Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-02

AUTHORS

Kazuhiro A. Fujita, Marek Ostaszewski, Yukiko Matsuoka, Samik Ghosh, Enrico Glaab, Christophe Trefois, Isaac Crespo, Thanneer M. Perumal, Wiktor Jurkowski, Paul M. A. Antony, Nico Diederich, Manuel Buttini, Akihiko Kodama, Venkata P. Satagopam, Serge Eifes, Antonio del Sol, Reinhard Schneider, Hiroaki Kitano, Rudi Balling

ABSTRACT

Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused by a complex interplay of genetic and environmental factors. Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. Here we introduce a computationally tractable, comprehensive molecular interaction map of PD. This map integrates pathways implicated in PD pathogenesis such as synaptic and mitochondrial dysfunction, impaired protein degradation, alpha-synuclein pathobiology and neuroinflammation. We also present bioinformatics tools for the analysis, enrichment and annotation of the map, allowing the research community to open new avenues in PD research. The PD map is accessible at http://minerva.uni.lu/pd_map . More... »

PAGES

88-102

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12035-013-8489-4

DOI

http://dx.doi.org/10.1007/s12035-013-8489-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031017148

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23832570


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