.jstrokecerebrovasdis.2009.07.010
    30 https://doi.org/10.1016/j.pharmthera.2005.07.003
    31 https://doi.org/10.1016/j.yjmcc.2012.04.003
    32 https://doi.org/10.1038/jcbfm.2008.157
    33 https://doi.org/10.1038/mtna.2016.62
    34 https://doi.org/10.1053/jscd.2000.7216
    35 https://doi.org/10.1073/pnas.1105254108
    36 https://doi.org/10.1074/jbc.m308952200
    37 https://doi.org/10.1080/00207454.2016.1261291
    38 https://doi.org/10.1093/nar/gkt852
    39 https://doi.org/10.1096/fj.04-3458fje
    40 https://doi.org/10.1101/gr.130435.111
    41 https://doi.org/10.1111/j.1476-5381.2011.01729.x
    42 https://doi.org/10.1124/mol.104.004853
    43 https://doi.org/10.1128/mcb.25.1.136-146.2005
    44 https://doi.org/10.1136/jnnp.2009.172072
    45 https://doi.org/10.1139/y96-081
    46 https://doi.org/10.1155/2012/896362
    47 https://doi.org/10.1158/1535-7163.mct-14-0209
    48 https://doi.org/10.1161/01.res.0000265065.26744.17
    49 https://doi.org/10.1161/01.str.0000157667.06542.b7
    50 https://doi.org/10.1161/atvbaha.110.206201
    51 https://doi.org/10.1161/circresaha.107.153916
    52 https://doi.org/10.1161/circresaha.108.185363
    53 https://doi.org/10.1161/strokeaha.107.500124
    54 https://doi.org/10.1161/strokeaha.107.500736
    55 https://doi.org/10.1172/jci.insight.89656
    56 https://doi.org/10.1177/0268355513497361
    57 https://doi.org/10.1182/blood-2006-01-012369
    58 https://doi.org/10.1182/blood-2011-08-373886
    59 https://doi.org/10.1210/jc.2012-1996
    60 https://doi.org/10.1212/01.wnl.0000437306.37850.22
    61 https://doi.org/10.1212/nxi.0000000000000267
    62 https://doi.org/10.1523/jneurosci.1260-14.2014
    63 https://doi.org/10.1586/ern.11.118
    64 https://doi.org/10.2337/dc13-1847
    65 https://doi.org/10.3109/10623320009072215
    66 https://doi.org/10.3389/fnins.2016.00071
    67 https://doi.org/10.3390/ijms15011418
    68 https://doi.org/10.7554/elife.05005
    69 schema:datePublished 2019-01-02
    70 schema:datePublishedReg 2019-01-02
    71 schema:description Endothelial dysfunction is a key element in cerebral small vessel disease (CSVD), which may cause stroke and cognitive decline. Cyclic nucleotide signaling modulates endothelial function. The cyclic adenosine monophosphate-degrading enzyme phosphodiesterase 3 (PDE3) is an important treatment target which may be modulated by microRNAs (miRNAs) important for regulating gene expression. We aimed to identify PDE3-targeting miRNAs to highlight potential therapeutic targets for endothelial dysfunction and CSVD. PDE3-targeting miRNAs were identified by in silico analysis (TargetScan, miRWalk, miRanda, and RNA22). The identified miRNAs were ranked on the basis of TargetScan context scores and their expression (log2 read counts) in a human brain endothelial cell line (hCMEC/D3) described recently. miRNAs were subjected to co-expression meta-analysis (CoMeTa) to create miRNA clusters. The pathways targeted by the miRNAs were assigned functional annotations via the KEGG pathway and COOL. hCMEC/D3 cells were transfected with miRNA mimics miR-27a-3p and miR-222-3p, and the effect on PDE3A protein expression was analyzed by Western blotting. Only PDE3A is expressed in hCMEC/D3 cells. The in silico prediction identified 67 PDE3A-related miRNAs, of which 49 were expressed in hCMEC/D3 cells. Further analysis of the top two miRNA clusters (miR-221/miR-222 and miR-27a/miR-27b/miR-128) indicated a potential link to pathways relevant to cerebral and vascular integrity and repair. hCMEC/D3 cells transfected with miR-27a-3p and miR-222-3p mimics had reduced relative expression of PDE3A protein. PDE3A-related miRNAs miR-221/miR-222 and miR-27a/miR-27b/miR-128 are potentially linked to pathways essential for immune regulation as well as cerebral and vascular integrity/function. Furthermore, relative PDE3A protein expression was reduced by miR27a-3p and miR-222-3p.
    72 schema:genre research_article
    73 schema:inLanguage en
    74 schema:isAccessibleForFree false
    75 schema:isPartOf sg:journal.1098844
    76 schema:name miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells
    77 schema:pagination 1-11
    78 schema:productId N13565d810d834c4b8e343c5e2f12a19d
    79 N36a7dacb6fe149f085551704f0f65a39
    80 Ne587cdd17417421ab8ae36c586015128
    81 Nf1cc6ec8f96f43438dddbc94a0f0b497
    82 Nf28ae3ce5f584f0397ed99161c8bc66c
    83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111058483
    84 https://doi.org/10.1007/s12035-018-1446-5
    85 schema:sdDatePublished 2019-04-11T08:33
    86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    87 schema:sdPublisher N4b56b897ab4845f4b9b93824e2363938
    88 schema:url https://link.springer.com/10.1007%2Fs12035-018-1446-5
    89 sgo:license sg:explorer/license/
    90 sgo:sdDataset articles
    91 rdf:type schema:ScholarlyArticle
    92 N022c132cb7eb426cad218a5e9f82fe64 rdf:first sg:person.01041742054.85
    93 rdf:rest N865397d0fab24e9190cbeadf26914c55
    94 N13565d810d834c4b8e343c5e2f12a19d schema:name nlm_unique_id
    95 schema:value 8900963
    96 rdf:type schema:PropertyValue
    97 N36a7dacb6fe149f085551704f0f65a39 schema:name dimensions_id
    98 schema:value pub.1111058483
    99 rdf:type schema:PropertyValue
    100 N4b56b897ab4845f4b9b93824e2363938 schema:name Springer Nature - SN SciGraph project
    101 rdf:type schema:Organization
    102 N813ea9bcbc894d69888df1ba19117e72 rdf:first sg:person.0601735511.25
    103 rdf:rest rdf:nil
    104 N865397d0fab24e9190cbeadf26914c55 rdf:first sg:person.01044036077.74
    105 rdf:rest N8b143172a0ff4ecbbef1e1e5c99b70d2
    106 N8b143172a0ff4ecbbef1e1e5c99b70d2 rdf:first sg:person.01013001674.99
    107 rdf:rest Nbd8ea3cba09340839108e1558420db5c
    108 Nbd8ea3cba09340839108e1558420db5c rdf:first sg:person.01025156504.08
    109 rdf:rest Nfbbac4acefb341968e689561f0ef419d
    110 Ne587cdd17417421ab8ae36c586015128 schema:name pubmed_id
    111 schema:value 30603956
    112 rdf:type schema:PropertyValue
    113 Nf1cc6ec8f96f43438dddbc94a0f0b497 schema:name readcube_id
    114 schema:value 0599aca76c7d84cb91895cf252a6b84963a657acebe1d2c70ecce62f687dc139
    115 rdf:type schema:PropertyValue
    116 Nf28ae3ce5f584f0397ed99161c8bc66c schema:name doi
    117 schema:value 10.1007/s12035-018-1446-5
    118 rdf:type schema:PropertyValue
    119 Nfbbac4acefb341968e689561f0ef419d rdf:first sg:person.01043742117.03
    120 rdf:rest N813ea9bcbc894d69888df1ba19117e72
    121 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    122 schema:name Biological Sciences
    123 rdf:type schema:DefinedTerm
    124 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    125 schema:name Biochemistry and Cell Biology
    126 rdf:type schema:DefinedTerm
    127 sg:journal.1098844 schema:issn 0893-7648
    128 1559-1182
    129 schema:name Molecular Neurobiology
    130 rdf:type schema:Periodical
    131 sg:person.01013001674.99 schema:affiliation https://www.grid.ac/institutes/grid.411900.d
    132 schema:familyName Mirza
    133 schema:givenName A. H.
    134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013001674.99
    135 rdf:type schema:Person
    136 sg:person.01025156504.08 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
    137 schema:familyName Brodin
    138 schema:givenName B.
    139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025156504.08
    140 rdf:type schema:Person
    141 sg:person.01041742054.85 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
    142 schema:familyName Yasmeen
    143 schema:givenName S.
    144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041742054.85
    145 rdf:type schema:Person
    146 sg:person.01043742117.03 schema:affiliation https://www.grid.ac/institutes/grid.419658.7
    147 schema:familyName Pociot
    148 schema:givenName F.
    149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043742117.03
    150 rdf:type schema:Person
    151 sg:person.01044036077.74 schema:affiliation https://www.grid.ac/institutes/grid.419658.7
    152 schema:familyName Kaur
    153 schema:givenName S.
    154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044036077.74
    155 rdf:type schema:Person
    156 sg:person.0601735511.25 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
    157 schema:familyName Kruuse
    158 schema:givenName C.
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601735511.25
    160 rdf:type schema:Person
    161 sg:pub.10.1007/978-3-642-17969-3_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053441577
    162 https://doi.org/10.1007/978-3-642-17969-3_8
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1007/s00125-010-1667-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043914303
    165 https://doi.org/10.1007/s00125-010-1667-2
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1007/s10571-012-9896-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006478380
    168 https://doi.org/10.1007/s10571-012-9896-1
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1007/s12035-016-0088-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034940219
    171 https://doi.org/10.1007/s12035-016-0088-8
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1007/s12975-014-0364-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007933636
    174 https://doi.org/10.1007/s12975-014-0364-8
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1038/hr.2015.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046742966
    177 https://doi.org/10.1038/hr.2015.4
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1038/ng.3302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028848086
    180 https://doi.org/10.1038/ng.3302
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1038/ng.3316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010952235
    183 https://doi.org/10.1038/ng.3316
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1038/nrd.2016.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083845449
    186 https://doi.org/10.1038/nrd.2016.246
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1038/s41588-018-0058-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101510806
    189 https://doi.org/10.1038/s41588-018-0058-3
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1038/srep41058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053983096
    192 https://doi.org/10.1038/srep41058
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/srep45284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084133121
    195 https://doi.org/10.1038/srep45284
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1186/s12883-014-0251-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005165106
    198 https://doi.org/10.1186/s12883-014-0251-7
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1186/s12883-017-0950-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1091371041
    201 https://doi.org/10.1186/s12883-017-0950-y
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1186/s40364-017-0104-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090603809
    204 https://doi.org/10.1186/s40364-017-0104-9
    205 rdf:type schema:CreativeWork
    206 https://app.dimensions.ai/details/publication/pub.1079259469 schema:CreativeWork
    207 https://doi.org/10.1002/jcp.25056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009516914
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/j.amjcard.2013.05.067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007865528
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/j.atherosclerosis.2010.12.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030833099
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/j.atherosclerosissup.2005.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039857449
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1016/j.celrep.2017.08.073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091490091
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1016/j.ejphar.2004.02.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032263705
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1016/j.jbi.2011.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006493344
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1016/j.jneuroim.2018.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100211796
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1016/j.jns.2012.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007560175
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1016/j.jstrokecerebrovasdis.2009.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036914750
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1016/j.pharmthera.2005.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012330802
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1016/j.yjmcc.2012.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001596757
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1038/jcbfm.2008.157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017726445
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1038/mtna.2016.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022488351
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1053/jscd.2000.7216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053436644
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1073/pnas.1105254108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010967358
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1074/jbc.m308952200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023007600
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1080/00207454.2016.1261291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009355678
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1093/nar/gkt852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053262454
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1096/fj.04-3458fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1002742563
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1101/gr.130435.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013886899
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1111/j.1476-5381.2011.01729.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023735247
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1124/mol.104.004853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053137326
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1128/mcb.25.1.136-146.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022053730
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1136/jnnp.2009.172072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020842647
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1139/y96-081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047913532
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1155/2012/896362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028919042
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1158/1535-7163.mct-14-0209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031395813
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1161/01.res.0000265065.26744.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036694006
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1161/01.str.0000157667.06542.b7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038035957
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1161/atvbaha.110.206201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014513638
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1161/circresaha.107.153916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003793114
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1161/circresaha.108.185363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046869411
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1161/strokeaha.107.500124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045828004
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1161/strokeaha.107.500736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006587292
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1172/jci.insight.89656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083939631
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1177/0268355513497361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005589736
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1182/blood-2006-01-012369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031346338
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1182/blood-2011-08-373886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013041116
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1210/jc.2012-1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011952757
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1212/01.wnl.0000437306.37850.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064351218
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1212/nxi.0000000000000267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018972319
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1523/jneurosci.1260-14.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020994189
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1586/ern.11.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042363159
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.2337/dc13-1847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016684242
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.3109/10623320009072215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033991269
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.3389/fnins.2016.00071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046255259
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.3390/ijms15011418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038700236
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.7554/elife.05005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046247280
    304 rdf:type schema:CreativeWork
    305 https://www.grid.ac/institutes/grid.411900.d schema:alternateName Herlev Hospital
    306 schema:name Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    307 Pediatric Department, Herlev University Hospital, Herlev ringvej 75, Herlev, Denmark
    308 rdf:type schema:Organization
    309 https://www.grid.ac/institutes/grid.419658.7 schema:alternateName Steno Diabetes Center
    310 schema:name Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    311 Pediatric Department, Herlev University Hospital, Herlev ringvej 75, Herlev, Denmark
    312 Steno Diabetes Center Copenhagen, Niels Steensens vej 2-4, 2820, Gentofte, Denmark
    313 rdf:type schema:Organization
    314 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
    315 schema:name CNS Drug Delivery and Barrier Modelling, University of Copenhagen, Nørre alle 67, Copenhagen, Denmark
    316 Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    317 Stroke Unit and Neurovascular Research Unit, Department of Neurology, Herlev and Gentofte Hospital, Herlev ringvej 75, Herlev, Denmark
    318 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...