Neurobiological Correlates of Alpha-Tocopherol Antiepileptogenic Effects and MicroRNA Expression Modulation in a Rat Model of Kainate-Induced Seizures View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10

AUTHORS

Patrizia Ambrogini, Maria Cristina Albertini, Michele Betti, Claudia Galati, Davide Lattanzi, David Savelli, Michael Di Palma, Stefania Saccomanno, Desirée Bartolini, Pierangelo Torquato, Gabriele Ruffolo, Fabiola Olivieri, Francesco Galli, Eleonora Palma, Andrea Minelli, Riccardo Cuppini

ABSTRACT

Seizure-triggered maladaptive neural plasticity and neuroinflammation occur during the latent period as a key underlying event in epilepsy chronicization. Previously, we showed that α-tocopherol (α-T) reduces hippocampal neuroglial activation and neurodegeneration in the rat model of kainic acid (KA)-induced status epilepticus (SE). These findings allowed us to postulate an antiepileptogenic potential for α-T in hippocampal excitotoxicity, in line with clinical evidence showing that α-T improves seizure control in drug-resistant patients. To explore neurobiological correlates of the α-T antiepileptogenic role, rats were injected with such vitamin during the latent period starting right after KA-induced SE, and the effects on circuitry excitability, neuroinflammation, neuronal death, and microRNA (miRNA) expression were investigated in the hippocampus. Results show that in α-T-treated epileptic rats, (1) the number of population spikes elicited by pyramidal neurons, as well as the latency to the onset of epileptiform-like network activity recover to control levels; (2) neuronal death is almost prevented; (3) down-regulation of claudin, a blood-brain barrier protein, is fully reversed; (4) neuroinflammation processes are quenched (as indicated by the decrease of TNF-α, IL-1β, GFAP, IBA-1, and increase of IL-6); (5) miR-146a, miR-124, and miR-126 expression is coherently modulated in hippocampus and serum by α-T. These findings support the potential of a timely intervention with α-T in clinical management of SE to reduce epileptogenesis, thus preventing chronic epilepsy development. In addition, we suggest that the analysis of miRNA levels in serum could provide clinicians with a tool to evaluate disease evolution and the efficacy of α-T therapy in SE. More... »

PAGES

7822-7838

References to SciGraph publications

  • 2000-06. Ischemia-Induced Interleukin-6 as a Potential Endogenous Neuroprotective Cytokine Against NMDA Receptor-Mediated Excitoxicity in the Brain in JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM
  • 2008-10. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases in CELL RESEARCH
  • 2013-05. Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction in NATURE REVIEWS NEUROSCIENCE
  • 2015-05. Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy in SCIENTIFIC REPORTS
  • 2001-01. Interleukin-6 Enhances Expression of Adenosine A1 Receptor mRNA and Signaling in Cultured Rat Cortical Astrocytes and Brain Slices in NEUROPSYCHOPHARMACOLOGY
  • 2011-11. The Neuroprotective Effect of Curcumin and Nigella sativa Oil Against Oxidative Stress in the Pilocarpine Model of Epilepsy: A Comparison with Valproate in NEUROCHEMICAL RESEARCH
  • 2016-12. Electrophysiological Properties of CA1 Pyramidal Neurons along the Longitudinal Axis of the Mouse Hippocampus in SCIENTIFIC REPORTS
  • 2014-08. Post-Seizure α-Tocopherol Treatment Decreases Neuroinflammation and Neuronal Degeneration Induced by Status Epilepticus in Rat Hippocampus in MOLECULAR NEUROBIOLOGY
  • 2014-02. MiR-146a Regulates IL-6 Production in Lipopolysaccharide-Induced RAW264.7 Macrophage Cells by Inhibiting Notch1 in INFLAMMATION
  • 2010-04. The Effects of Alpha-Tocopherol on Hippocampal Oxidative Stress Prior to in Pilocarpine-Induced Seizures in NEUROCHEMICAL RESEARCH
  • 2009-07. Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal in NATURE CELL BIOLOGY
  • 2009-12. Role of Selenium on Calcium Signaling and Oxidative Stress-induced Molecular Pathways in Epilepsy in NEUROCHEMICAL RESEARCH
  • 2006. Microtransplantation of Neurotransmitter Receptors From Cells to Xenopus Oocyte Membranes in XENOPUS PROTOCOLS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12035-018-0946-7

    DOI

    http://dx.doi.org/10.1007/s12035-018-0946-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1101145232

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29468563


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