High preoperative serum CA19-9 level is predictive of poor prognosis for patients with colorectal liver oligometastases undergoing hepatic resection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-10-08

AUTHORS

Zhenhai Lu, Jianhong Peng, Zhiqiang Wang, Zhizhong Pan, Yunfei Yuan, Desen Wan, Binkui Li

ABSTRACT

Oligometastasis is defined as a transitional state between localized and widespread systemic metastatic cancers. In colorectal cancer, the prognostic factors and prognostic value of preoperative serum carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) for patients with colorectal liver oligometastases (CLOM) undergoing hepatic resection have not been well explored. Therefore, the present study included 141 patients with CLOM (≤5 liver metastases) who underwent R0 resection from 2005 to 2012. The association of clinicopathological factors including preoperative CA19-9 and CEA levels with overall survival (OS) was analyzed with univariate and multivariate analyses. Kaplan–Meier analysis showed that patients with high CA19-9 levels tended to have poorer OS than those with low levels (median OS 21.5 vs. 64.0 months, P = 0.002). Preoperative CEA levels were not significantly associated with OS (P > 0.05). Univariate and multivariate analyses demonstrated that larger tumor size of liver metastases (HR 1.911; 95 % CI 1.172–3.114; P = 0.009), bilobar distribution (HR 1.776; 95 % CI 1.097–2.873; P = 0.019), and higher preoperative CA19-9 levels (HR 1.954; 95 % CI 1.177–3.242; P = 0.010) were independent predictors of poor OS for patients with CLOM. Our study identified tumor size, distribution, and preoperative CA19-9 levels as independent prognostic factors for OS of patients with CLOM. In particular, measurement of preoperative CA19-9 levels offers an easy tool that could help identify high-risk patients and aid in improving the management of patients with CLOM. More... »

PAGES

121

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12032-016-0838-5

DOI

http://dx.doi.org/10.1007/s12032-016-0838-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052669411

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27722895


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79 poor OS
80 poor prognosis
81 predictors
82 preoperative CA19-9
83 preoperative CA19-9 levels
84 preoperative CEA level
85 preoperative serum CA19-9 level
86 preoperative serum carbohydrate antigen 19
87 present study
88 prognosis
89 prognostic factors
90 prognostic value
91 resection
92 serum CA19-9 levels
93 serum carbohydrate antigen 19
94 size
95 state
96 study
97 survival
98 systemic metastatic cancer
99 tool
100 transitional state
101 tumor size
102 univariate
103 values
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