Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

Aya Shoukry Sayed, Iman Emam Omar Gomaa, Michael Bader, Nesrine Salah El Dine El Sayed

ABSTRACT

Neuroinflammation is one of the most important mechanisms underlying neurodegeneration. Lipopolysaccharide (LPS) is a potent inflammogen which causes cognitive dysfunction. Boswellia serrata is known since many years as a powerful anti-inflammatory herbal drug. Its beneficial effect mainly arises from inhibition of 5-lipoxygenase (5-LO) enzyme. 3-acetyl-11-keto-β-boswellic acid (AKBA) is the most potent 5-LO inhibitor extracted from the oleo-gum-resin of Boswellia serrata. The aim of the present work is to study the molecular mechanisms underlying the anti-inflammatory and neuroprotective effects of AKBA and dexamethasone (DEX) in LPS-induced neuroinflammatory model. A single intraperitoneal (i.p.) dose of LPS (0.8 mg/kg) was injected to induce cognitive dysfunction. The LPS-treated mice were administered for 7 days with either AKBA or DEX at intraperitoneal doses of 5 and 1 mg/kg, respectively. Cognitive, locomotor functions, and anxiety level were first examined. The level of the phosphorylated inhibitory protein for NF-κB, IκB-α (P-IκB-α), was measured, and the expression levels of the inflammatory microRNA-155 (miR-155) and its target gene, suppressor of cytokine signaling-1 (SOCS-1), were determined in the brain. Moreover, the level of carbonyl proteins as a measure of oxidative stress and several cytokines as well as markers for apoptosis and amyloidogenesis was detected. Results showed that AKBA and DEX reversed the behavioral dysfunction induced by LPS. AKBA decreased P-IκB-α, miRNA-155 expression level, and carbonyl protein content. It restored normal cytokine level and increased SOCS-1 expression level. It also showed anti-apoptotic and anti-amyloidogenic effects in LPS-injected mice. These findings suggest AKBA as a therapeutic drug for alleviating the symptoms of neuroinflammatory disorders. More... »

PAGES

5798-5808

References to SciGraph publications

  • 2016-08. Cerebral Oedema, Blood–Brain Barrier Breakdown and the Decrease in Na+,K+-ATPase Activity in the Cerebral Cortex and Hippocampus are Prevented by Dexamethasone in an Animal Model of Maple Syrup Urine Disease in MOLECULAR NEUROBIOLOGY
  • 1986-06. Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent in INFLAMMATION RESEARCH
  • 2006-08. Effect of Lipopolysaccharide on Global Gene Expression in the Immature Rat Brain in PEDIATRIC RESEARCH
  • 2016-05. Co-administration of 3-Acetyl-11-Keto-Beta-Boswellic Acid Potentiates the Protective Effect of Celecoxib in Lipopolysaccharide-Induced Cognitive Impairment in Mice: Possible Implication of Anti-inflammatory and Antiglutamatergic Pathways in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2015-01. Effects of Centrally Administered Etanercept on Behavior, Microglia, and Astrocytes in Mice Following a Peripheral Immune Challenge in NEUROPSYCHOPHARMACOLOGY
  • 2015-05. Neuroprotection by Acetyl-11-Keto-β-Boswellic Acid, in Ischemic Brain Injury Involves the Nrf2/HO-1 defense Pathway in SCIENTIFIC REPORTS
  • 2016-07. Osmotin attenuates LPS-induced neuroinflammation and memory impairments via the TLR4/NFκB signaling pathway in SCIENTIFIC REPORTS
  • 2012-12. Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells in JOURNAL OF NEUROINFLAMMATION
  • 2013-12. Fluoxetine treatment promotes functional recovery in a rat model of cervical spinal cord injury in SCIENTIFIC REPORTS
  • 2015-01. Effect of Boswellia serrata gum resin on the morphology of hippocampal CA1 pyramidal cells in aged rat in ANATOMICAL SCIENCE INTERNATIONAL
  • 2009. Protein Carbonylation in Neurodegenerative and Demyelinating CNS Diseases in HANDBOOK OF NEUROCHEMISTRY AND MOLECULAR NEUROBIOLOGY
  • 2014-12. Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress in JOURNAL OF NEUROINFLAMMATION
  • 2015-12. Spermine reverses lipopolysaccharide-induced memory deficit in mice in JOURNAL OF NEUROINFLAMMATION
  • 2007-02. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents in NATURE PROTOCOLS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12035-017-0801-2

    DOI

    http://dx.doi.org/10.1007/s12035-017-0801-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092414424

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29079998


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "German University in Cairo", 
              "id": "https://www.grid.ac/institutes/grid.187323.c", 
              "name": [
                "Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Main Entrance of Al Tagamoa Al Khames, 11835, New Cairo City, Egypt"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sayed", 
            "givenName": "Aya Shoukry", 
            "id": "sg:person.01006624371.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006624371.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kafrelsheikh University", 
              "id": "https://www.grid.ac/institutes/grid.411978.2", 
              "name": [
                "Biotechnology Sector, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt", 
                "School of Engineering and Applied Sciences, Nile University, Cairo, Egypt", 
                "Nano Science and Technology Institute, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt", 
                "Juhayna Square, Sheik Zayed District, 6 October City, Giza, 12588, Cairo, Egypt"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gomaa", 
            "givenName": "Iman Emam Omar", 
            "id": "sg:person.01066613064.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066613064.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Delbr\u00fcck Center for Molecular Medicine", 
              "id": "https://www.grid.ac/institutes/grid.419491.0", 
              "name": [
                "Max-Delbr\u00fcck-Center for Molecular Medicine (MDC), Robert-R\u00f6ssle-Strasse 10, 13125, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bader", 
            "givenName": "Michael", 
            "id": "sg:person.0737041220.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737041220.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German University in Cairo", 
              "id": "https://www.grid.ac/institutes/grid.187323.c", 
              "name": [
                "Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 12613, Giza, Egypt", 
                "Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Main Entrance of Al Tagamoa Al Khames, 11835, New Cairo City, Egypt"
              ], 
              "type": "Organization"
            }, 
            "familyName": "El Sayed", 
            "givenName": "Nesrine Salah El Dine", 
            "id": "sg:person.010460034567.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010460034567.11"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s0378-1119(01)00612-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003684057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-30375-8_23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003685626", 
              "https://doi.org/10.1007/978-0-387-30375-8_23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-30375-8_23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003685626", 
              "https://doi.org/10.1007/978-0-387-30375-8_23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phymed.2014.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004064919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12565-014-0228-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004768444", 
              "https://doi.org/10.1007/s12565-014-0228-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m600504200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004808946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2014.03.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005598327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-11-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005962581", 
              "https://doi.org/10.1186/1742-2094-11-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms141223910", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008789769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/254683", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009774775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/dmd.107.018424", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011019002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2868-05.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011687907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-9961(03)00069-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011945419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-9961(03)00069-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011945419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2007.44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012369107", 
              "https://doi.org/10.1038/nprot.2007.44"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9822(02)00809-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012534253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12031-016-0734-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012538752", 
              "https://doi.org/10.1007/s12031-016-0734-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4236/jbbs.2014.44019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014559870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1037/h0058536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015944666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.00562.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017997748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.23454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019491003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-9-260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020759129", 
              "https://doi.org/10.1186/1742-2094-9-260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12974-014-0220-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021240009", 
              "https://doi.org/10.1186/s12974-014-0220-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12974-014-0220-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021240009", 
              "https://doi.org/10.1186/s12974-014-0220-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1582-4934.2006.tb00407.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022156950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.freeradbiomed.2012.01.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024592944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0069123", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025213976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.foodchem.2004.08.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026786664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/01.pdr.0000228323.32445.7d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027340771", 
              "https://doi.org/10.1203/01.pdr.0000228323.32445.7d"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1203/01.pdr.0000228323.32445.7d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027340771", 
              "https://doi.org/10.1203/01.pdr.0000228323.32445.7d"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1469-7793.2000.t01-1-00333.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027429334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2015/610813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028204813"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep02217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028556493", 
              "https://doi.org/10.1038/srep02217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.169367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029952338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.107.155606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029992624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.107.155606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029992624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3791/1204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030069380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(04)00045-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031254572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1254/jjp.87.195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033325352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2014.199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033379538", 
              "https://doi.org/10.1038/npp.2014.199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbi.2012.07.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033420305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jnutbio.2012.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034124242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1432609100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034227933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01965005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035784771", 
              "https://doi.org/10.1007/bf01965005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01965005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035784771", 
              "https://doi.org/10.1007/bf01965005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep07002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037191134", 
              "https://doi.org/10.1038/srep07002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1167/iovs.09-3525", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038423763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/08820139.2016.1157814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039768476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2008.28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039936102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/jcbfm.2008.28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039936102"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0015163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045915805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0080547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046951461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2013/186872", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048297962"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-015-9313-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050429031", 
              "https://doi.org/10.1007/s12035-015-9313-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbi.2012.12.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050730575"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3727/036012909803860997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050763240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.trsl.2011.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051695523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gki836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052161238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep24493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052853892", 
              "https://doi.org/10.1038/srep24493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.270.5234.286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062551441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18203/2319-2003.ijbcp20150038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068579155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18203/2319-2003.ijbcp20150038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068579155"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138161210793176572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069167429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr.2016.5716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071524380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3906/sag-1503-43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071569788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/rna.7227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072310621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4236/aad.2014.32009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072382644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.9790/3008-0342127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074176430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.174.1.498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1076982662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077106143", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4103/0250-474x.93507", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078539177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078927876", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-07", 
        "datePublishedReg": "2018-07-01", 
        "description": "Neuroinflammation is one of the most important mechanisms underlying neurodegeneration. Lipopolysaccharide (LPS) is a potent inflammogen which causes cognitive dysfunction. Boswellia serrata is known since many years as a powerful anti-inflammatory herbal drug. Its beneficial effect mainly arises from inhibition of 5-lipoxygenase (5-LO) enzyme. 3-acetyl-11-keto-\u03b2-boswellic acid (AKBA) is the most potent 5-LO inhibitor extracted from the oleo-gum-resin of Boswellia serrata. The aim of the present work is to study the molecular mechanisms underlying the anti-inflammatory and neuroprotective effects of AKBA and dexamethasone (DEX) in LPS-induced neuroinflammatory model. A single intraperitoneal (i.p.) dose of LPS (0.8\u00a0mg/kg) was injected to induce cognitive dysfunction. The LPS-treated mice were administered for 7\u00a0days with either AKBA or DEX at intraperitoneal doses of 5 and 1\u00a0mg/kg, respectively. Cognitive, locomotor functions, and anxiety level were first examined. The level of the phosphorylated inhibitory protein for NF-\u03baB, I\u03baB-\u03b1 (P-I\u03baB-\u03b1), was measured, and the expression levels of the inflammatory microRNA-155 (miR-155) and its target gene, suppressor of cytokine signaling-1 (SOCS-1), were determined in the brain. Moreover, the level of carbonyl proteins as a measure of oxidative stress and several cytokines as well as markers for apoptosis and amyloidogenesis was detected. Results showed that AKBA and DEX reversed the behavioral dysfunction induced by LPS. AKBA decreased P-I\u03baB-\u03b1, miRNA-155 expression level, and carbonyl protein content. It restored normal cytokine level and increased SOCS-1 expression level. It also showed anti-apoptotic and anti-amyloidogenic effects in LPS-injected mice. These findings suggest AKBA as a therapeutic drug for alleviating the symptoms of neuroinflammatory disorders.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s12035-017-0801-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1098844", 
            "issn": [
              "0893-7648", 
              "1559-1182"
            ], 
            "name": "Molecular Neurobiology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "55"
          }
        ], 
        "name": "Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155", 
        "pagination": "5798-5808", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "befef875cb428ebabf87840cb47a9fd55566f3f438d09f29ddc30f28e2b8f6e6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29079998"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8900963"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12035-017-0801-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1092414424"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12035-017-0801-2", 
          "https://app.dimensions.ai/details/publication/pub.1092414424"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000601.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs12035-017-0801-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12035-017-0801-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12035-017-0801-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12035-017-0801-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12035-017-0801-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    305 TRIPLES      21 PREDICATES      93 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12035-017-0801-2 schema:about anzsrc-for:11
    2 anzsrc-for:1109
    3 schema:author Nbc68705252a8446fadd94acbb00d649b
    4 schema:citation sg:pub.10.1007/978-0-387-30375-8_23
    5 sg:pub.10.1007/bf01965005
    6 sg:pub.10.1007/s12031-016-0734-7
    7 sg:pub.10.1007/s12035-015-9313-0
    8 sg:pub.10.1007/s12565-014-0228-z
    9 sg:pub.10.1038/npp.2014.199
    10 sg:pub.10.1038/nprot.2007.44
    11 sg:pub.10.1038/srep02217
    12 sg:pub.10.1038/srep07002
    13 sg:pub.10.1038/srep24493
    14 sg:pub.10.1186/1742-2094-11-8
    15 sg:pub.10.1186/1742-2094-9-260
    16 sg:pub.10.1186/s12974-014-0220-5
    17 sg:pub.10.1203/01.pdr.0000228323.32445.7d
    18 https://app.dimensions.ai/details/publication/pub.1077106143
    19 https://app.dimensions.ai/details/publication/pub.1078927876
    20 https://doi.org/10.1002/jnr.23454
    21 https://doi.org/10.1016/j.bbi.2012.07.003
    22 https://doi.org/10.1016/j.bbi.2012.12.017
    23 https://doi.org/10.1016/j.foodchem.2004.08.033
    24 https://doi.org/10.1016/j.freeradbiomed.2012.01.031
    25 https://doi.org/10.1016/j.jnutbio.2012.06.011
    26 https://doi.org/10.1016/j.neuroscience.2014.03.039
    27 https://doi.org/10.1016/j.phymed.2014.02.001
    28 https://doi.org/10.1016/j.trsl.2011.01.007
    29 https://doi.org/10.1016/s0092-8674(04)00045-5
    30 https://doi.org/10.1016/s0378-1119(01)00612-6
    31 https://doi.org/10.1016/s0960-9822(02)00809-6
    32 https://doi.org/10.1016/s0969-9961(03)00069-x
    33 https://doi.org/10.1037/h0058536
    34 https://doi.org/10.1038/jcbfm.2008.28
    35 https://doi.org/10.1073/pnas.1432609100
    36 https://doi.org/10.1074/jbc.m110.169367
    37 https://doi.org/10.1074/jbc.m600504200
    38 https://doi.org/10.1093/nar/gki836
    39 https://doi.org/10.1111/j.1469-7793.2000.t01-1-00333.x
    40 https://doi.org/10.1111/j.1582-4934.2006.tb00407.x
    41 https://doi.org/10.1124/dmd.107.018424
    42 https://doi.org/10.1126/science.270.5234.286
    43 https://doi.org/10.1152/ajpgi.00562.2005
    44 https://doi.org/10.1155/2013/186872
    45 https://doi.org/10.1155/2014/254683
    46 https://doi.org/10.1155/2015/610813
    47 https://doi.org/10.1161/atvbaha.107.155606
    48 https://doi.org/10.1167/iovs.09-3525
    49 https://doi.org/10.1254/jjp.87.195
    50 https://doi.org/10.1371/journal.pone.0015163
    51 https://doi.org/10.1371/journal.pone.0069123
    52 https://doi.org/10.1371/journal.pone.0080547
    53 https://doi.org/10.1523/jneurosci.2868-05.2005
    54 https://doi.org/10.18203/2319-2003.ijbcp20150038
    55 https://doi.org/10.2174/138161210793176572
    56 https://doi.org/10.3109/08820139.2016.1157814
    57 https://doi.org/10.3390/ijms141223910
    58 https://doi.org/10.3727/036012909803860997
    59 https://doi.org/10.3791/1204
    60 https://doi.org/10.3892/mmr.2016.5716
    61 https://doi.org/10.3906/sag-1503-43
    62 https://doi.org/10.4049/jimmunol.174.1.498
    63 https://doi.org/10.4103/0250-474x.93507
    64 https://doi.org/10.4161/rna.7227
    65 https://doi.org/10.4236/aad.2014.32009
    66 https://doi.org/10.4236/jbbs.2014.44019
    67 https://doi.org/10.9790/3008-0342127
    68 schema:datePublished 2018-07
    69 schema:datePublishedReg 2018-07-01
    70 schema:description Neuroinflammation is one of the most important mechanisms underlying neurodegeneration. Lipopolysaccharide (LPS) is a potent inflammogen which causes cognitive dysfunction. Boswellia serrata is known since many years as a powerful anti-inflammatory herbal drug. Its beneficial effect mainly arises from inhibition of 5-lipoxygenase (5-LO) enzyme. 3-acetyl-11-keto-β-boswellic acid (AKBA) is the most potent 5-LO inhibitor extracted from the oleo-gum-resin of Boswellia serrata. The aim of the present work is to study the molecular mechanisms underlying the anti-inflammatory and neuroprotective effects of AKBA and dexamethasone (DEX) in LPS-induced neuroinflammatory model. A single intraperitoneal (i.p.) dose of LPS (0.8 mg/kg) was injected to induce cognitive dysfunction. The LPS-treated mice were administered for 7 days with either AKBA or DEX at intraperitoneal doses of 5 and 1 mg/kg, respectively. Cognitive, locomotor functions, and anxiety level were first examined. The level of the phosphorylated inhibitory protein for NF-κB, IκB-α (P-IκB-α), was measured, and the expression levels of the inflammatory microRNA-155 (miR-155) and its target gene, suppressor of cytokine signaling-1 (SOCS-1), were determined in the brain. Moreover, the level of carbonyl proteins as a measure of oxidative stress and several cytokines as well as markers for apoptosis and amyloidogenesis was detected. Results showed that AKBA and DEX reversed the behavioral dysfunction induced by LPS. AKBA decreased P-IκB-α, miRNA-155 expression level, and carbonyl protein content. It restored normal cytokine level and increased SOCS-1 expression level. It also showed anti-apoptotic and anti-amyloidogenic effects in LPS-injected mice. These findings suggest AKBA as a therapeutic drug for alleviating the symptoms of neuroinflammatory disorders.
    71 schema:genre research_article
    72 schema:inLanguage en
    73 schema:isAccessibleForFree false
    74 schema:isPartOf N3e581791e3af49f1b0fd8647be4b1ca9
    75 N6b80061b346e4b63bae5d9f1e737e1eb
    76 sg:journal.1098844
    77 schema:name Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155
    78 schema:pagination 5798-5808
    79 schema:productId N03e877fd74a84ab5bfeb48de11a32742
    80 N20d72c73cb5e4c83b6458ff8338c0945
    81 N94c00697edd54d98a324bb61d95bc9bf
    82 Nbdf3f1854f25461c8877ec01eb5ad130
    83 Ne67c0bd7434c4494af056e818ae32a3f
    84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092414424
    85 https://doi.org/10.1007/s12035-017-0801-2
    86 schema:sdDatePublished 2019-04-10T16:04
    87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    88 schema:sdPublisher N5e3e4cec77794df78ca83f4d6ff4c7cd
    89 schema:url https://link.springer.com/10.1007%2Fs12035-017-0801-2
    90 sgo:license sg:explorer/license/
    91 sgo:sdDataset articles
    92 rdf:type schema:ScholarlyArticle
    93 N03e877fd74a84ab5bfeb48de11a32742 schema:name readcube_id
    94 schema:value befef875cb428ebabf87840cb47a9fd55566f3f438d09f29ddc30f28e2b8f6e6
    95 rdf:type schema:PropertyValue
    96 N1efadf3fcc7e4c02b6e8da061d09b2e6 rdf:first sg:person.010460034567.11
    97 rdf:rest rdf:nil
    98 N20d72c73cb5e4c83b6458ff8338c0945 schema:name dimensions_id
    99 schema:value pub.1092414424
    100 rdf:type schema:PropertyValue
    101 N3e581791e3af49f1b0fd8647be4b1ca9 schema:volumeNumber 55
    102 rdf:type schema:PublicationVolume
    103 N5e3e4cec77794df78ca83f4d6ff4c7cd schema:name Springer Nature - SN SciGraph project
    104 rdf:type schema:Organization
    105 N6b80061b346e4b63bae5d9f1e737e1eb schema:issueNumber 7
    106 rdf:type schema:PublicationIssue
    107 N87f65e12180c4f3cacf5ad7f44efe257 rdf:first sg:person.0737041220.34
    108 rdf:rest N1efadf3fcc7e4c02b6e8da061d09b2e6
    109 N94c00697edd54d98a324bb61d95bc9bf schema:name doi
    110 schema:value 10.1007/s12035-017-0801-2
    111 rdf:type schema:PropertyValue
    112 Nbc68705252a8446fadd94acbb00d649b rdf:first sg:person.01006624371.35
    113 rdf:rest Nf68460f65e8542cfb6a6bca0666fc89e
    114 Nbdf3f1854f25461c8877ec01eb5ad130 schema:name pubmed_id
    115 schema:value 29079998
    116 rdf:type schema:PropertyValue
    117 Ne67c0bd7434c4494af056e818ae32a3f schema:name nlm_unique_id
    118 schema:value 8900963
    119 rdf:type schema:PropertyValue
    120 Nf68460f65e8542cfb6a6bca0666fc89e rdf:first sg:person.01066613064.86
    121 rdf:rest N87f65e12180c4f3cacf5ad7f44efe257
    122 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    123 schema:name Medical and Health Sciences
    124 rdf:type schema:DefinedTerm
    125 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    126 schema:name Neurosciences
    127 rdf:type schema:DefinedTerm
    128 sg:journal.1098844 schema:issn 0893-7648
    129 1559-1182
    130 schema:name Molecular Neurobiology
    131 rdf:type schema:Periodical
    132 sg:person.01006624371.35 schema:affiliation https://www.grid.ac/institutes/grid.187323.c
    133 schema:familyName Sayed
    134 schema:givenName Aya Shoukry
    135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006624371.35
    136 rdf:type schema:Person
    137 sg:person.010460034567.11 schema:affiliation https://www.grid.ac/institutes/grid.187323.c
    138 schema:familyName El Sayed
    139 schema:givenName Nesrine Salah El Dine
    140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010460034567.11
    141 rdf:type schema:Person
    142 sg:person.01066613064.86 schema:affiliation https://www.grid.ac/institutes/grid.411978.2
    143 schema:familyName Gomaa
    144 schema:givenName Iman Emam Omar
    145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066613064.86
    146 rdf:type schema:Person
    147 sg:person.0737041220.34 schema:affiliation https://www.grid.ac/institutes/grid.419491.0
    148 schema:familyName Bader
    149 schema:givenName Michael
    150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737041220.34
    151 rdf:type schema:Person
    152 sg:pub.10.1007/978-0-387-30375-8_23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003685626
    153 https://doi.org/10.1007/978-0-387-30375-8_23
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1007/bf01965005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035784771
    156 https://doi.org/10.1007/bf01965005
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1007/s12031-016-0734-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012538752
    159 https://doi.org/10.1007/s12031-016-0734-7
    160 rdf:type schema:CreativeWork
    161 sg:pub.10.1007/s12035-015-9313-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050429031
    162 https://doi.org/10.1007/s12035-015-9313-0
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1007/s12565-014-0228-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1004768444
    165 https://doi.org/10.1007/s12565-014-0228-z
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1038/npp.2014.199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033379538
    168 https://doi.org/10.1038/npp.2014.199
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1038/nprot.2007.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012369107
    171 https://doi.org/10.1038/nprot.2007.44
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1038/srep02217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028556493
    174 https://doi.org/10.1038/srep02217
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1038/srep07002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037191134
    177 https://doi.org/10.1038/srep07002
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.1038/srep24493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052853892
    180 https://doi.org/10.1038/srep24493
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1186/1742-2094-11-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005962581
    183 https://doi.org/10.1186/1742-2094-11-8
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1186/1742-2094-9-260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020759129
    186 https://doi.org/10.1186/1742-2094-9-260
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1186/s12974-014-0220-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021240009
    189 https://doi.org/10.1186/s12974-014-0220-5
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1203/01.pdr.0000228323.32445.7d schema:sameAs https://app.dimensions.ai/details/publication/pub.1027340771
    192 https://doi.org/10.1203/01.pdr.0000228323.32445.7d
    193 rdf:type schema:CreativeWork
    194 https://app.dimensions.ai/details/publication/pub.1077106143 schema:CreativeWork
    195 https://app.dimensions.ai/details/publication/pub.1078927876 schema:CreativeWork
    196 https://doi.org/10.1002/jnr.23454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019491003
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1016/j.bbi.2012.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033420305
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1016/j.bbi.2012.12.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050730575
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1016/j.foodchem.2004.08.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026786664
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1016/j.freeradbiomed.2012.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024592944
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/j.jnutbio.2012.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034124242
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/j.neuroscience.2014.03.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005598327
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/j.phymed.2014.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004064919
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/j.trsl.2011.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051695523
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/s0092-8674(04)00045-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031254572
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/s0378-1119(01)00612-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003684057
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/s0960-9822(02)00809-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012534253
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/s0969-9961(03)00069-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011945419
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1037/h0058536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015944666
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1038/jcbfm.2008.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039936102
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1073/pnas.1432609100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034227933
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1074/jbc.m110.169367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029952338
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1074/jbc.m600504200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004808946
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1093/nar/gki836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052161238
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1111/j.1469-7793.2000.t01-1-00333.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027429334
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1111/j.1582-4934.2006.tb00407.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022156950
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1124/dmd.107.018424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011019002
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1126/science.270.5234.286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062551441
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1152/ajpgi.00562.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017997748
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1155/2013/186872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048297962
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1155/2014/254683 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009774775
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1155/2015/610813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028204813
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1161/atvbaha.107.155606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029992624
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1167/iovs.09-3525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038423763
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1254/jjp.87.195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033325352
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1371/journal.pone.0015163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045915805
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1371/journal.pone.0069123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025213976
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1371/journal.pone.0080547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046951461
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1523/jneurosci.2868-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011687907
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.18203/2319-2003.ijbcp20150038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068579155
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.2174/138161210793176572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069167429
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.3109/08820139.2016.1157814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039768476
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.3390/ijms141223910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008789769
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.3727/036012909803860997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050763240
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.3791/1204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030069380
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.3892/mmr.2016.5716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071524380
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.3906/sag-1503-43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071569788
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.4049/jimmunol.174.1.498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076982662
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.4103/0250-474x.93507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078539177
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.4161/rna.7227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072310621
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.4236/aad.2014.32009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072382644
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.4236/jbbs.2014.44019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014559870
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.9790/3008-0342127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074176430
    291 rdf:type schema:CreativeWork
    292 https://www.grid.ac/institutes/grid.187323.c schema:alternateName German University in Cairo
    293 schema:name Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Main Entrance of Al Tagamoa Al Khames, 11835, New Cairo City, Egypt
    294 Department of Pharmacology and Toxicology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Main Entrance of Al Tagamoa Al Khames, 11835, New Cairo City, Egypt
    295 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, 12613, Giza, Egypt
    296 rdf:type schema:Organization
    297 https://www.grid.ac/institutes/grid.411978.2 schema:alternateName Kafrelsheikh University
    298 schema:name Biotechnology Sector, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt
    299 Juhayna Square, Sheik Zayed District, 6 October City, Giza, 12588, Cairo, Egypt
    300 Nano Science and Technology Institute, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt
    301 School of Engineering and Applied Sciences, Nile University, Cairo, Egypt
    302 rdf:type schema:Organization
    303 https://www.grid.ac/institutes/grid.419491.0 schema:alternateName Max Delbrück Center for Molecular Medicine
    304 schema:name Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Strasse 10, 13125, Berlin, Germany
    305 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...