Cerebrospinal Fluid Biomarkers in the Diagnosis of Creutzfeldt-Jakob Disease in Slovak Patients: over 10-Year Period Review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-09-24

AUTHORS

Silvia Koscova, Dana Zakova Slivarichova, Ivana Tomeckova, Katarina Melicherova, Martin Stelzer, Alzbeta Janakova, Dana Kosorinova, Girma Belay, Eva Mitrova

ABSTRACT

Creutzfeldt-Jakob disease is a rare, but rapidly progressive, up to now untreatable and fatal neurodegenerative disorder. Clinical diagnosis of Creutzfeldt-Jakob disease (CJD) is difficult; however, it can be facilitated by suitable biomarkers. Aim of the present study is to compare levels of cerebrospinal fluid biomarkers (total tau protein, phosphorylated-tau protein, protein 14-3-3 and amyloid beta) in Slovak population of CJD suspect cases, retrospectively in over a 10-year period. One thousand three hundred sixty-four CSF samples from patients with suspect CJD, forming a homogenous group in terms of geographical as well as of equal transport conditions, storage and laboratory processing, were analysed. Definite diagnosis of Creutzfeldt-Jakob disease was confirmed in 101 patients with genetic form, and 60 patients with its sporadic form of the disease. Specificity of protein 14-3-3 and total tau in both forms CJD was similar (87 % for P14-3-3/85 % for total tau), sensitivity to P 14-3-3 and total tau was higher in sporadic Creutzfeldt-Jakob disease (sCJD) (90/95 %) than in genetic Creutzfeldt-Jakob disease (gCJD) (89/74 %). As expected, the total tau levels were significantly higher in CJD patients than in controls, but there was also significant difference between gCJD and sCJD (levels in gCJD were lower; p = 0.003). There was no significant difference in p-tau and Aβ 1-42 levels neither between both CJD forms nor between CJD patients and control group. More... »

PAGES

5919-5927

References to SciGraph publications

  • 1991-07. Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease in NATURE
  • 2015-06-16. Clinical findings and diagnosis in genetic prion diseases in Germany in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2009-05-06. Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients in JOURNAL OF NEUROLOGY
  • 1998-07. Coexistence of Alzheimer-type neuropathology in Creutzfeldt-Jakob disease in ACTA NEUROPATHOLOGICA
  • 2006-02. 14-3-3 Protein, Total Tau and Phosphorylated Tau in Cerebrospinal Fluid of Patients with Creutzfeldt-Jakob Disease and Neurodegenerative Disease in Japan in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • 2008-08-27. Cerebrospinal fluid markers in Creutzfeldt-Jakob disease in FLUIDS AND BARRIERS OF THE CNS
  • 2011-10-27. Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt-Jakob disease in Canada: a 6-year prospective study in BMC NEUROLOGY
  • 2007-03-25. Influence of timing on CSF tests value for Creutzfeldt-Jakob disease diagnosis in JOURNAL OF NEUROLOGY
  • 2010-09-09. Tau and 14-3-3 of genetic and sporadic Creutzfeldt–Jakob disease patients in Israel in JOURNAL OF NEUROLOGY
  • 2009-05-15. Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies in JOURNAL OF NEUROLOGY
  • 1991-09. Some new aspects of CJD epidemiology in Slovakia in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2015-05-07. Validation of 14-3-3 Protein as a Marker in Sporadic Creutzfeldt-Jakob Disease Diagnostic in MOLECULAR NEUROBIOLOGY
  • 2011-03-01. Serum tau protein as a marker for the diagnosis of Creutzfeldt-Jakob disease in JOURNAL OF NEUROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12035-016-0128-4

    DOI

    http://dx.doi.org/10.1007/s12035-016-0128-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048270868

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27665282


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "14-3-3 Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amyloid beta-Peptides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Creutzfeldt-Jakob Syndrome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diagnosis, Differential", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurodegenerative Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphorylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prions", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Slovakia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "tau Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia", 
              "id": "http://www.grid.ac/institutes/grid.9982.a", 
              "name": [
                "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koscova", 
            "givenName": "Silvia", 
            "id": "sg:person.0577033142.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577033142.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia", 
              "id": "http://www.grid.ac/institutes/grid.9982.a", 
              "name": [
                "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zakova Slivarichova", 
            "givenName": "Dana", 
            "id": "sg:person.012724520305.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012724520305.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia", 
              "id": "http://www.grid.ac/institutes/grid.9982.a", 
              "name": [
                "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tomeckova", 
            "givenName": "Ivana", 
            "id": "sg:person.01275126254.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275126254.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia", 
              "id": "http://www.grid.ac/institutes/grid.9982.a", 
              "name": [
                "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Melicherova", 
            "givenName": "Katarina", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia", 
              "id": "http://www.grid.ac/institutes/grid.9982.a", 
              "name": [
                "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stelzer", 
            "givenName": "Martin", 
            "id": "sg:person.010155566755.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010155566755.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia", 
              "id": "http://www.grid.ac/institutes/grid.9982.a", 
              "name": [
                "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Janakova", 
            "givenName": "Alzbeta", 
            "id": "sg:person.015712422305.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015712422305.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia", 
              "id": "http://www.grid.ac/institutes/grid.9982.a", 
              "name": [
                "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kosorinova", 
            "givenName": "Dana", 
            "id": "sg:person.01112564454.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112564454.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia", 
              "id": "http://www.grid.ac/institutes/grid.9982.a", 
              "name": [
                "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Belay", 
            "givenName": "Girma", 
            "id": "sg:person.01000223647.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000223647.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia", 
              "id": "http://www.grid.ac/institutes/grid.9982.a", 
              "name": [
                "Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mitrova", 
            "givenName": "Eva", 
            "id": "sg:person.070747435.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.070747435.06"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00415-006-0472-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048126214", 
              "https://doi.org/10.1007/s00415-006-0472-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-011-5960-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035229116", 
              "https://doi.org/10.1007/s00415-011-5960-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1743-8454-5-14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016093250", 
              "https://doi.org/10.1186/1743-8454-5-14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-015-9167-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015253753", 
              "https://doi.org/10.1007/s12035-015-9167-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-009-5160-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046952192", 
              "https://doi.org/10.1007/s00415-009-5160-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-010-5738-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020106318", 
              "https://doi.org/10.1007/s00415-010-5738-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2377-11-133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029238880", 
              "https://doi.org/10.1186/1471-2377-11-133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-015-0049-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015288038", 
              "https://doi.org/10.1007/s10654-015-0049-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00143119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008191766", 
              "https://doi.org/10.1007/bf00143119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-009-5163-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043762731", 
              "https://doi.org/10.1007/s00415-009-5163-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s004010050870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043951466", 
              "https://doi.org/10.1007/s004010050870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/352340a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005851331", 
              "https://doi.org/10.1038/352340a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10571-006-9370-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028828314", 
              "https://doi.org/10.1007/s10571-006-9370-z"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-09-24", 
        "datePublishedReg": "2016-09-24", 
        "description": "Creutzfeldt-Jakob disease is a rare, but rapidly progressive, up to now untreatable and fatal neurodegenerative disorder. Clinical diagnosis of Creutzfeldt-Jakob disease (CJD) is difficult; however, it can be facilitated by suitable biomarkers. Aim of the present study is to compare levels of cerebrospinal fluid biomarkers (total tau protein, phosphorylated-tau protein, protein 14-3-3 and amyloid beta) in Slovak population of CJD suspect cases, retrospectively in over a 10-year period. One thousand three hundred sixty-four CSF samples from patients with suspect CJD, forming a homogenous group in terms of geographical as well as of equal transport conditions, storage and laboratory processing, were analysed. Definite diagnosis of Creutzfeldt-Jakob disease was confirmed in 101 patients with genetic form, and 60 patients with its sporadic form of the disease. Specificity of protein 14-3-3 and total tau in both forms CJD was similar (87\u00a0% for P14-3-3/85\u00a0% for total tau), sensitivity to P 14-3-3 and total tau was higher in sporadic Creutzfeldt-Jakob disease (sCJD) (90/95\u00a0%) than in genetic Creutzfeldt-Jakob disease (gCJD) (89/74\u00a0%). As expected, the total tau levels were significantly higher in CJD patients than in controls, but there was also significant difference between gCJD and sCJD (levels in gCJD were lower; p\u00a0=\u00a00.003). There was no significant difference in p-tau and A\u03b2 1-42 levels neither between both CJD forms nor between CJD patients and control group.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12035-016-0128-4", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1098844", 
            "issn": [
              "0893-7648", 
              "1559-1182"
            ], 
            "name": "Molecular Neurobiology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "8", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "54"
          }
        ], 
        "keywords": [
          "Creutzfeldt-Jakob disease", 
          "sporadic Creutzfeldt-Jakob disease", 
          "genetic Creutzfeldt-Jakob disease", 
          "cerebrospinal fluid (CSF) biomarkers", 
          "total tau", 
          "fluid biomarkers", 
          "CJD patients", 
          "total tau levels", 
          "significant differences", 
          "fatal neurodegenerative disorder", 
          "tau levels", 
          "definite diagnosis", 
          "Slovak patients", 
          "CSF samples", 
          "patients", 
          "control group", 
          "suspect cases", 
          "clinical diagnosis", 
          "sporadic forms", 
          "neurodegenerative disorders", 
          "disease", 
          "A\u03b2 1", 
          "suitable biomarkers", 
          "genetic forms", 
          "diagnosis", 
          "Slovak population", 
          "biomarkers", 
          "tau", 
          "present study", 
          "protein 14", 
          "homogenous group", 
          "group", 
          "levels", 
          "laboratory processing", 
          "disorders", 
          "period review", 
          "differences", 
          "review", 
          "population", 
          "specificity", 
          "period", 
          "control", 
          "study", 
          "cases", 
          "sensitivity", 
          "form", 
          "samples", 
          "conditions", 
          "terms", 
          "processing", 
          "storage", 
          "transport conditions", 
          "CJD suspect cases", 
          "suspect CJD", 
          "equal transport conditions", 
          "forms CJD", 
          "CJD forms"
        ], 
        "name": "Cerebrospinal Fluid Biomarkers in the Diagnosis of Creutzfeldt-Jakob Disease in Slovak Patients: over 10-Year Period Review", 
        "pagination": "5919-5927", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1048270868"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12035-016-0128-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27665282"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12035-016-0128-4", 
          "https://app.dimensions.ai/details/publication/pub.1048270868"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:27", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_697.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12035-016-0128-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12035-016-0128-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12035-016-0128-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12035-016-0128-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12035-016-0128-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    298 TRIPLES      22 PREDICATES      114 URIs      93 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12035-016-0128-4 schema:about N253f31f6d4fd43df94384a8caef33d5e
    2 N31bd3944ad2c4b01927c82dbecbd20bd
    3 N402b91e3971d4c4a9266f7e92b0bcb00
    4 N468e4a4afb5445cdba0becff7ce3d13e
    5 N4e316b40b3cb41a59d84be3cd67a572e
    6 N4f719b8095ca4a3f80f2e41219dd7ddd
    7 N57b6669fb5434414b70553b75efef3f1
    8 N6456e98fceeb4f7a8f5559aa6085e49e
    9 N69372b8239114225b2e3342ef6eb544d
    10 N936bd38258cd421db02ce268cfabed84
    11 N9b1c2b34a58c4f61851e9a249c67cb0a
    12 Na96bf53f249b4faa91adfcdd6ef1de37
    13 Nb0e335748f6945faaef52b2de438bbb0
    14 Ncc1999099c62405ebe221e4906cf475b
    15 Nd4c7e50905ae4a19a23e446f30974f92
    16 Ndafa6614931341be962b77c479ddb59e
    17 Ndb725a9461f64c22880f74b8c1184ac5
    18 Ndf44b603199c4aa5ac3390929942898d
    19 anzsrc-for:11
    20 anzsrc-for:1109
    21 schema:author Nfadf25bb3f7149258bc12b1c32dd5877
    22 schema:citation sg:pub.10.1007/bf00143119
    23 sg:pub.10.1007/s004010050870
    24 sg:pub.10.1007/s00415-006-0472-9
    25 sg:pub.10.1007/s00415-009-5160-0
    26 sg:pub.10.1007/s00415-009-5163-x
    27 sg:pub.10.1007/s00415-010-5738-6
    28 sg:pub.10.1007/s00415-011-5960-x
    29 sg:pub.10.1007/s10571-006-9370-z
    30 sg:pub.10.1007/s10654-015-0049-y
    31 sg:pub.10.1007/s12035-015-9167-5
    32 sg:pub.10.1038/352340a0
    33 sg:pub.10.1186/1471-2377-11-133
    34 sg:pub.10.1186/1743-8454-5-14
    35 schema:datePublished 2016-09-24
    36 schema:datePublishedReg 2016-09-24
    37 schema:description Creutzfeldt-Jakob disease is a rare, but rapidly progressive, up to now untreatable and fatal neurodegenerative disorder. Clinical diagnosis of Creutzfeldt-Jakob disease (CJD) is difficult; however, it can be facilitated by suitable biomarkers. Aim of the present study is to compare levels of cerebrospinal fluid biomarkers (total tau protein, phosphorylated-tau protein, protein 14-3-3 and amyloid beta) in Slovak population of CJD suspect cases, retrospectively in over a 10-year period. One thousand three hundred sixty-four CSF samples from patients with suspect CJD, forming a homogenous group in terms of geographical as well as of equal transport conditions, storage and laboratory processing, were analysed. Definite diagnosis of Creutzfeldt-Jakob disease was confirmed in 101 patients with genetic form, and 60 patients with its sporadic form of the disease. Specificity of protein 14-3-3 and total tau in both forms CJD was similar (87 % for P14-3-3/85 % for total tau), sensitivity to P 14-3-3 and total tau was higher in sporadic Creutzfeldt-Jakob disease (sCJD) (90/95 %) than in genetic Creutzfeldt-Jakob disease (gCJD) (89/74 %). As expected, the total tau levels were significantly higher in CJD patients than in controls, but there was also significant difference between gCJD and sCJD (levels in gCJD were lower; p = 0.003). There was no significant difference in p-tau and Aβ 1-42 levels neither between both CJD forms nor between CJD patients and control group.
    38 schema:genre article
    39 schema:inLanguage en
    40 schema:isAccessibleForFree false
    41 schema:isPartOf N970649bb3c324e05ae8fb34960afb26e
    42 Ne6512a0f4efa498bb4428370d8322129
    43 sg:journal.1098844
    44 schema:keywords Aβ 1
    45 CJD forms
    46 CJD patients
    47 CJD suspect cases
    48 CSF samples
    49 Creutzfeldt-Jakob disease
    50 Slovak patients
    51 Slovak population
    52 biomarkers
    53 cases
    54 cerebrospinal fluid (CSF) biomarkers
    55 clinical diagnosis
    56 conditions
    57 control
    58 control group
    59 definite diagnosis
    60 diagnosis
    61 differences
    62 disease
    63 disorders
    64 equal transport conditions
    65 fatal neurodegenerative disorder
    66 fluid biomarkers
    67 form
    68 forms CJD
    69 genetic Creutzfeldt-Jakob disease
    70 genetic forms
    71 group
    72 homogenous group
    73 laboratory processing
    74 levels
    75 neurodegenerative disorders
    76 patients
    77 period
    78 period review
    79 population
    80 present study
    81 processing
    82 protein 14
    83 review
    84 samples
    85 sensitivity
    86 significant differences
    87 specificity
    88 sporadic Creutzfeldt-Jakob disease
    89 sporadic forms
    90 storage
    91 study
    92 suitable biomarkers
    93 suspect CJD
    94 suspect cases
    95 tau
    96 tau levels
    97 terms
    98 total tau
    99 total tau levels
    100 transport conditions
    101 schema:name Cerebrospinal Fluid Biomarkers in the Diagnosis of Creutzfeldt-Jakob Disease in Slovak Patients: over 10-Year Period Review
    102 schema:pagination 5919-5927
    103 schema:productId N451ff1125d3c4bf1bad2ed9645d2f614
    104 N54502a921fec4163a237ffb04bbe0a9f
    105 N728c064deb8c4e31810b8c77e4dd6a4d
    106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048270868
    107 https://doi.org/10.1007/s12035-016-0128-4
    108 schema:sdDatePublished 2021-11-01T18:27
    109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    110 schema:sdPublisher Nc742558597f44a98a571288921258734
    111 schema:url https://doi.org/10.1007/s12035-016-0128-4
    112 sgo:license sg:explorer/license/
    113 sgo:sdDataset articles
    114 rdf:type schema:ScholarlyArticle
    115 N048b1d891c044d5c8eaa2da696cf285c rdf:first sg:person.01000223647.65
    116 rdf:rest Nc23d6e7b73a241bbb0b6dceaac45f757
    117 N253f31f6d4fd43df94384a8caef33d5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Phosphorylation
    119 rdf:type schema:DefinedTerm
    120 N25a159701c0c41d58912b01aeb400171 schema:affiliation grid-institutes:grid.9982.a
    121 schema:familyName Melicherova
    122 schema:givenName Katarina
    123 rdf:type schema:Person
    124 N31bd3944ad2c4b01927c82dbecbd20bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Male
    126 rdf:type schema:DefinedTerm
    127 N402b91e3971d4c4a9266f7e92b0bcb00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Neurodegenerative Diseases
    129 rdf:type schema:DefinedTerm
    130 N451ff1125d3c4bf1bad2ed9645d2f614 schema:name dimensions_id
    131 schema:value pub.1048270868
    132 rdf:type schema:PropertyValue
    133 N468e4a4afb5445cdba0becff7ce3d13e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Slovakia
    135 rdf:type schema:DefinedTerm
    136 N4e316b40b3cb41a59d84be3cd67a572e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Adult
    138 rdf:type schema:DefinedTerm
    139 N4f719b8095ca4a3f80f2e41219dd7ddd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name tau Proteins
    141 rdf:type schema:DefinedTerm
    142 N54502a921fec4163a237ffb04bbe0a9f schema:name pubmed_id
    143 schema:value 27665282
    144 rdf:type schema:PropertyValue
    145 N57b6669fb5434414b70553b75efef3f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Diagnosis, Differential
    147 rdf:type schema:DefinedTerm
    148 N6456e98fceeb4f7a8f5559aa6085e49e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Aged, 80 and over
    150 rdf:type schema:DefinedTerm
    151 N69372b8239114225b2e3342ef6eb544d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Prions
    153 rdf:type schema:DefinedTerm
    154 N71a35b6825ac49c38e9453fa44646894 rdf:first sg:person.01275126254.45
    155 rdf:rest Ne03a62718bd847309d0322fd9091d041
    156 N728c064deb8c4e31810b8c77e4dd6a4d schema:name doi
    157 schema:value 10.1007/s12035-016-0128-4
    158 rdf:type schema:PropertyValue
    159 N8a3f1d9df7b749e092e4fcf6df0e4153 rdf:first sg:person.015712422305.52
    160 rdf:rest Nd3abfa2f84f34871add3c4c8873b1296
    161 N936bd38258cd421db02ce268cfabed84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name 14-3-3 Proteins
    163 rdf:type schema:DefinedTerm
    164 N970649bb3c324e05ae8fb34960afb26e schema:issueNumber 8
    165 rdf:type schema:PublicationIssue
    166 N9b1c2b34a58c4f61851e9a249c67cb0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Young Adult
    168 rdf:type schema:DefinedTerm
    169 Na96bf53f249b4faa91adfcdd6ef1de37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Aged
    171 rdf:type schema:DefinedTerm
    172 Nb0e335748f6945faaef52b2de438bbb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Middle Aged
    174 rdf:type schema:DefinedTerm
    175 Nc23d6e7b73a241bbb0b6dceaac45f757 rdf:first sg:person.070747435.06
    176 rdf:rest rdf:nil
    177 Nc742558597f44a98a571288921258734 schema:name Springer Nature - SN SciGraph project
    178 rdf:type schema:Organization
    179 Ncc1999099c62405ebe221e4906cf475b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Amyloid beta-Peptides
    181 rdf:type schema:DefinedTerm
    182 Nd3abfa2f84f34871add3c4c8873b1296 rdf:first sg:person.01112564454.08
    183 rdf:rest N048b1d891c044d5c8eaa2da696cf285c
    184 Nd4c7e50905ae4a19a23e446f30974f92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Biomarkers
    186 rdf:type schema:DefinedTerm
    187 Ndafa6614931341be962b77c479ddb59e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Female
    189 rdf:type schema:DefinedTerm
    190 Ndb725a9461f64c22880f74b8c1184ac5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Humans
    192 rdf:type schema:DefinedTerm
    193 Ndf44b603199c4aa5ac3390929942898d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Creutzfeldt-Jakob Syndrome
    195 rdf:type schema:DefinedTerm
    196 Ne03a62718bd847309d0322fd9091d041 rdf:first N25a159701c0c41d58912b01aeb400171
    197 rdf:rest Nec86bf9b183946f693c08e918a736986
    198 Ne6512a0f4efa498bb4428370d8322129 schema:volumeNumber 54
    199 rdf:type schema:PublicationVolume
    200 Ne9a8c7b6eb8a40a1b89e86e926e065a6 rdf:first sg:person.012724520305.07
    201 rdf:rest N71a35b6825ac49c38e9453fa44646894
    202 Nec86bf9b183946f693c08e918a736986 rdf:first sg:person.010155566755.25
    203 rdf:rest N8a3f1d9df7b749e092e4fcf6df0e4153
    204 Nfadf25bb3f7149258bc12b1c32dd5877 rdf:first sg:person.0577033142.27
    205 rdf:rest Ne9a8c7b6eb8a40a1b89e86e926e065a6
    206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    207 schema:name Medical and Health Sciences
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Neurosciences
    211 rdf:type schema:DefinedTerm
    212 sg:journal.1098844 schema:issn 0893-7648
    213 1559-1182
    214 schema:name Molecular Neurobiology
    215 schema:publisher Springer Nature
    216 rdf:type schema:Periodical
    217 sg:person.01000223647.65 schema:affiliation grid-institutes:grid.9982.a
    218 schema:familyName Belay
    219 schema:givenName Girma
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000223647.65
    221 rdf:type schema:Person
    222 sg:person.010155566755.25 schema:affiliation grid-institutes:grid.9982.a
    223 schema:familyName Stelzer
    224 schema:givenName Martin
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010155566755.25
    226 rdf:type schema:Person
    227 sg:person.01112564454.08 schema:affiliation grid-institutes:grid.9982.a
    228 schema:familyName Kosorinova
    229 schema:givenName Dana
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112564454.08
    231 rdf:type schema:Person
    232 sg:person.012724520305.07 schema:affiliation grid-institutes:grid.9982.a
    233 schema:familyName Zakova Slivarichova
    234 schema:givenName Dana
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012724520305.07
    236 rdf:type schema:Person
    237 sg:person.01275126254.45 schema:affiliation grid-institutes:grid.9982.a
    238 schema:familyName Tomeckova
    239 schema:givenName Ivana
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275126254.45
    241 rdf:type schema:Person
    242 sg:person.015712422305.52 schema:affiliation grid-institutes:grid.9982.a
    243 schema:familyName Janakova
    244 schema:givenName Alzbeta
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015712422305.52
    246 rdf:type schema:Person
    247 sg:person.0577033142.27 schema:affiliation grid-institutes:grid.9982.a
    248 schema:familyName Koscova
    249 schema:givenName Silvia
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577033142.27
    251 rdf:type schema:Person
    252 sg:person.070747435.06 schema:affiliation grid-institutes:grid.9982.a
    253 schema:familyName Mitrova
    254 schema:givenName Eva
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.070747435.06
    256 rdf:type schema:Person
    257 sg:pub.10.1007/bf00143119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008191766
    258 https://doi.org/10.1007/bf00143119
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1007/s004010050870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043951466
    261 https://doi.org/10.1007/s004010050870
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s00415-006-0472-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048126214
    264 https://doi.org/10.1007/s00415-006-0472-9
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1007/s00415-009-5160-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046952192
    267 https://doi.org/10.1007/s00415-009-5160-0
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1007/s00415-009-5163-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043762731
    270 https://doi.org/10.1007/s00415-009-5163-x
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1007/s00415-010-5738-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020106318
    273 https://doi.org/10.1007/s00415-010-5738-6
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1007/s00415-011-5960-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035229116
    276 https://doi.org/10.1007/s00415-011-5960-x
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1007/s10571-006-9370-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1028828314
    279 https://doi.org/10.1007/s10571-006-9370-z
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1007/s10654-015-0049-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015288038
    282 https://doi.org/10.1007/s10654-015-0049-y
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1007/s12035-015-9167-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015253753
    285 https://doi.org/10.1007/s12035-015-9167-5
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/352340a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005851331
    288 https://doi.org/10.1038/352340a0
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1186/1471-2377-11-133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029238880
    291 https://doi.org/10.1186/1471-2377-11-133
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1186/1743-8454-5-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016093250
    294 https://doi.org/10.1186/1743-8454-5-14
    295 rdf:type schema:CreativeWork
    296 grid-institutes:grid.9982.a schema:alternateName Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia
    297 schema:name Department of Prion Diseases, Slovak Medical University, Limbova 14, 833 01, Bratislava, Slovakia
    298 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...