Granulocyte–macrophage colony-stimulating factor: not just another haematopoietic growth factor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-11-22

AUTHORS

Alejandro Francisco-Cruz, Miguel Aguilar-Santelises, Octavio Ramos-Espinosa, Dulce Mata-Espinosa, Brenda Marquina-Castillo, Jorge Barrios-Payan, Rogelio Hernandez-Pando

ABSTRACT

Granulocyte–macrophage colony-stimulating factor (GM-CSF) is often used to treat leucopenia. Other haematopoietins may increase the number of circulating leucocytes with higher efficiency, but GM-CSF has additional effects that may be far more relevant than its haematopoietic activity. GM-CSF induces differentiation, proliferation and activation of macrophages and dendritic cells which are necessary for the subsequent T helper cell type 1 and cytotoxic T lymphocyte activation. GM-CSF haematopoietic and non-haematopoietic functions have pro-inflammatory and immune regulatory potential to treat a variety of autoimmune diseases and tumours. On the other hand, GM-CSF deficiency leads to various immune dysfunctions and the current utilization of GM-CSF as haematopoietic factor might be an accurate but very incomplete indication for a cytokine with vast clinical potential. More... »

PAGES

774

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12032-013-0774-6

DOI

http://dx.doi.org/10.1007/s12032-013-0774-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006601785

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24264600


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