Serum Uric Acid Levels and Diabetic Peripheral Neuropathy in Type 2 Diabetes: a Systematic Review and Meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01-12

AUTHORS

Shuai Yu, Ying Chen, Xu Hou, Donghua Xu, Kui Che, Changgui Li, Shengli Yan, Yangang Wang, Bin Wang

ABSTRACT

Previous studies suggested a possible association between serum uric acid levels and peripheral neuropathy in patients with type 2 diabetes, but no definite evidence was available. A systematic review and meta-analysis of relevant studies were performed to comprehensively estimate the association. Pubmed, Web of Science, Embase, and China Biology Medicine (CBM) databases were searched for eligible studies. Study-specific data were combined using random-effect or fixed-effect models of meta-analysis according to between-study heterogeneity. Twelve studies were finally included into the meta-analysis, which involved a total of 1388 type 2 diabetic patients with peripheral neuropathy and 4746 patients without peripheral neuropathy. Meta-analysis showed that there were obvious increased serum uric acid levels in diabetic patients with peripheral neuropathy (weighted mean difference [WMD] = 50.03 μmol/L, 95 % confidence interval [95%CI] 22.14–77.93, P = 0.0004). Hyperuricemia was also significantly associated with increased risk of peripheral neuropathy in patients with type 2 diabetes (risk ratio [RR] = 2.83, 95%CI 2.13–3.76, P < 0.00001). Meta-analysis of two studies with adjusted risk estimates showed that hyperuricemia was independently associated with increased risk of peripheral neuropathy in type 2 diabetic patients (RR = 1.95, 95%CI 1.23–3.11, P = 0.005). Type 2 diabetic patients with peripheral neuropathy have obvious increased serum uric acid levels, and hyperuricemia is associated with increased risk of peripheral neuropathy. Further prospective cohort studies are needed to validate the impact of serum uric acid levels on peripheral neuropathy risk. More... »

PAGES

1045-1051

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12035-014-9075-0

DOI

http://dx.doi.org/10.1007/s12035-014-9075-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049371726

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25579387


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