The Toolbox for Modified Aptamers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-02

AUTHORS

Sergey A. Lapa, Alexander V. Chudinov, Edward N. Timofeev

ABSTRACT

Aptamers are nucleic acid-based scaffolds that can bind with high affinity to a variety of biological targets. Aptamers are identified from large DNA or RNA libraries through a process of directed molecular evolution (SELEX). Chemical modification of nucleic acids considerably increases the functional and structural diversity of aptamer libraries and substantially increases the affinity of the aptamers. Additionally, modified aptamers exhibit much greater resistance to biodegradation. The evolutionary selection of modified aptamers is conditioned by the possibility of the enzymatic synthesis and replication of non-natural nucleic acids. Wild-type or mutant polymerases and their non-natural nucleotide substrates that can support SELEX are highlighted in the present review. A focus is made on the efforts to find the most suitable type of nucleotide modifications and the engineering of new polymerases. Post-SELEX modification as a complementary method will be briefly considered as well. More... »

PAGES

79-92

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12033-015-9907-9

DOI

http://dx.doi.org/10.1007/s12033-015-9907-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029149787

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26607475


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aptamers, Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Directed DNA Polymerase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nucleotides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SELEX Aptamer Technique", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Engelhardt Institute of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.418899.5", 
          "name": [
            "Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lapa", 
        "givenName": "Sergey A.", 
        "id": "sg:person.01005625735.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005625735.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Engelhardt Institute of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.418899.5", 
          "name": [
            "Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chudinov", 
        "givenName": "Alexander V.", 
        "id": "sg:person.01306621145.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306621145.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Engelhardt Institute of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.418899.5", 
          "name": [
            "Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Timofeev", 
        "givenName": "Edward N.", 
        "id": "sg:person.01227261213.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227261213.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/chem.201201662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000431435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0908463107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000572076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules15085423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000639951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules15085423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000639951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001103261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cbpa.2008.06.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001854973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-005-5117-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002757045", 
          "https://doi.org/10.1007/s00018-005-5117-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003121845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2012.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003508604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/nat.2014.0506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004129024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/22.14.2817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004240591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1013804107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004393126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m113.532580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004810873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2015.00755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004905962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b903307f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006265715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b903307f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006265715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja909180c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006503436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja909180c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006503436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja067098n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006844781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja067098n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006844781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2015.05.075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006912800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201503652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007165921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbic.201402116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007362183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibtech.2014.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008464613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpc.2009.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008715727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.1685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008792176", 
          "https://doi.org/10.1038/nchembio.1685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201404742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009018420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkh542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009070738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo5020799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011689629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbapap.2009.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012086322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013772976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.6.1561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015209663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biotechadv.2015.02.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015237675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbic.201000215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015764779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbic.201000215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015764779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/22.15.3226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016334748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15257770500377714", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016737554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules200711959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016998831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules200711959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016998831"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c2sc21510a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018066750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201303577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018105774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio.966", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018428867", 
          "https://doi.org/10.1038/nchembio.966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c1ob05359k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018891173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b803664k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019168174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules171113569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019442915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules171113569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019442915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019496304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ab.2004.09.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020368210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biotechadv.2010.07.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021614975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0320(19970701)28:3<206::aid-cyto4>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022274777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cbic.201100648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023077496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/mtna.2014.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023639282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201105717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023849731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/0471142727.mb1512s105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025419873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0102126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026337538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ejoc.200800381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026580323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chembiol.2009.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028192655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1389-0352(99)00002-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028756299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1263/jbb.101.449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029780934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c3ob40842f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029933057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030447477", 
          "https://doi.org/10.1038/nature02908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030447477", 
          "https://doi.org/10.1038/nature02908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.122247199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030575576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031041883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/25.22.4581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031134412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gnf138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032083313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkf502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032347250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/chem.201103270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032473828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1217622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033371431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/chem.201406392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033463239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0798-652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033712419", 
          "https://doi.org/10.1038/nbt0798-652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034594144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja908035g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035095791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja908035g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035095791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1373/clinchem.2013.205211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035775146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c2cc34181f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036195102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja411212q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037084086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.14.5107-5112.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037624047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0070892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038878568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cmdc.201300047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039103664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c5cc00530b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039555805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkq1053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039643976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00239-010-9415-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040264103", 
          "https://doi.org/10.1007/s00239-010-9415-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2006.06.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040469753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1213933109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041959091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2009.03.063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042074946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/mtna.2014.34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043088384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043570132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c4cc07588a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044052733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/530963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044470311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/22.16.3418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045232833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature13982", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045605313", 
          "https://doi.org/10.1038/nature13982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules200916643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045966488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules200916643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045966488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2010.09.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046180943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja4012222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046452182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046706129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/27.8.1788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047139543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gki628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047175644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047661951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1521-3773(20010417)40:8<1427::aid-anie1427>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047753769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/15257770.2014.978011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048234278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2014.00565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048803916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nass/nrl016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048959344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmicb.2014.00465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050303742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.16.7137-7143.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050647069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c2sc20404e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051158078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052656868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2013.10.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052969571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.15.3154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053319781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/346818a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053479478", 
          "https://doi.org/10.1038/346818a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/co3001378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053922623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc5003554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055155215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi001578o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055163039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi001578o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055163039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi034948s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055197515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi034948s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055197515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi901523y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055210256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi901523y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055210256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja051725b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055838838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja051725b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055838838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja3017889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055852145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja312148q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055853968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja405346s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055854880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja9816436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055870045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo301684b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056027845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2200121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062527213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/05382rr02", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069097008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138161212799958387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069168129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1389450043345074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069180156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/adna.28422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072289403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076869294", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/nat.2012.0382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078652684"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-02", 
    "datePublishedReg": "2016-02-01", 
    "description": "Aptamers are nucleic acid-based scaffolds that can bind with high affinity to a variety of biological targets. Aptamers are identified from large DNA or RNA libraries through a process of directed molecular evolution (SELEX). Chemical modification of nucleic acids considerably increases the functional and structural diversity of aptamer libraries and substantially increases the affinity of the aptamers. Additionally, modified aptamers exhibit much greater resistance to biodegradation. The evolutionary selection of modified aptamers is conditioned by the possibility of the enzymatic synthesis and replication of non-natural nucleic acids. Wild-type or mutant polymerases and their non-natural nucleotide substrates that can support SELEX are highlighted in the present review. A focus is made on the efforts to find the most suitable type of nucleotide modifications and the engineering of new polymerases. Post-SELEX modification as a complementary method will be briefly considered as well.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12033-015-9907-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106201", 
        "issn": [
          "1073-6085", 
          "1559-0305"
        ], 
        "name": "Molecular Biotechnology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "58"
      }
    ], 
    "name": "The Toolbox for Modified Aptamers", 
    "pagination": "79-92", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8add8bd79fa2bf5398f976bc9b66534853f677be32f12ba253bd7ca240f929ed"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26607475"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9423533"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12033-015-9907-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029149787"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12033-015-9907-9", 
      "https://app.dimensions.ai/details/publication/pub.1029149787"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12033-015-9907-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12033-015-9907-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12033-015-9907-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12033-015-9907-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12033-015-9907-9'


 

This table displays all metadata directly associated to this object as RDF triples.

463 TRIPLES      21 PREDICATES      152 URIs      25 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12033-015-9907-9 schema:about N50f293fa264344a6b41b6889817718be
2 N8432e7284def49699cda657981a7f237
3 N90775cc264d54268a9a0c05269117a2c
4 Ndc38f57a14b548b3b7126f94697bd404
5 anzsrc-for:06
6 anzsrc-for:0604
7 schema:author N082c641fb4f44cd1adf26ffda50cfb92
8 schema:citation sg:pub.10.1007/s00018-005-5117-0
9 sg:pub.10.1007/s00239-010-9415-2
10 sg:pub.10.1038/346818a0
11 sg:pub.10.1038/nature02908
12 sg:pub.10.1038/nature13982
13 sg:pub.10.1038/nbt0798-652
14 sg:pub.10.1038/nchembio.1685
15 sg:pub.10.1038/nchembio.966
16 https://app.dimensions.ai/details/publication/pub.1076869294
17 https://doi.org/10.1002/(sici)1097-0320(19970701)28:3<206::aid-cyto4>3.0.co;2-b
18 https://doi.org/10.1002/0471142727.mb1512s105
19 https://doi.org/10.1002/1521-3773(20010417)40:8<1427::aid-anie1427>3.0.co;2-t
20 https://doi.org/10.1002/anie.201105717
21 https://doi.org/10.1002/anie.201303577
22 https://doi.org/10.1002/anie.201404742
23 https://doi.org/10.1002/anie.201503652
24 https://doi.org/10.1002/cbic.201000215
25 https://doi.org/10.1002/cbic.201100648
26 https://doi.org/10.1002/cbic.201402116
27 https://doi.org/10.1002/chem.201103270
28 https://doi.org/10.1002/chem.201201662
29 https://doi.org/10.1002/chem.201406392
30 https://doi.org/10.1002/cmdc.201300047
31 https://doi.org/10.1002/ejoc.200800381
32 https://doi.org/10.1016/j.ab.2004.09.043
33 https://doi.org/10.1016/j.bbapap.2009.08.023
34 https://doi.org/10.1016/j.biotechadv.2010.07.004
35 https://doi.org/10.1016/j.biotechadv.2015.02.008
36 https://doi.org/10.1016/j.bmc.2009.03.063
37 https://doi.org/10.1016/j.bmcl.2010.09.044
38 https://doi.org/10.1016/j.bmcl.2015.05.075
39 https://doi.org/10.1016/j.bpc.2009.09.011
40 https://doi.org/10.1016/j.cbpa.2008.06.028
41 https://doi.org/10.1016/j.chembiol.2009.02.004
42 https://doi.org/10.1016/j.chembiol.2012.07.011
43 https://doi.org/10.1016/j.febslet.2013.10.040
44 https://doi.org/10.1016/j.jmb.2006.06.050
45 https://doi.org/10.1016/j.tibtech.2014.03.010
46 https://doi.org/10.1016/s1389-0352(99)00002-1
47 https://doi.org/10.1021/bc5003554
48 https://doi.org/10.1021/bi001578o
49 https://doi.org/10.1021/bi034948s
50 https://doi.org/10.1021/bi901523y
51 https://doi.org/10.1021/co3001378
52 https://doi.org/10.1021/ja051725b
53 https://doi.org/10.1021/ja067098n
54 https://doi.org/10.1021/ja3017889
55 https://doi.org/10.1021/ja312148q
56 https://doi.org/10.1021/ja4012222
57 https://doi.org/10.1021/ja405346s
58 https://doi.org/10.1021/ja411212q
59 https://doi.org/10.1021/ja908035g
60 https://doi.org/10.1021/ja909180c
61 https://doi.org/10.1021/ja9816436
62 https://doi.org/10.1021/jo301684b
63 https://doi.org/10.1021/jo5020799
64 https://doi.org/10.1038/mtna.2014.34
65 https://doi.org/10.1038/mtna.2014.49
66 https://doi.org/10.1039/b803664k
67 https://doi.org/10.1039/b903307f
68 https://doi.org/10.1039/c1ob05359k
69 https://doi.org/10.1039/c2cc34181f
70 https://doi.org/10.1039/c2sc20404e
71 https://doi.org/10.1039/c2sc21510a
72 https://doi.org/10.1039/c3ob40842f
73 https://doi.org/10.1039/c4cc07588a
74 https://doi.org/10.1039/c5cc00530b
75 https://doi.org/10.1073/pnas.0908463107
76 https://doi.org/10.1073/pnas.1013804107
77 https://doi.org/10.1073/pnas.1213933109
78 https://doi.org/10.1073/pnas.122247199
79 https://doi.org/10.1074/jbc.m113.532580
80 https://doi.org/10.1080/15257770.2014.978011
81 https://doi.org/10.1080/15257770500377714
82 https://doi.org/10.1089/nat.2012.0382
83 https://doi.org/10.1089/nat.2014.0506
84 https://doi.org/10.1093/nar/22.14.2817
85 https://doi.org/10.1093/nar/22.15.3226
86 https://doi.org/10.1093/nar/22.16.3418
87 https://doi.org/10.1093/nar/25.22.4581
88 https://doi.org/10.1093/nar/27.6.1561
89 https://doi.org/10.1093/nar/27.8.1788
90 https://doi.org/10.1093/nar/29.15.3154
91 https://doi.org/10.1093/nar/gkf502
92 https://doi.org/10.1093/nar/gkg370
93 https://doi.org/10.1093/nar/gkg371
94 https://doi.org/10.1093/nar/gkh542
95 https://doi.org/10.1093/nar/gki628
96 https://doi.org/10.1093/nar/gkl637
97 https://doi.org/10.1093/nar/gkm395
98 https://doi.org/10.1093/nar/gkm520
99 https://doi.org/10.1093/nar/gkn404
100 https://doi.org/10.1093/nar/gkn956
101 https://doi.org/10.1093/nar/gkq1053
102 https://doi.org/10.1093/nar/gkv367
103 https://doi.org/10.1093/nar/gkv734
104 https://doi.org/10.1093/nar/gkv789
105 https://doi.org/10.1093/nar/gnf138
106 https://doi.org/10.1093/nass/nrl016
107 https://doi.org/10.1126/science.1217622
108 https://doi.org/10.1126/science.2200121
109 https://doi.org/10.1128/mcb.23.14.5107-5112.2003
110 https://doi.org/10.1128/mcb.25.16.7137-7143.2005
111 https://doi.org/10.1155/2012/530963
112 https://doi.org/10.1263/jbb.101.449
113 https://doi.org/10.1371/journal.pone.0070892
114 https://doi.org/10.1371/journal.pone.0102126
115 https://doi.org/10.1373/clinchem.2013.205211
116 https://doi.org/10.2144/05382rr02
117 https://doi.org/10.2174/138161212799958387
118 https://doi.org/10.2174/1389450043345074
119 https://doi.org/10.3389/fmicb.2014.00465
120 https://doi.org/10.3389/fmicb.2014.00565
121 https://doi.org/10.3389/fmicb.2015.00755
122 https://doi.org/10.3390/molecules15085423
123 https://doi.org/10.3390/molecules171113569
124 https://doi.org/10.3390/molecules200711959
125 https://doi.org/10.3390/molecules200916643
126 https://doi.org/10.4161/adna.28422
127 schema:datePublished 2016-02
128 schema:datePublishedReg 2016-02-01
129 schema:description Aptamers are nucleic acid-based scaffolds that can bind with high affinity to a variety of biological targets. Aptamers are identified from large DNA or RNA libraries through a process of directed molecular evolution (SELEX). Chemical modification of nucleic acids considerably increases the functional and structural diversity of aptamer libraries and substantially increases the affinity of the aptamers. Additionally, modified aptamers exhibit much greater resistance to biodegradation. The evolutionary selection of modified aptamers is conditioned by the possibility of the enzymatic synthesis and replication of non-natural nucleic acids. Wild-type or mutant polymerases and their non-natural nucleotide substrates that can support SELEX are highlighted in the present review. A focus is made on the efforts to find the most suitable type of nucleotide modifications and the engineering of new polymerases. Post-SELEX modification as a complementary method will be briefly considered as well.
130 schema:genre research_article
131 schema:inLanguage en
132 schema:isAccessibleForFree false
133 schema:isPartOf N3121d61e773f4298a5f5cc92797489a5
134 N3bcf3d1818204d87afc60bf2cdab2a97
135 sg:journal.1106201
136 schema:name The Toolbox for Modified Aptamers
137 schema:pagination 79-92
138 schema:productId N17af8ff3eb82418b8dad3cafc73fa713
139 N435b09ad6c4a4a9e917f4a877e54beb9
140 N771f9fe5871d484fb5741cab855d0d00
141 Na8211362786f4964923a5156f1cdb0ed
142 Naa6ce2ce3abb4572a0e941bfcaf120c1
143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029149787
144 https://doi.org/10.1007/s12033-015-9907-9
145 schema:sdDatePublished 2019-04-10T14:12
146 schema:sdLicense https://scigraph.springernature.com/explorer/license/
147 schema:sdPublisher Neae1b0f342fc46be9e045649f55aa329
148 schema:url http://link.springer.com/10.1007%2Fs12033-015-9907-9
149 sgo:license sg:explorer/license/
150 sgo:sdDataset articles
151 rdf:type schema:ScholarlyArticle
152 N082c641fb4f44cd1adf26ffda50cfb92 rdf:first sg:person.01005625735.20
153 rdf:rest N3444304235594b08981732201e289164
154 N17af8ff3eb82418b8dad3cafc73fa713 schema:name dimensions_id
155 schema:value pub.1029149787
156 rdf:type schema:PropertyValue
157 N3121d61e773f4298a5f5cc92797489a5 schema:issueNumber 2
158 rdf:type schema:PublicationIssue
159 N3444304235594b08981732201e289164 rdf:first sg:person.01306621145.93
160 rdf:rest N5087042028034084b812c4c26f1ed4c6
161 N3bcf3d1818204d87afc60bf2cdab2a97 schema:volumeNumber 58
162 rdf:type schema:PublicationVolume
163 N435b09ad6c4a4a9e917f4a877e54beb9 schema:name pubmed_id
164 schema:value 26607475
165 rdf:type schema:PropertyValue
166 N5087042028034084b812c4c26f1ed4c6 rdf:first sg:person.01227261213.28
167 rdf:rest rdf:nil
168 N50f293fa264344a6b41b6889817718be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name SELEX Aptamer Technique
170 rdf:type schema:DefinedTerm
171 N771f9fe5871d484fb5741cab855d0d00 schema:name readcube_id
172 schema:value 8add8bd79fa2bf5398f976bc9b66534853f677be32f12ba253bd7ca240f929ed
173 rdf:type schema:PropertyValue
174 N8432e7284def49699cda657981a7f237 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Nucleotides
176 rdf:type schema:DefinedTerm
177 N90775cc264d54268a9a0c05269117a2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Aptamers, Nucleotide
179 rdf:type schema:DefinedTerm
180 Na8211362786f4964923a5156f1cdb0ed schema:name doi
181 schema:value 10.1007/s12033-015-9907-9
182 rdf:type schema:PropertyValue
183 Naa6ce2ce3abb4572a0e941bfcaf120c1 schema:name nlm_unique_id
184 schema:value 9423533
185 rdf:type schema:PropertyValue
186 Ndc38f57a14b548b3b7126f94697bd404 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name DNA-Directed DNA Polymerase
188 rdf:type schema:DefinedTerm
189 Neae1b0f342fc46be9e045649f55aa329 schema:name Springer Nature - SN SciGraph project
190 rdf:type schema:Organization
191 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
192 schema:name Biological Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
195 schema:name Genetics
196 rdf:type schema:DefinedTerm
197 sg:journal.1106201 schema:issn 1073-6085
198 1559-0305
199 schema:name Molecular Biotechnology
200 rdf:type schema:Periodical
201 sg:person.01005625735.20 schema:affiliation https://www.grid.ac/institutes/grid.418899.5
202 schema:familyName Lapa
203 schema:givenName Sergey A.
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005625735.20
205 rdf:type schema:Person
206 sg:person.01227261213.28 schema:affiliation https://www.grid.ac/institutes/grid.418899.5
207 schema:familyName Timofeev
208 schema:givenName Edward N.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227261213.28
210 rdf:type schema:Person
211 sg:person.01306621145.93 schema:affiliation https://www.grid.ac/institutes/grid.418899.5
212 schema:familyName Chudinov
213 schema:givenName Alexander V.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306621145.93
215 rdf:type schema:Person
216 sg:pub.10.1007/s00018-005-5117-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002757045
217 https://doi.org/10.1007/s00018-005-5117-0
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s00239-010-9415-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040264103
220 https://doi.org/10.1007/s00239-010-9415-2
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/346818a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053479478
223 https://doi.org/10.1038/346818a0
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/nature02908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030447477
226 https://doi.org/10.1038/nature02908
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nature13982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045605313
229 https://doi.org/10.1038/nature13982
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nbt0798-652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033712419
232 https://doi.org/10.1038/nbt0798-652
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nchembio.1685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008792176
235 https://doi.org/10.1038/nchembio.1685
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nchembio.966 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018428867
238 https://doi.org/10.1038/nchembio.966
239 rdf:type schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1076869294 schema:CreativeWork
241 https://doi.org/10.1002/(sici)1097-0320(19970701)28:3<206::aid-cyto4>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1022274777
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/0471142727.mb1512s105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025419873
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/1521-3773(20010417)40:8<1427::aid-anie1427>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1047753769
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/anie.201105717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023849731
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/anie.201303577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018105774
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/anie.201404742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009018420
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/anie.201503652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007165921
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1002/cbic.201000215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015764779
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1002/cbic.201100648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023077496
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/cbic.201402116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007362183
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/chem.201103270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032473828
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/chem.201201662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000431435
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/chem.201406392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033463239
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/cmdc.201300047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039103664
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/ejoc.200800381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026580323
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.ab.2004.09.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020368210
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.bbapap.2009.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012086322
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.biotechadv.2010.07.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021614975
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.biotechadv.2015.02.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015237675
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.bmc.2009.03.063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042074946
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.bmcl.2010.09.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046180943
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.bmcl.2015.05.075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006912800
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.bpc.2009.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008715727
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.cbpa.2008.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001854973
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.chembiol.2009.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028192655
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/j.chembiol.2012.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003508604
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.febslet.2013.10.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052969571
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.jmb.2006.06.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040469753
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.tibtech.2014.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008464613
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s1389-0352(99)00002-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028756299
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1021/bc5003554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055155215
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1021/bi001578o schema:sameAs https://app.dimensions.ai/details/publication/pub.1055163039
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1021/bi034948s schema:sameAs https://app.dimensions.ai/details/publication/pub.1055197515
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1021/bi901523y schema:sameAs https://app.dimensions.ai/details/publication/pub.1055210256
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1021/co3001378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053922623
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1021/ja051725b schema:sameAs https://app.dimensions.ai/details/publication/pub.1055838838
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1021/ja067098n schema:sameAs https://app.dimensions.ai/details/publication/pub.1006844781
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1021/ja3017889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055852145
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1021/ja312148q schema:sameAs https://app.dimensions.ai/details/publication/pub.1055853968
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1021/ja4012222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046452182
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1021/ja405346s schema:sameAs https://app.dimensions.ai/details/publication/pub.1055854880
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1021/ja411212q schema:sameAs https://app.dimensions.ai/details/publication/pub.1037084086
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1021/ja908035g schema:sameAs https://app.dimensions.ai/details/publication/pub.1035095791
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1021/ja909180c schema:sameAs https://app.dimensions.ai/details/publication/pub.1006503436
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1021/ja9816436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055870045
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1021/jo301684b schema:sameAs https://app.dimensions.ai/details/publication/pub.1056027845
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1021/jo5020799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011689629
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1038/mtna.2014.34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043088384
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1038/mtna.2014.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023639282
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1039/b803664k schema:sameAs https://app.dimensions.ai/details/publication/pub.1019168174
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1039/b903307f schema:sameAs https://app.dimensions.ai/details/publication/pub.1006265715
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1039/c1ob05359k schema:sameAs https://app.dimensions.ai/details/publication/pub.1018891173
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1039/c2cc34181f schema:sameAs https://app.dimensions.ai/details/publication/pub.1036195102
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1039/c2sc20404e schema:sameAs https://app.dimensions.ai/details/publication/pub.1051158078
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1039/c2sc21510a schema:sameAs https://app.dimensions.ai/details/publication/pub.1018066750
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1039/c3ob40842f schema:sameAs https://app.dimensions.ai/details/publication/pub.1029933057
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1039/c4cc07588a schema:sameAs https://app.dimensions.ai/details/publication/pub.1044052733
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1039/c5cc00530b schema:sameAs https://app.dimensions.ai/details/publication/pub.1039555805
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1073/pnas.0908463107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000572076
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1073/pnas.1013804107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004393126
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1073/pnas.1213933109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041959091
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1073/pnas.122247199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030575576
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1074/jbc.m113.532580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004810873
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1080/15257770.2014.978011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048234278
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1080/15257770500377714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016737554
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1089/nat.2012.0382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078652684
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1089/nat.2014.0506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004129024
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1093/nar/22.14.2817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004240591
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1093/nar/22.15.3226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016334748
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1093/nar/22.16.3418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045232833
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1093/nar/25.22.4581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031134412
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1093/nar/27.6.1561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015209663
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1093/nar/27.8.1788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047139543
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1093/nar/29.15.3154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053319781
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1093/nar/gkf502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032347250
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1093/nar/gkg370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003121845
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1093/nar/gkg371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043570132
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1093/nar/gkh542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009070738
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1093/nar/gki628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047175644
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1093/nar/gkl637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001103261
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1093/nar/gkm395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013772976
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1093/nar/gkm520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019496304
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1093/nar/gkn404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034594144
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1093/nar/gkn956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052656868
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1093/nar/gkq1053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039643976
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1093/nar/gkv367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047661951
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1093/nar/gkv734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046706129
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1093/nar/gkv789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031041883
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1093/nar/gnf138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032083313
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1093/nass/nrl016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048959344
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1126/science.1217622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033371431
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1126/science.2200121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062527213
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1128/mcb.23.14.5107-5112.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037624047
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1128/mcb.25.16.7137-7143.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050647069
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1155/2012/530963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044470311
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1263/jbb.101.449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029780934
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1371/journal.pone.0070892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038878568
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1371/journal.pone.0102126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026337538
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1373/clinchem.2013.205211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035775146
438 rdf:type schema:CreativeWork
439 https://doi.org/10.2144/05382rr02 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069097008
440 rdf:type schema:CreativeWork
441 https://doi.org/10.2174/138161212799958387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069168129
442 rdf:type schema:CreativeWork
443 https://doi.org/10.2174/1389450043345074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069180156
444 rdf:type schema:CreativeWork
445 https://doi.org/10.3389/fmicb.2014.00465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050303742
446 rdf:type schema:CreativeWork
447 https://doi.org/10.3389/fmicb.2014.00565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048803916
448 rdf:type schema:CreativeWork
449 https://doi.org/10.3389/fmicb.2015.00755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004905962
450 rdf:type schema:CreativeWork
451 https://doi.org/10.3390/molecules15085423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000639951
452 rdf:type schema:CreativeWork
453 https://doi.org/10.3390/molecules171113569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019442915
454 rdf:type schema:CreativeWork
455 https://doi.org/10.3390/molecules200711959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016998831
456 rdf:type schema:CreativeWork
457 https://doi.org/10.3390/molecules200916643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045966488
458 rdf:type schema:CreativeWork
459 https://doi.org/10.4161/adna.28422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072289403
460 rdf:type schema:CreativeWork
461 https://www.grid.ac/institutes/grid.418899.5 schema:alternateName Engelhardt Institute of Molecular Biology
462 schema:name Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
463 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...