Prognostic significance of serum beta-2 microglobulin level in Hodgkin lymphoma treated with ABVD-based therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08-21

AUTHORS

Yuki Nakajima, Naoto Tomita, Reina Watanabe, Yasufumi Ishiyama, Eri Yamamoto, Daisuke Ishibashi, Megumi Itabashi, Satoshi Koyama, Hiroyuki Takahashi, Ayumi Numata, Hirotaka Takasaki, Rika Kawasaki, Hideyuki Kuwabara, Masatsugu Tanaka, Chizuko Hashimoto, Katsumichi Fujimaki, Rika Sakai, Shigeki Motomura, Yoshiaki Ishigatsubo

ABSTRACT

The levels of serum beta-2 microglobulin (β2MG) are determined mainly from lymphoid tissue. To examine its prognostic value in Hodgkin lymphoma (HL), we conducted a retrospective analysis. We analyzed 67 patients with HL diagnosed and treated at seven institutes of the Yokohama City University Hematology Group between 1998 and 2011. The patients included 40 males and 27 females with a median age of 41 years (range 16–81 years). The HL subtypes were nodular sclerosis classical HL in 37 patients, mixed cellular classical HL in 23, lymphocyte-rich classical HL in 6, and nodular lymphocyte-predominant HL in 1. The 4-year overall survival (OS) rate of all 67 patients was 89 %. Patients with β2MG levels ≥2.5 mg/L (n = 18) showed inferior progression-free survival (PFS; 4-year PFS rate, 42 %) and inferior OS (4-year OS rate, 60 %) compared to patients who had β2MG levels <2.5 mg/L (n = 49; 4-year PFS rate, 87 %; 4-year OS rate, 98 %; P < 0.001). In multivariate analysis, only a serum β2MG level ≥2.5 mg/L was a significant adverse prognostic factor in regard to PFS (P = 0.04; relative risk 3.57). However, it was not significant prognostic factor for OS (P = 0.16) in the multivariate analysis. The serum β2MG level at diagnosis is a useful prognostic marker in patients with HL. More... »

PAGES

185

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12032-014-0185-3

DOI

http://dx.doi.org/10.1007/s12032-014-0185-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052474285

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25142947


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364 grid-institutes:grid.414944.8 schema:alternateName Department of Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan
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370 grid-institutes:grid.460144.3 schema:alternateName Department of Hematology, Yamato Municipal Hospital, Yamato, Japan
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