N-Glycosylation in progression of skin cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-29

AUTHORS

Ling Tang, Xiaoping Chen, Xu Zhang, Yeye Guo, Juan Su, Jianglin Zhang, Cong Peng, Xiang Chen

ABSTRACT

Skin cancer can be classified as cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Due to the high level of morbidity and mortality, skin cancer has become a global public health issue worldwide while the pathogenesis of skin cancer is still unclear. It is necessary to further identify the pathogenesis of skin cancer and find candidate targets to diagnose and treat skin cancer. A variety of factors are known to be associated with skin cancer including N-glycosylation, which partly explained the malignant behaviors of skin cancer. In this review, we retrieved databases such as PubMed and Web of Science to elucidate its relationship between glycosylation and skin cancer. We summarized some key glycosyltransferases and proteins during the process of N-glycosylation related to skin cancer, which was helpful to unmask the additional mechanism of skin cancer and find some novel targets of skin cancer. More... »

PAGES

50

References to SciGraph publications

  • 2005-10-27. Characterization of glycosylation and adherent properties of melanoma cell lines in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2013-10-31. α2,6 Sialylation associated with increased β1,6-branched N-oligosaccharides influences cellular adhesion and invasion in JOURNAL OF BIOSCIENCES
  • 2012-06-22. Vertebrate protein glycosylation: diversity, synthesis and function in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2002-08-06. Tissue distribution and differential expression of melanocortin 1 receptor, a malignant melanoma marker in BRITISH JOURNAL OF CANCER
  • 2011-09-13. Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database in SCIENTIFIC REPORTS
  • 2017-10-03. Ibrutinib modulates the immunosuppressive CLL microenvironment through STAT3-mediated suppression of regulatory B-cell function and inhibition of the PD-1/PD-L1 pathway in LEUKEMIA
  • 2016-11-21. N-linked glycosylation at Asn152 on CD147 affects protein folding and stability: promoting tumour metastasis in hepatocellular carcinoma in SCIENTIFIC REPORTS
  • 2016-07-18. Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma in NATURE COMMUNICATIONS
  • 1995-06. Changes of β-1,4-N-acetylglucosaminyltransferase III (GnT-III) in patients with leukaemia in GLYCOCONJUGATE JOURNAL
  • 2016-08-30. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity in NATURE COMMUNICATIONS
  • 1999-09. Cell Adhesion Molecules in the Development and Progression of Malignant Melanoma in CANCER AND METASTASIS REVIEWS
  • 2017-02-06. An unexpected N-terminal loop in PD-1 dominates binding by nivolumab in NATURE COMMUNICATIONS
  • 2018-02-05. Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death in JOURNAL OF OVARIAN RESEARCH
  • 2015-01-29. β1,6-N-acetylglucosaminyltransferase V predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection in WORLD JOURNAL OF UROLOGY
  • 2017-10-05. FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation in BREAST CANCER RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s12032-019-1270-4

    DOI

    http://dx.doi.org/10.1007/s12032-019-1270-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113808636

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31037368


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Basal Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Squamous Cell", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glycoproteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glycosylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glycosyltransferases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Melanoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Skin Neoplasms", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China", 
              "id": "http://www.grid.ac/institutes/grid.216417.7", 
              "name": [
                "Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China", 
                "Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China", 
                "Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China", 
                "Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tang", 
            "givenName": "Ling", 
            "id": "sg:person.014175436460.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014175436460.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China", 
              "id": "http://www.grid.ac/institutes/grid.216417.7", 
              "name": [
                "Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Xiaoping", 
            "id": "sg:person.01116642052.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116642052.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China", 
              "id": "http://www.grid.ac/institutes/grid.452223.0", 
              "name": [
                "Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China", 
                "Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China", 
                "Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Xu", 
            "id": "sg:person.0722054711.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722054711.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China", 
              "id": "http://www.grid.ac/institutes/grid.452223.0", 
              "name": [
                "Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China", 
                "Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China", 
                "Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guo", 
            "givenName": "Yeye", 
            "id": "sg:person.014260433663.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014260433663.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China", 
              "id": "http://www.grid.ac/institutes/grid.452223.0", 
              "name": [
                "Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China", 
                "Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China", 
                "Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Su", 
            "givenName": "Juan", 
            "id": "sg:person.0617704142.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617704142.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China", 
              "id": "http://www.grid.ac/institutes/grid.452223.0", 
              "name": [
                "Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China", 
                "Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China", 
                "Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Jianglin", 
            "id": "sg:person.01242657264.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242657264.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China", 
              "id": "http://www.grid.ac/institutes/grid.216417.7", 
              "name": [
                "Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China", 
                "Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China", 
                "Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China", 
                "Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peng", 
            "givenName": "Cong", 
            "id": "sg:person.0715767315.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715767315.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China", 
              "id": "http://www.grid.ac/institutes/grid.216417.7", 
              "name": [
                "Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China", 
                "Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China", 
                "Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China", 
                "Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Xiang", 
            "id": "sg:person.016317172774.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016317172774.87"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00262-005-0019-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005549827", 
              "https://doi.org/10.1007/s00262-005-0019-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13058-017-0904-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092106901", 
              "https://doi.org/10.1186/s13058-017-0904-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00731325", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005997993", 
              "https://doi.org/10.1007/bf00731325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00345-014-1451-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032321979", 
              "https://doi.org/10.1007/s00345-014-1451-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms14369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083685765", 
              "https://doi.org/10.1038/ncomms14369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms12632", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038663513", 
              "https://doi.org/10.1038/ncomms12632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13048-018-0385-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100823977", 
              "https://doi.org/10.1186/s13048-018-0385-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep35210", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007475546", 
              "https://doi.org/10.1038/srep35210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1006304806799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044128575", 
              "https://doi.org/10.1023/a:1006304806799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12038-013-9382-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005327074", 
              "https://doi.org/10.1007/s12038-013-9382-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2017.304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092063518", 
              "https://doi.org/10.1038/leu.2017.304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep00090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028756424", 
              "https://doi.org/10.1038/srep00090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6600441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020366732", 
              "https://doi.org/10.1038/sj.bjc.6600441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030860102", 
              "https://doi.org/10.1038/nrm3383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms12048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012084839", 
              "https://doi.org/10.1038/ncomms12048"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04-29", 
        "datePublishedReg": "2019-04-29", 
        "description": "Skin cancer can be classified as cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Due to the high level of morbidity and mortality, skin cancer has become a global public health issue worldwide while the pathogenesis of skin cancer is still unclear. It is necessary to further identify the pathogenesis of skin cancer and find candidate targets to diagnose and treat skin cancer. A variety of factors are known to be associated with skin cancer including N-glycosylation, which partly explained the malignant behaviors of skin cancer. In this review, we retrieved databases such as PubMed and Web of Science to elucidate its relationship between glycosylation and skin cancer. We summarized some key glycosyltransferases and proteins during the process of N-glycosylation related to skin cancer, which was helpful to unmask the additional mechanism of skin cancer and find some novel targets of skin cancer.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s12032-019-1270-4", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8342843", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8370827", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8339084", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8351515", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8356772", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1094524", 
            "issn": [
              "1357-0560", 
              "1559-131X"
            ], 
            "name": "Medical Oncology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "36"
          }
        ], 
        "keywords": [
          "skin cancer", 
          "cell carcinoma", 
          "global public health issue", 
          "squamous cell carcinoma", 
          "cutaneous malignant melanoma", 
          "basal cell carcinoma", 
          "public health issue", 
          "Web of Science", 
          "malignant melanoma", 
          "malignant behavior", 
          "cancer", 
          "novel target", 
          "health issues", 
          "carcinoma", 
          "pathogenesis", 
          "candidate targets", 
          "key glycosyltransferases", 
          "variety of factors", 
          "additional mechanism", 
          "high levels", 
          "morbidity", 
          "melanoma", 
          "PubMed", 
          "mortality", 
          "progression", 
          "target", 
          "N-glycosylation", 
          "review", 
          "levels", 
          "factors", 
          "database", 
          "protein", 
          "mechanism", 
          "glycosylation", 
          "relationship", 
          "Web", 
          "variety", 
          "glycosyltransferases", 
          "issues", 
          "behavior", 
          "science", 
          "process"
        ], 
        "name": "N-Glycosylation in progression of skin cancer", 
        "pagination": "50", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113808636"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s12032-019-1270-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "31037368"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s12032-019-1270-4", 
          "https://app.dimensions.ai/details/publication/pub.1113808636"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:45", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_803.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s12032-019-1270-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12032-019-1270-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12032-019-1270-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12032-019-1270-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12032-019-1270-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    270 TRIPLES      21 PREDICATES      92 URIs      69 LITERALS      17 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s12032-019-1270-4 schema:about N00d3ee1ae80845e0b5a30e9db74e11da
    2 N03564c7481504bb891f38cf11a1a7c00
    3 N589de486144243ad9ba4e780e901e261
    4 N8cc2bd3977194fcaa9a867e478f837ba
    5 N91971ea54b454bc185c0c300a71cce5b
    6 Nb53e82e1ab304d4096d5793763372122
    7 Nbb4a77d5bdb34859af92718e052db3a3
    8 Ncff7f89d085343fa84eec118fc9589ae
    9 Nec7dea8935db4828b614b7dfa5eefb09
    10 Nf0c54e74aa2c495daca4954aa1e255c9
    11 anzsrc-for:11
    12 anzsrc-for:1112
    13 schema:author Na051223e15d744eeabbc1926d563bb5f
    14 schema:citation sg:pub.10.1007/bf00731325
    15 sg:pub.10.1007/s00262-005-0019-4
    16 sg:pub.10.1007/s00345-014-1451-x
    17 sg:pub.10.1007/s12038-013-9382-z
    18 sg:pub.10.1023/a:1006304806799
    19 sg:pub.10.1038/leu.2017.304
    20 sg:pub.10.1038/ncomms12048
    21 sg:pub.10.1038/ncomms12632
    22 sg:pub.10.1038/ncomms14369
    23 sg:pub.10.1038/nrm3383
    24 sg:pub.10.1038/sj.bjc.6600441
    25 sg:pub.10.1038/srep00090
    26 sg:pub.10.1038/srep35210
    27 sg:pub.10.1186/s13048-018-0385-0
    28 sg:pub.10.1186/s13058-017-0904-8
    29 schema:datePublished 2019-04-29
    30 schema:datePublishedReg 2019-04-29
    31 schema:description Skin cancer can be classified as cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma. Due to the high level of morbidity and mortality, skin cancer has become a global public health issue worldwide while the pathogenesis of skin cancer is still unclear. It is necessary to further identify the pathogenesis of skin cancer and find candidate targets to diagnose and treat skin cancer. A variety of factors are known to be associated with skin cancer including N-glycosylation, which partly explained the malignant behaviors of skin cancer. In this review, we retrieved databases such as PubMed and Web of Science to elucidate its relationship between glycosylation and skin cancer. We summarized some key glycosyltransferases and proteins during the process of N-glycosylation related to skin cancer, which was helpful to unmask the additional mechanism of skin cancer and find some novel targets of skin cancer.
    32 schema:genre article
    33 schema:isAccessibleForFree false
    34 schema:isPartOf N15522fb23397465e96b0f68c49671201
    35 Nf25516f38eb64461b1ef3a0b4afc296c
    36 sg:journal.1094524
    37 schema:keywords N-glycosylation
    38 PubMed
    39 Web
    40 Web of Science
    41 additional mechanism
    42 basal cell carcinoma
    43 behavior
    44 cancer
    45 candidate targets
    46 carcinoma
    47 cell carcinoma
    48 cutaneous malignant melanoma
    49 database
    50 factors
    51 global public health issue
    52 glycosylation
    53 glycosyltransferases
    54 health issues
    55 high levels
    56 issues
    57 key glycosyltransferases
    58 levels
    59 malignant behavior
    60 malignant melanoma
    61 mechanism
    62 melanoma
    63 morbidity
    64 mortality
    65 novel target
    66 pathogenesis
    67 process
    68 progression
    69 protein
    70 public health issue
    71 relationship
    72 review
    73 science
    74 skin cancer
    75 squamous cell carcinoma
    76 target
    77 variety
    78 variety of factors
    79 schema:name N-Glycosylation in progression of skin cancer
    80 schema:pagination 50
    81 schema:productId N3e4a8ea3b02049019c0b64949764da10
    82 N5500837526eb4b729680c2ef93b5401b
    83 Nef3a9bac658a494f92bec65aebddb5cf
    84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113808636
    85 https://doi.org/10.1007/s12032-019-1270-4
    86 schema:sdDatePublished 2022-10-01T06:45
    87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    88 schema:sdPublisher Ncfd76b8c04154b12baa1b562a97633ab
    89 schema:url https://doi.org/10.1007/s12032-019-1270-4
    90 sgo:license sg:explorer/license/
    91 sgo:sdDataset articles
    92 rdf:type schema:ScholarlyArticle
    93 N00d3ee1ae80845e0b5a30e9db74e11da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Humans
    95 rdf:type schema:DefinedTerm
    96 N03564c7481504bb891f38cf11a1a7c00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Carcinoma, Basal Cell
    98 rdf:type schema:DefinedTerm
    99 N15522fb23397465e96b0f68c49671201 schema:volumeNumber 36
    100 rdf:type schema:PublicationVolume
    101 N2c452f9e4fea44c3b26dc9742c8f9832 rdf:first sg:person.0715767315.55
    102 rdf:rest N54a0c764238e4241bfd5027fbf8b23de
    103 N3e4a8ea3b02049019c0b64949764da10 schema:name dimensions_id
    104 schema:value pub.1113808636
    105 rdf:type schema:PropertyValue
    106 N54a0c764238e4241bfd5027fbf8b23de rdf:first sg:person.016317172774.87
    107 rdf:rest rdf:nil
    108 N5500837526eb4b729680c2ef93b5401b schema:name doi
    109 schema:value 10.1007/s12032-019-1270-4
    110 rdf:type schema:PropertyValue
    111 N589de486144243ad9ba4e780e901e261 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Glycosyltransferases
    113 rdf:type schema:DefinedTerm
    114 N686b538cb4cf4b4389b8d2942738a911 rdf:first sg:person.014260433663.13
    115 rdf:rest Nfa30341776e341c3afa83be83a043c22
    116 N6d8ca4cbc0fd46379985d3e4c80dc3da rdf:first sg:person.01242657264.33
    117 rdf:rest N2c452f9e4fea44c3b26dc9742c8f9832
    118 N8cc2bd3977194fcaa9a867e478f837ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Carcinoma, Squamous Cell
    120 rdf:type schema:DefinedTerm
    121 N91971ea54b454bc185c0c300a71cce5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Glycoproteins
    123 rdf:type schema:DefinedTerm
    124 N93d265236a0c48c897e03532dfca54bb rdf:first sg:person.01116642052.50
    125 rdf:rest Nfce9dc1b3ffe4fe6805b33eb2e90587d
    126 Na051223e15d744eeabbc1926d563bb5f rdf:first sg:person.014175436460.42
    127 rdf:rest N93d265236a0c48c897e03532dfca54bb
    128 Nb53e82e1ab304d4096d5793763372122 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Skin Neoplasms
    130 rdf:type schema:DefinedTerm
    131 Nbb4a77d5bdb34859af92718e052db3a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Melanoma
    133 rdf:type schema:DefinedTerm
    134 Ncfd76b8c04154b12baa1b562a97633ab schema:name Springer Nature - SN SciGraph project
    135 rdf:type schema:Organization
    136 Ncff7f89d085343fa84eec118fc9589ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Signal Transduction
    138 rdf:type schema:DefinedTerm
    139 Nec7dea8935db4828b614b7dfa5eefb09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Biomarkers, Tumor
    141 rdf:type schema:DefinedTerm
    142 Nef3a9bac658a494f92bec65aebddb5cf schema:name pubmed_id
    143 schema:value 31037368
    144 rdf:type schema:PropertyValue
    145 Nf0c54e74aa2c495daca4954aa1e255c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Glycosylation
    147 rdf:type schema:DefinedTerm
    148 Nf25516f38eb64461b1ef3a0b4afc296c schema:issueNumber 6
    149 rdf:type schema:PublicationIssue
    150 Nfa30341776e341c3afa83be83a043c22 rdf:first sg:person.0617704142.91
    151 rdf:rest N6d8ca4cbc0fd46379985d3e4c80dc3da
    152 Nfce9dc1b3ffe4fe6805b33eb2e90587d rdf:first sg:person.0722054711.00
    153 rdf:rest N686b538cb4cf4b4389b8d2942738a911
    154 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    155 schema:name Medical and Health Sciences
    156 rdf:type schema:DefinedTerm
    157 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    158 schema:name Oncology and Carcinogenesis
    159 rdf:type schema:DefinedTerm
    160 sg:grant.8339084 http://pending.schema.org/fundedItem sg:pub.10.1007/s12032-019-1270-4
    161 rdf:type schema:MonetaryGrant
    162 sg:grant.8342843 http://pending.schema.org/fundedItem sg:pub.10.1007/s12032-019-1270-4
    163 rdf:type schema:MonetaryGrant
    164 sg:grant.8351515 http://pending.schema.org/fundedItem sg:pub.10.1007/s12032-019-1270-4
    165 rdf:type schema:MonetaryGrant
    166 sg:grant.8356772 http://pending.schema.org/fundedItem sg:pub.10.1007/s12032-019-1270-4
    167 rdf:type schema:MonetaryGrant
    168 sg:grant.8370827 http://pending.schema.org/fundedItem sg:pub.10.1007/s12032-019-1270-4
    169 rdf:type schema:MonetaryGrant
    170 sg:journal.1094524 schema:issn 1357-0560
    171 1559-131X
    172 schema:name Medical Oncology
    173 schema:publisher Springer Nature
    174 rdf:type schema:Periodical
    175 sg:person.01116642052.50 schema:affiliation grid-institutes:grid.216417.7
    176 schema:familyName Chen
    177 schema:givenName Xiaoping
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116642052.50
    179 rdf:type schema:Person
    180 sg:person.01242657264.33 schema:affiliation grid-institutes:grid.452223.0
    181 schema:familyName Zhang
    182 schema:givenName Jianglin
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242657264.33
    184 rdf:type schema:Person
    185 sg:person.014175436460.42 schema:affiliation grid-institutes:grid.216417.7
    186 schema:familyName Tang
    187 schema:givenName Ling
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014175436460.42
    189 rdf:type schema:Person
    190 sg:person.014260433663.13 schema:affiliation grid-institutes:grid.452223.0
    191 schema:familyName Guo
    192 schema:givenName Yeye
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014260433663.13
    194 rdf:type schema:Person
    195 sg:person.016317172774.87 schema:affiliation grid-institutes:grid.216417.7
    196 schema:familyName Chen
    197 schema:givenName Xiang
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016317172774.87
    199 rdf:type schema:Person
    200 sg:person.0617704142.91 schema:affiliation grid-institutes:grid.452223.0
    201 schema:familyName Su
    202 schema:givenName Juan
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617704142.91
    204 rdf:type schema:Person
    205 sg:person.0715767315.55 schema:affiliation grid-institutes:grid.216417.7
    206 schema:familyName Peng
    207 schema:givenName Cong
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715767315.55
    209 rdf:type schema:Person
    210 sg:person.0722054711.00 schema:affiliation grid-institutes:grid.452223.0
    211 schema:familyName Zhang
    212 schema:givenName Xu
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722054711.00
    214 rdf:type schema:Person
    215 sg:pub.10.1007/bf00731325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005997993
    216 https://doi.org/10.1007/bf00731325
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1007/s00262-005-0019-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005549827
    219 https://doi.org/10.1007/s00262-005-0019-4
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1007/s00345-014-1451-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032321979
    222 https://doi.org/10.1007/s00345-014-1451-x
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1007/s12038-013-9382-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1005327074
    225 https://doi.org/10.1007/s12038-013-9382-z
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1023/a:1006304806799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044128575
    228 https://doi.org/10.1023/a:1006304806799
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/leu.2017.304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092063518
    231 https://doi.org/10.1038/leu.2017.304
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/ncomms12048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012084839
    234 https://doi.org/10.1038/ncomms12048
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/ncomms12632 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038663513
    237 https://doi.org/10.1038/ncomms12632
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/ncomms14369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083685765
    240 https://doi.org/10.1038/ncomms14369
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nrm3383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030860102
    243 https://doi.org/10.1038/nrm3383
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/sj.bjc.6600441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020366732
    246 https://doi.org/10.1038/sj.bjc.6600441
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1038/srep00090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028756424
    249 https://doi.org/10.1038/srep00090
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1038/srep35210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007475546
    252 https://doi.org/10.1038/srep35210
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1186/s13048-018-0385-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100823977
    255 https://doi.org/10.1186/s13048-018-0385-0
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1186/s13058-017-0904-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092106901
    258 https://doi.org/10.1186/s13058-017-0904-8
    259 rdf:type schema:CreativeWork
    260 grid-institutes:grid.216417.7 schema:alternateName Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China
    261 schema:name Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China
    262 Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
    263 Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China
    264 Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China
    265 rdf:type schema:Organization
    266 grid-institutes:grid.452223.0 schema:alternateName Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China
    267 schema:name Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China
    268 Hunan Engineering Research Center of Skin Health and Disease, Changsha, Hunan, China
    269 Hunan Key Laboratory of Skin Cancer and Psoriasis, Changsha, Hunan, China
    270 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...