Serum ferritin level is prognostic of patient outcome in extranodal NK/T cell lymphoma, nasal type View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-08-10

AUTHORS

Etsuko Yamazaki, Naoto Tomita, Satoshi Koyama, Eriko Ogusa, Yoshimi Ishii, Hiroyuki Takahashi, Kazuho Miyashita, Shiro Matsuura, Takayoshi Tachibana, Hirotaka Takasaki, Sachiya Takemura, Katsumichi Fujimaki, Rika Sakai, Shin Fujisawa, Yoshiaki Ishigatsubo

ABSTRACT

The objective of the current study was to assess the prognostic factors in patients with extranodal natural killer (NK)/T cell lymphoma, nasal type (ENKL). We retrospectively analyzed 35 patients who were diagnosed with ENKL between 1998 and 2011. The median patient age was 63 years, and the male/female ratio was 22:13; twenty patients had localized ENKL, and 26 had a good Eastern Cooperative Oncology Group performance status (score 0 or 1). B symptoms were present in 17 patients. Twenty-five patients presented with nasal or paranasal lesions, or both. With a median follow-up duration among patients still alive at their last follow-up of 47 months (range 8–93 months), the 3-year overall survival (OS) rate was 44.5 %. Multivariate analysis revealed that advanced disease stage (P = 0.002), the presence of extranasal disease (P = 0.013), and serum ferritin levels greater than 300 ng/ml (P < 0.001) were significant and independent (negative) prognostic factors. High serum ferritin levels were associated with the presence of B symptoms, elevated lactate dehydrogenase levels, and high soluble interleukin-2 receptor levels, but not with clinical stage. Patients with high ferritin levels had a remarkably low remission rate (23 %) and a short OS time (median: 4 months). Serum ferritin level at the time of diagnosis of ENKL was a useful prognostic factor. More... »

PAGES

149

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12032-014-0149-7

DOI

http://dx.doi.org/10.1007/s12032-014-0149-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021716822

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25108598


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23 schema:description The objective of the current study was to assess the prognostic factors in patients with extranodal natural killer (NK)/T cell lymphoma, nasal type (ENKL). We retrospectively analyzed 35 patients who were diagnosed with ENKL between 1998 and 2011. The median patient age was 63 years, and the male/female ratio was 22:13; twenty patients had localized ENKL, and 26 had a good Eastern Cooperative Oncology Group performance status (score 0 or 1). B symptoms were present in 17 patients. Twenty-five patients presented with nasal or paranasal lesions, or both. With a median follow-up duration among patients still alive at their last follow-up of 47 months (range 8–93 months), the 3-year overall survival (OS) rate was 44.5 %. Multivariate analysis revealed that advanced disease stage (P = 0.002), the presence of extranasal disease (P = 0.013), and serum ferritin levels greater than 300 ng/ml (P < 0.001) were significant and independent (negative) prognostic factors. High serum ferritin levels were associated with the presence of B symptoms, elevated lactate dehydrogenase levels, and high soluble interleukin-2 receptor levels, but not with clinical stage. Patients with high ferritin levels had a remarkably low remission rate (23 %) and a short OS time (median: 4 months). Serum ferritin level at the time of diagnosis of ENKL was a useful prognostic factor.
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30 schema:keywords Cooperative Oncology Group performance status
31 ENKL
32 Eastern Cooperative Oncology Group performance status
33 Group performance status
34 NK/T cell lymphoma
35 OS time
36 Oncology Group performance status
37 T cell lymphoma
38 advanced disease stage
39 age
40 analysis
41 cell lymphoma
42 clinical stage
43 current study
44 dehydrogenase levels
45 diagnosis
46 disease
47 disease stage
48 duration
49 elevated lactate dehydrogenase level
50 extranodal NK/T cell lymphoma
51 extranodal natural killer
52 factors
53 female ratio
54 ferritin levels
55 follow
56 good Eastern Cooperative Oncology Group performance status
57 high ferritin levels
58 high serum ferritin levels
59 high soluble interleukin-2 receptor levels
60 independent prognostic factor
61 interleukin-2 receptor levels
62 killer
63 lactate dehydrogenase levels
64 lesions
65 levels
66 lower remission rate
67 lymphoma
68 median follow
69 median patient age
70 months
71 multivariate analysis
72 nasal type
73 natural killer
74 objective
75 outcomes
76 overall survival rate
77 paranasal lesions
78 patient age
79 patient outcomes
80 patients
81 performance status
82 presence
83 prognostic factors
84 rate
85 ratio
86 receptor levels
87 remission rate
88 serum ferritin levels
89 shorter OS times
90 soluble interleukin-2 receptor levels
91 stage
92 status
93 study
94 survival rate
95 symptoms
96 time
97 time of diagnosis
98 types
99 useful prognostic factor
100 years
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