Changes in Tryptophan Catabolite (TRYCAT) Pathway Patterning Are Associated with Mild Impairments in Declarative Memory in Schizophrenia and Deficits in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-09-05

AUTHORS

Buranee Kanchanatawan, Solaphat Hemrungrojn, Supaksorn Thika, Sunee Sirivichayakul, Kiat Ruxrungtham, André F. Carvalho, Michel Geffard, George Anderson, Michael Maes

ABSTRACT

Evidence indicates that schizophrenia and in particular negative symptoms and deficit schizophrenia are accompanied by neurocognitive impairments and changes in the patterning of the tryptophan catabolite (TRYCAT) pathway. This cross-sectional study was carried out to examine the associations between cognitive functions (as measured with Consortium to Establish a Registry for Alzheimer’s disease (CERAD)) and TRYCAT pathway patterning in patients with (n = 40) and without (n = 40) deficit schizophrenia and normal controls (n = 40). Cognitive measures were assessed with the Verbal Fluency Test (VFT), Boston Naming Test (BNT), Mini-Mental State Examination (MMSE), Word List Memory (WLM), Constructional Praxis, Word List Recall (WLRecall), and Word List Recognition (WLRecognition), while TRYCAT measurements assessed the IgA/IgM responses to noxious TRYCATs, namely quinolinic acid (QA), 3-OH-kynurenine (3HK), picolinic acid (PA), and xanthurenic (XA) acid, and more protective (PRO) TRYCATs, including kynurenic acid (KA) and anthranilic acid (AA). IgA NOX/PRO, IgM KA/3HK, and IgA/IgM NOX/PRO ratios were computed. Schizophrenia was accompanied by lower VFT and WLM, while BNT (dysnomia) and MMSE are significantly lower in multiple- than first-episode schizophrenia. Deficit schizophrenia is strongly associated with worse outcomes on VFT, MMSE, WLM, WLRecall, WLRecognition, and delayed recall savings and increased false memories. Around 40–50% of the variance in negative symptoms’ scores was explained by VFT, WLM, WLRecall, and MMSE. Increases in IgA NOX/PRO, IgM KA/3HK, and/or IgA/IgM NOX/PRO ratios were associated with impairments in VFT, BNT, MMSE, WLM, WLRecall, WLRecognition, and false-memory creation. In conclusion, nondeficit schizophrenia is accompanied by mild memory impairments, while disease progression is accompanied by broader cognitive impairments. Deficit schizophrenia and negative symptoms are strongly associated with deficits in working memory, delayed recall and recognition, and increased false-memory creation. These cognitive impairments and memory deficits are in part explained by increased production and/or attenuated regulation of TRYCATs with neurotoxic, excitotoxic, immune-inflammatory, oxidative, and nitrosative potential, which may contribute to neuroprogression. More... »

PAGES

5184-5201

References to SciGraph publications

  • 2000-05. Age-dependent memory loss, synaptic pathology and altered brain plasticity in the Drosophila mutant cardinal accumulating 3-hydroxykynurenine in JOURNAL OF NEURAL TRANSMISSION
  • 2017-03-03. Physio-somatic symptoms in schizophrenia: association with depression, anxiety, neurocognitive deficits and the tryptophan catabolite pathway in METABOLIC BRAIN DISEASE
  • 2015-12-08. Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia in SCIENTIFIC REPORTS
  • 2012-07-26. Cognitive Impairment in Schizophrenia in NOVEL ANTISCHIZOPHRENIA TREATMENTS
  • 1991. Negative Symptoms in Schizophrenia: Relationship to Positive Symptoms and Outcome in NEGATIVE VERSUS POSITIVE SCHIZOPHRENIA
  • 2017-02-08. Deficit, but Not Nondeficit, Schizophrenia Is Characterized by Mucosa-Associated Activation of the Tryptophan Catabolite (TRYCAT) Pathway with Highly Specific Increases in IgA Responses Directed to Picolinic, Xanthurenic, and Quinolinic Acid in MOLECULAR NEUROBIOLOGY
  • 1991. Methodological Problems in Identifying and Measuring First-Rank Symptoms of Schizophrenia in NEGATIVE VERSUS POSITIVE SCHIZOPHRENIA
  • 1999-03. Kynurenine metabolism in Alzheimer's disease in JOURNAL OF NEURAL TRANSMISSION
  • 1995-08. Kynurenic acid and 5,7-dichlorokynurenic acids improve social and object recognition in male rats in PSYCHOPHARMACOLOGY
  • 1991. Long-Term Monomorphism of Negative and Positive Schizophrenic Episodes in NEGATIVE VERSUS POSITIVE SCHIZOPHRENIA
  • 2009-07-30. Episodic Memory in Schizophrenia in NEUROPSYCHOLOGY REVIEW
  • 2016-11-07. Quinolinic acid injection in mouse medial prefrontal cortex affects reversal learning abilities, cortical connectivity and hippocampal synaptic plasticity in SCIENTIFIC REPORTS
  • 2017-03-14. Deficit Schizophrenia Is Characterized by Defects in IgM-Mediated Responses to Tryptophan Catabolites (TRYCATs): a Paradigm Shift Towards Defects in Natural Self-Regulatory Immune Responses Coupled with Mucosa-Derived TRYCAT Pathway Activation in MOLECULAR NEUROBIOLOGY
  • 2014-03-04. Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats in PSYCHOPHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12035-017-0751-8

    DOI

    http://dx.doi.org/10.1007/s12035-017-0751-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091490944

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28875464


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Psychology and Cognitive Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Psychology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Case-Control Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Linear Models", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Memory Disorders", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Memory, Episodic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multivariate Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neuropsychological Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Schizophrenia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Semantics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tryptophan", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand", 
              "id": "http://www.grid.ac/institutes/grid.7922.e", 
              "name": [
                "Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanchanatawan", 
            "givenName": "Buranee", 
            "id": "sg:person.01110617547.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110617547.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand", 
              "id": "http://www.grid.ac/institutes/grid.7922.e", 
              "name": [
                "Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hemrungrojn", 
            "givenName": "Solaphat", 
            "id": "sg:person.01231604301.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231604301.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand", 
              "id": "http://www.grid.ac/institutes/grid.7922.e", 
              "name": [
                "Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thika", 
            "givenName": "Supaksorn", 
            "id": "sg:person.016451025617.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016451025617.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 10330, Bangkok, Thailand", 
              "id": "http://www.grid.ac/institutes/grid.7922.e", 
              "name": [
                "Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 10330, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sirivichayakul", 
            "givenName": "Sunee", 
            "id": "sg:person.01056127333.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056127333.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 10330, Bangkok, Thailand", 
              "id": "http://www.grid.ac/institutes/grid.7922.e", 
              "name": [
                "Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 10330, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ruxrungtham", 
            "givenName": "Kiat", 
            "id": "sg:person.01127272612.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127272612.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE, Brazil", 
              "id": "http://www.grid.ac/institutes/grid.8395.7", 
              "name": [
                "Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Cear\u00e1, Fortaleza, CE, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carvalho", 
            "givenName": "Andr\u00e9 F.", 
            "id": "sg:person.015337101342.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015337101342.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "GEMAC, Saint Jean d\u2019Illac, France", 
              "id": "http://www.grid.ac/institutes/grid.463882.3", 
              "name": [
                "Research Department, IDRPHT, Talence, France", 
                "GEMAC, Saint Jean d\u2019Illac, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Geffard", 
            "givenName": "Michel", 
            "id": "sg:person.01250133511.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250133511.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "CRC Scotland & London, Eccleston Square, London, UK", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "CRC Scotland & London, Eccleston Square, London, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Anderson", 
            "givenName": "George", 
            "id": "sg:person.01242565026.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242565026.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria", 
              "id": "http://www.grid.ac/institutes/grid.35371.33", 
              "name": [
                "Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand", 
                "IMPACT Strategic Research Center, Deakin University, Geelong, Australia", 
                "Revitalis, Waalre, the Netherlands", 
                "Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maes", 
            "givenName": "Michael", 
            "id": "sg:person.012515577577.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012515577577.25"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s007020070080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035749945", 
              "https://doi.org/10.1007/s007020070080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-014-3452-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008908120", 
              "https://doi.org/10.1007/s00213-014-3452-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-25758-2_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018843516", 
              "https://doi.org/10.1007/978-3-642-25758-2_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-76841-5_5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032265693", 
              "https://doi.org/10.1007/978-3-642-76841-5_5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11011-017-9982-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084028726", 
              "https://doi.org/10.1007/s11011-017-9982-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s007020050149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045423711", 
              "https://doi.org/10.1007/s007020050149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11065-009-9107-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036980022", 
              "https://doi.org/10.1007/s11065-009-9107-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep36489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046095179", 
              "https://doi.org/10.1038/srep36489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep17799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003543962", 
              "https://doi.org/10.1038/srep17799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-017-0417-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083736232", 
              "https://doi.org/10.1007/s12035-017-0417-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-017-0465-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084033858", 
              "https://doi.org/10.1007/s12035-017-0465-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-76841-5_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017385377", 
              "https://doi.org/10.1007/978-3-642-76841-5_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-76841-5_12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023901620", 
              "https://doi.org/10.1007/978-3-642-76841-5_12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02245819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005121042", 
              "https://doi.org/10.1007/bf02245819"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-09-05", 
        "datePublishedReg": "2017-09-05", 
        "description": "Evidence indicates that schizophrenia and in particular negative symptoms and deficit schizophrenia are accompanied by neurocognitive impairments and changes in the patterning of the tryptophan catabolite (TRYCAT) pathway. This cross-sectional study was carried out to examine the associations between cognitive functions (as measured with Consortium to Establish a Registry for Alzheimer\u2019s disease (CERAD)) and TRYCAT pathway patterning in patients with (n\u00a0=\u00a040) and without (n\u00a0=\u00a040) deficit schizophrenia and normal controls (n\u00a0=\u00a040). Cognitive measures were assessed with the Verbal Fluency Test (VFT), Boston Naming Test (BNT), Mini-Mental State Examination (MMSE), Word List Memory (WLM), Constructional Praxis, Word List Recall (WLRecall), and Word List Recognition (WLRecognition), while TRYCAT measurements assessed the IgA/IgM responses to noxious TRYCATs, namely quinolinic acid (QA), 3-OH-kynurenine (3HK), picolinic acid (PA), and xanthurenic (XA) acid, and more protective (PRO) TRYCATs, including kynurenic acid (KA) and anthranilic acid (AA). IgA NOX/PRO, IgM KA/3HK, and IgA/IgM NOX/PRO ratios were computed. Schizophrenia was accompanied by lower VFT and WLM, while BNT (dysnomia) and MMSE are significantly lower in multiple- than first-episode schizophrenia. Deficit schizophrenia is strongly associated with worse outcomes on VFT, MMSE, WLM, WLRecall, WLRecognition, and delayed recall savings and increased false memories. Around 40\u201350% of the variance in negative symptoms\u2019 scores was explained by VFT, WLM, WLRecall, and MMSE. Increases in IgA NOX/PRO, IgM KA/3HK, and/or IgA/IgM NOX/PRO ratios were associated with impairments in VFT, BNT, MMSE, WLM, WLRecall, WLRecognition, and false-memory creation. In conclusion, nondeficit schizophrenia is accompanied by mild memory impairments, while disease progression is accompanied by broader cognitive impairments. Deficit schizophrenia and negative symptoms are strongly associated with deficits in working memory, delayed recall and recognition, and increased false-memory creation. These cognitive impairments and memory deficits are in part explained by increased production and/or attenuated regulation of TRYCATs with neurotoxic, excitotoxic, immune-inflammatory, oxidative, and nitrosative potential, which may contribute to neuroprogression.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12035-017-0751-8", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1098844", 
            "issn": [
              "0893-7648", 
              "1559-1182"
            ], 
            "name": "Molecular Neurobiology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "55"
          }
        ], 
        "keywords": [
          "Mini-Mental State Examination", 
          "word list memory", 
          "verbal fluency test", 
          "false memory creation", 
          "Boston Naming Test", 
          "deficit schizophrenia", 
          "negative symptoms", 
          "kynurenic acid", 
          "quinolinic acid", 
          "cognitive impairment", 
          "tryptophan catabolite (TRYCAT) pathway", 
          "first-episode schizophrenia", 
          "cross-sectional study", 
          "IgA/IgM", 
          "broad cognitive impairments", 
          "word list recall", 
          "mild memory impairment", 
          "word list recognition", 
          "TRYCAT pathway", 
          "worse outcomes", 
          "disease progression", 
          "nondeficit schizophrenia", 
          "neurocognitive impairment", 
          "normal controls", 
          "episodic memory", 
          "State Examination", 
          "list memory", 
          "false memories", 
          "cognitive measures", 
          "list recall", 
          "declarative memory", 
          "mild impairment", 
          "particular negative symptoms", 
          "memory impairment", 
          "xanthurenic acid", 
          "fluency test", 
          "constructional praxis", 
          "Pro ratio", 
          "memory deficits", 
          "Naming Test", 
          "list recognition", 
          "cognitive function", 
          "TRYCATs", 
          "schizophrenia", 
          "impairment", 
          "symptoms", 
          "memory", 
          "deficits", 
          "recall", 
          "excitotoxic", 
          "neuroprogression", 
          "patients", 
          "IgM", 
          "pathway", 
          "kynurenine", 
          "progression", 
          "neurotoxic", 
          "anthranilic acid", 
          "recognition", 
          "outcomes", 
          "picolinic acid", 
          "scores", 
          "acid", 
          "examination", 
          "association", 
          "conclusion", 
          "test", 
          "changes", 
          "evidence", 
          "measures", 
          "pros", 
          "control", 
          "study", 
          "variance", 
          "regulation", 
          "ratio", 
          "increase", 
          "praxis", 
          "function", 
          "semantics", 
          "potential", 
          "production", 
          "part", 
          "creation", 
          "measurements", 
          "patterning", 
          "savings"
        ], 
        "name": "Changes in Tryptophan Catabolite (TRYCAT) Pathway Patterning Are Associated with Mild Impairments in Declarative Memory in Schizophrenia and Deficits in Semantic and Episodic Memory Coupled with Increased False-Memory Creation in Deficit Schizophrenia", 
        "pagination": "5184-5201", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1091490944"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12035-017-0751-8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28875464"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12035-017-0751-8", 
          "https://app.dimensions.ai/details/publication/pub.1091490944"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T21:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_752.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12035-017-0751-8"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12035-017-0751-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12035-017-0751-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12035-017-0751-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12035-017-0751-8'


     

    This table displays all metadata directly associated to this object as RDF triples.

    330 TRIPLES      21 PREDICATES      139 URIs      117 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12035-017-0751-8 schema:about N136bc2f1637e4840b1dc4364fb2ca456
    2 N1d1cc097e99741bdab7818531aa5db04
    3 N5620b632dd0044e59d0bc4bdb9997bab
    4 N586e2e75230d4618a51e8b51b84b017d
    5 N5ebf8a5176a2492ca401812b24abd6a2
    6 N7f9d24cf50fb49e1b0a98c21350e91e8
    7 N87104846dfff48989c9e5cb58f0f60af
    8 N99fe5c9513fb4c44a05ddd14c7fd0357
    9 Na2004a0c199c4239a4959f015f7faa25
    10 Nb3c1e098a18d438a8e72d8868a462065
    11 Nd7600f31cc6241e98a4157807f5f23d7
    12 Ne5cd77d326b447cbadeca7c7807d632f
    13 Nf346b4d3562c484f9bab9f5e7c419a9b
    14 anzsrc-for:17
    15 anzsrc-for:1701
    16 schema:author N4a4d935b8fcb4b498bb817e31fe17184
    17 schema:citation sg:pub.10.1007/978-3-642-25758-2_2
    18 sg:pub.10.1007/978-3-642-76841-5_12
    19 sg:pub.10.1007/978-3-642-76841-5_5
    20 sg:pub.10.1007/978-3-642-76841-5_8
    21 sg:pub.10.1007/bf02245819
    22 sg:pub.10.1007/s00213-014-3452-2
    23 sg:pub.10.1007/s007020050149
    24 sg:pub.10.1007/s007020070080
    25 sg:pub.10.1007/s11011-017-9982-7
    26 sg:pub.10.1007/s11065-009-9107-0
    27 sg:pub.10.1007/s12035-017-0417-6
    28 sg:pub.10.1007/s12035-017-0465-y
    29 sg:pub.10.1038/srep17799
    30 sg:pub.10.1038/srep36489
    31 schema:datePublished 2017-09-05
    32 schema:datePublishedReg 2017-09-05
    33 schema:description Evidence indicates that schizophrenia and in particular negative symptoms and deficit schizophrenia are accompanied by neurocognitive impairments and changes in the patterning of the tryptophan catabolite (TRYCAT) pathway. This cross-sectional study was carried out to examine the associations between cognitive functions (as measured with Consortium to Establish a Registry for Alzheimer’s disease (CERAD)) and TRYCAT pathway patterning in patients with (n = 40) and without (n = 40) deficit schizophrenia and normal controls (n = 40). Cognitive measures were assessed with the Verbal Fluency Test (VFT), Boston Naming Test (BNT), Mini-Mental State Examination (MMSE), Word List Memory (WLM), Constructional Praxis, Word List Recall (WLRecall), and Word List Recognition (WLRecognition), while TRYCAT measurements assessed the IgA/IgM responses to noxious TRYCATs, namely quinolinic acid (QA), 3-OH-kynurenine (3HK), picolinic acid (PA), and xanthurenic (XA) acid, and more protective (PRO) TRYCATs, including kynurenic acid (KA) and anthranilic acid (AA). IgA NOX/PRO, IgM KA/3HK, and IgA/IgM NOX/PRO ratios were computed. Schizophrenia was accompanied by lower VFT and WLM, while BNT (dysnomia) and MMSE are significantly lower in multiple- than first-episode schizophrenia. Deficit schizophrenia is strongly associated with worse outcomes on VFT, MMSE, WLM, WLRecall, WLRecognition, and delayed recall savings and increased false memories. Around 40–50% of the variance in negative symptoms’ scores was explained by VFT, WLM, WLRecall, and MMSE. Increases in IgA NOX/PRO, IgM KA/3HK, and/or IgA/IgM NOX/PRO ratios were associated with impairments in VFT, BNT, MMSE, WLM, WLRecall, WLRecognition, and false-memory creation. In conclusion, nondeficit schizophrenia is accompanied by mild memory impairments, while disease progression is accompanied by broader cognitive impairments. Deficit schizophrenia and negative symptoms are strongly associated with deficits in working memory, delayed recall and recognition, and increased false-memory creation. These cognitive impairments and memory deficits are in part explained by increased production and/or attenuated regulation of TRYCATs with neurotoxic, excitotoxic, immune-inflammatory, oxidative, and nitrosative potential, which may contribute to neuroprogression.
    34 schema:genre article
    35 schema:isAccessibleForFree false
    36 schema:isPartOf N35bb897949e64bdebf6da9b7f2cb6619
    37 N97678ad351184947a8d76ac6d095cb31
    38 sg:journal.1098844
    39 schema:keywords Boston Naming Test
    40 IgA/IgM
    41 IgM
    42 Mini-Mental State Examination
    43 Naming Test
    44 Pro ratio
    45 State Examination
    46 TRYCAT pathway
    47 TRYCATs
    48 acid
    49 anthranilic acid
    50 association
    51 broad cognitive impairments
    52 changes
    53 cognitive function
    54 cognitive impairment
    55 cognitive measures
    56 conclusion
    57 constructional praxis
    58 control
    59 creation
    60 cross-sectional study
    61 declarative memory
    62 deficit schizophrenia
    63 deficits
    64 disease progression
    65 episodic memory
    66 evidence
    67 examination
    68 excitotoxic
    69 false memories
    70 false memory creation
    71 first-episode schizophrenia
    72 fluency test
    73 function
    74 impairment
    75 increase
    76 kynurenic acid
    77 kynurenine
    78 list memory
    79 list recall
    80 list recognition
    81 measurements
    82 measures
    83 memory
    84 memory deficits
    85 memory impairment
    86 mild impairment
    87 mild memory impairment
    88 negative symptoms
    89 neurocognitive impairment
    90 neuroprogression
    91 neurotoxic
    92 nondeficit schizophrenia
    93 normal controls
    94 outcomes
    95 part
    96 particular negative symptoms
    97 pathway
    98 patients
    99 patterning
    100 picolinic acid
    101 potential
    102 praxis
    103 production
    104 progression
    105 pros
    106 quinolinic acid
    107 ratio
    108 recall
    109 recognition
    110 regulation
    111 savings
    112 schizophrenia
    113 scores
    114 semantics
    115 study
    116 symptoms
    117 test
    118 tryptophan catabolite (TRYCAT) pathway
    119 variance
    120 verbal fluency test
    121 word list memory
    122 word list recall
    123 word list recognition
    124 worse outcomes
    125 xanthurenic acid
    126 schema:name Changes in Tryptophan Catabolite (TRYCAT) Pathway Patterning Are Associated with Mild Impairments in Declarative Memory in Schizophrenia and Deficits in Semantic and Episodic Memory Coupled with Increased False-Memory Creation in Deficit Schizophrenia
    127 schema:pagination 5184-5201
    128 schema:productId N1650cbd4c0d5448f8516152e76d14b66
    129 N6fb480d1e02a497580b530670a489a4f
    130 N75088b5afe5344caa40ff9ec13349f39
    131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091490944
    132 https://doi.org/10.1007/s12035-017-0751-8
    133 schema:sdDatePublished 2022-11-24T21:03
    134 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    135 schema:sdPublisher N20fe5a8341f845e18a5c40434d25f2db
    136 schema:url https://doi.org/10.1007/s12035-017-0751-8
    137 sgo:license sg:explorer/license/
    138 sgo:sdDataset articles
    139 rdf:type schema:ScholarlyArticle
    140 N136bc2f1637e4840b1dc4364fb2ca456 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Memory, Episodic
    142 rdf:type schema:DefinedTerm
    143 N1650cbd4c0d5448f8516152e76d14b66 schema:name dimensions_id
    144 schema:value pub.1091490944
    145 rdf:type schema:PropertyValue
    146 N1d1cc097e99741bdab7818531aa5db04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Schizophrenia
    148 rdf:type schema:DefinedTerm
    149 N20fe5a8341f845e18a5c40434d25f2db schema:name Springer Nature - SN SciGraph project
    150 rdf:type schema:Organization
    151 N35bb897949e64bdebf6da9b7f2cb6619 schema:volumeNumber 55
    152 rdf:type schema:PublicationVolume
    153 N4a4d935b8fcb4b498bb817e31fe17184 rdf:first sg:person.01110617547.37
    154 rdf:rest Nb96860b4f6b34b21b03d10ccbe767020
    155 N5620b632dd0044e59d0bc4bdb9997bab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Male
    157 rdf:type schema:DefinedTerm
    158 N586e2e75230d4618a51e8b51b84b017d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Memory Disorders
    160 rdf:type schema:DefinedTerm
    161 N5ebf8a5176a2492ca401812b24abd6a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Neuropsychological Tests
    163 rdf:type schema:DefinedTerm
    164 N68f06ed4a1a14dd79122797c35e56503 rdf:first sg:person.01250133511.47
    165 rdf:rest Nf550e7dc0735481d94d9d8f74611b88b
    166 N6fb480d1e02a497580b530670a489a4f schema:name doi
    167 schema:value 10.1007/s12035-017-0751-8
    168 rdf:type schema:PropertyValue
    169 N75088b5afe5344caa40ff9ec13349f39 schema:name pubmed_id
    170 schema:value 28875464
    171 rdf:type schema:PropertyValue
    172 N7f9d24cf50fb49e1b0a98c21350e91e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Tryptophan
    174 rdf:type schema:DefinedTerm
    175 N86ab30f20a1641eda16fc1148affbe7a rdf:first sg:person.01056127333.90
    176 rdf:rest Nb8ef3ecead01456cac776366af92ab6e
    177 N87104846dfff48989c9e5cb58f0f60af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Humans
    179 rdf:type schema:DefinedTerm
    180 N97678ad351184947a8d76ac6d095cb31 schema:issueNumber 6
    181 rdf:type schema:PublicationIssue
    182 N99fe5c9513fb4c44a05ddd14c7fd0357 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Multivariate Analysis
    184 rdf:type schema:DefinedTerm
    185 N9f9a0f9dc9bb47269dc4d86b1b0efe04 rdf:first sg:person.012515577577.25
    186 rdf:rest rdf:nil
    187 Na2004a0c199c4239a4959f015f7faa25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Linear Models
    189 rdf:type schema:DefinedTerm
    190 Nb3c1e098a18d438a8e72d8868a462065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Semantics
    192 rdf:type schema:DefinedTerm
    193 Nb8ef3ecead01456cac776366af92ab6e rdf:first sg:person.01127272612.97
    194 rdf:rest Nf9b3abece7304593a9f180e52f792b40
    195 Nb96860b4f6b34b21b03d10ccbe767020 rdf:first sg:person.01231604301.28
    196 rdf:rest Neeb7b224c85940e2a958e269fe867d8d
    197 Nd7600f31cc6241e98a4157807f5f23d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Female
    199 rdf:type schema:DefinedTerm
    200 Ne5cd77d326b447cbadeca7c7807d632f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Adult
    202 rdf:type schema:DefinedTerm
    203 Neeb7b224c85940e2a958e269fe867d8d rdf:first sg:person.016451025617.24
    204 rdf:rest N86ab30f20a1641eda16fc1148affbe7a
    205 Nf346b4d3562c484f9bab9f5e7c419a9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Case-Control Studies
    207 rdf:type schema:DefinedTerm
    208 Nf550e7dc0735481d94d9d8f74611b88b rdf:first sg:person.01242565026.34
    209 rdf:rest N9f9a0f9dc9bb47269dc4d86b1b0efe04
    210 Nf9b3abece7304593a9f180e52f792b40 rdf:first sg:person.015337101342.22
    211 rdf:rest N68f06ed4a1a14dd79122797c35e56503
    212 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Psychology and Cognitive Sciences
    214 rdf:type schema:DefinedTerm
    215 anzsrc-for:1701 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Psychology
    217 rdf:type schema:DefinedTerm
    218 sg:journal.1098844 schema:issn 0893-7648
    219 1559-1182
    220 schema:name Molecular Neurobiology
    221 schema:publisher Springer Nature
    222 rdf:type schema:Periodical
    223 sg:person.01056127333.90 schema:affiliation grid-institutes:grid.7922.e
    224 schema:familyName Sirivichayakul
    225 schema:givenName Sunee
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056127333.90
    227 rdf:type schema:Person
    228 sg:person.01110617547.37 schema:affiliation grid-institutes:grid.7922.e
    229 schema:familyName Kanchanatawan
    230 schema:givenName Buranee
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110617547.37
    232 rdf:type schema:Person
    233 sg:person.01127272612.97 schema:affiliation grid-institutes:grid.7922.e
    234 schema:familyName Ruxrungtham
    235 schema:givenName Kiat
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127272612.97
    237 rdf:type schema:Person
    238 sg:person.01231604301.28 schema:affiliation grid-institutes:grid.7922.e
    239 schema:familyName Hemrungrojn
    240 schema:givenName Solaphat
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231604301.28
    242 rdf:type schema:Person
    243 sg:person.01242565026.34 schema:affiliation grid-institutes:None
    244 schema:familyName Anderson
    245 schema:givenName George
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242565026.34
    247 rdf:type schema:Person
    248 sg:person.01250133511.47 schema:affiliation grid-institutes:grid.463882.3
    249 schema:familyName Geffard
    250 schema:givenName Michel
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250133511.47
    252 rdf:type schema:Person
    253 sg:person.012515577577.25 schema:affiliation grid-institutes:grid.35371.33
    254 schema:familyName Maes
    255 schema:givenName Michael
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012515577577.25
    257 rdf:type schema:Person
    258 sg:person.015337101342.22 schema:affiliation grid-institutes:grid.8395.7
    259 schema:familyName Carvalho
    260 schema:givenName André F.
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015337101342.22
    262 rdf:type schema:Person
    263 sg:person.016451025617.24 schema:affiliation grid-institutes:grid.7922.e
    264 schema:familyName Thika
    265 schema:givenName Supaksorn
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016451025617.24
    267 rdf:type schema:Person
    268 sg:pub.10.1007/978-3-642-25758-2_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018843516
    269 https://doi.org/10.1007/978-3-642-25758-2_2
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1007/978-3-642-76841-5_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023901620
    272 https://doi.org/10.1007/978-3-642-76841-5_12
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1007/978-3-642-76841-5_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032265693
    275 https://doi.org/10.1007/978-3-642-76841-5_5
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1007/978-3-642-76841-5_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017385377
    278 https://doi.org/10.1007/978-3-642-76841-5_8
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1007/bf02245819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005121042
    281 https://doi.org/10.1007/bf02245819
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1007/s00213-014-3452-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008908120
    284 https://doi.org/10.1007/s00213-014-3452-2
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1007/s007020050149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045423711
    287 https://doi.org/10.1007/s007020050149
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/s007020070080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035749945
    290 https://doi.org/10.1007/s007020070080
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/s11011-017-9982-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084028726
    293 https://doi.org/10.1007/s11011-017-9982-7
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/s11065-009-9107-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036980022
    296 https://doi.org/10.1007/s11065-009-9107-0
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1007/s12035-017-0417-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083736232
    299 https://doi.org/10.1007/s12035-017-0417-6
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1007/s12035-017-0465-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1084033858
    302 https://doi.org/10.1007/s12035-017-0465-y
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/srep17799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003543962
    305 https://doi.org/10.1038/srep17799
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/srep36489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046095179
    308 https://doi.org/10.1038/srep36489
    309 rdf:type schema:CreativeWork
    310 grid-institutes:None schema:alternateName CRC Scotland & London, Eccleston Square, London, UK
    311 schema:name CRC Scotland & London, Eccleston Square, London, UK
    312 rdf:type schema:Organization
    313 grid-institutes:grid.35371.33 schema:alternateName Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria
    314 schema:name Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    315 Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria
    316 IMPACT Strategic Research Center, Deakin University, Geelong, Australia
    317 Revitalis, Waalre, the Netherlands
    318 rdf:type schema:Organization
    319 grid-institutes:grid.463882.3 schema:alternateName GEMAC, Saint Jean d’Illac, France
    320 schema:name GEMAC, Saint Jean d’Illac, France
    321 Research Department, IDRPHT, Talence, France
    322 rdf:type schema:Organization
    323 grid-institutes:grid.7922.e schema:alternateName Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    324 Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 10330, Bangkok, Thailand
    325 schema:name Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
    326 Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, 10330, Bangkok, Thailand
    327 rdf:type schema:Organization
    328 grid-institutes:grid.8395.7 schema:alternateName Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil
    329 schema:name Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil
    330 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...