Deficiency of mismatch repair genes is less frequently observed in signet ring cell compared with non-signet ring cell gastric cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-01-29

AUTHORS

Yosuke Hirotsu, Hitoshi Mochizuki, Kenji Amemiya, Hiroshi Ohyama, Dai Yoshimura, Hiroyuki Amano, Yuko Miura, Hiroshi Ashizawa, Keiko Nakagomi, Shinya Takaoka, Kenji Hosoda, Yoji Suzuki, Toshio Oyama, Masao Hada, Yuichiro Kojima, Masao Omata

ABSTRACT

Signet ring cell (SRC) gastric cancer at advanced stage has poor prognosis. While a recent study reported nearly one-third of SRC cases contain tumors with deficient mismatch repair (MMR) genes, other studies in SRC have been inconclusive. To re-analyze the results, we performed immunohistochemical staining of MLH1, MSH2, MSH6 and PMS2 proteins in 38 SRC gastric tumors compared with 109 non-SRC (NSRC) tumors from 94 patients. In contrast to the previous study, all SRC gastric tumors normally expressed MMR proteins, whereas 22 of 109 of NSRC (20%) showed deficient MMR proteins. To reinforce our results, we referred to the Cancer Genome Atlas (TCGA) genomic database and found that only 6 (6%) of 99 samples with diffuse gastric tumors showed deficient MMR, whereas 64 (21%) of 304 in intestinal gastric tumors showed deficient MMR. Our results as well as the TCGA database indicated that MMR genes are infrequently inactivated in SRC gastric cancer. These findings indicate that SRC patients may not be the best candidates for immuno-oncology therapy. More... »

PAGES

23

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12032-019-1246-4

DOI

http://dx.doi.org/10.1007/s12032-019-1246-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111764345

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30694393


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29 schema:description Signet ring cell (SRC) gastric cancer at advanced stage has poor prognosis. While a recent study reported nearly one-third of SRC cases contain tumors with deficient mismatch repair (MMR) genes, other studies in SRC have been inconclusive. To re-analyze the results, we performed immunohistochemical staining of MLH1, MSH2, MSH6 and PMS2 proteins in 38 SRC gastric tumors compared with 109 non-SRC (NSRC) tumors from 94 patients. In contrast to the previous study, all SRC gastric tumors normally expressed MMR proteins, whereas 22 of 109 of NSRC (20%) showed deficient MMR proteins. To reinforce our results, we referred to the Cancer Genome Atlas (TCGA) genomic database and found that only 6 (6%) of 99 samples with diffuse gastric tumors showed deficient MMR, whereas 64 (21%) of 304 in intestinal gastric tumors showed deficient MMR. Our results as well as the TCGA database indicated that MMR genes are infrequently inactivated in SRC gastric cancer. These findings indicate that SRC patients may not be the best candidates for immuno-oncology therapy.
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37 MMR
38 MMR genes
39 MMR proteins
40 MSH2
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42 NSRC
43 PMS2 proteins
44 Recent studies
45 SRC cases
46 SRC gastric cancer
47 SRC patients
48 Src
49 TCGA database
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52 candidates
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54 cells
55 contrast
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57 deficiency
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63 genes
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69 one-third
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74 protein
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