Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Min-Jung Park, Hyun-Sun Park, Min-Jung You, Jongman Yoo, Seung Hyun Kim, Min-Soo Kwon

ABSTRACT

The functional status of dynamic microglial cells plays an important role in maintaining homeostasis of microenvironment in CNS. In a previous study, we reported that microglia phenotype might be involved in stress vulnerability and depression recurrence. Here, we aimed to clarify a character of microglia exposed persistently to glucocorticoid (GC), which is representative a stress hormone, in primary cultured microglial cells. Five nanomolars of dexamethasone (DEX, GC agonist) for 72 h decreased CX3CR1 and CD200R expression and induced ramified form of microglial cells in similar morphology to in vivo resident microglia. However, the ramified form of microglia did not increase microglia signature genes such as P2RY12, OLFML3, TMEM119, and TGFBR1. In addition, DEX-treated microglia showed a reduction of phagocytosis function, pro-and anti-inflammatory cytokine production, and cell proliferation. DEX washout did not restore these changes. Based on transcriptomic analysis and functional characters of DEX-treated microglia, we performed senescence-associated beta-galactosidase (SA-β gal) assay in DEX-treated microglia and DEX-treated microglia showed more SA-β gal activity with alteration of cell cycle-related genes. Thus, our results suggest that DEX can induce a specific phenotype of microglia (like-senescence). More... »

PAGES

1421-1436

References to SciGraph publications

  • 2014-07. Cellular senescence: from physiology to pathology in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-06. Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis in MOLECULAR PSYCHIATRY
  • 2010-01. Microglia: biology and pathology in ACTA NEUROPATHOLOGICA
  • 2005-06. IDO and interferon-α-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity in MOLECULAR PSYCHIATRY
  • 2006-07. Control of microglial neurotoxicity by the fractalkine receptor in NATURE NEUROSCIENCE
  • 2017-08. Transcriptomic analysis of purified human cortical microglia reveals age-associated changes in NATURE NEUROSCIENCE
  • 2005-06. Stress and the brain: from adaptation to disease in NATURE REVIEWS NEUROSCIENCE
  • 2013-12. The microglial sensome revealed by direct RNA sequencing in NATURE NEUROSCIENCE
  • 2010-04. Microglia in neurodegenerative disease in NATURE REVIEWS NEUROLOGY
  • 2008-02. Autophagy fights disease through cellular self-digestion in NATURE
  • 2015-12. IL-4/10 prevents stress vulnerability following imipramine discontinuation in JOURNAL OF NEUROINFLAMMATION
  • 2016-08. A polarizing question: do M1 and M2 microglia exist? in NATURE NEUROSCIENCE
  • 2007-09. Cellular senescence: when bad things happen to good cells in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2008-01. From inflammation to sickness and depression: when the immune system subjugates the brain in NATURE REVIEWS NEUROSCIENCE
  • 2014-01. Identification of a unique TGF-β–dependent molecular and functional signature in microglia in NATURE NEUROSCIENCE
  • 2011-11. Microglial cell origin and phenotypes in health and disease in NATURE REVIEWS IMMUNOLOGY
  • 2009-05. Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice in MOLECULAR PSYCHIATRY
  • 2014-05. Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease in NATURE REVIEWS NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12035-018-1156-z

    DOI

    http://dx.doi.org/10.1007/s12035-018-1156-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104496281

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29948944


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "CHA University", 
              "id": "https://www.grid.ac/institutes/grid.410886.3", 
              "name": [
                "Department of Pharmacology, School of Medicine, CHA University, CHABIOCOMPLEX, 335 Pangyo, Bundang-gu, 13488, Seongnam-si, Gyeonggi-do, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Min-Jung", 
            "id": "sg:person.01023751165.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023751165.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHA University", 
              "id": "https://www.grid.ac/institutes/grid.410886.3", 
              "name": [
                "Department of Pharmacology, School of Medicine, CHA University, CHABIOCOMPLEX, 335 Pangyo, Bundang-gu, 13488, Seongnam-si, Gyeonggi-do, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Hyun-Sun", 
            "id": "sg:person.0673411033.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673411033.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHA University", 
              "id": "https://www.grid.ac/institutes/grid.410886.3", 
              "name": [
                "Department of Pharmacology, School of Medicine, CHA University, CHABIOCOMPLEX, 335 Pangyo, Bundang-gu, 13488, Seongnam-si, Gyeonggi-do, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "You", 
            "givenName": "Min-Jung", 
            "id": "sg:person.016135311327.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016135311327.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHA University", 
              "id": "https://www.grid.ac/institutes/grid.410886.3", 
              "name": [
                "Department of Microbiology and School of Medicine, CHA University, CHABIOCOMPLEX, 335 Pangyo, Bundang-gu, 13488, Seongnam-si, Gyeonggi-do, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoo", 
            "givenName": "Jongman", 
            "id": "sg:person.01006162446.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006162446.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hanyang University", 
              "id": "https://www.grid.ac/institutes/grid.49606.3d", 
              "name": [
                "Cell Therapy Center and Department of Neurology, College of Medicine, Hanyang University, Haengdang-dong, Seoul, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kim", 
            "givenName": "Seung Hyun", 
            "id": "sg:person.0715565724.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715565724.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CHA University", 
              "id": "https://www.grid.ac/institutes/grid.410886.3", 
              "name": [
                "Department of Pharmacology, School of Medicine, CHA University, CHABIOCOMPLEX, 335 Pangyo, Bundang-gu, 13488, Seongnam-si, Gyeonggi-do, Republic of Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kwon", 
            "givenName": "Min-Soo", 
            "id": "sg:person.0604140564.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604140564.76"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.tins.2005.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002770331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnint.2013.00053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003117910"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awv066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003810511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.devcel.2015.01.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004089792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2190/1b32-79ea-b6h5-395v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004392390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2190/1b32-79ea-b6h5-395v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004392390"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000166389.85273.38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005909818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000166389.85273.38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005909818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000166389.85273.38", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005909818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00713.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006256932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006979823", 
              "https://doi.org/10.1038/nrn1683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006979823", 
              "https://doi.org/10.1038/nrn1683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006979823", 
              "https://doi.org/10.1038/nrn1683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1860-14.2014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007098650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-physiol-030212-183653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007476995"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000049025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007722417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn3722", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008765454", 
              "https://doi.org/10.1038/nrn3722"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2003.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009128459"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2015.08.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009894358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2013.155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011599492", 
              "https://doi.org/10.1038/mp.2013.155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2013.155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011599492", 
              "https://doi.org/10.1038/mp.2013.155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1104836108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014394923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3554", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016133129", 
              "https://doi.org/10.1038/nn.3554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017349450", 
              "https://doi.org/10.1038/nn.3599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12974-015-0416-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017755581", 
              "https://doi.org/10.1186/s12974-015-0416-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017867309", 
              "https://doi.org/10.1038/nri3086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1037/0278-6133.21.6.531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019802683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1037/0278-6133.21.6.531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019802683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020622734", 
              "https://doi.org/10.1038/nrn2297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021332650", 
              "https://doi.org/10.1038/nn1715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021332650", 
              "https://doi.org/10.1038/nn1715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbi.2006.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021787447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2011.08.053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021877006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2990.2012.01306.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023964874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(90)90229-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024998641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(90)90229-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024998641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025718085", 
              "https://doi.org/10.1038/nature06639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030616797", 
              "https://doi.org/10.1038/nrm2233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/joe.0.1620371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030922436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1677/joe.0.1620371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030922436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031160532", 
              "https://doi.org/10.1038/sj.mp.4001600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031160532", 
              "https://doi.org/10.1038/sj.mp.4001600"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2014.01.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033331685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m412170200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034603148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.2003.01604.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036387037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fncel.2013.00022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043664675"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.clinpsy.1.102803.144141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043995657"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-032713-120240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044022904"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/mcp.m115.053926", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044036951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2013.06.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044108769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ceb.2009.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044451367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrneurol.2010.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045968907", 
              "https://doi.org/10.1038/nrneurol.2010.17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrneurol.2010.17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045968907", 
              "https://doi.org/10.1038/nrneurol.2010.17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0622-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047010389", 
              "https://doi.org/10.1007/s00401-009-0622-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0622-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047010389", 
              "https://doi.org/10.1007/s00401-009-0622-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0622-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047010389", 
              "https://doi.org/10.1007/s00401-009-0622-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047909787", 
              "https://doi.org/10.1038/nn.4338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fncel.2014.00152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052507471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053250436", 
              "https://doi.org/10.1038/nrm3823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4002148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053365396", 
              "https://doi.org/10.1038/sj.mp.4002148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.4035356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062623813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr.2016.5662", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071524328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.29272", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072297689"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.06-08-02163.1986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079509370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molmed.2017.03.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085126533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090329025", 
              "https://doi.org/10.1038/nn.4597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.4597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090329025", 
              "https://doi.org/10.1038/nn.4597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2017.07.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091142674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci90606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091436856"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-02", 
        "datePublishedReg": "2019-02-01", 
        "description": "The functional status of dynamic microglial cells plays an important role in maintaining homeostasis of microenvironment in CNS. In a previous study, we reported that microglia phenotype might be involved in stress vulnerability and depression recurrence. Here, we aimed to clarify a character of microglia exposed persistently to glucocorticoid (GC), which is representative a stress hormone, in primary cultured microglial cells. Five nanomolars of dexamethasone (DEX, GC agonist) for 72\u00a0h decreased CX3CR1 and CD200R expression and induced ramified form of microglial cells in similar morphology to in vivo resident microglia. However, the ramified form of microglia did not increase microglia signature genes such as P2RY12, OLFML3, TMEM119, and TGFBR1. In addition, DEX-treated microglia showed a reduction of phagocytosis function, pro-and anti-inflammatory cytokine production, and cell proliferation. DEX washout did not restore these changes. Based on transcriptomic analysis and functional characters of DEX-treated microglia, we performed senescence-associated beta-galactosidase (SA-\u03b2 gal) assay in DEX-treated microglia and DEX-treated microglia showed more SA-\u03b2 gal activity with alteration of cell cycle-related genes. Thus, our results suggest that DEX can induce a specific phenotype of microglia (like-senescence).", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s12035-018-1156-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1098844", 
            "issn": [
              "0893-7648", 
              "1559-1182"
            ], 
            "name": "Molecular Neurobiology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "56"
          }
        ], 
        "name": "Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia", 
        "pagination": "1421-1436", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "181f3dc8bc2847e067e073585c05eb0f8661a5ba86e5be6eb083f1061e6c8de4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29948944"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8900963"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12035-018-1156-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1104496281"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12035-018-1156-z", 
          "https://app.dimensions.ai/details/publication/pub.1104496281"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:13", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000353_0000000353/records_45369_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs12035-018-1156-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1156-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1156-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1156-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12035-018-1156-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    288 TRIPLES      21 PREDICATES      83 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12035-018-1156-z schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N2c7bc8366cc44578a4c751128e8564bc
    4 schema:citation sg:pub.10.1007/s00401-009-0622-0
    5 sg:pub.10.1038/mp.2013.155
    6 sg:pub.10.1038/nature06639
    7 sg:pub.10.1038/nn.3554
    8 sg:pub.10.1038/nn.3599
    9 sg:pub.10.1038/nn.4338
    10 sg:pub.10.1038/nn.4597
    11 sg:pub.10.1038/nn1715
    12 sg:pub.10.1038/nri3086
    13 sg:pub.10.1038/nrm2233
    14 sg:pub.10.1038/nrm3823
    15 sg:pub.10.1038/nrn1683
    16 sg:pub.10.1038/nrn2297
    17 sg:pub.10.1038/nrn3722
    18 sg:pub.10.1038/nrneurol.2010.17
    19 sg:pub.10.1038/sj.mp.4001600
    20 sg:pub.10.1038/sj.mp.4002148
    21 sg:pub.10.1186/s12974-015-0416-3
    22 https://doi.org/10.1016/0306-4522(90)90229-w
    23 https://doi.org/10.1016/j.bbi.2006.11.006
    24 https://doi.org/10.1016/j.brainres.2011.08.053
    25 https://doi.org/10.1016/j.ceb.2009.12.005
    26 https://doi.org/10.1016/j.cell.2017.07.023
    27 https://doi.org/10.1016/j.celrep.2013.06.018
    28 https://doi.org/10.1016/j.devcel.2015.01.018
    29 https://doi.org/10.1016/j.molmed.2017.03.008
    30 https://doi.org/10.1016/j.neurobiolaging.2003.08.007
    31 https://doi.org/10.1016/j.neuron.2014.01.013
    32 https://doi.org/10.1016/j.tins.2005.12.005
    33 https://doi.org/10.1016/j.tins.2015.08.001
    34 https://doi.org/10.1037/0278-6133.21.6.531
    35 https://doi.org/10.1046/j.1471-4159.2003.01604.x
    36 https://doi.org/10.1073/pnas.1104836108
    37 https://doi.org/10.1074/jbc.m412170200
    38 https://doi.org/10.1074/mcp.m115.053926
    39 https://doi.org/10.1093/brain/awv066
    40 https://doi.org/10.1097/01.ccm.0000166389.85273.38
    41 https://doi.org/10.1111/j.1365-2990.2012.01306.x
    42 https://doi.org/10.1126/science.4035356
    43 https://doi.org/10.1146/annurev-immunol-032713-120240
    44 https://doi.org/10.1146/annurev-physiol-030212-183653
    45 https://doi.org/10.1146/annurev.clinpsy.1.102803.144141
    46 https://doi.org/10.1152/ajpheart.00713.2007
    47 https://doi.org/10.1159/000049025
    48 https://doi.org/10.1172/jci90606
    49 https://doi.org/10.1523/jneurosci.06-08-02163.1986
    50 https://doi.org/10.1523/jneurosci.1860-14.2014
    51 https://doi.org/10.1677/joe.0.1620371
    52 https://doi.org/10.2190/1b32-79ea-b6h5-395v
    53 https://doi.org/10.3389/fncel.2013.00022
    54 https://doi.org/10.3389/fncel.2014.00152
    55 https://doi.org/10.3389/fnint.2013.00053
    56 https://doi.org/10.3892/mmr.2016.5662
    57 https://doi.org/10.4161/cc.29272
    58 schema:datePublished 2019-02
    59 schema:datePublishedReg 2019-02-01
    60 schema:description The functional status of dynamic microglial cells plays an important role in maintaining homeostasis of microenvironment in CNS. In a previous study, we reported that microglia phenotype might be involved in stress vulnerability and depression recurrence. Here, we aimed to clarify a character of microglia exposed persistently to glucocorticoid (GC), which is representative a stress hormone, in primary cultured microglial cells. Five nanomolars of dexamethasone (DEX, GC agonist) for 72 h decreased CX3CR1 and CD200R expression and induced ramified form of microglial cells in similar morphology to in vivo resident microglia. However, the ramified form of microglia did not increase microglia signature genes such as P2RY12, OLFML3, TMEM119, and TGFBR1. In addition, DEX-treated microglia showed a reduction of phagocytosis function, pro-and anti-inflammatory cytokine production, and cell proliferation. DEX washout did not restore these changes. Based on transcriptomic analysis and functional characters of DEX-treated microglia, we performed senescence-associated beta-galactosidase (SA-β gal) assay in DEX-treated microglia and DEX-treated microglia showed more SA-β gal activity with alteration of cell cycle-related genes. Thus, our results suggest that DEX can induce a specific phenotype of microglia (like-senescence).
    61 schema:genre research_article
    62 schema:inLanguage en
    63 schema:isAccessibleForFree false
    64 schema:isPartOf N2e279a069a7444dd97eba729ef56e968
    65 Nd3f3e7f9b8004770a596315ba04bcf7c
    66 sg:journal.1098844
    67 schema:name Dexamethasone Induces a Specific Form of Ramified Dysfunctional Microglia
    68 schema:pagination 1421-1436
    69 schema:productId N6605ce394c0f406e8e120d70c5b97f2c
    70 N968afbf0af774dc2a20ac75a6594eb94
    71 Na0f303584853441ba74a5ffd72c58290
    72 Nb0985f6ecb24454eaf4fd2fe8bbfbd20
    73 Nef145d2f13cd45f780d1fab2032c618c
    74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104496281
    75 https://doi.org/10.1007/s12035-018-1156-z
    76 schema:sdDatePublished 2019-04-11T11:13
    77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    78 schema:sdPublisher N925d960e7a15476da45e08f9f0009f53
    79 schema:url https://link.springer.com/10.1007%2Fs12035-018-1156-z
    80 sgo:license sg:explorer/license/
    81 sgo:sdDataset articles
    82 rdf:type schema:ScholarlyArticle
    83 N0273bbcd31934595a738d2a70afd6264 rdf:first sg:person.01006162446.46
    84 rdf:rest N1b8ae1d82f5d4ee6bc69967f59fa673d
    85 N1b8ae1d82f5d4ee6bc69967f59fa673d rdf:first sg:person.0715565724.15
    86 rdf:rest Nbc61902e3939414eae0a6ec86392db1e
    87 N2c7bc8366cc44578a4c751128e8564bc rdf:first sg:person.01023751165.45
    88 rdf:rest Nfe11a786db9744579d3013c48de82a85
    89 N2e279a069a7444dd97eba729ef56e968 schema:volumeNumber 56
    90 rdf:type schema:PublicationVolume
    91 N6605ce394c0f406e8e120d70c5b97f2c schema:name pubmed_id
    92 schema:value 29948944
    93 rdf:type schema:PropertyValue
    94 N925d960e7a15476da45e08f9f0009f53 schema:name Springer Nature - SN SciGraph project
    95 rdf:type schema:Organization
    96 N968afbf0af774dc2a20ac75a6594eb94 schema:name dimensions_id
    97 schema:value pub.1104496281
    98 rdf:type schema:PropertyValue
    99 Na0f303584853441ba74a5ffd72c58290 schema:name nlm_unique_id
    100 schema:value 8900963
    101 rdf:type schema:PropertyValue
    102 Nb0985f6ecb24454eaf4fd2fe8bbfbd20 schema:name readcube_id
    103 schema:value 181f3dc8bc2847e067e073585c05eb0f8661a5ba86e5be6eb083f1061e6c8de4
    104 rdf:type schema:PropertyValue
    105 Nb3dd5ac3f7934be996421ed13b91d065 rdf:first sg:person.016135311327.99
    106 rdf:rest N0273bbcd31934595a738d2a70afd6264
    107 Nbc61902e3939414eae0a6ec86392db1e rdf:first sg:person.0604140564.76
    108 rdf:rest rdf:nil
    109 Nd3f3e7f9b8004770a596315ba04bcf7c schema:issueNumber 2
    110 rdf:type schema:PublicationIssue
    111 Nef145d2f13cd45f780d1fab2032c618c schema:name doi
    112 schema:value 10.1007/s12035-018-1156-z
    113 rdf:type schema:PropertyValue
    114 Nfe11a786db9744579d3013c48de82a85 rdf:first sg:person.0673411033.12
    115 rdf:rest Nb3dd5ac3f7934be996421ed13b91d065
    116 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    117 schema:name Biological Sciences
    118 rdf:type schema:DefinedTerm
    119 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    120 schema:name Biochemistry and Cell Biology
    121 rdf:type schema:DefinedTerm
    122 sg:journal.1098844 schema:issn 0893-7648
    123 1559-1182
    124 schema:name Molecular Neurobiology
    125 rdf:type schema:Periodical
    126 sg:person.01006162446.46 schema:affiliation https://www.grid.ac/institutes/grid.410886.3
    127 schema:familyName Yoo
    128 schema:givenName Jongman
    129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006162446.46
    130 rdf:type schema:Person
    131 sg:person.01023751165.45 schema:affiliation https://www.grid.ac/institutes/grid.410886.3
    132 schema:familyName Park
    133 schema:givenName Min-Jung
    134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023751165.45
    135 rdf:type schema:Person
    136 sg:person.016135311327.99 schema:affiliation https://www.grid.ac/institutes/grid.410886.3
    137 schema:familyName You
    138 schema:givenName Min-Jung
    139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016135311327.99
    140 rdf:type schema:Person
    141 sg:person.0604140564.76 schema:affiliation https://www.grid.ac/institutes/grid.410886.3
    142 schema:familyName Kwon
    143 schema:givenName Min-Soo
    144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604140564.76
    145 rdf:type schema:Person
    146 sg:person.0673411033.12 schema:affiliation https://www.grid.ac/institutes/grid.410886.3
    147 schema:familyName Park
    148 schema:givenName Hyun-Sun
    149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673411033.12
    150 rdf:type schema:Person
    151 sg:person.0715565724.15 schema:affiliation https://www.grid.ac/institutes/grid.49606.3d
    152 schema:familyName Kim
    153 schema:givenName Seung Hyun
    154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715565724.15
    155 rdf:type schema:Person
    156 sg:pub.10.1007/s00401-009-0622-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047010389
    157 https://doi.org/10.1007/s00401-009-0622-0
    158 rdf:type schema:CreativeWork
    159 sg:pub.10.1038/mp.2013.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011599492
    160 https://doi.org/10.1038/mp.2013.155
    161 rdf:type schema:CreativeWork
    162 sg:pub.10.1038/nature06639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025718085
    163 https://doi.org/10.1038/nature06639
    164 rdf:type schema:CreativeWork
    165 sg:pub.10.1038/nn.3554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016133129
    166 https://doi.org/10.1038/nn.3554
    167 rdf:type schema:CreativeWork
    168 sg:pub.10.1038/nn.3599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017349450
    169 https://doi.org/10.1038/nn.3599
    170 rdf:type schema:CreativeWork
    171 sg:pub.10.1038/nn.4338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047909787
    172 https://doi.org/10.1038/nn.4338
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1038/nn.4597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090329025
    175 https://doi.org/10.1038/nn.4597
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1038/nn1715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021332650
    178 https://doi.org/10.1038/nn1715
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1038/nri3086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017867309
    181 https://doi.org/10.1038/nri3086
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1038/nrm2233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030616797
    184 https://doi.org/10.1038/nrm2233
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1038/nrm3823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053250436
    187 https://doi.org/10.1038/nrm3823
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1038/nrn1683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006979823
    190 https://doi.org/10.1038/nrn1683
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/nrn2297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020622734
    193 https://doi.org/10.1038/nrn2297
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/nrn3722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008765454
    196 https://doi.org/10.1038/nrn3722
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/nrneurol.2010.17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045968907
    199 https://doi.org/10.1038/nrneurol.2010.17
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/sj.mp.4001600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031160532
    202 https://doi.org/10.1038/sj.mp.4001600
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/sj.mp.4002148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053365396
    205 https://doi.org/10.1038/sj.mp.4002148
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1186/s12974-015-0416-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017755581
    208 https://doi.org/10.1186/s12974-015-0416-3
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/0306-4522(90)90229-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1024998641
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/j.bbi.2006.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021787447
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/j.brainres.2011.08.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021877006
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/j.ceb.2009.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044451367
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/j.cell.2017.07.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091142674
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/j.celrep.2013.06.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044108769
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/j.devcel.2015.01.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004089792
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/j.molmed.2017.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085126533
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/j.neurobiolaging.2003.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009128459
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/j.neuron.2014.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033331685
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1016/j.tins.2005.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002770331
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1016/j.tins.2015.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009894358
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1037/0278-6133.21.6.531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019802683
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1046/j.1471-4159.2003.01604.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036387037
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1073/pnas.1104836108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014394923
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1074/jbc.m412170200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034603148
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1074/mcp.m115.053926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044036951
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1093/brain/awv066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003810511
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1097/01.ccm.0000166389.85273.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005909818
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1111/j.1365-2990.2012.01306.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023964874
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1126/science.4035356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062623813
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1146/annurev-immunol-032713-120240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044022904
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1146/annurev-physiol-030212-183653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007476995
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1146/annurev.clinpsy.1.102803.144141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043995657
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1152/ajpheart.00713.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006256932
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1159/000049025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007722417
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1172/jci90606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091436856
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1523/jneurosci.06-08-02163.1986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079509370
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1523/jneurosci.1860-14.2014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007098650
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1677/joe.0.1620371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030922436
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.2190/1b32-79ea-b6h5-395v schema:sameAs https://app.dimensions.ai/details/publication/pub.1004392390
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.3389/fncel.2013.00022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043664675
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.3389/fncel.2014.00152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052507471
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.3389/fnint.2013.00053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003117910
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.3892/mmr.2016.5662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071524328
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.4161/cc.29272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072297689
    281 rdf:type schema:CreativeWork
    282 https://www.grid.ac/institutes/grid.410886.3 schema:alternateName CHA University
    283 schema:name Department of Microbiology and School of Medicine, CHA University, CHABIOCOMPLEX, 335 Pangyo, Bundang-gu, 13488, Seongnam-si, Gyeonggi-do, Republic of Korea
    284 Department of Pharmacology, School of Medicine, CHA University, CHABIOCOMPLEX, 335 Pangyo, Bundang-gu, 13488, Seongnam-si, Gyeonggi-do, Republic of Korea
    285 rdf:type schema:Organization
    286 https://www.grid.ac/institutes/grid.49606.3d schema:alternateName Hanyang University
    287 schema:name Cell Therapy Center and Department of Neurology, College of Medicine, Hanyang University, Haengdang-dong, Seoul, Republic of Korea
    288 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...