Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Ruimin Wang, Yan Dong, Yujiao Lu, Wenli Zhang, Darrell W. Brann, Quanguang Zhang

ABSTRACT

Hypothermia is currently the only approved therapy for global cerebral ischemia (GCI) after cardiac arrest; however, it unfortunately has multiple adverse effects. As a noninvasive procedure, photobiomodulation (PBM) therapy has emerged as a potential novel treatment for brain injury. PBM involves the use of low-level laser light therapy to influence cell behavior. In this study, we evaluated the therapeutic effects of PBM treatment with an 808-nm diode laser initiated 6 h after GCI. It was noted that PBM dose-dependently protected against GCI-induced neuronal death in the vulnerable hippocampal CA1 subregion. Functional assessments demonstrated that PBM markedly preserved both short-term (a week) and long-term (6 months) spatial learning and memory function following GCI. Further mechanistic studies revealed that PBM post-treatment (a) preserved healthy mitochondrial dynamics and suppressed substantial mitochondrial fragmentation of CA1 neurons, by reducing the detrimental Drp1 GTPase activity and its interactions with adaptor proteins Mff and Fis1 and by balancing mitochondrial targeting fission and fusion protein levels; (b) reduced mitochondrial oxidative damage and excessive mitophagy and restored mitochondrial overall health status and preserved mitochondrial function; and (c) suppressed mitochondria-dependent apoptosome formation/caspase-3/9 apoptosis-processing activities. Additionally, we validated, in an in vitro ischemia model, that cytochrome c oxidase served as a key PBM target for mitochondrial function preservation and neuroprotection. Our findings suggest that PBM serves as a promising therapeutic strategy for the functional recovery after GCI, with mechanisms involving PBM's preservation on mitochondrial dynamics and functions and the inhibition of delayed apoptotic neuronal death in GCI. More... »

PAGES

1852-1869

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12035-018-1191-9

DOI

http://dx.doi.org/10.1007/s12035-018-1191-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105170925

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29951942


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hebei United University", 
          "id": "https://www.grid.ac/institutes/grid.440734.0", 
          "name": [
            "Neurobiology Institute of Medical Research Center, North China University of Science and Technology, 063000, Tangshan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Ruimin", 
        "id": "sg:person.014162721737.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014162721737.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Augusta University", 
          "id": "https://www.grid.ac/institutes/grid.410427.4", 
          "name": [
            "Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, 30912, Augusta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dong", 
        "givenName": "Yan", 
        "id": "sg:person.01033070126.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033070126.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Augusta University", 
          "id": "https://www.grid.ac/institutes/grid.410427.4", 
          "name": [
            "Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, 30912, Augusta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Yujiao", 
        "id": "sg:person.013160543771.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013160543771.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hebei United University", 
          "id": "https://www.grid.ac/institutes/grid.440734.0", 
          "name": [
            "Neurobiology Institute of Medical Research Center, North China University of Science and Technology, 063000, Tangshan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Wenli", 
        "id": "sg:person.01266270650.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266270650.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Augusta University", 
          "id": "https://www.grid.ac/institutes/grid.410427.4", 
          "name": [
            "Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, 30912, Augusta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brann", 
        "givenName": "Darrell W.", 
        "id": "sg:person.01306403774.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306403774.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Augusta University", 
          "id": "https://www.grid.ac/institutes/grid.410427.4", 
          "name": [
            "Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, 30912, Augusta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Quanguang", 
        "id": "sg:person.01045741637.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045741637.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.pharep.2016.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000083751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2013.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000548529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.12.8.2245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000684296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbio.201300125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001931898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2009.05867.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003987043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2009.05867.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003987043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m505970200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004666093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neulet.2016.08.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005907762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.114.005795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006748747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.114.005795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006748747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.114.005795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006748747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007190504", 
          "https://doi.org/10.1038/13014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007190504", 
          "https://doi.org/10.1038/13014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-4975(93)90737-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007659273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2203/dose-response.14-032.agrawal", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007825227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2203/dose-response.14-032.agrawal", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007825227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mcn.2016.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008430634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbr.2010.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008713379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/toxsci/kfi164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009386214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c200677200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012973683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-015-1257-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014340398", 
          "https://doi.org/10.1007/s00109-015-1257-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pmrj.2010.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014387620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbadis.2009.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015186061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0407043101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016931281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.410110509", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017395337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000131808.69640.b7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018998686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000131808.69640.b7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018998686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.30.3.514", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020785451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-015-9455-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021646444", 
          "https://doi.org/10.1007/s12035-015-9455-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tem.2012.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022362753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00691853", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023089702", 
          "https://doi.org/10.1007/bf00691853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201511036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024047272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.114.006750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026528019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.114.006750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026528019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cns.12325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027392784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.resuscitation.2008.10.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028593224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.1304-15.2015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030438803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(02)01116-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030687037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(02)01116-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030687037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2016.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032681249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2008.07.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035441403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuro.2015.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035836658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10439-011-0454-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036426413", 
          "https://doi.org/10.1007/s10439-011-0454-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.12.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037015752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1104391108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037211437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.516393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038438166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.108.516393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038438166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1516729112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038464736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ncl.2005.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038479123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.resuscitation.2011.07.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042211976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1996.67010064.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042399854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.579011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043068275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/strokeaha.110.579011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043068275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-016-9983-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044351830", 
          "https://doi.org/10.1007/s12035-016-9983-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-016-9983-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044351830", 
          "https://doi.org/10.1007/s12035-016-9983-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11011-014-9515-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044794873", 
          "https://doi.org/10.1007/s11011-014-9515-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5115/acb.2014.47.3.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045542048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2010.166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045924416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2010.166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045924416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mce.2013.12.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046291487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1993.03500020071034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046586115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0808249105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046951123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awt046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049129642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2007.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049152885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.embor.7401062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049591180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/cir.0b013e3182009701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050811077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(82)90833-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050986588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(82)90833-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050986588"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3574-09.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051354052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-004-6869-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052199205", 
          "https://doi.org/10.1007/s11064-004-6869-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijcard.2010.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053003317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053030408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200207071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053483527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.26.8.1478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063341701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.1999.79.4.1431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074529426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075232983", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077693384", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0733-8619(18)30164-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082753580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082895491", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-160869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083525908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jphotobiol.2017.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083804331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep42660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083843199", 
          "https://doi.org/10.1038/srep42660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jns.2017.02.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083916605"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tox.2017.07.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091048289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-017-0712-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091340328", 
          "https://doi.org/10.1007/s12035-017-0712-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fendo.2017.00296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092515109"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03", 
    "datePublishedReg": "2019-03-01", 
    "description": "Hypothermia is currently the only approved therapy for global cerebral ischemia (GCI) after cardiac arrest; however, it unfortunately has multiple adverse effects. As a noninvasive procedure, photobiomodulation (PBM) therapy has emerged as a potential novel treatment for brain injury. PBM involves the use of low-level laser light therapy to influence cell behavior. In this study, we evaluated the therapeutic effects of PBM treatment with an 808-nm diode laser initiated 6\u00a0h after GCI. It was noted that PBM dose-dependently protected against GCI-induced neuronal death in the vulnerable hippocampal CA1 subregion. Functional assessments demonstrated that PBM markedly preserved both short-term (a week) and long-term (6\u00a0months) spatial learning and memory function following GCI. Further mechanistic studies revealed that PBM post-treatment (a) preserved healthy mitochondrial dynamics and suppressed substantial mitochondrial fragmentation of CA1 neurons, by reducing the detrimental Drp1 GTPase activity and its interactions with adaptor proteins Mff and Fis1 and by balancing mitochondrial targeting fission and fusion protein levels; (b) reduced mitochondrial oxidative damage and excessive mitophagy and restored mitochondrial overall health status and preserved mitochondrial function; and (c) suppressed mitochondria-dependent apoptosome formation/caspase-3/9 apoptosis-processing activities. Additionally, we validated, in an in vitro ischemia model, that cytochrome c oxidase served as a key PBM target for mitochondrial function preservation and neuroprotection. Our findings suggest that PBM serves as a promising therapeutic strategy for the functional recovery after GCI, with mechanisms involving PBM's preservation on mitochondrial dynamics and functions and the inhibition of delayed apoptotic neuronal death in GCI.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12035-018-1191-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3867788", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3805410", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1098844", 
        "issn": [
          "0893-7648", 
          "1559-1182"
        ], 
        "name": "Molecular Neurobiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "56"
      }
    ], 
    "name": "Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions", 
    "pagination": "1852-1869", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "69749c6216bd889b8c148cc40607fd900492da35c99ae22304f3794ca246658a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29951942"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8900963"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12035-018-1191-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105170925"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12035-018-1191-9", 
      "https://app.dimensions.ai/details/publication/pub.1105170925"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113661_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs12035-018-1191-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1191-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1191-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1191-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1191-9'


 

This table displays all metadata directly associated to this object as RDF triples.

337 TRIPLES      21 PREDICATES      102 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12035-018-1191-9 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N8d5b94097b4d4facbf9d56652880919a
4 schema:citation sg:pub.10.1007/bf00691853
5 sg:pub.10.1007/s00109-015-1257-3
6 sg:pub.10.1007/s10439-011-0454-7
7 sg:pub.10.1007/s11011-014-9515-6
8 sg:pub.10.1007/s11064-004-6869-x
9 sg:pub.10.1007/s12035-015-9455-0
10 sg:pub.10.1007/s12035-016-9983-2
11 sg:pub.10.1007/s12035-017-0712-2
12 sg:pub.10.1038/13014
13 sg:pub.10.1038/srep42660
14 https://app.dimensions.ai/details/publication/pub.1075232983
15 https://app.dimensions.ai/details/publication/pub.1077693384
16 https://app.dimensions.ai/details/publication/pub.1082895491
17 https://doi.org/10.1001/jama.1993.03500020071034
18 https://doi.org/10.1002/ana.410110509
19 https://doi.org/10.1002/jbio.201300125
20 https://doi.org/10.1016/0003-4975(93)90737-3
21 https://doi.org/10.1016/0006-8993(82)90833-2
22 https://doi.org/10.1016/j.bbadis.2009.09.002
23 https://doi.org/10.1016/j.bbr.2010.12.004
24 https://doi.org/10.1016/j.bcp.2013.11.010
25 https://doi.org/10.1016/j.cell.2006.06.025
26 https://doi.org/10.1016/j.febslet.2008.07.047
27 https://doi.org/10.1016/j.ijcard.2010.06.008
28 https://doi.org/10.1016/j.jns.2017.02.043
29 https://doi.org/10.1016/j.jphotobiol.2017.02.008
30 https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.12.021
31 https://doi.org/10.1016/j.mce.2013.12.019
32 https://doi.org/10.1016/j.mcn.2016.08.010
33 https://doi.org/10.1016/j.ncl.2005.10.004
34 https://doi.org/10.1016/j.neulet.2016.08.026
35 https://doi.org/10.1016/j.neuro.2015.10.008
36 https://doi.org/10.1016/j.neurobiolaging.2016.10.003
37 https://doi.org/10.1016/j.neuroscience.2007.07.002
38 https://doi.org/10.1016/j.pharep.2016.01.006
39 https://doi.org/10.1016/j.pmrj.2010.10.013
40 https://doi.org/10.1016/j.resuscitation.2008.10.034
41 https://doi.org/10.1016/j.resuscitation.2011.07.031
42 https://doi.org/10.1016/j.tem.2012.06.005
43 https://doi.org/10.1016/j.tox.2017.07.019
44 https://doi.org/10.1016/s0304-3940(02)01116-3
45 https://doi.org/10.1016/s0733-8619(18)30164-6
46 https://doi.org/10.1038/jcbfm.2010.166
47 https://doi.org/10.1038/sj.embor.7401062
48 https://doi.org/10.1046/j.1471-4159.1996.67010064.x
49 https://doi.org/10.1073/pnas.0407043101
50 https://doi.org/10.1073/pnas.0808249105
51 https://doi.org/10.1073/pnas.1104391108
52 https://doi.org/10.1073/pnas.1516729112
53 https://doi.org/10.1074/jbc.c200677200
54 https://doi.org/10.1074/jbc.m505970200
55 https://doi.org/10.1083/jcb.200207071
56 https://doi.org/10.1083/jcb.201511036
57 https://doi.org/10.1091/mbc.12.8.2245
58 https://doi.org/10.1093/brain/awt046
59 https://doi.org/10.1093/toxsci/kfi164
60 https://doi.org/10.1111/cns.12325
61 https://doi.org/10.1111/j.1471-4159.2009.05867.x
62 https://doi.org/10.1152/physrev.1999.79.4.1431
63 https://doi.org/10.1161/01.str.0000131808.69640.b7
64 https://doi.org/10.1161/01.str.26.8.1478
65 https://doi.org/10.1161/01.str.30.3.514
66 https://doi.org/10.1161/cir.0b013e3182009701
67 https://doi.org/10.1161/strokeaha.108.516393
68 https://doi.org/10.1161/strokeaha.110.579011
69 https://doi.org/10.1161/strokeaha.114.005795
70 https://doi.org/10.1161/strokeaha.114.006750
71 https://doi.org/10.1523/jneurosci.1304-15.2015
72 https://doi.org/10.1523/jneurosci.3574-09.2009
73 https://doi.org/10.2203/dose-response.14-032.agrawal
74 https://doi.org/10.3233/jad-160869
75 https://doi.org/10.3389/fendo.2017.00296
76 https://doi.org/10.5115/acb.2014.47.3.149
77 schema:datePublished 2019-03
78 schema:datePublishedReg 2019-03-01
79 schema:description Hypothermia is currently the only approved therapy for global cerebral ischemia (GCI) after cardiac arrest; however, it unfortunately has multiple adverse effects. As a noninvasive procedure, photobiomodulation (PBM) therapy has emerged as a potential novel treatment for brain injury. PBM involves the use of low-level laser light therapy to influence cell behavior. In this study, we evaluated the therapeutic effects of PBM treatment with an 808-nm diode laser initiated 6 h after GCI. It was noted that PBM dose-dependently protected against GCI-induced neuronal death in the vulnerable hippocampal CA1 subregion. Functional assessments demonstrated that PBM markedly preserved both short-term (a week) and long-term (6 months) spatial learning and memory function following GCI. Further mechanistic studies revealed that PBM post-treatment (a) preserved healthy mitochondrial dynamics and suppressed substantial mitochondrial fragmentation of CA1 neurons, by reducing the detrimental Drp1 GTPase activity and its interactions with adaptor proteins Mff and Fis1 and by balancing mitochondrial targeting fission and fusion protein levels; (b) reduced mitochondrial oxidative damage and excessive mitophagy and restored mitochondrial overall health status and preserved mitochondrial function; and (c) suppressed mitochondria-dependent apoptosome formation/caspase-3/9 apoptosis-processing activities. Additionally, we validated, in an in vitro ischemia model, that cytochrome c oxidase served as a key PBM target for mitochondrial function preservation and neuroprotection. Our findings suggest that PBM serves as a promising therapeutic strategy for the functional recovery after GCI, with mechanisms involving PBM's preservation on mitochondrial dynamics and functions and the inhibition of delayed apoptotic neuronal death in GCI.
80 schema:genre research_article
81 schema:inLanguage en
82 schema:isAccessibleForFree false
83 schema:isPartOf N99b6db96591a4e7baac591efb49117a4
84 Nb2f98d2464e644819de285926a59045b
85 sg:journal.1098844
86 schema:name Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions
87 schema:pagination 1852-1869
88 schema:productId N387e12bebe974835b213b38332b5dd5a
89 N6bb39dd783c04c99ae70463a5aa2e259
90 N75dbdb67b383402c9317b097f8e14579
91 N7bff7a99519446969c9001b472a65832
92 N9ae6acc3c0814491a5a94fe339fabe1a
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105170925
94 https://doi.org/10.1007/s12035-018-1191-9
95 schema:sdDatePublished 2019-04-11T10:34
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N1916950b1bcb49cea5f944eefd37d1f1
98 schema:url https://link.springer.com/10.1007%2Fs12035-018-1191-9
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N16c38369c139423ba6bdce2a7a8fa01e rdf:first sg:person.01266270650.64
103 rdf:rest Nf95a3eaeba204667a49862c5cc0f3362
104 N1916950b1bcb49cea5f944eefd37d1f1 schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N387e12bebe974835b213b38332b5dd5a schema:name nlm_unique_id
107 schema:value 8900963
108 rdf:type schema:PropertyValue
109 N6b8de852240342df915cd83f29876b1d rdf:first sg:person.01033070126.44
110 rdf:rest N8325223f83274ea9b90d848fce395e6c
111 N6bb39dd783c04c99ae70463a5aa2e259 schema:name doi
112 schema:value 10.1007/s12035-018-1191-9
113 rdf:type schema:PropertyValue
114 N75dbdb67b383402c9317b097f8e14579 schema:name readcube_id
115 schema:value 69749c6216bd889b8c148cc40607fd900492da35c99ae22304f3794ca246658a
116 rdf:type schema:PropertyValue
117 N7bff7a99519446969c9001b472a65832 schema:name dimensions_id
118 schema:value pub.1105170925
119 rdf:type schema:PropertyValue
120 N8325223f83274ea9b90d848fce395e6c rdf:first sg:person.013160543771.67
121 rdf:rest N16c38369c139423ba6bdce2a7a8fa01e
122 N8699d0fd2d6d4029ad56edd0e4796560 rdf:first sg:person.01045741637.19
123 rdf:rest rdf:nil
124 N8d5b94097b4d4facbf9d56652880919a rdf:first sg:person.014162721737.66
125 rdf:rest N6b8de852240342df915cd83f29876b1d
126 N99b6db96591a4e7baac591efb49117a4 schema:issueNumber 3
127 rdf:type schema:PublicationIssue
128 N9ae6acc3c0814491a5a94fe339fabe1a schema:name pubmed_id
129 schema:value 29951942
130 rdf:type schema:PropertyValue
131 Nb2f98d2464e644819de285926a59045b schema:volumeNumber 56
132 rdf:type schema:PublicationVolume
133 Nf95a3eaeba204667a49862c5cc0f3362 rdf:first sg:person.01306403774.11
134 rdf:rest N8699d0fd2d6d4029ad56edd0e4796560
135 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
136 schema:name Medical and Health Sciences
137 rdf:type schema:DefinedTerm
138 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
139 schema:name Neurosciences
140 rdf:type schema:DefinedTerm
141 sg:grant.3805410 http://pending.schema.org/fundedItem sg:pub.10.1007/s12035-018-1191-9
142 rdf:type schema:MonetaryGrant
143 sg:grant.3867788 http://pending.schema.org/fundedItem sg:pub.10.1007/s12035-018-1191-9
144 rdf:type schema:MonetaryGrant
145 sg:journal.1098844 schema:issn 0893-7648
146 1559-1182
147 schema:name Molecular Neurobiology
148 rdf:type schema:Periodical
149 sg:person.01033070126.44 schema:affiliation https://www.grid.ac/institutes/grid.410427.4
150 schema:familyName Dong
151 schema:givenName Yan
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033070126.44
153 rdf:type schema:Person
154 sg:person.01045741637.19 schema:affiliation https://www.grid.ac/institutes/grid.410427.4
155 schema:familyName Zhang
156 schema:givenName Quanguang
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045741637.19
158 rdf:type schema:Person
159 sg:person.01266270650.64 schema:affiliation https://www.grid.ac/institutes/grid.440734.0
160 schema:familyName Zhang
161 schema:givenName Wenli
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266270650.64
163 rdf:type schema:Person
164 sg:person.01306403774.11 schema:affiliation https://www.grid.ac/institutes/grid.410427.4
165 schema:familyName Brann
166 schema:givenName Darrell W.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306403774.11
168 rdf:type schema:Person
169 sg:person.013160543771.67 schema:affiliation https://www.grid.ac/institutes/grid.410427.4
170 schema:familyName Lu
171 schema:givenName Yujiao
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013160543771.67
173 rdf:type schema:Person
174 sg:person.014162721737.66 schema:affiliation https://www.grid.ac/institutes/grid.440734.0
175 schema:familyName Wang
176 schema:givenName Ruimin
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014162721737.66
178 rdf:type schema:Person
179 sg:pub.10.1007/bf00691853 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023089702
180 https://doi.org/10.1007/bf00691853
181 rdf:type schema:CreativeWork
182 sg:pub.10.1007/s00109-015-1257-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014340398
183 https://doi.org/10.1007/s00109-015-1257-3
184 rdf:type schema:CreativeWork
185 sg:pub.10.1007/s10439-011-0454-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036426413
186 https://doi.org/10.1007/s10439-011-0454-7
187 rdf:type schema:CreativeWork
188 sg:pub.10.1007/s11011-014-9515-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044794873
189 https://doi.org/10.1007/s11011-014-9515-6
190 rdf:type schema:CreativeWork
191 sg:pub.10.1007/s11064-004-6869-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052199205
192 https://doi.org/10.1007/s11064-004-6869-x
193 rdf:type schema:CreativeWork
194 sg:pub.10.1007/s12035-015-9455-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021646444
195 https://doi.org/10.1007/s12035-015-9455-0
196 rdf:type schema:CreativeWork
197 sg:pub.10.1007/s12035-016-9983-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044351830
198 https://doi.org/10.1007/s12035-016-9983-2
199 rdf:type schema:CreativeWork
200 sg:pub.10.1007/s12035-017-0712-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091340328
201 https://doi.org/10.1007/s12035-017-0712-2
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/13014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007190504
204 https://doi.org/10.1038/13014
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/srep42660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083843199
207 https://doi.org/10.1038/srep42660
208 rdf:type schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1075232983 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1077693384 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1082895491 schema:CreativeWork
212 https://doi.org/10.1001/jama.1993.03500020071034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046586115
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1002/ana.410110509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017395337
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/jbio.201300125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001931898
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/0003-4975(93)90737-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007659273
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/0006-8993(82)90833-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050986588
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.bbadis.2009.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015186061
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.bbr.2010.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008713379
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.bcp.2013.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000548529
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.cell.2006.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053030408
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.febslet.2008.07.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035441403
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.ijcard.2010.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053003317
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.jns.2017.02.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083916605
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.jphotobiol.2017.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083804331
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.12.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037015752
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.mce.2013.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046291487
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.mcn.2016.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008430634
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.ncl.2005.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038479123
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.neulet.2016.08.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005907762
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.neuro.2015.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035836658
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.neurobiolaging.2016.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032681249
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.neuroscience.2007.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049152885
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.pharep.2016.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000083751
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.pmrj.2010.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014387620
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.resuscitation.2008.10.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028593224
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.resuscitation.2011.07.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042211976
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.tem.2012.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022362753
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.tox.2017.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091048289
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s0304-3940(02)01116-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030687037
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0733-8619(18)30164-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082753580
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1038/jcbfm.2010.166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045924416
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1038/sj.embor.7401062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049591180
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1046/j.1471-4159.1996.67010064.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042399854
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1073/pnas.0407043101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016931281
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1073/pnas.0808249105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046951123
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1073/pnas.1104391108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037211437
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1073/pnas.1516729112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038464736
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1074/jbc.c200677200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012973683
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1074/jbc.m505970200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004666093
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1083/jcb.200207071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053483527
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1083/jcb.201511036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024047272
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1091/mbc.12.8.2245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000684296
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1093/brain/awt046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049129642
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1093/toxsci/kfi164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009386214
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1111/cns.12325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027392784
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1111/j.1471-4159.2009.05867.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003987043
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1152/physrev.1999.79.4.1431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074529426
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1161/01.str.0000131808.69640.b7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018998686
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1161/01.str.26.8.1478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063341701
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1161/01.str.30.3.514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020785451
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1161/cir.0b013e3182009701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050811077
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1161/strokeaha.108.516393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038438166
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1161/strokeaha.110.579011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043068275
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1161/strokeaha.114.005795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006748747
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1161/strokeaha.114.006750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026528019
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1523/jneurosci.1304-15.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030438803
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1523/jneurosci.3574-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051354052
323 rdf:type schema:CreativeWork
324 https://doi.org/10.2203/dose-response.14-032.agrawal schema:sameAs https://app.dimensions.ai/details/publication/pub.1007825227
325 rdf:type schema:CreativeWork
326 https://doi.org/10.3233/jad-160869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083525908
327 rdf:type schema:CreativeWork
328 https://doi.org/10.3389/fendo.2017.00296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092515109
329 rdf:type schema:CreativeWork
330 https://doi.org/10.5115/acb.2014.47.3.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045542048
331 rdf:type schema:CreativeWork
332 https://www.grid.ac/institutes/grid.410427.4 schema:alternateName Augusta University
333 schema:name Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, 30912, Augusta, GA, USA
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.440734.0 schema:alternateName Hebei United University
336 schema:name Neurobiology Institute of Medical Research Center, North China University of Science and Technology, 063000, Tangshan, China
337 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...