Klotho at the Edge of Alzheimer’s Disease and Senile Depression View Full Text


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Article Info

DATE

2018-07-05

AUTHORS

Giulia Paroni, Francesco Panza, Salvatore De Cosmo, Antonio Greco, Davide Seripa, Gianluigi Mazzoccoli

ABSTRACT

Klotho, encoded by the KL gene, is a single-pass transmembrane protein and a circulating factor that plays a key role in cellular metabolism and body homeostasis and has been associated with age-related diseases. Alterations of this protein seem to influence the development of serotonergic neurons and could play a role in major depression in the elderly. Pretreatment of neurons with Klotho protein can avoid neuronal injury related to the toxic amyloid-β and glutamate, centrally related to the pathogenesis of Alzheimer’s disease (AD), in order that Klotho protein could play a neuroprotective role in AD patients. Late-life depression, mild cognitive impairment, and dementia are different nosological entities but share common neurobiological facets and could represent a clinical continuum. Enhancement of Klotho levels in the early stages of the disease could represent a therapeutic strategy to prevent further deterioration and to ameliorate the outcome of elderly AD patients with or without major depression. More... »

PAGES

1908-1920

References to SciGraph publications

  • 2004-03-24. Persistent reduction in brain serotonin1A receptor binding in recovered depressed men measured by positron emission tomography with [11C]WAY-100635 in MOLECULAR PSYCHIATRY
  • 2016-01-05. G-395A polymorphism in the promoter region of the KLOTHO gene associates with reduced cognitive impairment among the oldest old in GEROSCIENCE
  • 2009-09-04. Klotho in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 2016-10-06. Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging in BRAIN IMAGING AND BEHAVIOR
  • 2015-04-29. Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice in NATURE COMMUNICATIONS
  • 2012-11-27. Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems in MOLECULAR PSYCHIATRY
  • 2012. Klotho and βKlotho in ENDOCRINE FGFS AND KLOTHOS
  • 2000-11. Genetic pathways that regulate ageing in model organisms in NATURE
  • 2007-12-02. Antidepressant actions of the exercise-regulated gene VGF in NATURE MEDICINE
  • 2013-08-11. FGF21 regulates circadian behavior and metabolism by acting on the nervous system in NATURE MEDICINE
  • 2015-05-15. Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer’s Disease? in MOLECULAR NEUROBIOLOGY
  • 2004-06-02. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ in NATURE
  • 2014-11-11. Cardiovascular risk factors and future risk of Alzheimer’s disease in BMC MEDICINE
  • 2006-01. Klotho-induced insulin resistance: a blessing in disguise? in NATURE MEDICINE
  • 2007-08-28. Adult hippocampal neurogenesis in depression in NATURE NEUROSCIENCE
  • 1997-11. Mutation of the mouse klotho gene leads to a syndrome resembling ageing in NATURE
  • 2018-03-05. Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease in NATURE NEUROSCIENCE
  • 2016-02-03. Klotho Gene and Selective Serotonin Reuptake Inhibitors: Response to Treatment in Late-Life Major Depressive Disorder in MOLECULAR NEUROBIOLOGY
  • 2018-01-17. αKlotho is a Non-Enzymatic Molecular Scaffold for FGF23 Hormone Signaling in NATURE
  • 2017-07-15. FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice in MOLECULAR NEUROBIOLOGY
  • 2011-05-03. Antidepressants recruit new neurons to improve stress response regulation in MOLECULAR PSYCHIATRY
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    http://scigraph.springernature.com/pub.10.1007/s12035-018-1200-z

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    36 schema:description Klotho, encoded by the KL gene, is a single-pass transmembrane protein and a circulating factor that plays a key role in cellular metabolism and body homeostasis and has been associated with age-related diseases. Alterations of this protein seem to influence the development of serotonergic neurons and could play a role in major depression in the elderly. Pretreatment of neurons with Klotho protein can avoid neuronal injury related to the toxic amyloid-β and glutamate, centrally related to the pathogenesis of Alzheimer’s disease (AD), in order that Klotho protein could play a neuroprotective role in AD patients. Late-life depression, mild cognitive impairment, and dementia are different nosological entities but share common neurobiological facets and could represent a clinical continuum. Enhancement of Klotho levels in the early stages of the disease could represent a therapeutic strategy to prevent further deterioration and to ameliorate the outcome of elderly AD patients with or without major depression.
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