SVCT2 Is Expressed by Cerebellar Precursor Cells, Which Differentiate into Neurons in Response to Ascorbic Acid View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-01-17

AUTHORS

Karina Oyarce, Carmen Silva-Alvarez, Luciano Ferrada, Fernando Martínez, Katterine Salazar, Francisco Nualart

ABSTRACT

Ascorbic acid (AA) is a known antioxidant that participates in a wide range of processes, including stem cell differentiation. It enters the cell through the sodium-ascorbate co-transporter SVCT2, which is mainly expressed by neurons in the adult brain. Here, we have characterized SVCT2 expression in the postnatal cerebellum in situ, a model used for studying neurogenesis, and have identified its expression in granular precursor cells and mature neurons. We have also detected SVCT2 expression in the cerebellar cell line C17.2 and in postnatal cerebellum-derived neurospheres in vitro and have identified a tight relationship between SVCT2 expression and that of the stem cell-like marker nestin. AA supplementation potentiates the neuronal phenotype in cerebellar neural stem cells by increasing the expression of the neuronal marker β III tubulin. Stable over-expression of SVCT2 in C17.2 cells enhances β III tubulin expression, but it also increases cell death, suggesting that AA transporter levels must be finely tuned during neural stem cell differentiation. More... »

PAGES

1136-1149

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12035-016-0366-5

DOI

http://dx.doi.org/10.1007/s12035-016-0366-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029146532

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28097475


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ascorbic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cerebellum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neural Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium-Coupled Vitamin C Transporters", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile", 
          "id": "http://www.grid.ac/institutes/grid.5380.e", 
          "name": [
            "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oyarce", 
        "givenName": "Karina", 
        "id": "sg:person.0747230362.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747230362.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile", 
          "id": "http://www.grid.ac/institutes/grid.5380.e", 
          "name": [
            "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silva-Alvarez", 
        "givenName": "Carmen", 
        "id": "sg:person.01202424530.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202424530.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile", 
          "id": "http://www.grid.ac/institutes/grid.5380.e", 
          "name": [
            "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrada", 
        "givenName": "Luciano", 
        "id": "sg:person.01244636304.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244636304.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile", 
          "id": "http://www.grid.ac/institutes/grid.5380.e", 
          "name": [
            "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00ednez", 
        "givenName": "Fernando", 
        "id": "sg:person.0662014235.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662014235.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile", 
          "id": "http://www.grid.ac/institutes/grid.5380.e", 
          "name": [
            "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salazar", 
        "givenName": "Katterine", 
        "id": "sg:person.0634052203.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634052203.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile", 
          "id": "http://www.grid.ac/institutes/grid.5380.e", 
          "name": [
            "Centro de Microscop\u00eda Avanzada CMA-BIOBIO, Departamento de Biolog\u00eda Celular, Laboratorio de Neurobiolog\u00eda y C\u00e9lulas Madres, Facultad de Ciencias Biol\u00f3gicas, Universidad de Concepci\u00f3n, Concepci\u00f3n, Chile"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nualart", 
        "givenName": "Francisco", 
        "id": "sg:person.0677567476.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677567476.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s004180100312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012408419", 
          "https://doi.org/10.1007/s004180100312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cr.2011.195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029717838", 
          "https://doi.org/10.1038/cr.2011.195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms3917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018898379", 
          "https://doi.org/10.1038/ncomms3917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-015-9553-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049589024", 
          "https://doi.org/10.1007/s12035-015-9553-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00403-011-1158-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024189001", 
          "https://doi.org/10.1007/s00403-011-1158-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-016-0081-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028184447", 
          "https://doi.org/10.1007/s12035-016-0081-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4402190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050095734", 
          "https://doi.org/10.1038/sj.cdd.4402190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/19986", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026500684", 
          "https://doi.org/10.1038/19986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn1473", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025570503", 
          "https://doi.org/10.1038/nn1473"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-01-17", 
    "datePublishedReg": "2017-01-17", 
    "description": "Ascorbic acid (AA) is a known antioxidant that participates in a wide range of processes, including stem cell differentiation. It enters the cell through the sodium-ascorbate co-transporter SVCT2, which is mainly expressed by neurons in the adult brain. Here, we have characterized SVCT2 expression in the postnatal cerebellum in situ, a model used for studying neurogenesis, and have identified its expression in granular precursor cells and mature neurons. We have also detected SVCT2 expression in the cerebellar cell line C17.2 and in postnatal cerebellum-derived neurospheres in vitro and have identified a tight relationship between SVCT2 expression and that of the stem cell-like marker nestin. AA supplementation potentiates the neuronal phenotype in cerebellar neural stem cells by increasing the expression of the neuronal marker \u03b2 III tubulin. Stable over-expression of SVCT2 in C17.2 cells enhances \u03b2 III tubulin expression, but it also increases cell death, suggesting that AA transporter levels must be finely tuned during neural stem cell differentiation.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s12035-016-0366-5", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.9278195", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9276314", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.9270447", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1098844", 
        "issn": [
          "0893-7648", 
          "1559-1182"
        ], 
        "name": "Molecular Neurobiology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "keywords": [
      "stem cell differentiation", 
      "SVCT2 expression", 
      "cell differentiation", 
      "precursor cells", 
      "cerebellar neural stem cells", 
      "neural stem cell differentiation", 
      "cerebellar precursor cells", 
      "neural stem cells", 
      "mature neurons", 
      "adult brain", 
      "neuronal phenotype", 
      "expression of SVCT2", 
      "marker nestin", 
      "AA supplementation", 
      "transporter levels", 
      "III-tubulin", 
      "postnatal cerebellum", 
      "C17.2 cells", 
      "cell death", 
      "neurons", 
      "tubulin expression", 
      "SVCT2", 
      "ascorbic acid", 
      "stem cells", 
      "expression", 
      "cells", 
      "differentiation", 
      "neurogenesis", 
      "cerebellum", 
      "nestin", 
      "tight relationship", 
      "brain", 
      "supplementation", 
      "neurospheres", 
      "death", 
      "C17.2", 
      "phenotype", 
      "tubulin", 
      "acid", 
      "antioxidants", 
      "response", 
      "levels", 
      "wide range", 
      "relationship", 
      "situ", 
      "process", 
      "model", 
      "range"
    ], 
    "name": "SVCT2 Is Expressed by Cerebellar Precursor Cells, Which Differentiate into Neurons in Response to Ascorbic Acid", 
    "pagination": "1136-1149", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029146532"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12035-016-0366-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28097475"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12035-016-0366-5", 
      "https://app.dimensions.ai/details/publication/pub.1029146532"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_737.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s12035-016-0366-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12035-016-0366-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12035-016-0366-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12035-016-0366-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12035-016-0366-5'


 

This table displays all metadata directly associated to this object as RDF triples.

222 TRIPLES      21 PREDICATES      91 URIs      74 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12035-016-0366-5 schema:about N1ca661f2a02f4983a387b49a8647745c
2 N560aa95ff24c4de5b28c4ba9763267e2
3 N5c79605678bf4012b3fc789532a43aa9
4 N6b282f8f9c694455b3edafdeb453957b
5 Nac2052191de140b081eeb7f019e01ce0
6 Nb6b45e89ee0344c48a5b6b5cdcfddd7d
7 Nc738c72052ac4054bc5badba28e467c0
8 Ne23feebc161943589ea48cd8ce0ef169
9 Ne753774a9d4a424397166949373a6e08
10 anzsrc-for:11
11 anzsrc-for:1109
12 schema:author N2dacce1558cd413d831f16277a3e81c6
13 schema:citation sg:pub.10.1007/s00403-011-1158-4
14 sg:pub.10.1007/s004180100312
15 sg:pub.10.1007/s12035-015-9553-z
16 sg:pub.10.1007/s12035-016-0081-2
17 sg:pub.10.1038/19986
18 sg:pub.10.1038/cr.2011.195
19 sg:pub.10.1038/ncomms3917
20 sg:pub.10.1038/nn1473
21 sg:pub.10.1038/sj.cdd.4402190
22 schema:datePublished 2017-01-17
23 schema:datePublishedReg 2017-01-17
24 schema:description Ascorbic acid (AA) is a known antioxidant that participates in a wide range of processes, including stem cell differentiation. It enters the cell through the sodium-ascorbate co-transporter SVCT2, which is mainly expressed by neurons in the adult brain. Here, we have characterized SVCT2 expression in the postnatal cerebellum in situ, a model used for studying neurogenesis, and have identified its expression in granular precursor cells and mature neurons. We have also detected SVCT2 expression in the cerebellar cell line C17.2 and in postnatal cerebellum-derived neurospheres in vitro and have identified a tight relationship between SVCT2 expression and that of the stem cell-like marker nestin. AA supplementation potentiates the neuronal phenotype in cerebellar neural stem cells by increasing the expression of the neuronal marker β III tubulin. Stable over-expression of SVCT2 in C17.2 cells enhances β III tubulin expression, but it also increases cell death, suggesting that AA transporter levels must be finely tuned during neural stem cell differentiation.
25 schema:genre article
26 schema:isAccessibleForFree false
27 schema:isPartOf N297daf745d9a491481906f44bfbf9050
28 N45da4731b2ac47e494b27b1aa2d6b940
29 sg:journal.1098844
30 schema:keywords AA supplementation
31 C17.2
32 C17.2 cells
33 III-tubulin
34 SVCT2
35 SVCT2 expression
36 acid
37 adult brain
38 antioxidants
39 ascorbic acid
40 brain
41 cell death
42 cell differentiation
43 cells
44 cerebellar neural stem cells
45 cerebellar precursor cells
46 cerebellum
47 death
48 differentiation
49 expression
50 expression of SVCT2
51 levels
52 marker nestin
53 mature neurons
54 model
55 nestin
56 neural stem cell differentiation
57 neural stem cells
58 neurogenesis
59 neuronal phenotype
60 neurons
61 neurospheres
62 phenotype
63 postnatal cerebellum
64 precursor cells
65 process
66 range
67 relationship
68 response
69 situ
70 stem cell differentiation
71 stem cells
72 supplementation
73 tight relationship
74 transporter levels
75 tubulin
76 tubulin expression
77 wide range
78 schema:name SVCT2 Is Expressed by Cerebellar Precursor Cells, Which Differentiate into Neurons in Response to Ascorbic Acid
79 schema:pagination 1136-1149
80 schema:productId N5b7ba657f52241c5aceb9307e5c28cd4
81 N64203e4a586c49068b865c9b4b76d362
82 Nbea2d1a75df14226b18b64e2c89c7786
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029146532
84 https://doi.org/10.1007/s12035-016-0366-5
85 schema:sdDatePublished 2022-12-01T06:36
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher N2ef2cad8c5cf4a259e7c827742f04a0c
88 schema:url https://doi.org/10.1007/s12035-016-0366-5
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N031eb7c937024ffca384e2003cd6762b rdf:first sg:person.0634052203.45
93 rdf:rest Na8be596a39114b6caf38a61665cc9d6b
94 N1ca661f2a02f4983a387b49a8647745c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Neural Stem Cells
96 rdf:type schema:DefinedTerm
97 N297daf745d9a491481906f44bfbf9050 schema:issueNumber 2
98 rdf:type schema:PublicationIssue
99 N2dacce1558cd413d831f16277a3e81c6 rdf:first sg:person.0747230362.81
100 rdf:rest Nfd33598574e6445f9c80c9928651ffa9
101 N2ef2cad8c5cf4a259e7c827742f04a0c schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N45da4731b2ac47e494b27b1aa2d6b940 schema:volumeNumber 55
104 rdf:type schema:PublicationVolume
105 N560aa95ff24c4de5b28c4ba9763267e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Cell Line
107 rdf:type schema:DefinedTerm
108 N588f371d4168411e828616c73902a152 rdf:first sg:person.0662014235.97
109 rdf:rest N031eb7c937024ffca384e2003cd6762b
110 N5b7ba657f52241c5aceb9307e5c28cd4 schema:name dimensions_id
111 schema:value pub.1029146532
112 rdf:type schema:PropertyValue
113 N5c79605678bf4012b3fc789532a43aa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Cerebellum
115 rdf:type schema:DefinedTerm
116 N64203e4a586c49068b865c9b4b76d362 schema:name pubmed_id
117 schema:value 28097475
118 rdf:type schema:PropertyValue
119 N6b282f8f9c694455b3edafdeb453957b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Mice
121 rdf:type schema:DefinedTerm
122 Na8be596a39114b6caf38a61665cc9d6b rdf:first sg:person.0677567476.14
123 rdf:rest rdf:nil
124 Nac2052191de140b081eeb7f019e01ce0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Neurons
126 rdf:type schema:DefinedTerm
127 Nb10c8b027bca446ea0e1dd99c06e4888 rdf:first sg:person.01244636304.20
128 rdf:rest N588f371d4168411e828616c73902a152
129 Nb6b45e89ee0344c48a5b6b5cdcfddd7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Neurogenesis
131 rdf:type schema:DefinedTerm
132 Nbea2d1a75df14226b18b64e2c89c7786 schema:name doi
133 schema:value 10.1007/s12035-016-0366-5
134 rdf:type schema:PropertyValue
135 Nc738c72052ac4054bc5badba28e467c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Ascorbic Acid
137 rdf:type schema:DefinedTerm
138 Ne23feebc161943589ea48cd8ce0ef169 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Animals
140 rdf:type schema:DefinedTerm
141 Ne753774a9d4a424397166949373a6e08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Sodium-Coupled Vitamin C Transporters
143 rdf:type schema:DefinedTerm
144 Nfd33598574e6445f9c80c9928651ffa9 rdf:first sg:person.01202424530.17
145 rdf:rest Nb10c8b027bca446ea0e1dd99c06e4888
146 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
147 schema:name Medical and Health Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
150 schema:name Neurosciences
151 rdf:type schema:DefinedTerm
152 sg:grant.9270447 http://pending.schema.org/fundedItem sg:pub.10.1007/s12035-016-0366-5
153 rdf:type schema:MonetaryGrant
154 sg:grant.9276314 http://pending.schema.org/fundedItem sg:pub.10.1007/s12035-016-0366-5
155 rdf:type schema:MonetaryGrant
156 sg:grant.9278195 http://pending.schema.org/fundedItem sg:pub.10.1007/s12035-016-0366-5
157 rdf:type schema:MonetaryGrant
158 sg:journal.1098844 schema:issn 0893-7648
159 1559-1182
160 schema:name Molecular Neurobiology
161 schema:publisher Springer Nature
162 rdf:type schema:Periodical
163 sg:person.01202424530.17 schema:affiliation grid-institutes:grid.5380.e
164 schema:familyName Silva-Alvarez
165 schema:givenName Carmen
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202424530.17
167 rdf:type schema:Person
168 sg:person.01244636304.20 schema:affiliation grid-institutes:grid.5380.e
169 schema:familyName Ferrada
170 schema:givenName Luciano
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244636304.20
172 rdf:type schema:Person
173 sg:person.0634052203.45 schema:affiliation grid-institutes:grid.5380.e
174 schema:familyName Salazar
175 schema:givenName Katterine
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634052203.45
177 rdf:type schema:Person
178 sg:person.0662014235.97 schema:affiliation grid-institutes:grid.5380.e
179 schema:familyName Martínez
180 schema:givenName Fernando
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662014235.97
182 rdf:type schema:Person
183 sg:person.0677567476.14 schema:affiliation grid-institutes:grid.5380.e
184 schema:familyName Nualart
185 schema:givenName Francisco
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677567476.14
187 rdf:type schema:Person
188 sg:person.0747230362.81 schema:affiliation grid-institutes:grid.5380.e
189 schema:familyName Oyarce
190 schema:givenName Karina
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747230362.81
192 rdf:type schema:Person
193 sg:pub.10.1007/s00403-011-1158-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024189001
194 https://doi.org/10.1007/s00403-011-1158-4
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/s004180100312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012408419
197 https://doi.org/10.1007/s004180100312
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/s12035-015-9553-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1049589024
200 https://doi.org/10.1007/s12035-015-9553-z
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/s12035-016-0081-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028184447
203 https://doi.org/10.1007/s12035-016-0081-2
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/19986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026500684
206 https://doi.org/10.1038/19986
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/cr.2011.195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029717838
209 https://doi.org/10.1038/cr.2011.195
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/ncomms3917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018898379
212 https://doi.org/10.1038/ncomms3917
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/nn1473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025570503
215 https://doi.org/10.1038/nn1473
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/sj.cdd.4402190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050095734
218 https://doi.org/10.1038/sj.cdd.4402190
219 rdf:type schema:CreativeWork
220 grid-institutes:grid.5380.e schema:alternateName Centro de Microscopía Avanzada CMA-BIOBIO, Departamento de Biología Celular, Laboratorio de Neurobiología y Células Madres, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile
221 schema:name Centro de Microscopía Avanzada CMA-BIOBIO, Departamento de Biología Celular, Laboratorio de Neurobiología y Células Madres, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile
222 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...