Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-04

AUTHORS

Yuqing Lou, Rong Li, Jielin Liu, Yanwei Zhang, Xueyan Zhang, Bo Jin, Ya Liu, Zuoguang Wang, Hua Zhong, Shaojun Wen, Baohui Han

ABSTRACT

Mitofusin-2 (MFN2) is a mitochondrial protein associated with mitochondrial fusion process. It was initially identified as a hyperplasia suppressor and implicated in Charcot-Marie-Tooth disease. Recent studies showed that MFN2 played important roles in the development of multiple tumors. Here we examined MFN2 expression in 30 lung adenocarcinoma samples and revealed that the expression of MFN2 was significantly higher in lung adenocarcinoma tissues as compared to adjacent normal tissues. We then investigated the impact of MFN2 knockdown on A549 human lung adenocarcinoma cells and showed that cell proliferation, cell cycle and invasion behavior were all deregulated by MFN2 knockdown. And deregulation of cell cycle pathway after MFN2 knockdown was confirmed by microarray analysis. Furthermore, microarray analysis also revealed that different oncogenes such as RAP1A, RALB and ITGA2 were oppositely regulated by MFN2, which provided molecular clues for the paradoxical functions of MFN2 in tumor development. Taken together, our study unraveled the tumor-promoting functions of MFN2 in lung adenocarcinoma and implicated that the role of MFN2 in cancer development might be more complicated than expected and should be explored in detail in the future. More... »

PAGES

132

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12032-015-0515-0

DOI

http://dx.doi.org/10.1007/s12032-015-0515-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006248197

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25796500


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