Astaxanthin Ameliorates Doxorubicin-Induced Cognitive Impairment (Chemobrain) in Experimental Rat Model: Impact on Oxidative, Inflammatory, and Apoptotic Machineries View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-07

AUTHORS

Sara Emad El-Agamy, Amal Kamal Abdel-Aziz, Sara Wahdan, Ahmed Esmat, Samar S. Azab

ABSTRACT

Chemobrain refers to a common sequelae experienced by 15-80% of cancer patients exposed to chemotherapeutics. The antineoplastic agent doxorubicin (DOX) has been implicated in a strenuous neurotoxicity manifested as decline in cognitive functions, most probably via cytokine-induced oxidative and nitrosative damage to brain tissues. Astaxanthin (AST), a naturally occurring carotenoid, is reputable for its outstanding antioxidant, anti-inflammatory, and antiapoptotic activities. Therefore, the aim of the current study was to investigate the potential neuroprotective and memory-enhancing effects of AST against DOX-induced behavioral and neurobiological abnormalities. Briefly, AST treatment (25 mg/kg) significantly protected against DOX-induced memory impairment. Furthermore, AST restored hippocampal histopathological architecture, halted DOX-induced oxidative and inflammatory insults, mitigated the increase in acetylcholinesterase activity, and consistently downregulated the overactive apoptotic machineries. In conclusion, these findings suggest that AST offers neuroprotection against DOX-induced cognitive impairment which could be explained at least partly by its antioxidant, anti-inflammatory, and antiapoptotic effects. More... »

PAGES

5727-5740

Journal

TITLE

Molecular Neurobiology

ISSUE

7

VOLUME

55

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12035-017-0797-7

DOI

http://dx.doi.org/10.1007/s12035-017-0797-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092245852

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29039023


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