Analysis of the clinico-hematological relevance of the breakpoint location within M-BCR in chronic myeloid leukemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-03

AUTHORS

Ayda Bennour, Ines Ouahchi, Bechir Achour, Monia Zaier, Yosra Ben Youssef, Abderrahim Khelif, Ali Saad, Halima Sennana

ABSTRACT

The Philadelphia chromosome (Ph) derives from the balanced translocation between chromosomes 9 and 22. This chromosomal translocation results in the fusion between the 5' part of the BCR gene, normally located on chromosome 22, and the 3' part of the ABL gene on chromosome 9 giving origin to a BCR-ABL fusion gene which is transcribed and then translated into a hybrid protein. In general, three breakpoint cluster regions in the BCR gene have been described: major (M-BCR), minor (m-BCR) and micro (μ-BCR). Three main variants of the BCR-ABL gene have been described depending on the length of the sequence of the BCR gene included that encode for the P190, P210, P230 proteins. Most patients (95 %) were found to have P210 protein that resulted from rearrangement in the M-BCR region in the BCR gene and thus gives rise to b2a2 or b3a2 variants. The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. These two variants are associated with distinct clinical types of human leukemias. In this study, we report the frequencies of M-BCR-ABL fusion transcripts in 44 CML patients and we review the data on the correlations between the type of M-BCR/ABL variant and the corresponding sex, age and biological features. Forty-four untreated chronic phase CML patients were studied. The type of BCR-ABL fusion transcripts was determined by reverse transcriptase polymerase chain reaction (RT-PCR). More than half of them showed b3a2 fusion transcript (64 %), while (36 %) showed b2a2 transcript. No patients coexpressed b3a2/b2a2. Correlation between biological data demonstrated that: (a) M-BCR rearrangements were not associated with the sex of the patients. (b) Patients with b3a2 rearrangements were older than patients with b2a2 transcripts. (c) M-BCR rearrangements were influenced neither by the white blood count (WBC) nor with hemoglobin levels. However, platelet level is more elevated in patients with b3a2 transcript (681.2/L vs. 207/L; P = 0.001). In conclusion, we observed significant correlations between age, platelet level and M-BCR-ABL transcript, these observations deserve further investigations. More... »

PAGES

348

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s12032-012-0348-z

DOI

http://dx.doi.org/10.1007/s12032-012-0348-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026427487

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23269583


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Breakpoints", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fusion Proteins, bcr-abl", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, abl", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukemia, Myelogenous, Chronic, BCR-ABL Positive", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multiplex Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Farhat Hached", 
          "id": "https://www.grid.ac/institutes/grid.412791.8", 
          "name": [
            "Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bennour", 
        "givenName": "Ayda", 
        "id": "sg:person.01047022623.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047022623.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Farhat Hached", 
          "id": "https://www.grid.ac/institutes/grid.412791.8", 
          "name": [
            "Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ouahchi", 
        "givenName": "Ines", 
        "id": "sg:person.01036432013.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036432013.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Farhat Hached", 
          "id": "https://www.grid.ac/institutes/grid.412791.8", 
          "name": [
            "Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Achour", 
        "givenName": "Bechir", 
        "id": "sg:person.012650461005.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012650461005.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Farhat Hached", 
          "id": "https://www.grid.ac/institutes/grid.412791.8", 
          "name": [
            "Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zaier", 
        "givenName": "Monia", 
        "id": "sg:person.01274406726.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274406726.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Farhat Hached", 
          "id": "https://www.grid.ac/institutes/grid.412791.8", 
          "name": [
            "Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Youssef", 
        "givenName": "Yosra Ben", 
        "id": "sg:person.01233270736.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233270736.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Farhat Hached", 
          "id": "https://www.grid.ac/institutes/grid.412791.8", 
          "name": [
            "Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khelif", 
        "givenName": "Abderrahim", 
        "id": "sg:person.01220773613.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220773613.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Farhat Hached", 
          "id": "https://www.grid.ac/institutes/grid.412791.8", 
          "name": [
            "Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saad", 
        "givenName": "Ali", 
        "id": "sg:person.0725660411.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725660411.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Farhat Hached", 
          "id": "https://www.grid.ac/institutes/grid.412791.8", 
          "name": [
            "Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sennana", 
        "givenName": "Halima", 
        "id": "sg:person.0725754374.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725754374.91"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1993.tb03062.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000608333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(00)00128-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003977228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trsl.2006.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003991995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-03-144790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005910896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2004.05100.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009900129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2009.009134", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010770814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(84)90077-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010898991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/243290a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012018569", 
          "https://doi.org/10.1038/243290a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1995.tb08362.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012508898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-4608(01)00515-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013369179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0145-2126(92)90039-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015074520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v98.7.2039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017936206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajh.20682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020857079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2000.02042.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021792984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2010.078311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022547207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10428199209067600", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023149540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.2870010211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024774830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2257.2002.00413.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025889145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2004.05119.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026328203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s1415-47572010005000037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026442663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19950915)76:6<992::aid-cncr2820760612>3.0.co;2-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031642677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034947020", 
          "https://doi.org/10.1038/sj.leu.2401592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.leu.2401592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034947020", 
          "https://doi.org/10.1038/sj.leu.2401592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2000.02216.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035348270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1990.tb02534.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037476101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038860727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1590/s1415-47572007000400003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041139564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-009-0822-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042485915", 
          "https://doi.org/10.1007/s00277-009-0822-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-009-0822-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042485915", 
          "https://doi.org/10.1007/s00277-009-0822-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00277-009-0822-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042485915", 
          "https://doi.org/10.1007/s00277-009-0822-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0609.2008.01170.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043104620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.2000.02216.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056733263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074701342", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074725983", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075059644", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077133620", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077188800", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077401174", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/08113/aim.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077637832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077745681", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078684723", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078747136", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078792352", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079286588", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079518676", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079593459", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082428034", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082428039", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082907725", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082972090", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082972092", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/97233rr01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083147709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083157854", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083379000", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-03", 
    "datePublishedReg": "2013-03-01", 
    "description": "The Philadelphia chromosome (Ph) derives from the balanced translocation between chromosomes 9 and 22. This chromosomal translocation results in the fusion between the 5' part of the BCR gene, normally located on chromosome 22, and the 3' part of the ABL gene on chromosome 9 giving origin to a BCR-ABL fusion gene which is transcribed and then translated into a hybrid protein. In general, three breakpoint cluster regions in the BCR gene have been described: major (M-BCR), minor (m-BCR) and micro (\u03bc-BCR). Three main variants of the BCR-ABL gene have been described depending on the length of the sequence of the BCR gene included that encode for the P190, P210, P230 proteins. Most patients (95 %) were found to have P210 protein that resulted from rearrangement in the M-BCR region in the BCR gene and thus gives rise to b2a2 or b3a2 variants. The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. These two variants are associated with distinct clinical types of human leukemias. In this study, we report the frequencies of M-BCR-ABL fusion transcripts in 44 CML patients and we review the data on the correlations between the type of M-BCR/ABL variant and the corresponding sex, age and biological features. Forty-four untreated chronic phase CML patients were studied. The type of BCR-ABL fusion transcripts was determined by reverse transcriptase polymerase chain reaction (RT-PCR). More than half of them showed b3a2 fusion transcript (64 %), while (36 %) showed b2a2 transcript. No patients coexpressed b3a2/b2a2. Correlation between biological data demonstrated that: (a) M-BCR rearrangements were not associated with the sex of the patients. (b) Patients with b3a2 rearrangements were older than patients with b2a2 transcripts. (c) M-BCR rearrangements were influenced neither by the white blood count (WBC) nor with hemoglobin levels. However, platelet level is more elevated in patients with b3a2 transcript (681.2/L vs. 207/L; P = 0.001). In conclusion, we observed significant correlations between age, platelet level and M-BCR-ABL transcript, these observations deserve further investigations.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s12032-012-0348-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094524", 
        "issn": [
          "1357-0560", 
          "1559-131X"
        ], 
        "name": "Medical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "30"
      }
    ], 
    "name": "Analysis of the clinico-hematological relevance of the breakpoint location within M-BCR in chronic myeloid leukemia", 
    "pagination": "348", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7de662f91d255d911512c5ab40ed170db8c814384f943478831758a2c82a5962"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23269583"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9435512"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s12032-012-0348-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026427487"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s12032-012-0348-z", 
      "https://app.dimensions.ai/details/publication/pub.1026427487"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000522.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs12032-012-0348-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s12032-012-0348-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s12032-012-0348-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s12032-012-0348-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s12032-012-0348-z'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      21 PREDICATES      91 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s12032-012-0348-z schema:about N00c37273d8f04d749c3d46de8034d3d3
2 N1f430c648e404b23b15e0e0dccb192e1
3 N262e0a0f3f914b948a8be4862ec6d6b1
4 N3455a0fa271b4a75b9b30ea36e5a6ffe
5 N61057fc2cde24162963c434fe36f11a2
6 N68c643cc9c304ffe8fe573624fc61da2
7 N7527ce3cc3ba40779f7e8bfa4f989911
8 N775df8345dbf4e459bc8fa0478426230
9 Nd41ed094baee4757bad75c01c2cfd1d5
10 Nd740fd100ebb4edc9ce9846fe0b56cce
11 Nf3792ab7d1e04bc0b043d857abac9819
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author N6cbe35f2f66a490fb1734949ffb0cb14
15 schema:citation sg:pub.10.1007/s00277-009-0822-7
16 sg:pub.10.1038/243290a0
17 sg:pub.10.1038/sj.leu.2401592
18 https://app.dimensions.ai/details/publication/pub.1074701342
19 https://app.dimensions.ai/details/publication/pub.1074725983
20 https://app.dimensions.ai/details/publication/pub.1075059644
21 https://app.dimensions.ai/details/publication/pub.1077133620
22 https://app.dimensions.ai/details/publication/pub.1077188800
23 https://app.dimensions.ai/details/publication/pub.1077401174
24 https://app.dimensions.ai/details/publication/pub.1077745681
25 https://app.dimensions.ai/details/publication/pub.1078684723
26 https://app.dimensions.ai/details/publication/pub.1078747136
27 https://app.dimensions.ai/details/publication/pub.1078792352
28 https://app.dimensions.ai/details/publication/pub.1079286588
29 https://app.dimensions.ai/details/publication/pub.1079518676
30 https://app.dimensions.ai/details/publication/pub.1079593459
31 https://app.dimensions.ai/details/publication/pub.1082428034
32 https://app.dimensions.ai/details/publication/pub.1082428039
33 https://app.dimensions.ai/details/publication/pub.1082907725
34 https://app.dimensions.ai/details/publication/pub.1082972090
35 https://app.dimensions.ai/details/publication/pub.1082972092
36 https://app.dimensions.ai/details/publication/pub.1083157854
37 https://app.dimensions.ai/details/publication/pub.1083379000
38 https://doi.org/08113/aim.003
39 https://doi.org/10.1002/1097-0142(19950915)76:6<992::aid-cncr2820760612>3.0.co;2-l
40 https://doi.org/10.1002/ajh.20682
41 https://doi.org/10.1002/cncr.10490
42 https://doi.org/10.1002/gcc.2870010211
43 https://doi.org/10.1016/0092-8674(84)90077-1
44 https://doi.org/10.1016/0145-2126(92)90039-a
45 https://doi.org/10.1016/j.trsl.2006.07.002
46 https://doi.org/10.1016/s0165-4608(01)00515-5
47 https://doi.org/10.1016/s0959-8049(00)00128-3
48 https://doi.org/10.1046/j.1365-2141.2000.02042.x
49 https://doi.org/10.1046/j.1365-2141.2000.02216.x
50 https://doi.org/10.1046/j.1365-2257.2002.00413.x
51 https://doi.org/10.1111/j.1365-2141.1990.tb02534.x
52 https://doi.org/10.1111/j.1365-2141.1993.tb03062.x
53 https://doi.org/10.1111/j.1365-2141.1995.tb08362.x
54 https://doi.org/10.1111/j.1365-2141.2000.02216.x
55 https://doi.org/10.1111/j.1365-2141.2004.05100.x
56 https://doi.org/10.1111/j.1365-2141.2004.05119.x
57 https://doi.org/10.1111/j.1600-0609.2008.01170.x
58 https://doi.org/10.1136/jcp.2010.078311
59 https://doi.org/10.1182/blood-2008-03-144790
60 https://doi.org/10.1182/blood.v98.7.2039
61 https://doi.org/10.1590/s1415-47572007000400003
62 https://doi.org/10.1590/s1415-47572010005000037
63 https://doi.org/10.2144/97233rr01
64 https://doi.org/10.3109/10428199209067600
65 https://doi.org/10.3324/haematol.2009.009134
66 schema:datePublished 2013-03
67 schema:datePublishedReg 2013-03-01
68 schema:description The Philadelphia chromosome (Ph) derives from the balanced translocation between chromosomes 9 and 22. This chromosomal translocation results in the fusion between the 5' part of the BCR gene, normally located on chromosome 22, and the 3' part of the ABL gene on chromosome 9 giving origin to a BCR-ABL fusion gene which is transcribed and then translated into a hybrid protein. In general, three breakpoint cluster regions in the BCR gene have been described: major (M-BCR), minor (m-BCR) and micro (μ-BCR). Three main variants of the BCR-ABL gene have been described depending on the length of the sequence of the BCR gene included that encode for the P190, P210, P230 proteins. Most patients (95 %) were found to have P210 protein that resulted from rearrangement in the M-BCR region in the BCR gene and thus gives rise to b2a2 or b3a2 variants. The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. These two variants are associated with distinct clinical types of human leukemias. In this study, we report the frequencies of M-BCR-ABL fusion transcripts in 44 CML patients and we review the data on the correlations between the type of M-BCR/ABL variant and the corresponding sex, age and biological features. Forty-four untreated chronic phase CML patients were studied. The type of BCR-ABL fusion transcripts was determined by reverse transcriptase polymerase chain reaction (RT-PCR). More than half of them showed b3a2 fusion transcript (64 %), while (36 %) showed b2a2 transcript. No patients coexpressed b3a2/b2a2. Correlation between biological data demonstrated that: (a) M-BCR rearrangements were not associated with the sex of the patients. (b) Patients with b3a2 rearrangements were older than patients with b2a2 transcripts. (c) M-BCR rearrangements were influenced neither by the white blood count (WBC) nor with hemoglobin levels. However, platelet level is more elevated in patients with b3a2 transcript (681.2/L vs. 207/L; P = 0.001). In conclusion, we observed significant correlations between age, platelet level and M-BCR-ABL transcript, these observations deserve further investigations.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree false
72 schema:isPartOf N822e4cc9a3724f07b5ff4e4dee242b48
73 Nc8c0538f98ad4a7c91fa1ee470ba2425
74 sg:journal.1094524
75 schema:name Analysis of the clinico-hematological relevance of the breakpoint location within M-BCR in chronic myeloid leukemia
76 schema:pagination 348
77 schema:productId N357f7fcc501d40d78765c4e8d17b594f
78 N6ec8979751f64ebba6cbcee578e62223
79 N8cb26dd8f2884b1c9dfd403c5c0eb6b1
80 Nb0a371ef9dff4eaea16a3fb85d1e57ff
81 Ne3dc7c8abb0446219b59d06c12b85e98
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026427487
83 https://doi.org/10.1007/s12032-012-0348-z
84 schema:sdDatePublished 2019-04-10T18:22
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N5c1dbf2192f84e4f9700c20447672a3a
87 schema:url http://link.springer.com/10.1007%2Fs12032-012-0348-z
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N00c37273d8f04d749c3d46de8034d3d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Male
93 rdf:type schema:DefinedTerm
94 N0a14b6819b6c4bc8bbe057800273d194 rdf:first sg:person.01233270736.60
95 rdf:rest Nf2957f769ae04f3f8130538ad1368e03
96 N1f430c648e404b23b15e0e0dccb192e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Genes, abl
98 rdf:type schema:DefinedTerm
99 N262e0a0f3f914b948a8be4862ec6d6b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Adult
101 rdf:type schema:DefinedTerm
102 N3455a0fa271b4a75b9b30ea36e5a6ffe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Leukemia, Myelogenous, Chronic, BCR-ABL Positive
104 rdf:type schema:DefinedTerm
105 N357f7fcc501d40d78765c4e8d17b594f schema:name pubmed_id
106 schema:value 23269583
107 rdf:type schema:PropertyValue
108 N3ff97b6f1b5449c9bbfa284a293beb02 rdf:first sg:person.01274406726.48
109 rdf:rest N0a14b6819b6c4bc8bbe057800273d194
110 N5c1dbf2192f84e4f9700c20447672a3a schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 N61057fc2cde24162963c434fe36f11a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Middle Aged
114 rdf:type schema:DefinedTerm
115 N66d73a4af051461cb644b27cf01dd866 rdf:first sg:person.01036432013.39
116 rdf:rest Ncf6baf28cad742819323ff946a6e4482
117 N68c643cc9c304ffe8fe573624fc61da2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Multiplex Polymerase Chain Reaction
119 rdf:type schema:DefinedTerm
120 N6cbe35f2f66a490fb1734949ffb0cb14 rdf:first sg:person.01047022623.76
121 rdf:rest N66d73a4af051461cb644b27cf01dd866
122 N6ec8979751f64ebba6cbcee578e62223 schema:name nlm_unique_id
123 schema:value 9435512
124 rdf:type schema:PropertyValue
125 N7527ce3cc3ba40779f7e8bfa4f989911 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N775df8345dbf4e459bc8fa0478426230 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Fusion Proteins, bcr-abl
130 rdf:type schema:DefinedTerm
131 N822e4cc9a3724f07b5ff4e4dee242b48 schema:volumeNumber 30
132 rdf:type schema:PublicationVolume
133 N8cb26dd8f2884b1c9dfd403c5c0eb6b1 schema:name readcube_id
134 schema:value 7de662f91d255d911512c5ab40ed170db8c814384f943478831758a2c82a5962
135 rdf:type schema:PropertyValue
136 Nad20d04650a244ce8c36164287fe587a rdf:first sg:person.0725754374.91
137 rdf:rest rdf:nil
138 Nb0a371ef9dff4eaea16a3fb85d1e57ff schema:name doi
139 schema:value 10.1007/s12032-012-0348-z
140 rdf:type schema:PropertyValue
141 Nc8c0538f98ad4a7c91fa1ee470ba2425 schema:issueNumber 1
142 rdf:type schema:PublicationIssue
143 Ncf6baf28cad742819323ff946a6e4482 rdf:first sg:person.012650461005.19
144 rdf:rest N3ff97b6f1b5449c9bbfa284a293beb02
145 Nd41ed094baee4757bad75c01c2cfd1d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Chromosome Breakpoints
147 rdf:type schema:DefinedTerm
148 Nd740fd100ebb4edc9ce9846fe0b56cce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Reverse Transcriptase Polymerase Chain Reaction
150 rdf:type schema:DefinedTerm
151 Ndff783b61e314f149f8c197436f36c2f rdf:first sg:person.0725660411.47
152 rdf:rest Nad20d04650a244ce8c36164287fe587a
153 Ne3dc7c8abb0446219b59d06c12b85e98 schema:name dimensions_id
154 schema:value pub.1026427487
155 rdf:type schema:PropertyValue
156 Nf2957f769ae04f3f8130538ad1368e03 rdf:first sg:person.01220773613.78
157 rdf:rest Ndff783b61e314f149f8c197436f36c2f
158 Nf3792ab7d1e04bc0b043d857abac9819 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Female
160 rdf:type schema:DefinedTerm
161 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
162 schema:name Biological Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
165 schema:name Genetics
166 rdf:type schema:DefinedTerm
167 sg:journal.1094524 schema:issn 1357-0560
168 1559-131X
169 schema:name Medical Oncology
170 rdf:type schema:Periodical
171 sg:person.01036432013.39 schema:affiliation https://www.grid.ac/institutes/grid.412791.8
172 schema:familyName Ouahchi
173 schema:givenName Ines
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036432013.39
175 rdf:type schema:Person
176 sg:person.01047022623.76 schema:affiliation https://www.grid.ac/institutes/grid.412791.8
177 schema:familyName Bennour
178 schema:givenName Ayda
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047022623.76
180 rdf:type schema:Person
181 sg:person.01220773613.78 schema:affiliation https://www.grid.ac/institutes/grid.412791.8
182 schema:familyName Khelif
183 schema:givenName Abderrahim
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220773613.78
185 rdf:type schema:Person
186 sg:person.01233270736.60 schema:affiliation https://www.grid.ac/institutes/grid.412791.8
187 schema:familyName Youssef
188 schema:givenName Yosra Ben
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233270736.60
190 rdf:type schema:Person
191 sg:person.012650461005.19 schema:affiliation https://www.grid.ac/institutes/grid.412791.8
192 schema:familyName Achour
193 schema:givenName Bechir
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012650461005.19
195 rdf:type schema:Person
196 sg:person.01274406726.48 schema:affiliation https://www.grid.ac/institutes/grid.412791.8
197 schema:familyName Zaier
198 schema:givenName Monia
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274406726.48
200 rdf:type schema:Person
201 sg:person.0725660411.47 schema:affiliation https://www.grid.ac/institutes/grid.412791.8
202 schema:familyName Saad
203 schema:givenName Ali
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725660411.47
205 rdf:type schema:Person
206 sg:person.0725754374.91 schema:affiliation https://www.grid.ac/institutes/grid.412791.8
207 schema:familyName Sennana
208 schema:givenName Halima
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725754374.91
210 rdf:type schema:Person
211 sg:pub.10.1007/s00277-009-0822-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042485915
212 https://doi.org/10.1007/s00277-009-0822-7
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/243290a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012018569
215 https://doi.org/10.1038/243290a0
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/sj.leu.2401592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034947020
218 https://doi.org/10.1038/sj.leu.2401592
219 rdf:type schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1074701342 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1074725983 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1075059644 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1077133620 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1077188800 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1077401174 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1077745681 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1078684723 schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1078747136 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1078792352 schema:CreativeWork
230 https://app.dimensions.ai/details/publication/pub.1079286588 schema:CreativeWork
231 https://app.dimensions.ai/details/publication/pub.1079518676 schema:CreativeWork
232 https://app.dimensions.ai/details/publication/pub.1079593459 schema:CreativeWork
233 https://app.dimensions.ai/details/publication/pub.1082428034 schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1082428039 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1082907725 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1082972090 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1082972092 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1083157854 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1083379000 schema:CreativeWork
240 https://doi.org/08113/aim.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077637832
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1002/1097-0142(19950915)76:6<992::aid-cncr2820760612>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1031642677
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/ajh.20682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020857079
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/cncr.10490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038860727
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/gcc.2870010211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024774830
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/0092-8674(84)90077-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010898991
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/0145-2126(92)90039-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1015074520
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.trsl.2006.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003991995
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/s0165-4608(01)00515-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013369179
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s0959-8049(00)00128-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003977228
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1046/j.1365-2141.2000.02042.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021792984
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1046/j.1365-2141.2000.02216.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056733263
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1046/j.1365-2257.2002.00413.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025889145
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1111/j.1365-2141.1990.tb02534.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037476101
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/j.1365-2141.1993.tb03062.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000608333
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1111/j.1365-2141.1995.tb08362.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012508898
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1111/j.1365-2141.2000.02216.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035348270
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1111/j.1365-2141.2004.05100.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009900129
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1111/j.1365-2141.2004.05119.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026328203
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1111/j.1600-0609.2008.01170.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043104620
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1136/jcp.2010.078311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022547207
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1182/blood-2008-03-144790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005910896
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1182/blood.v98.7.2039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017936206
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1590/s1415-47572007000400003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041139564
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1590/s1415-47572010005000037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026442663
289 rdf:type schema:CreativeWork
290 https://doi.org/10.2144/97233rr01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083147709
291 rdf:type schema:CreativeWork
292 https://doi.org/10.3109/10428199209067600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023149540
293 rdf:type schema:CreativeWork
294 https://doi.org/10.3324/haematol.2009.009134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010770814
295 rdf:type schema:CreativeWork
296 https://www.grid.ac/institutes/grid.412791.8 schema:alternateName Hôpital Farhat Hached
297 schema:name Department of Clinical Hematology, Farhat Hached University Teaching Hospital, Sousse, Tunisia
298 Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...